ES2139588T3 - Derivado de ciclopropano. - Google Patents
Derivado de ciclopropano.Info
- Publication number
- ES2139588T3 ES2139588T3 ES92301802T ES92301802T ES2139588T3 ES 2139588 T3 ES2139588 T3 ES 2139588T3 ES 92301802 T ES92301802 T ES 92301802T ES 92301802 T ES92301802 T ES 92301802T ES 2139588 T3 ES2139588 T3 ES 2139588T3
- Authority
- ES
- Spain
- Prior art keywords
- derivative
- cyclopropane
- elevated
- independently
- cyclopropanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
UN DERIVADO CICLOPROPANO DE LA FORMULA (I) EN LA QUE B ELEVADO 1 ES UN RESIDUO DE PURINA O PIRIMIDINA, R ELEVADO 1 Y R (AL CUADRADO) SON, INDEPENDIENTEMENTE, HIDROGENO O UN GRUPO PROTECTOR PARA EL HIDROXIL Y CADA UNO DE K, M Y N REPRESENTA, INDEPENDIENTEMENTE, UN ENTERO DE 1 A 2, QUE ES UTIL POR SU EFECTO ANTIVIRAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12323991 | 1991-03-05 | ||
JP18470991 | 1991-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2139588T3 true ES2139588T3 (es) | 2000-02-16 |
Family
ID=26460224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92301802T Expired - Lifetime ES2139588T3 (es) | 1991-03-05 | 1992-03-03 | Derivado de ciclopropano. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5342840A (es) |
EP (1) | EP0502690B1 (es) |
JP (1) | JP2923933B2 (es) |
KR (1) | KR100232619B1 (es) |
AT (1) | ATE187173T1 (es) |
CA (1) | CA2062299C (es) |
DE (1) | DE69230349T2 (es) |
DK (1) | DK0502690T3 (es) |
ES (1) | ES2139588T3 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR950011530A (ko) * | 1993-10-21 | 1995-05-15 | 도바 다다스 | 사이클로프로판 유도체 및 이를 함유하는 항바이러스제 |
TW282470B (es) * | 1993-11-18 | 1996-08-01 | Ajinomoto Kk | |
JP3769737B2 (ja) * | 1994-03-30 | 2006-04-26 | 味の素株式会社 | シクロプロパン誘導体及びその製造法 |
EP0845454A1 (en) * | 1996-12-02 | 1998-06-03 | Ajinomoto Co., Inc. | Method for the production of optically active cyclopropane derivatives |
JPH1129572A (ja) * | 1997-07-10 | 1999-02-02 | Ajinomoto Co Inc | 核酸誘導体の精製法 |
JPH11255768A (ja) * | 1998-03-09 | 1999-09-21 | Ajinomoto Co Inc | 抗ウイルス剤の製造方法 |
MY141789A (en) * | 2001-01-19 | 2010-06-30 | Lg Chem Investment Ltd | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same. |
US7241890B2 (en) | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
JP2004026695A (ja) * | 2002-06-24 | 2004-01-29 | M's Science Corp | 水性点眼用製剤 |
KR20060070572A (ko) | 2003-09-18 | 2006-06-23 | 콘포마 세러퓨틱스 코포레이션 | Hsp90-저해제로서의 신규 헤테로시클릭 화합물 |
FR2864901B1 (fr) | 2004-01-09 | 2007-10-05 | Philippe Perovitch | Composition pour le traitement au contact des hyposialies, incluant de la pilocarpine et a effets multiples |
NZ561939A (en) | 2005-03-30 | 2011-03-31 | Conforma Therapeutics Corp | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
DE102005053153B4 (de) * | 2005-11-04 | 2007-07-19 | Helmut Ristl | Ristl-Getriebe |
GB0814065D0 (en) * | 2008-08-01 | 2008-09-10 | Univ Leuven Kath | Use of nucleoside analogs as anti-koi herpes virus molecules |
EP2768799B1 (en) | 2011-10-17 | 2019-08-07 | Biotheryx Inc. | Substituted biaryl alkyl amides |
EP2776414B1 (en) * | 2011-11-10 | 2016-03-16 | Aratana Therapeutics NV | Method for preparing cyclopropane derivatives |
CN104144677B (zh) | 2012-01-20 | 2016-11-23 | 阿拉塔纳医疗有限公司 | 滴眼剂组合物 |
CN104447749B (zh) * | 2014-11-21 | 2016-06-01 | 河南师范大学 | 一种通过嘌呤对乙烯基环丙烷的选择性开环构建非环核苷的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4016267A (en) * | 1974-06-19 | 1977-04-05 | Hoffmann-La Roche Inc. | Sulfacytosine derivatives |
US3923792A (en) * | 1974-06-19 | 1975-12-02 | Hoffmann La Roche | Sulfacytosine derivatives |
US4065480A (en) * | 1975-06-12 | 1977-12-27 | The Procter & Gamble Company | Process for preparing substituted cyclopropycarbinyl compounds |
CA1150299A (en) * | 1978-08-17 | 1983-07-19 | Pieter A. Verbrugge | Intermediates in the preparation of cyclopropane-carboxylate esters and process for their manufacture |
SE7810947L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
US4859680A (en) * | 1984-04-10 | 1989-08-22 | Merck & Co., Inc. | Pyrimidine derivatives as antiviral compounds |
US4617304A (en) * | 1984-04-10 | 1986-10-14 | Merck & Co., Inc. | Purine derivatives |
US4714777A (en) * | 1984-06-21 | 1987-12-22 | University Of Pittsburgh | Cyclopropanone hydrate derivatives |
US4782062A (en) * | 1987-05-11 | 1988-11-01 | Merck & Co., Inc. | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines |
DE3869299D1 (de) * | 1987-09-24 | 1992-04-23 | Mitsubishi Chem Ind | Verfahren zur herstellung eines cycloalkanols. |
US5126345A (en) * | 1988-03-30 | 1992-06-30 | E. R. Squibb & Sons, Inc. | Bis (hydroxymethyl) cyclobutyl triazolopyrimidines |
US5208388A (en) * | 1988-07-19 | 1993-05-04 | Bayer Aktiengesellschaft | 2,2-difluorocyclopropyl derivatives |
DE3824432A1 (de) * | 1988-07-19 | 1990-03-22 | Bayer Ag | 2,2-difluorcyclopropyl-derivate |
US4918075A (en) * | 1988-12-20 | 1990-04-17 | E. R. Squibb & Sons, Inc. | Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents |
US4988703A (en) * | 1989-05-22 | 1991-01-29 | Abbott Laboratories | Carbocyclic nucleoside analogs with antiviral activity |
US5064961A (en) * | 1989-12-18 | 1991-11-12 | E. R. Squibb & Sons, Inc. | Process for preparing an optically active cyclobutane nucleoside |
US5095136A (en) * | 1990-08-27 | 1992-03-10 | E. R. Squibb & Sons, Inc. | Method for preparing isoprenoid cyclopropane 1,1-dicarboxylates and derivatives thereof and novel intermediates |
DE4222497A1 (de) * | 1992-07-09 | 1994-01-13 | Huels Chemische Werke Ag | Verfahren zur Herstellung von chlorfreiem Cyclopropancarbonsäuremethylester |
-
1992
- 1992-03-03 AT AT92301802T patent/ATE187173T1/de active
- 1992-03-03 ES ES92301802T patent/ES2139588T3/es not_active Expired - Lifetime
- 1992-03-03 EP EP92301802A patent/EP0502690B1/en not_active Expired - Lifetime
- 1992-03-03 DK DK92301802T patent/DK0502690T3/da active
- 1992-03-03 DE DE69230349T patent/DE69230349T2/de not_active Expired - Lifetime
- 1992-03-04 JP JP4047178A patent/JP2923933B2/ja not_active Expired - Lifetime
- 1992-03-04 CA CA002062299A patent/CA2062299C/en not_active Expired - Lifetime
- 1992-03-05 US US07/846,615 patent/US5342840A/en not_active Expired - Lifetime
- 1992-03-05 KR KR1019920003673A patent/KR100232619B1/ko not_active IP Right Cessation
-
1994
- 1994-12-16 US US08/357,927 patent/US5449840A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69230349D1 (de) | 2000-01-05 |
DE69230349T2 (de) | 2000-07-27 |
JP2923933B2 (ja) | 1999-07-26 |
EP0502690B1 (en) | 1999-12-01 |
DK0502690T3 (da) | 2000-05-22 |
EP0502690A3 (en) | 1992-12-09 |
CA2062299C (en) | 1999-05-25 |
KR100232619B1 (ko) | 1999-12-01 |
KR920018052A (ko) | 1992-10-21 |
US5449840A (en) | 1995-09-12 |
EP0502690A2 (en) | 1992-09-09 |
JPH0578357A (ja) | 1993-03-30 |
US5342840A (en) | 1994-08-30 |
CA2062299A1 (en) | 1992-09-06 |
ATE187173T1 (de) | 1999-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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