ES2185460B1 - Microparticula de liberacion prolongada y metodo para su preparacion. - Google Patents

Microparticula de liberacion prolongada y metodo para su preparacion.

Info

Publication number
ES2185460B1
ES2185460B1 ES200002485A ES200002485A ES2185460B1 ES 2185460 B1 ES2185460 B1 ES 2185460B1 ES 200002485 A ES200002485 A ES 200002485A ES 200002485 A ES200002485 A ES 200002485A ES 2185460 B1 ES2185460 B1 ES 2185460B1
Authority
ES
Spain
Prior art keywords
dispersed
preparation
microparticles
release
microparticle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200002485A
Other languages
English (en)
Other versions
ES2185460A1 (es
Inventor
Jin Kyu Park
Mork Soon Park
Dong Scon Kim
Il Ho Lim
Ung Kil Jee
Pyung Keun Myung
Sang Beom Kim
Goo Young Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Kook Pharmaceutical Co Ltd
Original Assignee
Dong Kook Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Kook Pharmaceutical Co Ltd filed Critical Dong Kook Pharmaceutical Co Ltd
Publication of ES2185460A1 publication Critical patent/ES2185460A1/es
Application granted granted Critical
Publication of ES2185460B1 publication Critical patent/ES2185460B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/64—Heating using microwaves
    • H05B6/80—Apparatus for specific applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
    • Y02B40/00—Technologies aiming at improving the efficiency of home appliances, e.g. induction cooking or efficient technologies for refrigerators, freezers or dish washers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Glanulating (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

Micropartícula de liberación prolongada y método para su preparación. Se describe un método para preparar micropartículas de liberación prolongada que liberan una sustancia fisiológicamente activa durante periodos de tiempo prolongados. Se prepara las micropartículas de liberación prolongada mediante un proceso multiemulsión. Se disuelve o se dispersa una droga de interés en cada uno de por lo menos dos aceites para dar al menos dos fases o emulsiones de aceites primarias. Cada fase o emulsión de aceite contiene un polímero biodegradable. Las dos fases o emulsiones de aceite primarias por lo menos se dispersan en una fase acuosa, de manera síncrona o en sucesión. De la solución dispersada de la droga se retira los disolventes orgánicos para producir micropartículas. Por consiguiente, las drogas tales como hormonas liberadoras de hormona luteinizante pueden liberarse continuamente in vivo durante periodos de tiempo prolongados, consiguiéndose una mejora en el efecto terapéutico.
ES200002485A 2000-06-28 2000-10-17 Microparticula de liberacion prolongada y metodo para su preparacion. Expired - Fee Related ES2185460B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR2000-36178 2000-06-28
KR20000036178A KR100392501B1 (ko) 2000-06-28 2000-06-28 다중 에멀젼법에 의한 서방출성 미립구의 제조방법

Publications (2)

Publication Number Publication Date
ES2185460A1 ES2185460A1 (es) 2003-04-16
ES2185460B1 true ES2185460B1 (es) 2004-06-16

Family

ID=19674602

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200002485A Expired - Fee Related ES2185460B1 (es) 2000-06-28 2000-10-17 Microparticula de liberacion prolongada y metodo para su preparacion.

Country Status (16)

Country Link
US (1) US6506410B1 (es)
JP (1) JP3641418B2 (es)
KR (1) KR100392501B1 (es)
CN (1) CN1330921A (es)
BR (2) BR0005287A (es)
CA (1) CA2317769C (es)
DE (1) DE10045374B4 (es)
ES (1) ES2185460B1 (es)
FR (1) FR2810885B1 (es)
GB (1) GB2363986B (es)
IN (1) IN189017B (es)
IT (1) IT1320273B1 (es)
MX (1) MXPA00009408A (es)
PL (1) PL348343A1 (es)
TR (1) TR200003123A2 (es)
ZA (1) ZA200004485B (es)

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