ES440831A1 - Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them - Google Patents

Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Info

Publication number
ES440831A1
ES440831A1 ES440831A ES440831A ES440831A1 ES 440831 A1 ES440831 A1 ES 440831A1 ES 440831 A ES440831 A ES 440831A ES 440831 A ES440831 A ES 440831A ES 440831 A1 ES440831 A1 ES 440831A1
Authority
ES
Spain
Prior art keywords
radical
lower alkoxy
alkoxy radical
formula
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440831A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES440831A1 publication Critical patent/ES440831A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/403—Saturated compounds containing a keto group being part of a ring of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/295—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with inorganic bases, e.g. by alkali fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Saccharide Compounds (AREA)

Abstract

A process for obtaining new benzylamino alkanoic acids from the compounds of general formula I **(See formula)** wherein R1 represents a lower alkoxy radical having 3 to 6 straight or branched chain carbon atoms, R2 and R4, simultaneously or distinctly, represent hydrogen, or a linear or branched lower alkoxy radical, R3 represents hydrogen, a halogen atom, a lower alkoxy radical or a trifluoromethyl radical, A and B, the same or different, represent hydrogen, a methyl radical or an ethyl radical, and n is an integer that varies from 4 to 10, salts of the compounds of formula I with a mineral or organic acid, as well as the salts of the compounds of formula I with a mineral or organic base, characterized by that an oxoalkanoic acid of general formula II is condensed **(See formula)** wherein R1 represents a lower alkoxy radical having 3 to 6 straight or branched chain carbon atoms, A and B, the same or different, represent hydrogen, a methyl radical or an ethyl radical, and n is an integer ranging from 4 to 10 with a benzylamine of general formula III **(See formula)** wherein R2 and R4 simultaneously or distinctly represent hydrogen or a linear or branched lower alkoxy radical, and R3 represents hydrogen, a halogen atom, a lower alkoxy radical or a trifluoromethyl radical, under reducing conditions, and the desired compound of the general formula I is isolated, which can, if necessary, be salified by adding a base or a mineral or organic acid, or cleaved into its optical isomers with the help of an optically active reagent. (Machine-translation by Google Translate, not legally binding)
ES440831A 1974-09-10 1975-09-09 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them Expired ES440831A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3944374A GB1472627A (en) 1974-09-10 1974-09-10 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES440831A1 true ES440831A1 (en) 1977-03-01

Family

ID=10409574

Family Applications (1)

Application Number Title Priority Date Filing Date
ES440831A Expired ES440831A1 (en) 1974-09-10 1975-09-09 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
JP (1) JPS5645905B2 (en)
BE (1) BE833238A (en)
CA (1) CA1063619A (en)
CH (1) CH608784A5 (en)
DE (1) DE2540334C2 (en)
DK (1) DK145080C (en)
ES (1) ES440831A1 (en)
FR (1) FR2284322A1 (en)
GB (1) GB1472627A (en)
NL (1) NL166253C (en)
PH (1) PH16279A (en)
SE (1) SE420917B (en)
SU (1) SU660588A3 (en)
ZA (1) ZA755777B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1545291A (en) * 1976-03-11 1979-05-10 Science Union & Cie Benzylamino-alkanamides process for their preparation and pharmaceutical compositions containing them
CA1137775A (en) * 1978-09-01 1982-12-21 Andrew J. Welebir Formulation comprising 1-triacontanol and its use as plant growth regulator
CN112920042A (en) * 2021-01-27 2021-06-08 北京岳达生物科技有限公司 Method for preparing alkane carboxylic acid by increasing alkane carbon chain

Also Published As

Publication number Publication date
DK145080B (en) 1982-08-23
ZA755777B (en) 1976-08-25
BE833238A (en) 1976-03-09
SU660588A3 (en) 1979-04-30
NL7510588A (en) 1976-03-12
AU8464875A (en) 1977-03-17
NL166253C (en) 1981-07-15
CA1063619A (en) 1979-10-02
DE2540334A1 (en) 1976-03-25
JPS5645905B2 (en) 1981-10-29
GB1472627A (en) 1977-05-04
PH16279A (en) 1983-08-26
DK396175A (en) 1976-03-11
SE7510024L (en) 1976-03-11
FR2284322B1 (en) 1978-07-28
DK145080C (en) 1983-01-24
CH608784A5 (en) 1979-01-31
JPS5159826A (en) 1976-05-25
FR2284322A1 (en) 1976-04-09
DE2540334C2 (en) 1983-03-10
NL166253B (en) 1981-02-16
SE420917B (en) 1981-11-09

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