ES438757A1 - Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them - Google Patents
Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing themInfo
- Publication number
- ES438757A1 ES438757A1 ES438757A ES438757A ES438757A1 ES 438757 A1 ES438757 A1 ES 438757A1 ES 438757 A ES438757 A ES 438757A ES 438757 A ES438757 A ES 438757A ES 438757 A1 ES438757 A1 ES 438757A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- radical
- benzylamine derivatives
- derivatives process
- cie
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A procedure for obtaining the nitrogen-substituted meta-trifluoromethylbenzylamines that respond to the general formula I ** (See formula) ** where X represents hydrogen, a halogen atom or a trifluoromethyl radical, R1 represents a lower alkoyl radical or a lower cycloalkoyl radical, R2 represents hydrogen or a lower alkoxy radical, R3 and R4 differently or simultaneously, represent hydrogen or a lower alkoxy radical or together form an alkoylene chain of 3 to 6 carbon atoms, as well as the salts of the compounds of general formula I with a mineral or organic acid, in racenic or optically active form, characterized in that a compound of general formula II is cyclized by heating. where the definition of the X, R1, R2, R3 and R4 substituents remains unchanged, B represents oxygen, and Hal represents a halogen atom to obtain a compound of general formula I ** (See formula) ** which can, if desired, be salified by the addition of a mineral or organic acid or cleaved, into its optical isomers by combination with an optically active reagent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2739274A GB1475513A (en) | 1974-06-20 | 1974-06-20 | Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ES438757A1 true ES438757A1 (en) | 1977-03-16 |
Family
ID=10258850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES438757A Expired ES438757A1 (en) | 1974-06-20 | 1975-06-20 | Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5231341B2 (en) |
AT (1) | AT342046B (en) |
AU (1) | AU497501B2 (en) |
BE (1) | BE830442A (en) |
CA (1) | CA1062265A (en) |
CH (1) | CH597206A5 (en) |
DE (1) | DE2526965A1 (en) |
DK (1) | DK136313B (en) |
ES (1) | ES438757A1 (en) |
FI (1) | FI751825A (en) |
FR (1) | FR2275207A1 (en) |
GB (1) | GB1475513A (en) |
HU (1) | HU173390B (en) |
IE (1) | IE41382B1 (en) |
NL (1) | NL7507422A (en) |
SE (2) | SE7507018L (en) |
SU (1) | SU578880A3 (en) |
ZA (1) | ZA753943B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2358890A1 (en) * | 1976-05-24 | 1978-02-17 | Science Union & Cie | NEW ARYL TRIFLUOROETHYLAMINES, THEIR METHODS OF OBTAINING AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING |
JPS53105752U (en) * | 1977-01-31 | 1978-08-25 | ||
JPS5495252A (en) * | 1978-01-11 | 1979-07-27 | Oki Electric Ind Co Ltd | Thermal printer |
FR2444673A1 (en) * | 1978-12-20 | 1980-07-18 | Science Union & Cie | NOVEL TRIFLUOROETHYLAMINES, PROCESSES FOR OBTAINING SAME AND THEIR USE AS MEDICAMENTS |
JPS57136755U (en) * | 1981-02-20 | 1982-08-26 | ||
AUPP020297A0 (en) * | 1997-11-05 | 1997-11-27 | University Of Melbourne, The | A novel receptor, and compounds which bind thereto |
-
1974
- 1974-06-20 GB GB2739274A patent/GB1475513A/en not_active Expired
-
1975
- 1975-06-13 CA CA229,350A patent/CA1062265A/en not_active Expired
- 1975-06-16 DE DE19752526965 patent/DE2526965A1/en active Pending
- 1975-06-17 IE IE1361/75A patent/IE41382B1/en unknown
- 1975-06-18 SE SE7507018A patent/SE7507018L/en unknown
- 1975-06-18 DK DK274375AA patent/DK136313B/en unknown
- 1975-06-18 FI FI751825A patent/FI751825A/fi not_active Application Discontinuation
- 1975-06-19 ZA ZA00753943A patent/ZA753943B/en unknown
- 1975-06-19 AU AU82246/75A patent/AU497501B2/en not_active Expired
- 1975-06-19 FR FR7519164A patent/FR2275207A1/en active Granted
- 1975-06-19 JP JP50074996A patent/JPS5231341B2/ja not_active Expired
- 1975-06-19 AT AT471675A patent/AT342046B/en not_active IP Right Cessation
- 1975-06-19 CH CH801275A patent/CH597206A5/xx not_active IP Right Cessation
- 1975-06-19 HU HU75SI1474A patent/HU173390B/en unknown
- 1975-06-19 BE BE157510A patent/BE830442A/en unknown
- 1975-06-19 SU SU7502145925A patent/SU578880A3/en active
- 1975-06-20 NL NL7507422A patent/NL7507422A/en not_active Application Discontinuation
- 1975-06-20 ES ES438757A patent/ES438757A1/en not_active Expired
-
1979
- 1979-01-25 SE SE7900681A patent/SE7900681L/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATA471675A (en) | 1977-07-15 |
CH597206A5 (en) | 1978-03-31 |
FR2275207B1 (en) | 1979-08-10 |
IE41382B1 (en) | 1979-12-19 |
BE830442A (en) | 1975-12-19 |
DK136313B (en) | 1977-09-26 |
NL7507422A (en) | 1975-12-23 |
DE2526965A1 (en) | 1976-01-02 |
DK136313C (en) | 1978-02-20 |
SE7507018L (en) | 1975-12-22 |
IE41382L (en) | 1975-12-20 |
AU8224675A (en) | 1976-12-23 |
FR2275207A1 (en) | 1976-01-16 |
CA1062265A (en) | 1979-09-11 |
FI751825A (en) | 1975-12-21 |
JPS5231341B2 (en) | 1977-08-13 |
AU497501B2 (en) | 1978-12-14 |
DK274375A (en) | 1975-12-21 |
ZA753943B (en) | 1976-06-30 |
JPS5116662A (en) | 1976-02-10 |
GB1475513A (en) | 1977-06-01 |
SE7900681L (en) | 1979-01-25 |
HU173390B (en) | 1979-04-28 |
SU578880A3 (en) | 1977-10-30 |
AT342046B (en) | 1978-03-10 |
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