ES438757A1 - Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them - Google Patents

Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Info

Publication number
ES438757A1
ES438757A1 ES438757A ES438757A ES438757A1 ES 438757 A1 ES438757 A1 ES 438757A1 ES 438757 A ES438757 A ES 438757A ES 438757 A ES438757 A ES 438757A ES 438757 A1 ES438757 A1 ES 438757A1
Authority
ES
Spain
Prior art keywords
general formula
radical
benzylamine derivatives
derivatives process
cie
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES438757A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES438757A1 publication Critical patent/ES438757A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A procedure for obtaining the nitrogen-substituted meta-trifluoromethylbenzylamines that respond to the general formula I ** (See formula) ** where X represents hydrogen, a halogen atom or a trifluoromethyl radical, R1 represents a lower alkoyl radical or a lower cycloalkoyl radical, R2 represents hydrogen or a lower alkoxy radical, R3 and R4 differently or simultaneously, represent hydrogen or a lower alkoxy radical or together form an alkoylene chain of 3 to 6 carbon atoms, as well as the salts of the compounds of general formula I with a mineral or organic acid, in racenic or optically active form, characterized in that a compound of general formula II is cyclized by heating. where the definition of the X, R1, R2, R3 and R4 substituents remains unchanged, B represents oxygen, and Hal represents a halogen atom to obtain a compound of general formula I ** (See formula) ** which can, if desired, be salified by the addition of a mineral or organic acid or cleaved, into its optical isomers by combination with an optically active reagent. (Machine-translation by Google Translate, not legally binding)
ES438757A 1974-06-20 1975-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them Expired ES438757A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2739274A GB1475513A (en) 1974-06-20 1974-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES438757A1 true ES438757A1 (en) 1977-03-16

Family

ID=10258850

Family Applications (1)

Application Number Title Priority Date Filing Date
ES438757A Expired ES438757A1 (en) 1974-06-20 1975-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Country Status (18)

Country Link
JP (1) JPS5231341B2 (en)
AT (1) AT342046B (en)
AU (1) AU497501B2 (en)
BE (1) BE830442A (en)
CA (1) CA1062265A (en)
CH (1) CH597206A5 (en)
DE (1) DE2526965A1 (en)
DK (1) DK136313B (en)
ES (1) ES438757A1 (en)
FI (1) FI751825A (en)
FR (1) FR2275207A1 (en)
GB (1) GB1475513A (en)
HU (1) HU173390B (en)
IE (1) IE41382B1 (en)
NL (1) NL7507422A (en)
SE (2) SE7507018L (en)
SU (1) SU578880A3 (en)
ZA (1) ZA753943B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358890A1 (en) * 1976-05-24 1978-02-17 Science Union & Cie NEW ARYL TRIFLUOROETHYLAMINES, THEIR METHODS OF OBTAINING AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING
JPS53105752U (en) * 1977-01-31 1978-08-25
JPS5495252A (en) * 1978-01-11 1979-07-27 Oki Electric Ind Co Ltd Thermal printer
FR2444673A1 (en) * 1978-12-20 1980-07-18 Science Union & Cie NOVEL TRIFLUOROETHYLAMINES, PROCESSES FOR OBTAINING SAME AND THEIR USE AS MEDICAMENTS
JPS57136755U (en) * 1981-02-20 1982-08-26
AUPP020297A0 (en) * 1997-11-05 1997-11-27 University Of Melbourne, The A novel receptor, and compounds which bind thereto

Also Published As

Publication number Publication date
ATA471675A (en) 1977-07-15
CH597206A5 (en) 1978-03-31
FR2275207B1 (en) 1979-08-10
IE41382B1 (en) 1979-12-19
BE830442A (en) 1975-12-19
DK136313B (en) 1977-09-26
NL7507422A (en) 1975-12-23
DE2526965A1 (en) 1976-01-02
DK136313C (en) 1978-02-20
SE7507018L (en) 1975-12-22
IE41382L (en) 1975-12-20
AU8224675A (en) 1976-12-23
FR2275207A1 (en) 1976-01-16
CA1062265A (en) 1979-09-11
FI751825A (en) 1975-12-21
JPS5231341B2 (en) 1977-08-13
AU497501B2 (en) 1978-12-14
DK274375A (en) 1975-12-21
ZA753943B (en) 1976-06-30
JPS5116662A (en) 1976-02-10
GB1475513A (en) 1977-06-01
SE7900681L (en) 1979-01-25
HU173390B (en) 1979-04-28
SU578880A3 (en) 1977-10-30
AT342046B (en) 1978-03-10

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