ES2160195T3 - Preparacion y utilizacion de enantiomeros puros de acido 8-cloro-6-sulfoniloxioctanoico y sus esteres de alquilo. - Google Patents

Preparacion y utilizacion de enantiomeros puros de acido 8-cloro-6-sulfoniloxioctanoico y sus esteres de alquilo.

Info

Publication number
ES2160195T3
ES2160195T3 ES96114417T ES96114417T ES2160195T3 ES 2160195 T3 ES2160195 T3 ES 2160195T3 ES 96114417 T ES96114417 T ES 96114417T ES 96114417 T ES96114417 T ES 96114417T ES 2160195 T3 ES2160195 T3 ES 2160195T3
Authority
ES
Spain
Prior art keywords
acid
formula
give
esters
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96114417T
Other languages
English (en)
Inventor
Rainer Gewald
Gunter Laban
Thomas Beisswenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2160195T3 publication Critical patent/ES2160195T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/08—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by replacement of hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

SE DESCRIBE LA OBTENCION DE LOS ENANTIOMEROS PUROS DEL ACIDO 8-CLORO-6-SULFONILOXI-OCTANOICO O DE SUS ESTERES ALQUILICOS Y DE LOS ENANTIOMEROS PUROS DEL ACIDO 6,8-DICLORO-OCTANOICO O DE SUS ESTERES ALQUILICOS COMO PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE ENANTIOMEROS DEL ACIDO {AL}-LIPOICO, ASI COMO UN PROCEDIMIENTO PARA TRANSFORMAR AMBOS ENANTIOMEROS DEL ACIDO 8-CLORO-6-HIDROXIOCTANOICO EN UN ENANTIOMERO DEL ACIDO LIPOICO.
ES96114417T 1995-09-13 1996-09-10 Preparacion y utilizacion de enantiomeros puros de acido 8-cloro-6-sulfoniloxioctanoico y sus esteres de alquilo. Expired - Lifetime ES2160195T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19533881A DE19533881A1 (de) 1995-09-13 1995-09-13 Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester

Publications (1)

Publication Number Publication Date
ES2160195T3 true ES2160195T3 (es) 2001-11-01

Family

ID=7772033

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96114417T Expired - Lifetime ES2160195T3 (es) 1995-09-13 1996-09-10 Preparacion y utilizacion de enantiomeros puros de acido 8-cloro-6-sulfoniloxioctanoico y sus esteres de alquilo.

Country Status (10)

Country Link
US (1) US5731448A (es)
EP (1) EP0763533B1 (es)
JP (1) JPH09221466A (es)
AT (1) ATE202098T1 (es)
DE (2) DE19533881A1 (es)
DK (1) DK0763533T3 (es)
ES (1) ES2160195T3 (es)
GR (1) GR3036578T3 (es)
PT (1) PT763533E (es)
RU (1) RU2176641C2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19601787C1 (de) * 1996-01-19 1997-07-24 Asta Medica Ag Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure
DE50111214D1 (de) 2000-07-27 2006-11-23 Meda Pharma Gmbh & Co Kg Verfahren zur enantioselektiven reduktion von 8-chlor-6-oxo-octansäurealkylestern
CN1680364A (zh) * 2000-08-02 2005-10-12 巴斯福股份公司 硫辛酸和二氢硫辛酸的制备方法
IT1319194B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Processo per la produzione dell'acido tiottico racemo.
IT1319196B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Sintesi dell'acido r(+)alfa-lipoico.
DE10137381A1 (de) 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10201464B4 (de) 2002-01-16 2005-06-16 Viatris Gmbh & Co. Kg Verfahren zur Herstellung reiner Thioctsäure
CN100593534C (zh) * 2007-09-30 2010-03-10 浙江工业大学 一种6,8-二氯辛酸乙酯的化学合成方法
CN101880224B (zh) * 2009-05-08 2013-02-20 上海医药工业研究院 一种6,8-二氯辛酸的拆分方法
CN105524040A (zh) * 2016-02-19 2016-04-27 苏州富士莱医药股份有限公司 一种r-硫辛酸的制备方法
CN105622571A (zh) * 2016-03-08 2016-06-01 苏州富士莱医药股份有限公司 一种r-硫辛酸氨基丁三醇盐的制备方法
DE102017000811A1 (de) * 2017-01-28 2018-08-02 Alzchem Trostberg Gmbh Verfahren zur Herstellung von Dihydroliponsäure

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2877235A (en) * 1954-05-28 1959-03-10 Du Pont Alpha-lipoic acid process
US2792406A (en) * 1954-06-01 1957-05-14 Du Pont Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
FR1176920A (fr) * 1954-07-22 1959-04-17 Merck & Co Inc Procédé de préparation de l'acide alpha-lipoïque et de ses intermédiaires
CH415604A (de) * 1961-02-02 1966-06-30 Fujisawa Pharmaceutical Co Verfahren zur Herstellung von Acylthiohalogencaprylsäurederivaten
GB8827885D0 (en) * 1988-11-30 1989-01-05 Wellcome Found Novel heterocyclic pesticidal compounds

Also Published As

Publication number Publication date
JPH09221466A (ja) 1997-08-26
DK0763533T3 (da) 2001-09-10
DE59607070D1 (de) 2001-07-19
US5731448A (en) 1998-03-24
RU2176641C2 (ru) 2001-12-10
EP0763533B1 (de) 2001-06-13
GR3036578T3 (en) 2001-12-31
DE19533881A1 (de) 1997-03-20
PT763533E (pt) 2001-12-28
ATE202098T1 (de) 2001-06-15
EP0763533A1 (de) 1997-03-19

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