ES2138092T3 - Utilizacion de los derivados de carbostirilo para la obtencion de un medicamento destinado para inhibir la produccion de la interleucina-8. - Google Patents

Utilizacion de los derivados de carbostirilo para la obtencion de un medicamento destinado para inhibir la produccion de la interleucina-8.

Info

Publication number
ES2138092T3
ES2138092T3 ES94929670T ES94929670T ES2138092T3 ES 2138092 T3 ES2138092 T3 ES 2138092T3 ES 94929670 T ES94929670 T ES 94929670T ES 94929670 T ES94929670 T ES 94929670T ES 2138092 T3 ES2138092 T3 ES 2138092T3
Authority
ES
Spain
Prior art keywords
interleukin
pct
production
inhibiting
carbostirile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929670T
Other languages
English (en)
Inventor
Takahide Matsuda
Shigeru Owada
Hiroshi Muta
Miki Aihara
Hisao Takizawa
Ken-Ichi Imagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2138092T3 publication Critical patent/ES2138092T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Abstract

LA PRESENTE INVENCION SE REFIERE A AGENTES PARA INHIBIR LA PRODUCCION DE INTERLEUQUINA-8 Y PARA INHIBIR LA ACTIVACION DE GRANULOCITOS ASI COMO UN NUEVO METODO PARA CURAR ENFERMEDADES INFLAMATORIAS. LOS AGENTES PARA LA PRODUCCION D INTERLEUQUINA-8, Y PARA LA ACTIVACION DE GRANULOCITOS Y PARA CURAR ENFERMEDADES INFLAMATORIAS QUE CONTIENEN COMO INGREDIENTE ACTIVO UN DERIVADO DE CARBOSTIRILO REPRESENTADO POR LA FORMULA GENERAL (I) (DONDE R ES UN ATOMO DE HALOGENO; EL LUGAR DE SUSTITUCION DE UNA CADENA LATERAL DE FORMULA (A) ESTA EN POSICION -3 O -4 EN LA ESTRUCTURA DE CARBOSTIRILO; Y EL ENLACE CARBONO-CARBONO EN POSICION-3 O -4 EN LA ESTRUCTURA DE CARBOSTIRILO ES UN ENLACE SENCILLO O UN ENLACE DOBLE O SUS SALE FARMCEUTICAMENTE ACEPTABLE.
ES94929670T 1993-10-21 1994-10-17 Utilizacion de los derivados de carbostirilo para la obtencion de un medicamento destinado para inhibir la produccion de la interleucina-8. Expired - Lifetime ES2138092T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26341993 1993-10-21
JP26341793 1993-10-21
JP26341893 1993-10-21
JP8964194 1994-04-27

Publications (1)

Publication Number Publication Date
ES2138092T3 true ES2138092T3 (es) 2000-01-01

Family

ID=27467652

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929670T Expired - Lifetime ES2138092T3 (es) 1993-10-21 1994-10-17 Utilizacion de los derivados de carbostirilo para la obtencion de un medicamento destinado para inhibir la produccion de la interleucina-8.

Country Status (14)

Country Link
US (1) US5637597A (es)
EP (1) EP0674515B1 (es)
JP (1) JP2839847B2 (es)
KR (1) KR100191191B1 (es)
CN (1) CN1073418C (es)
AT (1) ATE184793T1 (es)
AU (1) AU683697B2 (es)
CA (1) CA2150546C (es)
DE (1) DE69420832T2 (es)
DK (1) DK0674515T3 (es)
ES (1) ES2138092T3 (es)
GR (1) GR3032091T3 (es)
TW (1) TW296983B (es)
WO (1) WO1995011026A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004214A1 (es) * 1995-10-12 1998-11-04 Otsuka Pharma Co Ltd Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
DE10029404B4 (de) * 2000-06-15 2009-10-29 Jagotec Ag Arzneiformulierung enthaltend Ciclosporin und deren Verwendung
FR2812548B1 (fr) * 2000-08-01 2002-09-20 Sanofi Synthelabo Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
WO2004091724A1 (en) * 2002-10-08 2004-10-28 Wyeth Anthranilic acid derivatives useful in treating infection with hepatitis c virus
ATE373502T1 (de) 2003-07-30 2007-10-15 Otsuka Pharma Co Ltd Carbostyril-derivative zur beschleunigten speichelabsonderung
TWI340650B (en) * 2004-01-21 2011-04-21 Otsuka Pharma Co Ltd Amine saly of carbostyril derivative
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
WO2009022674A1 (en) * 2007-08-10 2009-02-19 Otsuka Pharmaceutical Co., Ltd. Medical composition containing rebamipide
KR101104634B1 (ko) * 2009-08-25 2012-01-12 한림제약(주) 레바미피드를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물
KR101182114B1 (ko) * 2010-03-05 2012-09-12 한림제약(주) 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물
WO2012114317A1 (en) 2011-02-25 2012-08-30 Nuformix Limited Novel rebamipide complexes and cocrystals
CA2829107A1 (en) 2011-03-24 2012-09-27 Otsuka Pharmaceutical Co., Ltd. A pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide
JP6294773B2 (ja) * 2014-06-27 2018-03-14 株式会社ナールスコーポレーション 口腔粘膜疾患の予防または治療用経口製剤
WO2022128054A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammatory conditions of human skin (iv)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
JPS63119467A (ja) * 1987-10-21 1988-05-24 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPH02178227A (ja) * 1988-12-28 1990-07-11 Otsuka Pharmaceut Co Ltd 腎炎治療剤
JP2812998B2 (ja) * 1989-08-14 1998-10-22 大塚製薬 株式会社 胃炎治療剤
WO1992021342A1 (en) * 1991-06-07 1992-12-10 Otsuka Pharmaceutical Co., Ltd. Antidiabetic
KR100196368B1 (ko) * 1991-07-03 1999-06-15 오쓰까 아끼히꼬 아폽토시스 조정제
TW227558B (es) * 1992-05-14 1994-08-01 Otsuka Pharma Co Ltd
JP2872546B2 (ja) * 1992-11-26 1999-03-17 大塚製薬株式会社 腸粘膜障害保護剤
WO1994014444A1 (en) * 1992-12-24 1994-07-07 Otsuka Pharmaceutical Co., Ltd. Psoriasis remedy
WO1994020107A1 (en) * 1993-03-02 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Rejection inhibitor for transplants and il-1 production inhibitor

Also Published As

Publication number Publication date
WO1995011026A1 (en) 1995-04-27
EP0674515A1 (en) 1995-10-04
DE69420832T2 (de) 2000-01-13
DE69420832D1 (de) 1999-10-28
AU7864194A (en) 1995-05-08
GR3032091T3 (en) 2000-03-31
CA2150546A1 (en) 1995-04-27
AU683697B2 (en) 1997-11-20
ATE184793T1 (de) 1999-10-15
CN1073418C (zh) 2001-10-24
JP2839847B2 (ja) 1998-12-16
US5637597A (en) 1997-06-10
DK0674515T3 (da) 1999-12-20
CN1117268A (zh) 1996-02-21
KR100191191B1 (ko) 1999-06-15
TW296983B (es) 1997-02-01
EP0674515B1 (en) 1999-09-22
JPH0812578A (ja) 1996-01-16
CA2150546C (en) 2004-11-09
KR950703957A (ko) 1995-11-17

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