ES2185460B1 - Microparticula de liberacion prolongada y metodo para su preparacion. - Google Patents
Microparticula de liberacion prolongada y metodo para su preparacion.Info
- Publication number
- ES2185460B1 ES2185460B1 ES200002485A ES200002485A ES2185460B1 ES 2185460 B1 ES2185460 B1 ES 2185460B1 ES 200002485 A ES200002485 A ES 200002485A ES 200002485 A ES200002485 A ES 200002485A ES 2185460 B1 ES2185460 B1 ES 2185460B1
- Authority
- ES
- Spain
- Prior art keywords
- dispersed
- preparation
- microparticles
- release
- microparticle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000011859 microparticle Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 230000002035 prolonged effect Effects 0.000 title 1
- 239000003921 oil Substances 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000000839 emulsion Substances 0.000 abstract 3
- 238000013265 extended release Methods 0.000 abstract 3
- 239000012071 phase Substances 0.000 abstract 3
- 102000009151 Luteinizing Hormone Human genes 0.000 abstract 1
- 108010073521 Luteinizing Hormone Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229940040129 luteinizing hormone Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003488 releasing hormone Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
- H05B6/80—Apparatus for specific applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B40/00—Technologies aiming at improving the efficiency of home appliances, e.g. induction cooking or efficient technologies for refrigerators, freezers or dish washers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Glanulating (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
Micropartícula de liberación prolongada y método para su preparación. Se describe un método para preparar micropartículas de liberación prolongada que liberan una sustancia fisiológicamente activa durante periodos de tiempo prolongados. Se prepara las micropartículas de liberación prolongada mediante un proceso multiemulsión. Se disuelve o se dispersa una droga de interés en cada uno de por lo menos dos aceites para dar al menos dos fases o emulsiones de aceites primarias. Cada fase o emulsión de aceite contiene un polímero biodegradable. Las dos fases o emulsiones de aceite primarias por lo menos se dispersan en una fase acuosa, de manera síncrona o en sucesión. De la solución dispersada de la droga se retira los disolventes orgánicos para producir micropartículas. Por consiguiente, las drogas tales como hormonas liberadoras de hormona luteinizante pueden liberarse continuamente in vivo durante periodos de tiempo prolongados, consiguiéndose una mejora en el efecto terapéutico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR2000-36178 | 2000-06-28 | ||
KR20000036178A KR100392501B1 (ko) | 2000-06-28 | 2000-06-28 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2185460A1 ES2185460A1 (es) | 2003-04-16 |
ES2185460B1 true ES2185460B1 (es) | 2004-06-16 |
Family
ID=19674602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002485A Expired - Fee Related ES2185460B1 (es) | 2000-06-28 | 2000-10-17 | Microparticula de liberacion prolongada y metodo para su preparacion. |
Country Status (16)
Country | Link |
---|---|
US (1) | US6506410B1 (es) |
JP (1) | JP3641418B2 (es) |
KR (1) | KR100392501B1 (es) |
CN (1) | CN1330921A (es) |
BR (2) | BR0005287A (es) |
CA (1) | CA2317769C (es) |
DE (1) | DE10045374B4 (es) |
ES (1) | ES2185460B1 (es) |
FR (1) | FR2810885B1 (es) |
GB (1) | GB2363986B (es) |
IN (1) | IN189017B (es) |
IT (1) | IT1320273B1 (es) |
MX (1) | MXPA00009408A (es) |
PL (1) | PL348343A1 (es) |
TR (1) | TR200003123A2 (es) |
ZA (1) | ZA200004485B (es) |
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2000
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- 2000-08-29 GB GB0020992A patent/GB2363986B/en not_active Expired - Lifetime
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- 2000-08-31 JP JP2000262542A patent/JP3641418B2/ja not_active Expired - Fee Related
- 2000-09-06 CA CA002317769A patent/CA2317769C/en not_active Expired - Lifetime
- 2000-09-14 DE DE10045374A patent/DE10045374B4/de not_active Expired - Lifetime
- 2000-09-20 FR FR0012129A patent/FR2810885B1/fr not_active Expired - Lifetime
- 2000-09-22 CN CN00128884A patent/CN1330921A/zh active Pending
- 2000-09-26 MX MXPA00009408A patent/MXPA00009408A/es unknown
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MXPA00009408A (es) | 2002-03-15 |
PL348343A1 (en) | 2002-01-02 |
ITTO20000963A1 (it) | 2002-04-13 |
BRPI0005287B1 (pt) | 2019-01-22 |
ZA200004485B (en) | 2001-02-28 |
JP3641418B2 (ja) | 2005-04-20 |
FR2810885A1 (fr) | 2002-01-04 |
KR20020000698A (ko) | 2002-01-05 |
CA2317769A1 (en) | 2001-12-28 |
GB2363986B (en) | 2002-12-11 |
DE10045374A1 (de) | 2002-01-24 |
CN1330921A (zh) | 2002-01-16 |
ITTO20000963A0 (it) | 2000-10-13 |
FR2810885B1 (fr) | 2003-10-17 |
DE10045374B4 (de) | 2007-08-30 |
GB2363986A (en) | 2002-01-16 |
GB0020992D0 (en) | 2000-10-11 |
ES2185460A1 (es) | 2003-04-16 |
IN189017B (es) | 2002-12-07 |
BR0005287A (pt) | 2002-02-13 |
KR100392501B1 (ko) | 2003-07-22 |
CA2317769C (en) | 2005-03-15 |
IT1320273B1 (it) | 2003-11-26 |
TR200003123A2 (tr) | 2002-01-21 |
JP2002020269A (ja) | 2002-01-23 |
US6506410B1 (en) | 2003-01-14 |
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