ES2533359T3 - Núcleos de fármaco para liberación sostenida de agentes terapéuticos - Google Patents

Núcleos de fármaco para liberación sostenida de agentes terapéuticos Download PDF

Info

Publication number
ES2533359T3
ES2533359T3 ES08830451.4T ES08830451T ES2533359T3 ES 2533359 T3 ES2533359 T3 ES 2533359T3 ES 08830451 T ES08830451 T ES 08830451T ES 2533359 T3 ES2533359 T3 ES 2533359T3
Authority
ES
Spain
Prior art keywords
drug core
agent
tear
eye
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08830451.4T
Other languages
English (en)
Inventor
Deepank Utkhede
Robert W. Shimizu
Rachna Jain
Stephen Boyd
Hanson S. Gifford
Eugene De Juan Jr.
Cary J. Reich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mati Therapeutics Inc
Original Assignee
Mati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mati Therapeutics Inc filed Critical Mati Therapeutics Inc
Application granted granted Critical
Publication of ES2533359T3 publication Critical patent/ES2533359T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2036—Silicones; Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00772—Apparatus for restoration of tear ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un inserto de fármaco adaptado para disposición dentro de un implante lacrimal, estando adaptado el implante lacrimal para inserción a través de un punto lacrimal del ojo para residir dentro del canalículo del ojo, comprendiendo el inserto un núcleo de fármaco y un cuerpo de vaina que cubre parcialmente el núcleo de fármaco, comprendiendo el núcleo de fármaco un agente terapéutico y una matriz, siendo seleccionado el agente terapéutico del grupo que consiste de bimatoprost, latanoprost, y travoprost, comprendiendo la matriz un polímero de silicona, estando dispuesto el cuerpo de vaina sobre una porción del núcleo de fármaco para inhibir la liberación del agente desde dicha porción y de tal manera que define al menos una superficie expuesta del núcleo de fármaco adaptado para liberar el agente al ojo o a los tejidos circundantes o a ambos al entrar en contacto con el líquido lacrimal cuando el implante es insertado en un paciente, y en donde una cantidad del agente terapéutico en una porción volumétrica macroscópica del núcleo de fármaco varía de una cantidad del agente terapéutico en cualquier otra porción volumétrica macroscópica igual del núcleo de fármaco por no más de 30%.

Description

imagen1
imagen2

Claims (1)

  1. imagen1
    imagen2
ES08830451.4T 2007-09-07 2008-09-05 Núcleos de fármaco para liberación sostenida de agentes terapéuticos Active ES2533359T3 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US97069907P 2007-09-07 2007-09-07
US97070907P 2007-09-07 2007-09-07
US97082007P 2007-09-07 2007-09-07
US970709P 2007-09-07
US970699P 2007-09-07
US970820P 2007-09-07
US4931708P 2008-04-30 2008-04-30
US49317 2008-04-30
PCT/US2008/010487 WO2009035562A2 (en) 2007-09-07 2008-09-05 Drug cores for sustained release of therapeutic agents

Publications (1)

Publication Number Publication Date
ES2533359T3 true ES2533359T3 (es) 2015-04-09

Family

ID=39874137

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12192860.0T Active ES2538838T3 (es) 2007-09-07 2008-09-05 Método para preparar insertos de fármacos para liberación sostenida de agentes terapéuticos
ES08830451.4T Active ES2533359T3 (es) 2007-09-07 2008-09-05 Núcleos de fármaco para liberación sostenida de agentes terapéuticos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES12192860.0T Active ES2538838T3 (es) 2007-09-07 2008-09-05 Método para preparar insertos de fármacos para liberación sostenida de agentes terapéuticos

Country Status (19)

Country Link
US (5) US20090104243A1 (es)
EP (2) EP2614844B1 (es)
JP (5) JP5555162B2 (es)
KR (3) KR101571434B1 (es)
CN (2) CN103349799B (es)
AU (1) AU2008300013A1 (es)
BR (1) BRPI0817075A2 (es)
CA (1) CA2698573C (es)
DK (2) DK2614844T3 (es)
ES (2) ES2538838T3 (es)
HK (2) HK1155104A1 (es)
IL (2) IL253005A0 (es)
MX (1) MX2010002616A (es)
NZ (2) NZ598483A (es)
RU (1) RU2478366C2 (es)
SG (1) SG184738A1 (es)
TW (1) TWI543776B (es)
WO (1) WO2009035562A2 (es)
ZA (1) ZA201001586B (es)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
RU2404821C2 (ru) 2005-05-04 2010-11-27 Синтез ГмбХ Соединительный элемент
NZ571758A (en) 2006-03-31 2012-06-29 Quadra Logic Tech Inc A drug insert surrounded by a sheath to expose a polymer containing a drug to surrounding tissues or an eye
US10669383B2 (en) * 2006-10-31 2020-06-02 Evonik Corporation Spheronized polymer particles
CN103349799B (zh) 2007-09-07 2016-01-20 马缇医疗股份有限公司 用于持续释放治疗药物的药物核心
MX2010002617A (es) * 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Implantes lagrimales y metodos relacionados.
MX2010002619A (es) 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Deteccion de implante lagrimal.
US8741329B2 (en) 2007-09-21 2014-06-03 Merck Sharp & Dohme B.V. Drug delivery system
JP5528356B2 (ja) * 2008-02-18 2014-06-25 キュー エル ティー インク． 涙管インプラントおよび関連する方法
CN102105137B (zh) 2008-04-30 2015-01-07 Qlt股份有限公司 复合泪管植入物及相关方法
CN105251007A (zh) * 2008-05-09 2016-01-20 马缇医疗股份有限公司 治疗青光眼和眼高血压的活性剂的持续释放递送
JP2011522720A (ja) 2008-05-30 2011-08-04 キューエルティー プラグ デリバリー，インク． 表面処理された埋め込み可能アーティクルおよび関連方法
DE102008002396A1 (de) * 2008-06-12 2009-12-17 Biotronik Vi Patent Ag Implantierbares Wirkstoffreservoir und Vorrichtung mit einem implantierbaren Wirkstoffreservoir
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
EP2303184A4 (en) * 2008-06-24 2013-06-19 Quadra Logic Tech Inc GLAUCOMA ASSOCIATION TREATMENT
EP2328527A1 (en) * 2008-07-08 2011-06-08 QLT Plug Delivery, Inc. Lacrimal implant body including comforting agent
JP2012512725A (ja) * 2008-12-19 2012-06-07 キュー エル ティー インク． 物質送達用涙点インプラントおよび物質送達方法
WO2010083129A2 (en) * 2009-01-13 2010-07-22 The Regents Of The University Of California Implantable delivery vehicle for ocular delivery of muscarinic antagonists
KR20110129869A (ko) * 2009-01-23 2011-12-02 큐엘티 인코포레이티드 하나 이상의 제제의 서방형 전달
EP3735947B1 (en) 2009-01-28 2022-05-04 Alcon Inc. Ocular implant delivery system
EP2391419B1 (en) 2009-01-29 2019-06-12 ForSight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US10238535B2 (en) * 2009-02-23 2019-03-26 Mati Therapeutics Inc. Lacrimal implants and related methods
US9421127B2 (en) 2009-03-31 2016-08-23 Johnson & Johnson Vision Care, Inc. Punctal plugs
TWI495459B (zh) * 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
US20120078362A1 (en) * 2009-05-18 2012-03-29 Dose Medical Corporation Drug eluting ocular implant
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
US8808257B2 (en) 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
WO2011066479A1 (en) 2009-11-27 2011-06-03 Qlt Plug Delivery, Inc. Lacrimal implants including split and insertable drug core
US8404270B2 (en) * 2009-12-23 2013-03-26 Alimera Sciences, Inc. Method of reducing incidence of intraocular pressure associated with intraocular use of corticosteroids
JP5723531B2 (ja) * 2010-01-20 2015-05-27 Ｄｓファーマアニマルヘルス株式会社 チューブ内に保持された凍結乾燥製剤
US11244745B2 (en) 2010-01-22 2022-02-08 Deka Products Limited Partnership Computer-implemented method, system, and apparatus for electronic patient care
US10453157B2 (en) 2010-01-22 2019-10-22 Deka Products Limited Partnership System, method, and apparatus for electronic patient care
US9259352B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US9259351B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US20130017243A1 (en) * 2010-04-06 2013-01-17 Allergan, Inc. Sustained-release reservoir implants for intracameral drug delivery
US11033624B2 (en) 2010-06-02 2021-06-15 Novaflux Inc. Medical item for prevention and treatment of ear infection
US20110301555A1 (en) * 2010-06-03 2011-12-08 Gonzalez-Zugasti Javier P Porous matrix drug core for lacrimal insert device
AU2011280054B2 (en) * 2010-06-30 2014-02-06 Evonik Corporation Core-sheath implant device having an inner core lobe
CN103313702A (zh) * 2010-06-30 2013-09-18 赢创有限公司 用于热不稳定及其它的生物活性剂的植入物的制备方法和由该方法制备的植入物
HUE057267T2 (hu) 2010-08-05 2022-05-28 Forsight Vision4 Inc Berendezés szem kezelésére
US10617557B2 (en) * 2010-08-05 2020-04-14 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
DK2600930T3 (da) 2010-08-05 2021-03-01 Forsight Vision4 Inc Injektionsapparat til lægemiddelafgivelse
US8591484B2 (en) 2010-09-15 2013-11-26 AlphaMed, Inc. Lacrimal punctum measurement and occlusion
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US20120157938A1 (en) * 2010-12-16 2012-06-21 Tokarski Jason M Punctal plug with drug core retention features
EP2701682A1 (en) * 2011-04-29 2014-03-05 Allergan, Inc. Solvent cast film sustained release latanoprost implant
US20120312840A1 (en) * 2011-05-13 2012-12-13 Ayako Hasegawa Container closure system with integral antimicrobial additives
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
ES2666857T3 (es) * 2011-07-18 2018-05-08 Mor-Research Applications Ltd. Un dispositivo para ajustar la presión intraocular
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE
EP2750660B1 (en) 2011-08-29 2016-10-12 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
JP5989780B2 (ja) 2011-09-14 2016-09-07 フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． 眼挿入装置および方法
CA2848385C (en) 2011-09-16 2021-10-26 Forsight Vision4, Inc. Methods and apparatus to exchange a fluid of an implantable device
US9107737B2 (en) * 2011-11-21 2015-08-18 Alan Schwartz Goggles with facial conforming eyepieces
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US9241829B2 (en) * 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
WO2013130547A1 (en) * 2012-03-01 2013-09-06 Synthes Usa, Llc Surgical suture with soft core
US20130245759A1 (en) * 2012-03-09 2013-09-19 The Florida International University Board Of Trustees Medical devices incorporating silicone nanoparticles, and uses thereof
WO2013154843A1 (en) 2012-04-11 2013-10-17 Sinopsys Surgical, Inc. Implantation tools, tool assemblies, kits and methods
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
CN105473130A (zh) 2012-05-03 2016-04-06 麦提疗法有限公司 治疗开角型青光眼和高眼压症的药物递送***和方法
ES2633185T3 (es) * 2012-09-17 2017-09-19 Novartis Ag Dispositivos de implante ocular expansibles
DK2911623T3 (da) 2012-10-26 2019-10-28 Forsight Vision5 Inc Oftalmisk system til langvarig frigivelse af lægemiddel til øjet
CN105142710A (zh) 2013-01-15 2015-12-09 科罗拉多州立大学董事会,公司实体 泪腺***给药装置
WO2014116980A1 (en) 2013-01-25 2014-07-31 Sinopsys Surgical, Inc. Paranasal sinus access implant devices and related tools, methods and kits
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP2978406A1 (en) * 2013-03-27 2016-02-03 Forsight Vision5, Inc. Bimatoprost ocular silicone inserts and methods of use thereof
CN105246438B (zh) 2013-03-28 2018-01-26 弗赛特影像4股份有限公司 用于输送治疗物质的眼科植入物
KR20140144843A (ko) * 2013-06-12 2014-12-22 주식회사 엘지화학 실링부가 경화성 물질로 절연되어 있는 파우치형 전지셀의 제조방법
US9931068B2 (en) 2013-08-21 2018-04-03 Senseonics, Incorporated Drug elution for in vivo protection of bio-sensing analytes
US9700459B2 (en) 2013-10-16 2017-07-11 Sinopsys Surgical, Inc. Apparatuses, tools and kits relating to fluid manipulation treatments of paranasal sinuses
CA2930027C (en) 2013-11-14 2019-10-29 Aquesys, Inc. Intraocular shunt inserter
EP3079659B1 (en) 2013-12-11 2020-10-28 Merck Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
US10413504B2 (en) 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
US10285865B2 (en) 2014-05-02 2019-05-14 Novaflux Inc. Drug-releasing device usable in mucosal body cavities
US20150342875A1 (en) * 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2955186C (en) 2014-07-15 2023-08-29 Forsight Vision4, Inc. Ocular implant delivery device and method
EP3179968B1 (en) 2014-07-24 2019-09-11 Sinopsys Surgical, Inc. Paranasal sinus access implant devices and related products and methods
JP2017524034A (ja) 2014-08-08 2017-08-24 フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法
CN111214701A (zh) * 2014-08-19 2020-06-02 加利福尼亚大学董事会 用于局部药物递送的植入物及其使用方法
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
MX2017005972A (es) 2014-11-10 2017-07-13 Forsight Vision4 Inc Dispositivo de entrega de farmacos expandibles y metodo de uso.
KR102511830B1 (ko) 2014-11-25 2023-03-17 엑시모어 엘티디. 단일 및 다수 생체활성제를 전달하기 위한 조성물 및 방법
KR101717585B1 (ko) 2014-12-31 2017-03-20 중앙대학교 산학협력단 약물 방출 조절이 가능한 스캐폴드
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
US20180193193A1 (en) * 2015-07-06 2018-07-12 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drainage system diagnostic implant
WO2017040855A1 (en) * 2015-09-02 2017-03-09 Dose Medical Corporation Drug delivery implants as intraocular drug depots and methods of using same
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) * 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CN113069681B (zh) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 制造用于缓释药物递送的治疗装置的方法
JP6885609B2 (ja) * 2015-11-23 2021-06-16 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 薬物送達のための涙器システム
US20190216639A1 (en) * 2016-03-01 2019-07-18 Bruder Healthcare Company, Llc Therapeutic eye compress system
US11998480B2 (en) * 2016-03-01 2024-06-04 The Hilsinger Company Parent, Llc Self-heating compress for moist heat delivery
US12011388B2 (en) * 2016-03-01 2024-06-18 The Hilsinger Company Parent, Llc Therapeutic thermal compress with phase-change material
US20170252210A1 (en) * 2016-03-01 2017-09-07 Bruder Healthcare Company, Llc Therapeutic eye mask system
WO2017176886A1 (en) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Implantable ocular drug delivery devices
EP3442479A1 (en) * 2016-04-20 2019-02-20 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
EP3458030B1 (en) 2016-05-20 2021-05-12 The Regents of The University of Colorado, A Body Corporate Lacrimal drug delivery device
USD871598S1 (en) 2016-11-30 2019-12-31 Bruder Healthcare Company, Llc Therapeutic eye mask
USD844795S1 (en) 2016-11-30 2019-04-02 Bruder Healthcare Company, Llc Therapeutic eye mask
CN108339147B (zh) * 2017-01-24 2021-05-07 沈阳何氏眼产业集团有限公司 玻璃体或视网膜手术切口用粘合剂及粘合***
US11523940B2 (en) 2017-03-17 2022-12-13 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
US20190053886A1 (en) * 2017-08-15 2019-02-21 Covidien Lp Methods and tools for treating diseased tissue
EP3675780A4 (en) 2017-09-20 2021-10-06 Sinopsys Surgical, Inc. IMPLANTATION TOOLS, ARRANGEMENTS, KITS, AND PROCEDURES FOR ACCESSING PERIODIC FLUIDS
CN115607358A (zh) 2017-11-21 2023-01-17 弗赛特影像4股份有限公司 用于可扩展端口递送***的流体交换装置及使用方法
KR20210100005A (ko) * 2018-03-29 2021-08-13 마티 테라퓨틱스 인코포레이티드 안과 약제의 서방성 제형 및 건성 증후군 치료 용도
CN111971026A (zh) 2018-05-24 2020-11-20 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
CN111989068A (zh) 2018-05-24 2020-11-24 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
CA3104468A1 (en) * 2018-06-19 2019-12-26 Cella Therapeutics, Llc Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a c-type natriuretic peptide compound, an natriuretic peptide receptor-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension
CA3104513A1 (en) * 2018-06-25 2020-01-02 Titan Pharmaceuticals, Inc. Implants for release of lipophilic or amphiphilic pharmaceutical substances
WO2020047622A1 (en) * 2018-09-05 2020-03-12 Dos Santos Neto Edson USE OF MIOTIC CHOLINERGIC SUBSTANCES AND F2α PROSTAGLANDIN ANALOGUES FOR PREVENTION AND TREATMENT OF MYOPIA
CA3111870C (en) * 2018-09-27 2022-04-12 Novaliq Gmbh Topical sunscreen formulation
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
IT201900003597A1 (it) * 2019-03-12 2020-09-12 Milano Politecnico Dispositivo per il rilascio controllato
US11207267B2 (en) 2019-10-02 2021-12-28 Segal Innovations LLC Bio-adhesive dissolving compounds and device
JP6925464B1 (ja) * 2020-02-21 2021-08-25 巨晰光纖股▲ふん▼有限公司 生体活性ガラス薬物キャリア機能付き分流器
US11173291B2 (en) 2020-03-20 2021-11-16 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11338119B2 (en) 2020-03-20 2022-05-24 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11344526B2 (en) 2020-03-20 2022-05-31 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
CA3177005A1 (en) * 2020-04-27 2021-11-04 Michael Goldstein Methods of treating allergic conjunctivitis
CN112618791A (zh) * 2020-12-25 2021-04-09 福建医科大学附属协和医院 聚醚醚酮三维多孔化并修饰聚多巴胺/庆大霉素用于植入物抗菌、抗炎及促进骨整合

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865108A (en) * 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3828777A (en) * 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3949750A (en) * 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4205128A (en) * 1976-03-31 1980-05-27 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing immobilized enzyme compositions
US4281654A (en) 1980-04-07 1981-08-04 Alza Corporation Drug delivery system for controlled ocular therapy
US4322323A (en) * 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
US4660546A (en) * 1984-11-07 1987-04-28 Robert S. Herrick Method for treating for deficiency of tears
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5049142A (en) * 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5229128A (en) * 1986-06-11 1993-07-20 Haddad Heskel M Drug delivery ophthalmic insert and method of preparing same
DE3775880D1 (es) * 1986-09-18 1992-02-20 London School Of Pharmacy Innovations Ltd., London, Gb
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4983390A (en) * 1987-04-01 1991-01-08 Lee County Mosquito Control District Terrestrial delivery compositions and methods for controlling insect and habitat-associated pest populations in terrestrial environments
FR2618329B1 (fr) * 1987-07-22 1997-03-28 Dow Corning Sa Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US4915684A (en) * 1988-06-21 1990-04-10 Mackeen Donald L Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus
US5133159A (en) * 1989-01-13 1992-07-28 Nestle S.A. Method for polishing silicone products
US4959048A (en) * 1989-01-17 1990-09-25 Helix Medical, Inc. Lacrimal duct occluder
US5098443A (en) * 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5128058A (en) * 1989-05-31 1992-07-07 Hoya Corporation Contact lens cleaner containing a microcapsular polishing agent
IE910450A1 (en) 1990-02-15 1991-08-28 Bausch & Lomb Soft contact lens processing aid
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5163959A (en) 1990-03-29 1992-11-17 Herrick Robert S Method for treating an eye with a canalicular implant having a collapsible flared section
US5041081A (en) * 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5116371A (en) * 1990-07-06 1992-05-26 Christensen James M Prosthesis with improved biocompatibility
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5334137A (en) 1992-02-21 1994-08-02 Eagle Vision, Inc. Lacrimal fluid control device
EP0572932B1 (en) * 1992-06-02 2000-09-13 C.R. Bard, Inc. Method and implant device for long term delivery of drugs
US5469867A (en) 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5318513A (en) * 1992-09-24 1994-06-07 Leib Martin L Canalicular balloon fixation stent
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
JP3000187B2 (ja) * 1993-02-26 2000-01-17 参天製薬株式会社 生体分解性強膜プラグ
US5417651A (en) * 1993-07-01 1995-05-23 Guena; Nicolas Punctum plug and monocanalicular probe for lacrimal pathology
WO1995003807A1 (en) * 1993-07-27 1995-02-09 The University Of Sydney Treatment of age-related macular degeneration
US5423777A (en) * 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
US5417744A (en) * 1993-12-29 1995-05-23 Ameron, Inc. Optically clear hydrophobic coating composition
US5426166A (en) * 1994-01-26 1995-06-20 Caschem, Inc. Urethane adhesive compositions
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
JP3486758B2 (ja) 1994-06-24 2004-01-13 株式会社高研 注入可能な涙小管閉鎖剤
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6149684A (en) 1995-06-07 2000-11-21 Herrick; Robert S. Punctum plug having a thin elongated lip and a distal starting tip and method of using
US5723005A (en) * 1995-06-07 1998-03-03 Herrick Family Limited Partnership Punctum plug having a collapsible flared section and method
AU6107696A (en) * 1995-06-07 1996-12-30 Keravision, Inc. Radial intrastromal corneal insert and a method of insertion
US5766243A (en) * 1995-08-21 1998-06-16 Oasis Medical, Inc. Abrasive polished canalicular implant
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5741292A (en) * 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
US5993407A (en) 1996-10-25 1999-11-30 Moazed; Kambiz Thomas Transnasal lacrimal insert
EP0935512B1 (en) * 1996-11-01 2002-05-29 Alcon Laboratories, Inc. Cryogenic polishing method for soft acrylic articles
US6254562B1 (en) * 1997-02-04 2001-07-03 Alain Fouere Meatus plug for lachrymal canal capable of being screwed
US6041785A (en) * 1997-03-27 2000-03-28 Eaglevision, Inc. Punctum plug
US6016806A (en) * 1997-03-27 2000-01-25 Eaglevision, Inc Punctum plug
US6027470A (en) * 1998-06-10 2000-02-22 Eagle Vision, Inc. Punctum plug and method for inserting the same into the punctual opening
US6082362A (en) * 1997-03-27 2000-07-04 Eagle Vision, Inc. Punctum plug
US5961370A (en) 1997-05-08 1999-10-05 Chiron Vision Corporation Intraocular lens tumbling process using coated beads
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
JPH1147183A (ja) * 1997-08-05 1999-02-23 Kaneka Medics:Kk 涙点プラグ装置
US6306426B1 (en) * 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5830171A (en) 1997-08-12 1998-11-03 Odyssey Medical, Inc. Punctal occluder
US6060439A (en) 1997-09-29 2000-05-09 Kyzen Corporation Cleaning compositions and methods for cleaning resin and polymeric materials used in manufacture
US6645963B2 (en) 1997-11-05 2003-11-11 Senju Pharmaceutical Co., Ltd. Prolonged-action eye drop
US6203513B1 (en) * 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6290684B1 (en) * 1998-03-02 2001-09-18 Herrick Family Limited Partnership Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same
US6196993B1 (en) * 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US6306114B1 (en) 1998-06-16 2001-10-23 Eagle Vision, Inc. Valved canalicular plug for lacrimal duct occlusion
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
JP2000070296A (ja) * 1998-08-27 2000-03-07 M L C:Kk 涙道内挿管器具
US6095901A (en) * 1998-12-09 2000-08-01 Alcon Laboratories, Inc. Polishing method for soft acrylic articles
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6234175B1 (en) * 1999-03-23 2001-05-22 Medennium, Inc. Smart ocular plug design and method of insertion for punctal and intracanalicular implants
US6383192B1 (en) * 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct
US6428502B1 (en) * 1999-06-25 2002-08-06 Alcon Manufacturing, Ltd. Punctal cannula
US6706275B1 (en) * 1999-09-08 2004-03-16 Matthew W. Camp Scleral plug system
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6264971B1 (en) * 1999-11-04 2001-07-24 Btg International Limited Ocular insert
US6706034B1 (en) 1999-12-30 2004-03-16 Advanced Cardiovascular Systems, Inc. Process for agent retention in biological tissues
AU2626601A (en) * 2000-01-03 2001-07-16 Johns Hopkins University, The Device and method for manual retinal vein catheterization
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20030096831A1 (en) 2000-01-18 2003-05-22 Stone Richard A. Ocular growth and nicotinic antagonists
US6344047B1 (en) * 2000-02-02 2002-02-05 Eagle Vision Instrument for inserting a punctum plug and method for manufacturing the instrument
US7708711B2 (en) * 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7867186B2 (en) * 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US20040175410A1 (en) * 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6371122B1 (en) * 2000-06-20 2002-04-16 Robert M. Mandelkorn Gauge/dilator apparatus
US6629533B1 (en) 2000-06-30 2003-10-07 Eagle Vision, Inc. Punctum plug with at least one anchoring arm
US6534693B2 (en) * 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
WO2002056863A2 (en) * 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
JP2004521882A (ja) 2001-01-03 2004-07-22 ボシュ・アンド・ロム・インコーポレイテッド 組立式透過性プラグを備えた徐放薬剤送達装置
JP2004520900A (ja) * 2001-01-26 2004-07-15 ボシュ・アンド・ロム・インコーポレイテッド 徐放薬剤送達装置の改良製造方法
WO2002072105A2 (en) 2001-02-21 2002-09-19 Alcon, Inc. Improved prostanoid therapies for the treatment of glaucoma
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
WO2002080811A2 (en) 2001-04-07 2002-10-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US6605108B2 (en) 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
US6982090B2 (en) * 2001-05-10 2006-01-03 Gillespie Donald E More easily visualized punctum plug configurations
WO2002096418A1 (en) 2001-05-25 2002-12-05 Valley Forge Pharmaceuticals Pirenzepine ophthalmic gel
US7404825B2 (en) 2001-06-11 2008-07-29 Herrick Ii Robert S Implant capable of forming a differential image in an eye
US20050129732A1 (en) * 2001-07-13 2005-06-16 Flow Focusing, Inc. Biodegradable, antibiotic, controlled release tape
FR2829019B3 (fr) 2001-08-31 2003-10-31 Alain Fouere Bouchons lacrymaux et methodes de mise en place de ces dispositifs
US20040234572A1 (en) * 2001-09-11 2004-11-25 Martinod Serge R. Preparation of sustained release pharmaceutical composition
WO2003045290A1 (en) * 2001-11-21 2003-06-05 Iscience Corporation Ophthalmic microsurgical system
US6729939B2 (en) * 2001-12-17 2004-05-04 Bausch & Lomb Incorporated Polishing method for intraocular lens
US7204995B2 (en) * 2002-01-31 2007-04-17 El-Sherif Dalia M Treatment and control of dry eye by use of biodegradable polymer capsules
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20040147870A1 (en) * 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6866563B2 (en) * 2002-06-27 2005-03-15 Bausch & Lomb Incorporated Apparatus and method for target polishing intraocular lenses
FR2841770B1 (fr) 2002-07-05 2004-10-01 Ioltechnologie Production Clou meatique d'obturation d'un meat lacrymal
DK1521573T3 (da) * 2002-07-15 2008-03-25 Alcon Inc Ikke-polymere, lipofile, farmaceutiske implantatsammensætninger til intrakulær anvendelse
FR2844182B1 (fr) * 2002-09-11 2004-12-03 Humanoptics Ag Bouchon d'obturation d'un canalicule lacrymal
US7169163B2 (en) * 2002-09-30 2007-01-30 Bruce Becker Transnasal method and catheter for lacrimal system
EA008496B1 (ru) * 2002-12-20 2007-06-29 Чакшу Рисерч, Инк. Офтальмологический препарат для профилактики и лечения болезненных состояний глаз
US20040137059A1 (en) * 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
SI1592407T1 (sl) * 2003-01-24 2010-04-30 Psivida Inc Naprava s podaljšanim sprošŽŤanjem in postopek za okularno dajanje inhibitorjev karboanhidraze
AR042917A1 (es) * 2003-01-24 2005-07-06 Control Delivery Sys Inc Dispositivo de liberacion sostenida para la administracion ocular de agentes adrenergicos y uso de agentes adrenergicos para su preparacion
WO2004075781A2 (en) * 2003-02-26 2004-09-10 Medivas, Llc Bioactive stents and methods for use thereof
US6699282B1 (en) 2003-03-06 2004-03-02 Gelsus Research And Consulting, Inc. Method and apparatus for delivery of medication
US20050283109A1 (en) 2003-03-07 2005-12-22 Peyman Gholam A Method and apparatus for lacrimal canal obstruction
JP4824549B2 (ja) * 2003-05-02 2011-11-30 サーモディクス，インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
US7017580B2 (en) * 2003-05-22 2006-03-28 Clarity Corporation Punctum plug system including a punctum plug and passive insertion tool therefor
US7204253B2 (en) 2003-05-22 2007-04-17 Clarity Corporation Punctum plug
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
JP4104137B2 (ja) 2003-05-30 2008-06-18 有限会社エム・エル・シー 涙点プラグ
US7662864B2 (en) * 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
JP4339635B2 (ja) 2003-06-12 2009-10-07 有限会社エム・エル・シー 涙点プラグ
US6994684B2 (en) 2003-06-16 2006-02-07 Alphamed Inc. Punctum plugs having fluid collecting recesses and methods of punctal occlusion
US20040265356A1 (en) 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
US20070043332A1 (en) * 2003-07-10 2007-02-22 Galen (Chemiclas) Liimited Intravaginal drug delivery devices
US7198205B1 (en) * 2003-07-24 2007-04-03 Anderson & Associates, Llc Silicone protective coating
JP4280128B2 (ja) 2003-08-19 2009-06-17 有限会社エム・エル・シー 涙点プラグ
JP2005110765A (ja) 2003-10-03 2005-04-28 M L C:Kk 涙点プラグセット
JP2005110930A (ja) 2003-10-07 2005-04-28 M L C:Kk 涙点プラグセット
US20050129731A1 (en) 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US20050095269A1 (en) * 2003-11-04 2005-05-05 Ainpour Parviz R. Gel plug for blockage of the canaliculus
US20050197614A1 (en) 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
US20050220882A1 (en) 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
JP2004202276A (ja) 2004-04-16 2004-07-22 M L C:Kk 涙道再建用挿管器具
US7589057B2 (en) * 2004-04-30 2009-09-15 Allergan, Inc. Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
JP2005312835A (ja) 2004-04-30 2005-11-10 M L C:Kk 糸で補強した涙道ステント
JP4644438B2 (ja) 2004-05-11 2011-03-02 有限会社エム・エル・シー ツバつき涙道ステント
JP4510511B2 (ja) 2004-05-18 2010-07-28 有限会社エム・エル・シー ツバを円盤で補強した涙道ステント及び涙道プラグ
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
CA2573892A1 (en) 2004-07-26 2006-02-09 Clarity Corporation Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20080038317A1 (en) * 2004-09-10 2008-02-14 Chin-Ming Chang Therapeutic Lacrimal Canalicular Inserts And Related Methods
US20060074370A1 (en) * 2004-09-24 2006-04-06 Medennium, Inc. Ocular occluder and method of insertion
JP2008521489A (ja) 2004-11-24 2008-06-26 テラカイン コーポレイション 眼球内薬物送達のための移植物
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US7862532B2 (en) * 2005-10-07 2011-01-04 Delta Life Sciences, Inc. Punctum plugs having insertion guides and strengthening beams
US20070132125A1 (en) * 2005-12-08 2007-06-14 Bausch & Lomb Incorporated Use of a super-cooled fluid in lens processing
JP4078371B2 (ja) 2006-01-27 2008-04-23 章弘 小栗 涙点プラグ
NZ571758A (en) 2006-03-31 2012-06-29 Quadra Logic Tech Inc A drug insert surrounded by a sheath to expose a polymer containing a drug to surrounding tissues or an eye
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
SG138567A1 (en) * 2006-06-21 2008-01-28 Johnson & Johnson Vision Care Punctal plugs for the delivery of active agents
US20080045911A1 (en) * 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US9173773B2 (en) 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
FR2908042B1 (fr) 2006-11-08 2009-06-05 Bruno Fayet Ensemble d'intubation monocanaliculonasal et/ou monocanaliculaire,notamment pour l'imperforation lacrymonasale.
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
WO2009012406A1 (en) 2007-07-17 2009-01-22 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities reference to priority document
CN103349799B (zh) 2007-09-07 2016-01-20 马缇医疗股份有限公司 用于持续释放治疗药物的药物核心
KR20100058620A (ko) * 2007-09-07 2010-06-03 큐엘티 플러그 딜리버리, 인코포레이티드 눈물 임플랜트용 삽입 및 적출 기구
MX2010002617A (es) * 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Implantes lagrimales y metodos relacionados.
CN102105137B (zh) 2008-04-30 2015-01-07 Qlt股份有限公司 复合泪管植入物及相关方法
CN105251007A (zh) 2008-05-09 2016-01-20 马缇医疗股份有限公司 治疗青光眼和眼高血压的活性剂的持续释放递送

Also Published As

Publication number Publication date
KR20170005905A (ko) 2017-01-16
EP2614844A1 (en) 2013-07-17
JP2020062381A (ja) 2020-04-23
CN101984745A (zh) 2011-03-09
IL273683A (en) 2020-05-31
RU2478366C2 (ru) 2013-04-10
KR20150136140A (ko) 2015-12-04
CA2698573C (en) 2017-12-05
AU2008300013A1 (en) 2009-03-19
JP2014236980A (ja) 2014-12-18
HK1155104A1 (en) 2012-05-11
EP2207529A2 (en) 2010-07-21
JP5933630B2 (ja) 2016-06-15
US20120187594A1 (en) 2012-07-26
TWI543776B (zh) 2016-08-01
NZ598483A (en) 2013-08-30
DK2207529T3 (en) 2015-03-09
SG184738A1 (en) 2012-10-30
MX2010002616A (es) 2010-08-04
JP2016165503A (ja) 2016-09-15
JP2017205545A (ja) 2017-11-24
JP2010538696A (ja) 2010-12-16
US8628792B2 (en) 2014-01-14
CA2698573A1 (en) 2009-03-19
ZA201001586B (en) 2011-05-25
KR101996336B1 (ko) 2019-07-04
BRPI0817075A2 (pt) 2016-07-26
HK1189521A1 (zh) 2014-06-13
WO2009035562A3 (en) 2009-07-02
US20090104243A1 (en) 2009-04-23
JP5555162B2 (ja) 2014-07-23
CN103349799B (zh) 2016-01-20
KR20100063111A (ko) 2010-06-10
IL253005A0 (en) 2017-08-31
DK2614844T3 (en) 2015-06-08
US20170304194A1 (en) 2017-10-26
TW201002367A (en) 2010-01-16
KR101696301B1 (ko) 2017-01-13
EP2207529B1 (en) 2014-12-31
NZ583678A (en) 2012-03-30
RU2010113387A (ru) 2011-10-20
US20190105265A1 (en) 2019-04-11
WO2009035562A2 (en) 2009-03-19
CN103349799A (zh) 2013-10-16
CN101984745B (zh) 2013-08-14
KR101571434B1 (ko) 2015-11-24
EP2614844B1 (en) 2015-04-15
ES2538838T3 (es) 2015-06-24
US20140186420A1 (en) 2014-07-03

Similar Documents

Publication Publication Date Title
ES2533359T3 (es) Núcleos de fármaco para liberación sostenida de agentes terapéuticos
AR117996A2 (es) Proceso para elaborar una lente de contacto blanda que libera un agente de confort hidrofóbico
NZ595623A (en) A drug insert surrounded by a sheath to expose a polymer containing a drug to surrounding tissues or an eye
KR101341364B1 (ko) 활성제 전달용 눈물점 마개
KR101388440B1 (ko) 활성제 전달용 눈물점 마개
EP2285321B1 (en) Ophthalmic devices for the controlled release of active agents
JP2011519301A5 (es)
JP2010538696A5 (es)
RU2530723C2 (ru) Пробки слезного канала
AR063619A1 (es) Dispositivos y metodos para la administraicion de un farmaco oftalmico
EP4316594A3 (en) Intraocular pressure reduction with intracameral bimatoprost implants
AR058620A1 (es) Formulacion farmaceutica para el suministro de compuestos inhibidores del receptor de tirosina quinasa (rtki) al ojo
BRPI1007318A2 (pt) distribuição com liberação sustentada de um ou mais agentes.
AR073460A1 (es) Dispositivo oftalmico con capacidad de administracion de agente terapeutico y metodo de formacion del mismo
WO2010068281A3 (en) Contact lens drug delivery device
AR062046A1 (es) Soluciones oftalmicas
NZ583861A (en) Lacrimal implants with an angled intersection between its sections so as to bias a portion of the body against the tissue surface
WO2015095772A3 (en) Formulations and methods for targeted ocular delivery of therapeutic agents
AR049979A1 (es) Composicion oftalmica util para la colocacion intraocular en un ojo de un ser humano o animal y uso de un componente corticosteroide, un componente polimerico biocompatible y un componente solvente oftalmicamente compatible en una cantidad efectiva para solubilizar el componente polimerico para prep
UY28509A1 (es) Formas de dosificacion de azitromicina con efectos secundarios reducidos
IL182650A0 (en) Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
UY28067A1 (es) Formulaciones de deposito de liberacion controlada
BRPI0510472A (pt) implantes intra-oculares de liberação prolongada antiexcitotóxicos e métodos relacionados
AU2010234879A1 (en) Punctal plugs
BR0106913A (pt) Composições transparentes de limpeza em barra que são eficazes e não são irritantes para os olhos