SE7510024L - WAY TO PRODUCE NEW BENZYLAMINOAL ACANIC ACIDS - Google Patents

WAY TO PRODUCE NEW BENZYLAMINOAL ACANIC ACIDS

Info

Publication number
SE7510024L
SE7510024L SE7510024A SE7510024A SE7510024L SE 7510024 L SE7510024 L SE 7510024L SE 7510024 A SE7510024 A SE 7510024A SE 7510024 A SE7510024 A SE 7510024A SE 7510024 L SE7510024 L SE 7510024L
Authority
SE
Sweden
Prior art keywords
formula
acid
condensing
acids
compounds
Prior art date
Application number
SE7510024A
Other languages
Swedish (sv)
Other versions
SE420917B (en
Inventor
C Malen
P Roger
J-C Poignant
Original Assignee
Science Union & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union & Cie filed Critical Science Union & Cie
Publication of SE7510024L publication Critical patent/SE7510024L/en
Publication of SE420917B publication Critical patent/SE420917B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/403—Saturated compounds containing a keto group being part of a ring of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/295—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with inorganic bases, e.g. by alkali fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Saccharide Compounds (AREA)

Abstract

1472627 Benzylamino - alkanoic acids SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 10 Sept 1975 [10 Sept 1974] 39443/74 Heading C2C The invention comprises compounds of the formula wherein R 1 is a (C 3 -C 6 ) straight or branched chain alkyl radical, each of R 2 and R 4 is H or a (C 1 -C 5 ) straight or branched chain alkyl radical, R 3 is H, halogen, diethylaminoethoxy alkoxy or CF 3 , A and B are each selected from H, CH 3 or C 2 H 5 , and n is an integer from 4 to 10; including optically active isomers thereof and salts with acids or bases. They may be obtained by condensing an oxoalkanoic acid of the formula with a benzylamine of the formula reducing the product obtained, and if salts are required, adding thereto a mineral or organic base or acid. Pharmaceutical compositions having anti. aggressive activity comprise compounds of formula I above in admixture with a pharmaceutically suitable carrier. They may be applied parenterally, orally or rectally. Compounds of formula II above may be obtained by submitting a cyclic #-diketone of the formula to alkaline cleavage and recovering the corresponding oxoalkanoic acid. Cyclic #-diketones of formula IV above may be obtained by condensing a cycloalkenylamine of the formula wherein X and Y are lower alkyl or phenyl or together form an alkylene chain which may contain another hetero atom, with a functional derivative of a carboxylic acid of the formula R 1 COZ wherein Z is halogen or R 1 COO. 1 - Morpholino - cyclohex - 1 - ene is obtained by condensing cyclohexanone with morpholine with the aid of p-toluene sulphonic acid, in the presence of benzene.
SE7510024A 1974-09-10 1975-09-09 SET TO MAKE NEW BENZYLAMINO ALKANIC ACIDS WITH ANTIAGGRESSIVE PROPERTIES SE420917B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3944374A GB1472627A (en) 1974-09-10 1974-09-10 Benzylaminoalkanoic acids process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
SE7510024L true SE7510024L (en) 1976-03-11
SE420917B SE420917B (en) 1981-11-09

Family

ID=10409574

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7510024A SE420917B (en) 1974-09-10 1975-09-09 SET TO MAKE NEW BENZYLAMINO ALKANIC ACIDS WITH ANTIAGGRESSIVE PROPERTIES

Country Status (14)

Country Link
JP (1) JPS5645905B2 (en)
BE (1) BE833238A (en)
CA (1) CA1063619A (en)
CH (1) CH608784A5 (en)
DE (1) DE2540334C2 (en)
DK (1) DK145080C (en)
ES (1) ES440831A1 (en)
FR (1) FR2284322A1 (en)
GB (1) GB1472627A (en)
NL (1) NL166253C (en)
PH (1) PH16279A (en)
SE (1) SE420917B (en)
SU (1) SU660588A3 (en)
ZA (1) ZA755777B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1545291A (en) * 1976-03-11 1979-05-10 Science Union & Cie Benzylamino-alkanamides process for their preparation and pharmaceutical compositions containing them
CA1137775A (en) * 1978-09-01 1982-12-21 Andrew J. Welebir Formulation comprising 1-triacontanol and its use as plant growth regulator
CN112920042A (en) * 2021-01-27 2021-06-08 北京岳达生物科技有限公司 Method for preparing alkane carboxylic acid by increasing alkane carbon chain

Also Published As

Publication number Publication date
DK145080B (en) 1982-08-23
ZA755777B (en) 1976-08-25
ES440831A1 (en) 1977-03-01
BE833238A (en) 1976-03-09
SU660588A3 (en) 1979-04-30
NL7510588A (en) 1976-03-12
AU8464875A (en) 1977-03-17
NL166253C (en) 1981-07-15
CA1063619A (en) 1979-10-02
DE2540334A1 (en) 1976-03-25
JPS5645905B2 (en) 1981-10-29
GB1472627A (en) 1977-05-04
PH16279A (en) 1983-08-26
DK396175A (en) 1976-03-11
FR2284322B1 (en) 1978-07-28
DK145080C (en) 1983-01-24
CH608784A5 (en) 1979-01-31
JPS5159826A (en) 1976-05-25
FR2284322A1 (en) 1976-04-09
DE2540334C2 (en) 1983-03-10
NL166253B (en) 1981-02-16
SE420917B (en) 1981-11-09

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