ES8101596A1 - Metodo para producir compuestos de beta-lactama - Google Patents

Metodo para producir compuestos de beta-lactama

Info

Publication number
ES8101596A1
ES8101596A1 ES488494A ES488494A ES8101596A1 ES 8101596 A1 ES8101596 A1 ES 8101596A1 ES 488494 A ES488494 A ES 488494A ES 488494 A ES488494 A ES 488494A ES 8101596 A1 ES8101596 A1 ES 8101596A1
Authority
ES
Spain
Prior art keywords
beta
carboxy group
stands
lactams
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488494A
Other languages
English (en)
Other versions
ES488494A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27449109&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8101596(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Publication of ES8101596A1 publication Critical patent/ES8101596A1/es
Publication of ES488494A0 publication Critical patent/ES488494A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE COMPUESTOS DE BETA-LACTAMA. CONSISTE EN EFECTUAR ALGUNA DE LAS SIGUIENTES ETAPAS: 1) HIDROGENOLISIS O HIDROLISIS CATALITICA DE UN COMPUESTO DE FORMULA GENERAL (I). 2) REACCION DE UN ESTER DE ACIDO 6-AMINOPENICILAMICO O UN DERIVADO DE TRIALQUILSILILO (II) CON UN DERIVADO REACTIVO DE UN ACIDO DE FORMULA. *FORMULA* 3) REACCION DE UN AMINOPENICILINA CON UN COMPUESTO DE FORMULA. *FORMULA* SE OBTIENE UN COMPUESTO DE FORMULA GENERAL (III) QUE SE RECUPERA EN FORMA DE SAL, EN LA DE DIASTOMEROS PUROS O MEZCLAS DE LOS MISMOS. TRATAMIETNO DE INFECCIONES BACTERIANAS. *FORMULA*
ES488494A 1979-02-13 1980-02-12 Metodo para producir compuestos de beta-lactama Granted ES488494A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB7905020 1979-02-13
GB7921341 1979-06-19
GB7927761 1979-08-09
GB7939473 1979-11-14

Publications (2)

Publication Number Publication Date
ES8101596A1 true ES8101596A1 (es) 1980-12-16
ES488494A0 ES488494A0 (es) 1980-12-16

Family

ID=27449109

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488494A Granted ES488494A0 (es) 1979-02-13 1980-02-12 Metodo para producir compuestos de beta-lactama

Country Status (33)

Country Link
US (2) US4840944A (es)
AR (1) AR230286A1 (es)
AT (1) AT368507B (es)
AU (1) AU532531B2 (es)
CA (1) CA1230113A (es)
CH (2) CH646436A5 (es)
CS (1) CS234015B2 (es)
CY (1) CY1205A (es)
DD (1) DD149529A5 (es)
DE (2) DE3005164C2 (es)
DK (1) DK160943C (es)
ES (1) ES488494A0 (es)
FI (2) FI73220C (es)
FR (1) FR2449089A1 (es)
GB (2) GB2044255B (es)
GR (1) GR74091B (es)
HK (1) HK5684A (es)
HU (1) HU182604B (es)
IE (2) IE49880B1 (es)
IL (1) IL59203A (es)
IT (1) IT1147306B (es)
KE (1) KE3309A (es)
LU (1) LU82164A1 (es)
MA (1) MA18731A1 (es)
MY (1) MY8500006A (es)
NL (1) NL8000775A (es)
NZ (1) NZ192762A (es)
PH (1) PH16326A (es)
PL (1) PL125079B1 (es)
PT (1) PT70805A (es)
SE (2) SE446186B (es)
SG (1) SG43783G (es)
YU (1) YU42659B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
ZA81306B (en) * 1980-01-21 1982-02-24 Bristol Myers Co Chemical compounds
US4340539A (en) 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE51516B1 (en) * 1980-10-06 1987-01-07 Leo Pharm Prod Ltd 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
IL64009A (en) * 1980-10-31 1984-09-30 Rech Applications Therap Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4380512A (en) * 1980-12-11 1983-04-19 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone and salts and esters thereof
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
IN159362B (es) * 1981-03-23 1987-05-09 Pfizer
IN157669B (es) * 1981-03-23 1986-05-17 Pfizer
US4376076A (en) 1981-03-23 1983-03-08 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
US4321196A (en) 1981-03-23 1982-03-23 Pfizer Inc. Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide
US4419284A (en) 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4393001A (en) 1981-03-23 1983-07-12 Pfizer Inc. Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
US4582829A (en) * 1981-09-09 1986-04-15 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4540687A (en) * 1981-09-09 1985-09-10 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
PL136237B1 (en) * 1981-09-09 1986-02-28 Pfizer Inc Process for preparing novel derivatives of 6'-/2-amino-/4-acyloxyphenyl/acetamido/-penicillanoyloxymethyl penicillanate 1,1-dioxide
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4457924A (en) * 1981-12-22 1984-07-03 Pfizer, Inc. 1,1-Alkanediol dicarboxylate linked antibacterial agents
US4359472A (en) 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0084730A1 (en) * 1982-01-22 1983-08-03 Beecham Group Plc Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
US4444686A (en) * 1982-01-25 1984-04-24 Pfizer Inc. Crystalline penicillin ester intermediate
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
EP0126090A1 (en) * 1982-10-26 1984-11-28 Beecham Group Plc Beta-lactam compounds, preparation and use
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
IL67637A0 (en) * 1983-01-07 1983-05-15 Orvet Bv Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates
US4868297A (en) * 1982-12-06 1989-09-19 Pfizer Inc. Process for preparing sultamicillin and analogs
US4462934A (en) 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
KR910009271B1 (ko) * 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
WO1991016326A1 (en) * 1990-04-13 1991-10-31 Pfizer Inc. Process for sultamicillin intermediate
ES2161602B1 (es) * 1999-04-08 2003-02-16 Asturpharma S A Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor
TR201922977A2 (tr) * 2019-12-31 2021-07-26 T C Erciyes Ueniversitesi Penisilin türevleri ve bunların sentezlenmesi için yöntem
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303491A (es) * 1970-03-24 1973-01-17
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
US3838152A (en) * 1971-10-07 1974-09-24 American Home Prod Poly alpha-amino penicillins
GB1467604A (en) * 1974-06-27 1977-03-16 Toyama Chemical Co Ltd Bis-type penicillins and process for producing the same
GB1573614A (en) * 1976-02-25 1980-08-28 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl cephalosporanates
GB1578128A (en) * 1976-03-30 1980-11-05 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl amoxycillinates
GB1579931A (en) * 1976-04-15 1980-11-26 Leo Pharm Prod Ltd Bis-penicillanoyl-oxy-alkanes
IN149747B (es) * 1977-06-07 1982-04-03 Pfizer
US4197240A (en) * 1977-12-23 1980-04-08 Yeda Research And Development Co. Ltd. Penicillin derivatives
US4244951A (en) 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
AT368507B (de) 1982-10-25
GB2108107A (en) 1983-05-11
MY8500006A (en) 1985-12-31
FI870555A (fi) 1987-02-11
IE832654L (en) 1980-08-13
DK160943C (da) 1991-10-21
FI73220C (fi) 1987-09-10
IT1147306B (it) 1986-11-19
FI76807C (fi) 1988-12-12
FI73220B (fi) 1987-05-29
IE49880B1 (en) 1986-01-08
GB2044255B (en) 1983-05-11
FR2449089A1 (fr) 1980-09-12
PT70805A (en) 1980-03-01
NZ192762A (en) 1984-10-19
DK59480A (da) 1980-08-14
DK160943B (da) 1991-05-06
SE461913B (sv) 1990-04-09
US4342772A (en) 1982-08-03
AU5546280A (en) 1980-08-21
FI76807B (fi) 1988-08-31
GR74091B (es) 1984-06-06
IL59203A (en) 1982-12-31
FI870555A0 (fi) 1987-02-11
PL221964A1 (es) 1980-12-01
PH16326A (en) 1983-09-05
LU82164A1 (fr) 1980-09-24
DD149529A5 (de) 1981-07-15
YU42659B (en) 1988-10-31
CH646436A5 (de) 1984-11-30
HU182604B (en) 1984-02-28
DE3005164A1 (de) 1980-08-21
CS234015B2 (en) 1985-03-14
SE8404462L (sv) 1984-09-05
SE446186B (sv) 1986-08-18
NL8000775A (nl) 1980-08-15
DE3050895C2 (es) 1989-05-03
IL59203A0 (en) 1980-05-30
AU532531B2 (en) 1983-10-06
IE49881B1 (en) 1986-01-08
FR2449089B1 (es) 1983-06-10
IT8019865A0 (it) 1980-02-12
ATA61580A (de) 1982-02-15
CY1205A (en) 1983-12-31
HK5684A (en) 1984-01-20
GB2044255A (en) 1980-10-15
US4840944A (en) 1989-06-20
CA1230113A (en) 1987-12-08
AR230286A1 (es) 1984-03-01
SE8404462D0 (sv) 1984-09-05
SG43783G (en) 1985-01-11
SE8001099L (sv) 1980-08-14
DE3005164C2 (de) 1986-06-26
PL125079B1 (en) 1983-03-31
YU24480A (en) 1983-04-30
CH645902A5 (de) 1984-10-31
FI800411A (fi) 1980-08-14
MA18731A1 (fr) 1980-10-01
KE3309A (en) 1983-08-19
GB2108107B (en) 1983-09-01
ES488494A0 (es) 1980-12-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001218