MX2017005972A - Dispositivo de entrega de farmacos expandibles y metodo de uso. - Google Patents

Dispositivo de entrega de farmacos expandibles y metodo de uso.

Info

Publication number
MX2017005972A
MX2017005972A MX2017005972A MX2017005972A MX2017005972A MX 2017005972 A MX2017005972 A MX 2017005972A MX 2017005972 A MX2017005972 A MX 2017005972A MX 2017005972 A MX2017005972 A MX 2017005972A MX 2017005972 A MX2017005972 A MX 2017005972A
Authority
MX
Mexico
Prior art keywords
dimensional shape
drug delivery
delivery devices
reservoir
outlet
Prior art date
Application number
MX2017005972A
Other languages
English (en)
Inventor
G Bachelder Bradley
E Campbell Randolph
G Doud Darren
R Erickson Signe
W Sacherman Kevin
Original Assignee
Forsight Vision4 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forsight Vision4 Inc filed Critical Forsight Vision4 Inc
Publication of MX2017005972A publication Critical patent/MX2017005972A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
    • A61F2250/001—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting a diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0069—Sealing means

Abstract

Se describen dispositivos implantables que tienen depósitos expandibles para la liberación sostenida de agentes terapéuticos. El dispositivo está configurado para ser implantado al menos parcialmente en un ojo e incluye una estructura de retención y un elemento penetrante acoplado a y que se extiende dentro de al menos una porción de la estructura de retención. Un mecanismo poroso de liberación de fármaco está posicionado en comunicación fluida con una salida del dispositivo; y un depositó que tiene un volumen configurado para contener uno o más agentes terapéuticos está en comunicación fluida con la salida a través del mecanismo poroso de liberación del fármaco. El dispositivo esta al menos parcialmente insertado a lo largo de un eje de inserción. El depositó se agranda desde una configuración de inserción que tiene una primera forma tridimensional hasta una configuración expandida que tiene una segunda forma tridimensional, la segunda forma tridimensional estando situada excéntricamente con respecto al eje de inserción.
MX2017005972A 2014-11-10 2015-11-10 Dispositivo de entrega de farmacos expandibles y metodo de uso. MX2017005972A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462077829P 2014-11-10 2014-11-10
PCT/US2015/059990 WO2016077371A1 (en) 2014-11-10 2015-11-10 Expandable drug delivery devices and method of use

Publications (1)

Publication Number Publication Date
MX2017005972A true MX2017005972A (es) 2017-07-13

Family

ID=55911344

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005972A MX2017005972A (es) 2014-11-10 2015-11-10 Dispositivo de entrega de farmacos expandibles y metodo de uso.

Country Status (14)

Country Link
US (3) US10500091B2 (es)
EP (1) EP3217924A4 (es)
JP (3) JP7037360B2 (es)
KR (1) KR20170106298A (es)
CN (3) CN107249515B (es)
AU (1) AU2015346450B2 (es)
BR (1) BR112017009660A2 (es)
CA (1) CA2967330A1 (es)
HK (1) HK1245065A1 (es)
IL (1) IL252172B (es)
MX (1) MX2017005972A (es)
RU (1) RU2708958C2 (es)
SG (1) SG11201703726XA (es)
WO (1) WO2016077371A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4302736A3 (en) 2013-03-28 2024-04-03 ForSight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US10258503B2 (en) 2014-07-15 2019-04-16 Forsight Vision4, Inc. Ocular implant delivery device and method
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US10500091B2 (en) 2014-11-10 2019-12-10 Forsight Vision4, Inc. Expandable drug delivery devices and methods of use
CN108430405B (zh) 2015-11-20 2021-04-13 弗赛特影像4股份有限公司 用于缓释药物递送装置的多孔结构
US11617680B2 (en) 2016-04-05 2023-04-04 Forsight Vision4, Inc. Implantable ocular drug delivery devices
WO2019103906A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
CA3160807A1 (en) * 2019-12-05 2021-06-10 Antons SIZOVS Stabilized drug formulations and methods of loading drug delivery implants
TW202140071A (zh) * 2020-02-14 2021-11-01 美商英福卡斯公司 用於治療眼部疾病之具有一自我密封儲存槽之可植入式藥物遞送裝置
CN113230019A (zh) * 2021-04-16 2021-08-10 南京佑羲医药科技有限公司 一种用于眼球玻璃体内植入的长效缓释给药装置

Family Cites Families (386)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2585815A (en) 1947-01-16 1952-02-12 Mclintock Duncan Menzies Injection syringe
US2564977A (en) 1949-01-19 1951-08-21 Hu Quang Hsi Medical injecting apparatus
US3232117A (en) 1962-09-14 1966-02-01 Roger Gilmont Instr Inc Micrometer buret
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3641237A (en) 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3831583A (en) 1971-03-05 1974-08-27 Univ California Implantable bulb for inflation of surgical implements
US3995635A (en) 1971-09-09 1976-12-07 Alza Corporation Ocular insert
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3845201A (en) 1972-04-24 1974-10-29 S Loucas Solid state ophthalmic medication delivery method
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3914402A (en) 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US4179497A (en) 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
US3902495A (en) 1974-01-28 1975-09-02 Cavitron Corp Flow control system
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949748A (en) 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US3926188A (en) 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4096238A (en) 1974-12-23 1978-06-20 Alza Corporation Method for administering drug to the gastrointestinal tract
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
NL188266C (nl) 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US3977404A (en) 1975-09-08 1976-08-31 Alza Corporation Osmotic device having microporous reservoir
US4014333A (en) 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4111201A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for delivering selected beneficial agents having varying degrees of solubility
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4186184A (en) 1977-12-27 1980-01-29 Alza Corporation Selective administration of drug with ocular therapeutic system
US4220152A (en) 1978-05-08 1980-09-02 Pfizer Inc. Delivery system
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4309776A (en) 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4439198A (en) 1981-07-09 1984-03-27 University Of Illinois Foundation Biodegradable ocular insert for controlled delivery of ophthalmic medication
US4730013A (en) 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
US4475916A (en) 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4673405A (en) 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4883459A (en) 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4774091A (en) 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4712550A (en) 1985-04-08 1987-12-15 Sinnett Kevin B Retinal tack
US4693886A (en) 1985-04-22 1987-09-15 Alza Corporation Osmotic device with inert core
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
EP0201611A1 (de) 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
CA1314481C (en) 1986-12-23 1993-03-16 Marcel B. Bally Liposomal preparation and antibiotic
US4781675A (en) 1985-11-27 1988-11-01 White Thomas C Infusion cannula
DE3672981D1 (de) 1985-11-27 1990-08-30 Thomas C White Gewebeimplantierbare fluessigkeitsverteileinrichtung.
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4853229A (en) 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
JP2702953B2 (ja) 1988-01-30 1998-01-26 オリンパス光学工業株式会社 薬液含浸セラミックス
US4865846A (en) 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US5174999A (en) 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
AU4951690A (en) 1988-12-30 1990-08-01 David M. Anderson Stabilized microporous materials and hydrogel materials
US5141748A (en) 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US4979938A (en) 1989-05-11 1990-12-25 Iomed, Inc. Method of iontophoretically treating acne, furuncles and like skin disorders
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5238687A (en) 1990-07-11 1993-08-24 Alza Corporation Delivery device with a protective sleeve
US5084021A (en) 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
AU650113B2 (en) 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5334189A (en) 1991-06-03 1994-08-02 Wade Stephen E Device for controlled diffusion of a chemical substance
US5213576A (en) 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
US5282829A (en) 1991-08-15 1994-02-01 United States Surgical Corporation Hollow body implants
FR2682090B1 (fr) 1991-10-03 1993-12-31 Holzstoff Holding Sa Systeme-reservoir pour diffusion prolongee d'un principe actif.
US5681572A (en) 1991-10-18 1997-10-28 Seare, Jr.; William J. Porous material product and process
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5770076A (en) 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5578042A (en) 1994-03-14 1996-11-26 Cumming; J. Stuart Ophthalmic kit and method for lens insertion
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
AU708529B2 (en) 1994-11-10 1999-08-05 University Of Kentucky Research Foundation, The Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5554132A (en) 1995-03-30 1996-09-10 Abbott Laboratories Hand grip for use with syringe
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
CN1283324C (zh) 1995-05-14 2006-11-08 奥普通诺尔有限公司 眼内植入物、植入装置、以及植入方法
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB2310149A (en) 1996-02-15 1997-08-20 Nomix Chipman Ltd Spray gun
US20090005864A1 (en) 1996-03-18 2009-01-01 Eggleston Harry C Modular intraocular implant
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
US5951512A (en) 1996-05-28 1999-09-14 Horizon Medical Products, Inc. Infusion port with modified drug reservoir
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
AU7533696A (en) 1996-12-13 1998-06-18 Ciba-Geigy Ag New materials
DK0973499T3 (da) 1997-03-31 2003-11-17 Alza Corp Implanterbart diffusionsafgivelsessystem
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US5993414A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
FR2784296B1 (fr) 1998-09-18 2001-01-05 Imedex Biomateriaux Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
DE19948783C2 (de) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implantat
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU770975B2 (en) 1999-06-18 2004-03-11 Alcon Laboratories, Inc. Topical ophthalmic mast cell stabilizers for treating allergic eye diseases
US6638263B1 (en) 1999-10-12 2003-10-28 Durect Corporation Regulation of drug delivery through flow diversion
ATE283013T1 (de) 1999-10-21 2004-12-15 Alcon Inc Medikamentenzuführvorrichtung
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20030212383A1 (en) 2001-01-05 2003-11-13 Dana Cote System and methods for reducing intraocular pressure
RU2262331C2 (ru) 2000-01-12 2005-10-20 Бектон, Дикинсон Энд Компани Шунт, имплантат, система и способ снижения внутриглазного давления, способ изготовления имплантата для роговицы (варианты)
DE10008826C2 (de) 2000-02-25 2002-03-14 Disetronic Licensing Ag Mikroperfusionsvorrichtung mit Sammelbehältnis
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
WO2001068377A1 (fr) 2000-03-13 2001-09-20 Seiko Epson Corporation Procede de traitement de surface, article traite en surface et dispositif de traitement de surface
US7141152B2 (en) 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
ATE547080T1 (de) * 2000-08-30 2012-03-15 Univ Johns Hopkins Vorrichtungen zur intraokularen arzneimittelabgabe
DE60131773T2 (de) 2000-09-06 2008-04-10 Alcon Inc. Beschichtungsmittel mit veränderbarer klebrigkeit für augenimplantate
US6303290B1 (en) 2000-09-13 2001-10-16 The Trustees Of The University Of Pennsylvania Encapsulation of biomaterials in porous glass-like matrices prepared via an aqueous colloidal sol-gel process
WO2002056863A2 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
WO2002053129A1 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with prefabricated permeable plugs
US6756058B2 (en) 2001-01-03 2004-06-29 Bausch & Lomb Incorporated Sustained release drug delivery devices with multiple agents
DE60130928T2 (de) 2001-01-03 2008-07-17 Bausch & Lomb Inc. Vorrichtung zur verzögerten wirkstofffreisetzung mit beschichteten medikamentenkernen
JP4657577B2 (ja) 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド 眼への適用および他への適用のための可撓性マイクロチップデバイス
JP2004520900A (ja) 2001-01-26 2004-07-15 ボシュ・アンド・ロム・インコーポレイテッド 徐放薬剤送達装置の改良製造方法
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
EP1404297B1 (en) 2001-06-12 2011-04-27 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
JP4426286B2 (ja) 2001-07-10 2010-03-03 テバ ファーマシューティカル インダストリーズ リミティド ０次、０次−二相性、上昇型又は下降型薬物放出のための薬物送達システム
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
AU2002319606B2 (en) 2001-07-23 2006-09-14 Alcon, Inc. Ophthalmic drug delivery device
EP1409065B1 (en) 2001-07-23 2007-01-17 Alcon, Inc. Ophthalmic drug delivery device
CN1538826A (zh) 2001-08-03 2004-10-20 青光眼研究科技公司 治疗青光眼及老花眼的方法及其内巩膜植入物
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
RU2311892C2 (ru) 2001-08-29 2007-12-10 КАРВАЛХО Рикардо А. П. ДЕ Имплантируемая и герметизируемая система для однонаправленной доставки терапевтических препаратов в ткани
US20030118649A1 (en) 2001-10-04 2003-06-26 Jinming Gao Drug delivery devices and methods
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
JP2005509883A (ja) 2001-11-15 2005-04-14 アリックス，インコーポレーテッド 試料チップ
CA2473355C (en) 2002-01-18 2012-01-03 Michael E. Snyder Sustained release ophthalmological device and method of making and using the same
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
MXPA04008903A (es) 2002-03-11 2004-11-26 Alcon Inc Sistema de suministro de farmaco implantable.
US7074426B2 (en) 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
WO2004006889A1 (en) 2002-07-15 2004-01-22 Alcon, Inc. Bioerodible film for ophthalmic drug delivery
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US20040019325A1 (en) 2002-07-29 2004-01-29 Medrip Ltd. Syringe Pump
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
AU2003272575B2 (en) 2002-09-18 2007-11-08 Allergan, Inc. Methods and apparatus for delivery of ocular implants
US20050143363A1 (en) 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
US7794437B2 (en) 2003-01-24 2010-09-14 Doheny Retina Institute Reservoirs with subretinal cannula for subretinal drug delivery
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US20060258000A1 (en) 2003-02-26 2006-11-16 Allen Jared W Use of steady-state oxygen gradients to modulate animal cell functions
US20050074497A1 (en) 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20050255144A1 (en) 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
EP1671624B1 (en) 2003-05-02 2010-08-11 SurModics, Inc. Delivery device for a controlled drug release of an active agent into the posterior section of the eye
CA2524271C (en) 2003-05-02 2012-09-04 Surmodics, Inc. Controlled release bioactive agent delivery device
CA2529048A1 (en) 2003-06-13 2005-02-24 Becton, Dickinson And Company Improved intra-dermal delivery of biologically active agents
US20040260381A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices and methods for forming stenting structures in situ
WO2004112653A2 (en) 2003-06-18 2004-12-29 D-Crown Ltd. Devices and methods for delivering and forming single and multiple stenting structures in situ
US20040260380A1 (en) 2003-06-18 2004-12-23 D-Crown Ltd Devices for delivering multiple stenting structures in situ
US8367410B2 (en) 2003-06-20 2013-02-05 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
ZA200508654B (en) 2003-07-10 2007-01-31 Alcon Inc Ophthalmic drug delivery device
FI120333B (fi) 2003-08-20 2009-09-30 Bioretec Oy Huokoinen lääketieteellinen väline ja menetelmä sen valmistamiseksi
AU2004274026A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
NZ546730A (en) 2003-09-24 2008-04-30 Medi Stream Pty Ltd Medication holder
AU2006225241B2 (en) 2003-09-24 2008-07-17 Tianda Pharmaceuticals (Australia) Pty Limited Medication Holder
US7615141B2 (en) 2003-10-03 2009-11-10 University Of Washington Electrochemical micromanufacturing system and method
US7211272B2 (en) 2003-12-22 2007-05-01 Bausch & Lomb Incorporated Drug delivery device
BRPI0507690A (pt) 2004-02-12 2007-07-24 Neovista Inc métodos e aparelho para a braquiterapia intra-ocular
US7276050B2 (en) 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US20050256499A1 (en) 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US20060182783A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Sustained release intraocular drug delivery systems
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060020253A1 (en) * 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
WO2006015385A2 (en) 2004-08-06 2006-02-09 Sopherion Therapeutics, Inc. Anti-angiogenic peptides and methods of use thereof
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006023530A2 (en) 2004-08-16 2006-03-02 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US20060052754A1 (en) 2004-09-04 2006-03-09 Fields Douglas W Thumb trigger syringe pole
WO2006031532A2 (en) 2004-09-10 2006-03-23 Surmodics, Inc. Methods, devices, and coatings for controlled active agent release
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
AU2005292145C1 (en) 2004-10-01 2011-07-21 Ramscor, Inc. Conveniently implantable sustained release drug compositions
WO2006044614A2 (en) 2004-10-14 2006-04-27 Sopherion Therapeutics, Inc. Anti-angiogenic peptides and methods of use thereof
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EP1817003B1 (en) 2004-10-29 2018-02-21 The Regents of The University of California Porous silicon microparticles for drug delivery to the eye
US20060129215A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060154981A1 (en) 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
WO2006082588A2 (en) 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
KR20070121754A (ko) 2005-03-21 2007-12-27 마커사이트, 인코포레이티드 질환 또는 상태의 치료를 위한 약물 송달 시스템
US20070066138A1 (en) 2005-04-05 2007-03-22 The Ohio State University Research Foundation Diffusion Delivery Systems and Methods of Fabrication
US20100168535A1 (en) 2006-04-12 2010-07-01 Mark Ries Robinson Methods and apparatuses related to blood analyte measurement system
US20060258994A1 (en) 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
US20070088414A1 (en) 2005-05-25 2007-04-19 Campbell Robert L Particulate formulations for intradermal delivery of biologically active agents
JP2009501700A (ja) 2005-06-17 2009-01-22 ダイナミス・セラピユーテイクス・インコーポレーテツド 炎症状態の治療
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
JP2009508593A (ja) 2005-09-16 2009-03-05 （オーエスアイ）アイテツク・インコーポレーテツド 眼科用シリンジ
US20070071756A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an agent to ameliorate inflammation
US20080003219A1 (en) 2005-09-26 2008-01-03 Minu, L.L.C. Delivery of an ocular agent
US20070072933A1 (en) 2005-09-26 2007-03-29 Peyman Gholam A Delivery of an ocular agent
WO2007038453A2 (en) 2005-09-26 2007-04-05 Advanced Ocular Systems Limited Use of an anti-vascular endothelial growth factor (vegf) agent to ameliorate inflammation
US20080167600A1 (en) 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
TW200732347A (en) 2005-10-06 2007-09-01 Trophogen Inc VEGF analogs and methods of use
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
EP1948112A4 (en) 2005-10-11 2011-04-13 Podaima Blake SMART MEDICAL COMPLIANCE PROCESS AND SYSTEM
US20080125406A1 (en) 2005-10-14 2008-05-29 Robin Alan L Method for Treating Primary and Secondary Forms of Glaucoma
WO2007047744A2 (en) 2005-10-14 2007-04-26 Alcon, Inc. Method for treating primary and secondary forms of glaucoma
MX2008006379A (es) 2005-11-29 2009-03-03 Smithkline Beecham Corp Metodo de tratamiento.
JP4721425B2 (ja) 2005-12-01 2011-07-13 キヤノン株式会社 流体移動方法および流体移動装置
WO2007066339A1 (en) 2005-12-07 2007-06-14 Ramot At Tel Aviv University Ltd. Drug-delivering composite structures
US20070131610A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based apparatus and associated method
US20070131611A1 (en) 2005-12-13 2007-06-14 General Electric Company Membrane-based article and associated method
EP3632385A1 (en) 2006-01-17 2020-04-08 Novartis AG Glaucoma treatment device
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
US20080216736A1 (en) 2006-01-19 2008-09-11 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
WO2007100986A2 (en) 2006-02-24 2007-09-07 Rosetta Inpharmatics Llc Extraction and diagnostic fluid devices, systems and methods of use
WO2007101204A1 (en) 2006-02-27 2007-09-07 Alcon Research, Ltd. Method of treating glaucoma
TW200800230A (en) 2006-03-31 2008-01-01 Dynamis Therapeutics Inc Composition and method related to fructosamine-3-kinase inhibitors
KR20110038144A (ko) * 2006-03-31 2011-04-13 큐엘티 플러그 딜리버리, 인코포레이티드 비루관계에 대한 약물 전달 방법, 구조, 및 조성물
US8007461B2 (en) 2006-04-18 2011-08-30 Pingan Huo Sterile drug-mixing syringe
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US20080124372A1 (en) 2006-06-06 2008-05-29 Hossainy Syed F A Morphology profiles for control of agent release rates from polymer matrices
EP2037882B1 (en) 2006-06-28 2014-12-10 SurModics, Inc. Combination degradable and non-degradable matrices for active agent delivery
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
WO2008009120A2 (en) 2006-07-19 2008-01-24 Noab Biodiscoveries Inc. Method and device to extract components contained in a fluid
CA2657380A1 (en) 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
US20080069854A1 (en) 2006-08-02 2008-03-20 Inframat Corporation Medical devices and methods of making and using
JP2008054521A (ja) 2006-08-29 2008-03-13 Canon Inc 細胞培養処理装置及び細胞培養処理方法
WO2008033924A2 (en) 2006-09-12 2008-03-20 Board Of Regents Of The University Of Nebraska Methods and compositions for targeted delivery of therapeutic agents
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US9149750B2 (en) 2006-09-29 2015-10-06 Mott Corporation Sinter bonded porous metallic coatings
US20080089923A1 (en) 2006-09-29 2008-04-17 Burkstrand Michael J Biodegradable ocular implants and methods for treating ocular conditions
TW200817039A (en) 2006-10-06 2008-04-16 Dynamis Therapeutics Inc Compositions and methods for skin lightening
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
WO2008052145A2 (en) 2006-10-25 2008-05-02 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
AU2007349224B2 (en) 2006-10-25 2014-04-03 Revalesio Corporation Methods of wound care and treatment
US8506515B2 (en) 2006-11-10 2013-08-13 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20080111282A1 (en) 2006-11-10 2008-05-15 Baojun Xie Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles
US20100286791A1 (en) * 2006-11-21 2010-11-11 Goldsmith David S Integrated system for the ballistic and nonballistic infixion and retrieval of implants
WO2008070118A1 (en) 2006-12-05 2008-06-12 Landec Corporation Drug delivery
US20090263346A1 (en) 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
WO2008073295A2 (en) 2006-12-07 2008-06-19 Surmodics, Inc. Latent stabilization of bioactive agents releasable from implantable medical articles
US20080147021A1 (en) 2006-12-15 2008-06-19 Jani Dharmendra M Drug delivery devices
WO2008076544A2 (en) 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
JP2010514517A (ja) 2006-12-26 2010-05-06 キューエルティー プラグ デリバリー，インク． 視覚欠損の抑制のための薬物送達インプラント
JP5201744B2 (ja) 2007-01-09 2013-06-05 フォヴェア ファルマシューティカル 眼内注射装置
AU2008206953A1 (en) 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
WO2008116165A2 (en) 2007-03-21 2008-09-25 Next Safety, Inc. Methods and systems of delivering medication via inhalation
US20080249501A1 (en) 2007-04-09 2008-10-09 Medtronic Vascular, Inc. Methods for Simultaneous Injection and Aspiration of Fluids During a Medical Procedure
US20080286338A1 (en) 2007-05-15 2008-11-20 Boston Foundation For Sight Drug delivery system with scleral lens
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CA2688344C (en) 2007-05-29 2019-09-03 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
WO2009023615A1 (en) 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
KR101996336B1 (ko) 2007-09-07 2019-07-04 마티 테라퓨틱스 인코포레이티드 치료 약제의 서방성 약물 코어
CA2698580C (en) 2007-09-07 2016-10-11 Qlt Plug Delivery, Inc. Lacrimal implant detection
EP2205192A2 (en) 2007-09-07 2010-07-14 QLT Plug Delivery, Inc. Insertion and extraction tools for lacrimal implants
US8308755B2 (en) 2007-09-24 2012-11-13 Ethicon Endo-Surgery, Inc. Elliptical retractor
US20090214601A1 (en) 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
KR101511497B1 (ko) 2007-10-05 2015-04-13 코비디엔 엘피 수술 절차에 사용하기 위한 밀봉부 고정구
US20100100043A1 (en) 2007-10-05 2010-04-22 Racenet Danyel J Flexible Access Device For Use In Surgical Procedure
US20100008997A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
AU2008316708A1 (en) 2007-10-25 2009-04-30 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
WO2010062628A1 (en) 2008-10-27 2010-06-03 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100303917A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating cystic fibrosis
US20100303918A1 (en) 2007-10-25 2010-12-02 Revalesio Corporation Compositions and methods for treating asthma and other lung disorders
US20100310665A1 (en) 2007-10-25 2010-12-09 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
US20090263495A1 (en) 2007-10-25 2009-10-22 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US20100009008A1 (en) 2007-10-25 2010-01-14 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20100004189A1 (en) 2007-10-25 2010-01-07 Revalesio Corporation Compositions and methods for treating cystic fibrosis
BRPI0819175A2 (pt) 2007-11-05 2015-05-05 Bausch & Lomb Composição farmacêutica oftálmica, e, método para proporcionar disponibilidade estendida de um componente farmacêutico em um ambiente ocular de um indivíduo, e, uso de pelo menos um componente farmacêutico, pelo menos um material imiscível em água e opcionalmente um composto modificador de viscosidade
US8114883B2 (en) 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
US20090192493A1 (en) 2008-01-03 2009-07-30 University Of Southern California Implantable drug-delivery devices, and apparatus and methods for refilling the devices
WO2009089409A2 (en) 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009094466A2 (en) 2008-01-22 2009-07-30 University Of Florida Research Foundation, Inc. Contact lenses for extended release of bioactive agents containing diffusion attenuators
US8201752B2 (en) 2008-03-10 2012-06-19 Vapore, Inc. Low energy vaporization of liquids: apparatus and methods
TNSN08110A1 (en) 2008-03-11 2009-07-14 Rekik Raouf Dr Drug delivery to the anterior and posterior segment of the eye from drops
WO2009117112A2 (en) 2008-03-21 2009-09-24 Novartis Ag Powder dispersion apparatus, method of making and using the apparatus, components that can be used on the apparatus and other devices, and various active agents
KR101674492B1 (ko) 2008-03-31 2016-11-09 닛토덴코 가부시키가이샤 침투제 전달 시스템 및 그의 사용방법
DK2285439T3 (en) 2008-04-04 2014-03-24 Nektar Therapeutics Aerosoliseringsanorning
US20090258069A1 (en) 2008-04-15 2009-10-15 John Burnier Delivery of LFA-1 antagonists to the gastrointestinal system
CA2722002C (en) 2008-04-30 2018-06-19 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
WO2009134929A2 (en) 2008-05-01 2009-11-05 Revalesio Corporation Compositions and methods for treating digestive disorders
CN103394142B (zh) 2008-05-08 2015-08-19 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
US8231609B2 (en) 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US20100197512A1 (en) 2008-07-11 2010-08-05 Intellicyt Multi-Sample Particle Analyzer and Method for High Throughput Screening
EP2312993A4 (en) 2008-07-21 2015-03-11 Arstasis Inc DEVICES, METHODS AND KITS FOR FORMING TISSUE TRAYS
US20100023033A1 (en) 2008-07-25 2010-01-28 Medtronic Vescular, Inc. Hydrodynamic Thrombectomy Catheter
US20100022943A1 (en) 2008-07-25 2010-01-28 Medtronic Vascular, Inc. Hydrodynamic Thrombectomy Catheter
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US8221353B2 (en) 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
US7678078B1 (en) 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
DE102008054431B3 (de) 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
US20100174272A1 (en) 2009-01-02 2010-07-08 Weiner Alan L In-situ refillable ophthalmic implant
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
PL2391419T3 (pl) 2009-01-29 2019-12-31 Forsight Vision4, Inc. Dostarczanie leku do tylnego odcinka
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
US8424367B2 (en) 2009-03-04 2013-04-23 University Of South Carolina Systems and methods for measurement of gas permeation through polymer films
JP2012525396A (ja) 2009-04-27 2012-10-22 レバレジオ コーポレイション インスリン耐性および真性糖尿病を治療するための組成物および方法
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
WO2010125416A1 (en) 2009-04-27 2010-11-04 Raouf Rekik Drug delivery to the anterior and posterior segments of the eye
CN102802541A (zh) 2009-05-15 2012-11-28 阿尔斯塔西斯公司 在组织中形成管道的装置、方法和成套用具
WO2010135369A1 (en) 2009-05-18 2010-11-25 Dose Medical Corporation Drug eluting ocular implant
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
WO2011008896A2 (en) 2009-07-14 2011-01-20 Board Of Regents, The University Of Texas System Therapeutic methods using controlled delivery devices having zero order kinetics
US20110033933A1 (en) 2009-07-15 2011-02-10 Morteza Gharib Method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves
US20110117083A1 (en) 2009-08-14 2011-05-19 Genentech, Inc. Biological markers for monitoring patient response to vegf antagonists
WO2011028850A1 (en) 2009-09-01 2011-03-10 Northwestern University Delivery of therapeutic agents using oligonucleotide-modified nanoparticles as carriers
EP2480270A4 (en) 2009-09-21 2015-07-08 Harvard Apparatus Regenerative Technology Inc METHODS AND APPARATUSES FOR INTRODUCING CELLS INTO A TISSUE SITE
US20110238036A1 (en) 2009-12-23 2011-09-29 Psivida Us, Inc. Sustained release delivery devices
US10166142B2 (en) * 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US8821474B2 (en) * 2010-02-22 2014-09-02 Microsert Ltd. Slow release liquid drug delivery device
US8038650B2 (en) 2010-02-22 2011-10-18 Microsert Ltd. Slow release liquid drug delivery device
AR081364A1 (es) 2010-05-05 2012-08-29 Glaxo Wellcome Mfg Pte Ltd Composiciones farmaceuticas de pazopanib y metodos para su elaboracion
DE102010026334B4 (de) * 2010-07-07 2014-10-23 Gebr. Brasseler Gmbh & Co. Kg Dentalwerkzeug
WO2012019139A1 (en) * 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
SI2600812T1 (sl) 2010-08-05 2021-12-31 ForSight Vision4, Inc., Naprava za zdravljenje očesa
EP3861969A1 (en) * 2010-08-05 2021-08-11 ForSight Vision4, Inc. Injector apparatus for drug delivery
EP2600920A4 (en) * 2010-08-05 2017-10-04 Forsight Vision4, Inc. Subconjunctival implant for posterior segment drug delivery
US8864703B2 (en) 2010-10-05 2014-10-21 Alcon Research, Ltd. Drug introduction and placement system
WO2012065006A2 (en) 2010-11-11 2012-05-18 Forsight Vision4, Inc. Methods and apparatus to determine porous structures for drug delivery
CA2818612C (en) * 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
WO2012131583A2 (en) 2011-03-27 2012-10-04 Microsert Ltd. Miniature implanted drug delivery devices and inserter systems for introducing such devices
EP4249059A3 (en) 2011-06-28 2023-11-29 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
SI2755600T1 (sl) 2011-09-16 2021-08-31 Forsight Vision4, Inc. Naprava za izmenjavo tekočine
US10010448B2 (en) * 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
AU2014236455B2 (en) * 2013-03-14 2018-07-12 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP4302736A3 (en) * 2013-03-28 2024-04-03 ForSight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US20140336619A1 (en) 2013-05-13 2014-11-13 Abbott Cardiovascular Systems Inc. Ophthalmic shunt and method
US10376413B2 (en) * 2013-10-27 2019-08-13 Microsert Ltd. Implantable drug delivery device and a system and method for deployment of such devices
US9445941B2 (en) 2013-11-07 2016-09-20 Drug Delivery Company, Llc Bioresorbable drug eluting intravitreal implant system and method
US20160302965A1 (en) * 2013-12-06 2016-10-20 Forsight Vision4, Inc. Implantable therapeutic devices
US10258503B2 (en) * 2014-07-15 2019-04-16 Forsight Vision4, Inc. Ocular implant delivery device and method
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US10500091B2 (en) * 2014-11-10 2019-12-10 Forsight Vision4, Inc. Expandable drug delivery devices and methods of use

Also Published As

Publication number Publication date
AU2015346450A1 (en) 2017-06-01
SG11201703726XA (en) 2017-06-29
EP3217924A1 (en) 2017-09-20
CN114587774A (zh) 2022-06-07
JP7037360B2 (ja) 2022-03-16
CN110478119B (zh) 2022-04-15
CN110478119A (zh) 2019-11-22
CA2967330A1 (en) 2016-05-19
BR112017009660A2 (pt) 2017-12-19
AU2015346450B2 (en) 2020-01-30
US20220087863A1 (en) 2022-03-24
RU2017120291A (ru) 2018-12-13
JP7203868B2 (ja) 2023-01-13
IL252172B (en) 2021-03-25
EP3217924A4 (en) 2018-07-11
US20200060874A1 (en) 2020-02-27
JP2017533054A (ja) 2017-11-09
JP7465616B2 (ja) 2024-04-11
HK1245065A1 (zh) 2018-08-24
IL252172A0 (en) 2017-07-31
US10500091B2 (en) 2019-12-10
CN107249515B (zh) 2019-10-01
CN107249515A (zh) 2017-10-13
WO2016077371A1 (en) 2016-05-19
RU2017120291A3 (es) 2019-05-29
JP2023024439A (ja) 2023-02-16
RU2708958C2 (ru) 2019-12-12
NZ731733A (en) 2020-10-30
US11110001B2 (en) 2021-09-07
JP2021094405A (ja) 2021-06-24
KR20170106298A (ko) 2017-09-20
US20160128867A1 (en) 2016-05-12

Similar Documents

Publication Publication Date Title
MX2017005972A (es) Dispositivo de entrega de farmacos expandibles y metodo de uso.
MX2021007933A (es) Dispositivos de suministro de farmacos con un componente permeable al farmaco y metodos.
PH12019500146A1 (en) Aerosol delivery device with a liquid transport element comprising a porous monolith and related method
SG179051A1 (en) Implantable device for controlled drug delivery
MX2021012349A (es) Dispositivos y metodos de unidades multiples para administracion de farmacos.
MX2018012021A (es) Dispositivos de administracion de farmacos oculares implantables.
MX2020003329A (es) Inyector y metodo de montaje.
MD20160079A2 (ro) Sistem de livrare a medicamentului
WO2015069773A8 (en) Devices and methods for continuous drug delivery via the mouth
WO2017091749A8 (en) Shape changing drug delivery devices and methods
MX2015003979A (es) Dispositivo de suministro de farmacos con multiples depositos.
MX2015015273A (es) Microagujas con geometrias mejoradas de seccion transversal de canal abierto.
AR084677A1 (es) Tapones lagrimales para la liberacion controlada de agentes terapeuticos
TN2016000162A1 (en) Eye device.
SA517390388B1 (ar) أداة تسليم سائل حقن تستخدم مرة واحدة لتسليم حجم عقار كبير مبرمج
MX2018008170A (es) Protesis para funcion mejorada del pene.
AU201716352S (en) Drug infusion device
MX2013000661A (es) Sistema de susministro de farmacos oculares.
EP3838328A3 (en) Drug delivery devices
GB2540110A (en) Corneal inlay delivery devices and methods
MX2017016925A (es) Sistema de infusion que se puede implantar.
EP2896504A3 (en) Liquid ejecting system, liquid ejecting apparatus, and containing unit
AR084697A1 (es) Tapones lagrimales con mecanismo de liberacion de farmacos continuo o pulsatil
EP4218855A3 (en) Adjustable rate drug delivery implantable device
EA201890988A1 (ru) Устройство для хранения и дозирования