ES2098127T3 - Procedimiento para la purificacion de taxoides. - Google Patents

Procedimiento para la purificacion de taxoides.

Info

Publication number
ES2098127T3
ES2098127T3 ES94910438T ES94910438T ES2098127T3 ES 2098127 T3 ES2098127 T3 ES 2098127T3 ES 94910438 T ES94910438 T ES 94910438T ES 94910438 T ES94910438 T ES 94910438T ES 2098127 T3 ES2098127 T3 ES 2098127T3
Authority
ES
Spain
Prior art keywords
taxoids
purification
procedure
desacetil
bacatina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910438T
Other languages
English (en)
Inventor
Andre Durand
Alain Gerbaud
Rodolphe Margraff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9445195&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2098127(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2098127T3 publication Critical patent/ES2098127T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Auxiliary Devices For Music (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PROCESO DE PURIFICACION DE LOS TAXOIDES (TAXOTERO, DESACETIL-10 BACATINA III) POR CROMATOGRAFIA DE PARTICION CENTRIFUGA.
ES94910438T 1993-03-22 1994-03-18 Procedimiento para la purificacion de taxoides. Expired - Lifetime ES2098127T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303251A FR2703049B1 (fr) 1993-03-22 1993-03-22 Procédé de purification des taxoïdes.

Publications (1)

Publication Number Publication Date
ES2098127T3 true ES2098127T3 (es) 1997-04-16

Family

ID=9445195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910438T Expired - Lifetime ES2098127T3 (es) 1993-03-22 1994-03-18 Procedimiento para la purificacion de taxoides.

Country Status (28)

Country Link
US (3) US5723635A (es)
EP (1) EP0690852B1 (es)
JP (3) JP3470721B2 (es)
KR (1) KR100320802B1 (es)
CN (2) CN1504465A (es)
AT (1) ATE149160T1 (es)
AU (1) AU687039B2 (es)
CA (1) CA2157905C (es)
CZ (2) CZ283363B6 (es)
DE (1) DE69401810T2 (es)
DK (1) DK0690852T3 (es)
EE (1) EE03100B1 (es)
ES (1) ES2098127T3 (es)
FI (1) FI119023B (es)
FR (1) FR2703049B1 (es)
GE (1) GEP20012581B (es)
GR (1) GR3022681T3 (es)
HU (1) HU221303B1 (es)
LT (1) LT3238B (es)
LV (1) LV11031B (es)
NO (1) NO312403B1 (es)
NZ (1) NZ262917A (es)
PL (1) PL178496B1 (es)
RU (1) RU2125563C1 (es)
SK (2) SK281542B6 (es)
UA (1) UA43333C2 (es)
WO (1) WO1994021622A1 (es)
ZA (1) ZA941968B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696462B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2729666A1 (fr) * 1995-01-25 1996-07-26 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
US6150541A (en) * 1995-12-14 2000-11-21 Aventis Pharma S.A. 4,10-β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-9-oxo-19-norcyclopropa[g]t ax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate and its process of preparation
FR2750133B1 (fr) * 1996-06-21 1998-08-28 Ifremer Procede de purification de phospholipides par chromatographie de partage centrifuge
US6174974B1 (en) 1996-07-05 2001-01-16 Bayer Aktiengesellschaft Method for producing thermoplastic elastomers
US6066748A (en) * 1997-12-17 2000-05-23 Han; Man Woo Process of extracting TAXOL® from taxus cuspidata
FR2774094B1 (fr) * 1998-01-26 2001-04-13 Ifremer Procede de purification de sulfoquinovosyldiacylglycerol par chromatographie de partage centrifuge
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7169307B2 (en) 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
US7563814B2 (en) * 2005-01-03 2009-07-21 Teva Pharmaceutical Industries Ltd. Olmesartan medoxomil with reduced levels of impurities
RU2457214C2 (ru) * 2005-03-11 2012-07-27 Вайет Способ хроматографии в режиме слабого распределения
CN1300131C (zh) * 2005-04-27 2007-02-14 浙江钱江生物化学股份有限公司 赤霉素ga3纯化分离方法
KR20070088784A (ko) * 2005-10-12 2007-08-29 시코르, 인크. 도세탁셀의 결정형 및 이의 제조 방법
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
FR2903104B1 (fr) * 2006-07-03 2008-09-26 Pierre Fabre Medicament Sa Purification de la 10-dab iii par chromatographie de partage centrifuge
CA2667416C (en) * 2006-10-20 2013-12-17 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
DE102008031208B4 (de) * 2008-07-03 2010-03-25 Technische Universität Dortmund Prozess zur großtechnischen Produktion von Taxanen
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
MX341082B (es) 2010-05-03 2016-08-08 Teikoku Pharma Usa Inc Formulaciones de pro-emulsion de taxano no acuosas y metodos para hacer y usar las mismas.
US8842114B1 (en) 2011-04-29 2014-09-23 Nvidia Corporation System, method, and computer program product for adjusting a depth of displayed objects within a region of a display
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
HUP1500603A2 (en) 2015-12-11 2017-06-28 Rotachrom Tech Kft Process for the separation of 10-deacetyl baccatin iii

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
JPH04367829A (ja) * 1991-06-17 1992-12-21 Toppan Printing Co Ltd 焼結体バリスタ素子の製造方法
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
CZ283363B6 (cs) 1998-03-18
NZ262917A (en) 1997-01-29
JP2003201287A (ja) 2003-07-18
CN1119860A (zh) 1996-04-03
UA43333C2 (uk) 2001-12-17
GR3022681T3 (en) 1997-05-31
FI954423A0 (fi) 1995-09-19
NO953617L (no) 1995-09-13
AU6285394A (en) 1994-10-11
SK282842B6 (sk) 2002-12-03
PL310697A1 (en) 1995-12-27
KR100320802B1 (ko) 2002-07-27
FI119023B (fi) 2008-06-30
CN1504465A (zh) 2004-06-16
HU221303B1 (en) 2002-09-28
DE69401810D1 (de) 1997-04-03
PL178496B1 (pl) 2000-05-31
EP0690852B1 (fr) 1997-02-26
JP3953428B2 (ja) 2007-08-08
LV11031B (en) 1996-06-20
LTIP1891A (en) 1994-10-25
NO953617D0 (no) 1995-09-13
SK116395A3 (en) 1996-01-10
JP3470721B2 (ja) 2003-11-25
FR2703049A1 (fr) 1994-09-30
JP4367829B2 (ja) 2009-11-18
CA2157905C (fr) 2006-10-10
JPH08508026A (ja) 1996-08-27
HUT73139A (en) 1996-06-28
GEP20012581B (en) 2001-11-26
SK281542B6 (sk) 2001-04-09
CZ208597A3 (en) 1997-12-17
RU2125563C1 (ru) 1999-01-27
FR2703049B1 (fr) 1995-04-21
CZ244295A3 (en) 1996-01-17
DE69401810T2 (de) 1997-07-31
HU9502758D0 (en) 1995-11-28
CZ283334B6 (cs) 1998-02-18
AU687039B2 (en) 1998-02-19
EP0690852A1 (fr) 1996-01-10
LT3238B (en) 1995-04-25
ZA941968B (en) 1994-10-19
WO1994021622A1 (fr) 1994-09-29
CA2157905A1 (fr) 1994-09-29
JP2003238549A (ja) 2003-08-27
US6008385A (en) 1999-12-28
LV11031A (lv) 1996-02-20
KR960701036A (ko) 1996-02-24
NO312403B1 (no) 2002-05-06
FI954423A (fi) 1995-09-19
EE03100B1 (et) 1998-06-15
US6197980B1 (en) 2001-03-06
ATE149160T1 (de) 1997-03-15
US5723635A (en) 1998-03-03
DK0690852T3 (es) 1997-03-17

Similar Documents

Publication Publication Date Title
ES2098127T3 (es) Procedimiento para la purificacion de taxoides.
FI913973A (fi) Belaeggningselement med ett eller flera skikt, som anbringats pao baeraraemnen, och framstaellning av dessa.
CO4780028A1 (es) Procedimiento para la preparacion de sildenafil
FI841261A (fi) Krotonesterhaltiga kopolymerisat, foerfaranden foer deras framstaellning och deras anvaendning som foertjockningsmedel i vattenhaltiga system och som klisteraemne.
FI834404A (fi) Betongtillsatsmedel, som omfattar en flerkomponentblandning, innehaollande silikadamm, framstaellningsfoerfarande och resulterande betongprodukt.
FI830269A0 (fi) System som varnar foer marknaerheten, vilket system har pao tid och hoejd baserad verkningssaettkoppling
FI903516A0 (fi) Foerfarande och system foer att staella hydraultrycket som verkar pao ett hydrauliskt gripelement.
SE8307023L (sv) Anordning for separation, foretredesvis av optiska isomerer, jemte forfarande for immobilisering av orosomucoid pa en berare och anvendning av denna for separation, foretredesvis av optiska isomerer
FI844560A0 (fi) Foerfarande och anordning foer sprutning av pulverpartiklar pao en yta, som skall oeverdragas elektrostatiskt.
FI834709A (fi) Substituerade fenylsulfonyloxibenzimidazolkarbamater, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ES514215A0 (es) Metodo para separar el plasma de la sangre.
FI874283A (fi) Isolerande produkt framstaelld pao platsen, fibrer och partiklar som ingaor i dess sammansaettning och framstaellningsfoerfarande.
FI832784A (fi) Kondenserade 4h-1,4-benzotiaziner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
FI900033A0 (fi) Foerfarande och system foer applicering av en maerkning pao ett underlag, speciellt pao en maolad list intill och omkring en vindruteskiva.
IT8024797A0 (it) Processo per la separazione di un isomero alchilfenolico.
FI890077A (fi) Anordning foer stoedning, vaendning och breddning av en bana.
FI821514A0 (fi) Foerfarande foer framstaellning av antihypertensiva kromonderivat
FI892289A (fi) Substituerade azoltioetrar, deras framstaellning och deras anvaendning som skadedjursbekaempningsmedel.
DK0931055T3 (da) Selektiv alkylering af en alkohol-substitueret phenolforbindelse
ES523060A0 (es) Procedimiento para la purificacion de n-metilpirrolidona.
FI832783A (fi) 4h-1,4-benzotiazinderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedfodertillsatsaemnen och konserveringsmedel
FI910177A0 (fi) Foerfarande foer framstaellning av pyridin-2,4- och pyridin-2,5-dikarboxylsyradi-(nitroxialkyl) amider och deras anvaendning.
ES507754A0 (es) Procedimiento para la preparacion de 2,3-dihidro piranos.
FI833443A (fi) 1,2,3,4-tetrahydro-1-aminometyl-4-fenylisokinoliner och foerfaranden foer framstaellning av dem
IT1228930B (it) Diclorotrifluorometilnitrotolueni e loro conversione in aminotrifluorometiltolueni

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 690852

Country of ref document: ES