ES8304095A1 - Un procedimiento para la preparacion de derivados de quinazolina. - Google Patents

Un procedimiento para la preparacion de derivados de quinazolina.

Info

Publication number
ES8304095A1
ES8304095A1 ES509434A ES509434A ES8304095A1 ES 8304095 A1 ES8304095 A1 ES 8304095A1 ES 509434 A ES509434 A ES 509434A ES 509434 A ES509434 A ES 509434A ES 8304095 A1 ES8304095 A1 ES 8304095A1
Authority
ES
Spain
Prior art keywords
tumor
quinazoline compounds
quinazoline
oxiranylmethoxy
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509434A
Other languages
English (en)
Other versions
ES509434A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES509434A0 publication Critical patent/ES509434A0/es
Publication of ES8304095A1 publication Critical patent/ES8304095A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINAZOLINA, DE FORMULA (I), EN LA QUE UNO DE R Y R ES OXIRANILMETILO Y EL OTRO ES METILO U OXIRANILMETILO; Y R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y UNO DE R<A Y R<B ES HIDROGENO Y EL OTRO ES HIDROGENO O METILO, CON HEPICLORHIDRINA O HEPIBROMHIDRINA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA PROXIMA A LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES509434A 1981-03-06 1982-02-08 Un procedimiento para la preparacion de derivados de quinazolina. Expired ES8304095A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (2)

Publication Number Publication Date
ES509434A0 ES509434A0 (es) 1983-02-16
ES8304095A1 true ES8304095A1 (es) 1983-02-16

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509434A Expired ES8304095A1 (es) 1981-03-06 1982-02-08 Un procedimiento para la preparacion de derivados de quinazolina.

Country Status (31)

Country Link
US (1) US4343940A (es)
JP (1) JPS57158780A (es)
KR (1) KR880001852B1 (es)
AR (1) AR231138A1 (es)
AT (1) AT380476B (es)
AU (1) AU556099B2 (es)
BE (1) BE891936A (es)
CA (1) CA1163995A (es)
CH (1) CH647776A5 (es)
CY (1) CY1371A (es)
DE (1) DE3203770C2 (es)
DK (1) DK159442C (es)
ES (1) ES8304095A1 (es)
FI (1) FI71559C (es)
FR (1) FR2501207B1 (es)
GB (1) GB2094295B (es)
GR (1) GR75903B (es)
HK (1) HK4588A (es)
HU (1) HU189997B (es)
IE (1) IE52385B1 (es)
IL (1) IL64875A0 (es)
IT (1) IT1154272B (es)
KE (1) KE3715A (es)
LU (1) LU83903A1 (es)
NL (1) NL8200473A (es)
NZ (1) NZ199576A (es)
PH (1) PH18529A (es)
PT (1) PT74394B (es)
SE (1) SE461732B (es)
SG (1) SG30787G (es)
YU (1) YU42031B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US6645969B1 (en) * 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (es) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
EP0832073B1 (en) * 1995-06-07 2002-01-16 Sugen, Inc. Quinazolines and pharmaceutical compositions
WO1997017329A1 (fr) * 1995-11-07 1997-05-15 Kirin Beer Kabushiki Kaisha Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE69729954T2 (de) * 1996-12-11 2005-09-08 Sugen, Inc., San Francisco Identifizierungsverfahren für Substanzen die an das Pyk2 Polypeptid binden
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
CA2318403A1 (en) * 1998-01-21 1999-07-29 Sugen, Inc. Human orthologues of wart
ATE302269T1 (de) 1998-04-14 2005-09-15 Sugen Inc Ste20-verwandte proteinkinasen
IL139641A0 (en) 1998-05-28 2002-02-10 Parker Hughes Inst Quinazolines for treating brain tumor
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
JP2002523403A (ja) * 1998-08-21 2002-07-30 パーカー ヒューズ インスティテュート キナゾリン誘導体
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
AU783082B2 (en) * 1999-10-22 2005-09-22 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
UA72946C2 (uk) 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
EP1265925A2 (en) * 2000-02-23 2002-12-18 PHARMACIA &amp; UPJOHN COMPANY G protein-coupled receptors
NZ521421A (en) * 2000-04-07 2004-09-24 Astrazeneca Ab Quinazoline compounds
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
KR101036866B1 (ko) 2002-08-02 2011-05-25 에이비 사이언스 2-(3-아미노아릴)아미노-4-아릴-티아졸 및 ｃ-ｋｉｔ억제제로서의 이의 용도
ATE465731T1 (de) * 2003-10-23 2010-05-15 Ab Science 2-aminoaryloxazol-verbindungen als tyrosinkinase- hemmer
JP5204643B2 (ja) 2005-04-04 2013-06-05 アブ サイエンス 置換オキサゾール誘導体、およびチロシンキナーゼ阻害薬としてのそれらの使用
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
JP2010505811A (ja) 2006-10-04 2010-02-25 ファイザー・プロダクツ・インク カルシウム受容体アンタゴニストとしてのピリド［４，３−ｄ］ピリミジン−４（３Ｈ）−オン誘導体
EP2088863A2 (en) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
JP2010511382A (ja) * 2006-12-01 2010-04-15 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 癌関連タンパク質キナーゼ
AU2012225693A1 (en) 2011-03-04 2013-09-19 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
AU438472B2 (en) * 1970-12-23 1973-08-09 Sumitomo Chemical Company, Limited Quinazolinone derivatives anda process for production thereof
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法

Also Published As

Publication number Publication date
HU189997B (en) 1986-08-28
NZ199576A (en) 1986-05-09
LU83903A1 (fr) 1982-09-13
IT1154272B (it) 1987-01-21
KE3715A (en) 1987-04-16
GB2094295B (en) 1984-09-12
PT74394A (en) 1982-03-01
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
KR830009050A (ko) 1983-12-17
DK50482A (da) 1982-09-07
JPS57158780A (en) 1982-09-30
FR2501207A1 (fr) 1982-09-10
FR2501207B1 (fr) 1985-12-06
GR75903B (es) 1984-08-02
AU556099B2 (en) 1986-10-23
BE891936A (fr) 1982-07-28
DK159442B (da) 1990-10-15
YU42031B (en) 1988-04-30
KR880001852B1 (ko) 1988-09-22
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06
DE3203770C2 (de) 1993-11-04
GB2094295A (en) 1982-09-15
FI71559C (fi) 1987-01-19
CA1163995A (en) 1984-03-20
NL8200473A (nl) 1982-10-01
CH647776A5 (de) 1985-02-15
AT380476B (de) 1986-05-26
DE3203770A1 (de) 1982-11-11
IL64875A0 (en) 1982-03-31
ATA39582A (de) 1985-10-15
DK159442C (da) 1991-03-18
IT8247713A0 (it) 1982-02-03
FI71559B (fi) 1986-10-10
AU7998182A (en) 1982-09-09
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
CY1371A (en) 1987-08-07
ES509434A0 (es) 1983-02-16
HK4588A (en) 1988-01-29
PH18529A (en) 1985-08-02
JPH0337552B2 (es) 1991-06-05
IE52385B1 (en) 1987-10-14
AR231138A1 (es) 1984-09-28
SE461732B (sv) 1990-03-19
PT74394B (en) 1984-10-22

Similar Documents

Publication Publication Date Title
ES8304095A1 (es) Un procedimiento para la preparacion de derivados de quinazolina.
GB2111336B (en) Substrate biassing
NL970024I1 (nl) Anti-tumor middelen.
FI863160A (fi) Anlaeggning foer fiskodling i havsvatten.
NO811226L (no) Sementholdig blanding.
DE3888197D1 (de) Gamma-interferon-formulierung.
JPS57204385A (en) Snapper
GB2110850B (en) Radiopaging arrangements
EP0083660A4 (en) DEVICE FOR POSITIONING A CROSS TABLE.
FI841649A (fi) Biologiskt aktiva polypeptider.
GB2098859B (en) Treatment chair
JPS5718612A (en) Biologically active mixture
GB2094139B (en) Chairs
DE3380759D1 (en) Distributed amplifier
FR2505107B1 (fr) Pupitre de diffusion
JPS57175309A (en) Chair
CA47793S (en) Chair
CA48508S (en) Chair
CA48144S (en) Chair
CA47990S (en) Chair
CA48104S (en) Chair
CA48514S (en) Chair
CA47855S (en) Chair
CA49117S (en) Chair
CA48882S (en) Chair

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519