ES8204715A1 - Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos - Google Patents
Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicosInfo
- Publication number
- ES8204715A1 ES8204715A1 ES503019A ES503019A ES8204715A1 ES 8204715 A1 ES8204715 A1 ES 8204715A1 ES 503019 A ES503019 A ES 503019A ES 503019 A ES503019 A ES 503019A ES 8204715 A1 ES8204715 A1 ES 8204715A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- amino
- trifluoromethyl
- halogen
- phenylacetamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENNTO DE OBTENCION DE 2-AMINO-3-BENZOIL-FENILAMETAMIDAS Y HOMOLOGOS CICLICOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I) CON UN COMPUESTO NAS-ALCOHOLICO INFERIOR. SE OBTIENE EL COMPUESTO (II), SIENDO R HIDROGENO O ALCOHILO INFERIOR; R1 Y R2 SON HIDROGENO, ALCOHILO INFERIOR, CICLO ALCOHILO, FENILO O FENILO SUSTITUIDO, ALCOXI INFERIOR, HALOGENO, NITRO Y TRIFLUROAMETILO; X ES HIDROGENO ALCOHILO INFERIOR, ALCOXI INFERIOR, HALOGENO O TRIFLUOROMETILO; Y ES ALCOHILTIO INFERIOR; AM ES AMINA PRIMARIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7886079A | 1979-09-26 | 1979-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES503019A0 ES503019A0 (es) | 1982-05-01 |
| ES8204715A1 true ES8204715A1 (es) | 1982-05-01 |
Family
ID=22146633
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495329A Expired ES8200329A1 (es) | 1979-09-26 | 1980-09-25 | Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos |
| ES503019A Expired ES8204715A1 (es) | 1979-09-26 | 1981-06-12 | Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495329A Expired ES8200329A1 (es) | 1979-09-26 | 1980-09-25 | Un procedimiento para preparar 2-amino-3-benzoil-fenilaceta-midas y homologos ciclicos |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5657751A (es) |
| KR (1) | KR840000763B1 (es) |
| AT (1) | AT374170B (es) |
| AU (1) | AU532359B2 (es) |
| BE (1) | BE885393A (es) |
| BR (1) | BR8006042A (es) |
| CA (1) | CA1128512A (es) |
| CH (1) | CH646138A5 (es) |
| CS (1) | CS227012B2 (es) |
| DE (1) | DE3035688A1 (es) |
| DK (1) | DK154136C (es) |
| EG (1) | EG15020A (es) |
| ES (2) | ES8200329A1 (es) |
| FI (1) | FI72967C (es) |
| FR (1) | FR2465710A1 (es) |
| GB (1) | GB2059963B (es) |
| GR (1) | GR70049B (es) |
| HK (1) | HK59383A (es) |
| HU (1) | HU183215B (es) |
| IE (1) | IE50268B1 (es) |
| IL (1) | IL60999A (es) |
| IN (3) | IN151313B (es) |
| IT (1) | IT1133823B (es) |
| KE (1) | KE3307A (es) |
| LU (1) | LU82797A1 (es) |
| MX (1) | MX7159E (es) |
| NL (1) | NL8005346A (es) |
| NO (1) | NO152128C (es) |
| NZ (1) | NZ195061A (es) |
| PH (1) | PH22628A (es) |
| PL (1) | PL128998B1 (es) |
| PT (1) | PT71839B (es) |
| SE (1) | SE448626B (es) |
| SG (1) | SG42983G (es) |
| YU (3) | YU41734B (es) |
| ZA (1) | ZA805476B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| GB9727523D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| MXPA04002009A (es) | 2001-09-03 | 2004-07-08 | Newron Pharm Spa | Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| CZ2009367A3 (cs) * | 2009-06-08 | 2010-06-16 | Farmak, A.S. | Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu |
| CN112794809B (zh) * | 2019-11-14 | 2023-12-29 | 南京济群医药科技股份有限公司 | 一种高纯度奈帕芬胺中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (es) * | 1967-07-31 | 1971-03-24 | ||
| SE400966B (sv) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
-
1980
- 1980-09-04 ZA ZA00805476A patent/ZA805476B/xx unknown
- 1980-09-08 AU AU62116/80A patent/AU532359B2/en not_active Ceased
- 1980-09-08 IL IL60999A patent/IL60999A/xx unknown
- 1980-09-11 CS CS806196A patent/CS227012B2/cs unknown
- 1980-09-17 IE IE1946/80A patent/IE50268B1/en unknown
- 1980-09-20 EG EG80573A patent/EG15020A/xx active
- 1980-09-22 GR GR62936A patent/GR70049B/el unknown
- 1980-09-22 BR BR8006042A patent/BR8006042A/pt unknown
- 1980-09-22 DE DE19803035688 patent/DE3035688A1/de active Granted
- 1980-09-23 AT AT0474580A patent/AT374170B/de not_active IP Right Cessation
- 1980-09-23 PH PH24613A patent/PH22628A/en unknown
- 1980-09-24 LU LU82797A patent/LU82797A1/fr unknown
- 1980-09-24 FI FI803002A patent/FI72967C/fi not_active IP Right Cessation
- 1980-09-24 SE SE8006668A patent/SE448626B/sv not_active IP Right Cessation
- 1980-09-25 PL PL1980226919A patent/PL128998B1/pl unknown
- 1980-09-25 HU HU802347A patent/HU183215B/hu not_active IP Right Cessation
- 1980-09-25 NO NO802834A patent/NO152128C/no unknown
- 1980-09-25 KR KR1019800003740A patent/KR840000763B1/ko active
- 1980-09-25 YU YU2450/80A patent/YU41734B/xx unknown
- 1980-09-25 CH CH719180A patent/CH646138A5/fr not_active IP Right Cessation
- 1980-09-25 FR FR8020596A patent/FR2465710A1/fr active Granted
- 1980-09-25 GB GB8030955A patent/GB2059963B/en not_active Expired
- 1980-09-25 NL NL8005346A patent/NL8005346A/nl not_active Application Discontinuation
- 1980-09-25 MX MX809050U patent/MX7159E/es unknown
- 1980-09-25 PT PT71839A patent/PT71839B/pt unknown
- 1980-09-25 DK DK405780A patent/DK154136C/da not_active IP Right Cessation
- 1980-09-25 ES ES495329A patent/ES8200329A1/es not_active Expired
- 1980-09-25 BE BE0/202226A patent/BE885393A/fr not_active IP Right Cessation
- 1980-09-25 CA CA361,068A patent/CA1128512A/en not_active Expired
- 1980-09-26 NZ NZ195061A patent/NZ195061A/en unknown
- 1980-09-26 IT IT24948/80A patent/IT1133823B/it active
- 1980-09-26 JP JP13415280A patent/JPS5657751A/ja active Granted
- 1980-09-26 IN IN1092/CAL/80A patent/IN151313B/en unknown
-
1981
- 1981-06-12 ES ES503019A patent/ES8204715A1/es not_active Expired
-
1982
- 1982-12-30 IN IN1509/CAL/82A patent/IN156255B/en unknown
- 1982-12-30 IN IN1508/CAL/82A patent/IN156254B/en unknown
-
1983
- 1983-03-28 YU YU731/83A patent/YU43306B/xx unknown
- 1983-03-28 YU YU730/83A patent/YU43305B/xx unknown
- 1983-07-19 SG SG42983A patent/SG42983G/en unknown
- 1983-07-21 KE KE3307A patent/KE3307A/xx unknown
- 1983-11-24 HK HK593/83A patent/HK59383A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |