ES2071636T3 - Uso de acidos oxapenem-3-carboxilicos estables para la fabricacion de medicamentos inhibidores de la b-lactamasa. - Google Patents

Uso de acidos oxapenem-3-carboxilicos estables para la fabricacion de medicamentos inhibidores de la b-lactamasa.

Info

Publication number
ES2071636T3
ES2071636T3 ES89117433T ES89117433T ES2071636T3 ES 2071636 T3 ES2071636 T3 ES 2071636T3 ES 89117433 T ES89117433 T ES 89117433T ES 89117433 T ES89117433 T ES 89117433T ES 2071636 T3 ES2071636 T3 ES 2071636T3
Authority
ES
Spain
Prior art keywords
manufacture
oxapenem
carboxyl acids
lactamase inhibiting
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89117433T
Other languages
English (en)
Inventor
Hans-Rudolf Prof Dr Pfaendler
Karl-Georg Dr Metzger
Rainer Dr Endermann
Ingo Dr Haller
Hanno Dr Wild
Wolfgang Dr Hartwig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2071636T3 publication Critical patent/ES2071636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL INVENTO CONSISTE EN LA APLICACION DE 1-OXAPENEM-3-ACIDO CARBONICO CON LAS SIGUIENTES ESTRUCTURAS (FORMULAS) EN LAS QUE R1 Y R2 TIENEN LA SIGNIFICACION QUE SE LES DA EN LA DESCRIPCION, COMO INHIBIDOR DE LAS (BETA)-LACTAMAS Y COMO PREPARADOS FARMACEUTICOS QUE CONTIENEN LOS SOBREDICHOS 1-OXAPENEM-3-ACIDO CARBONICOS Y UN ANTIBIOTICO COMUN.
ES89117433T 1988-10-04 1989-09-21 Uso de acidos oxapenem-3-carboxilicos estables para la fabricacion de medicamentos inhibidores de la b-lactamasa. Expired - Lifetime ES2071636T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833693A DE3833693A1 (de) 1988-10-04 1988-10-04 Stabile oxapenem-3-carbonsaeuren und ihre verwendung als ss-lactamasehemmer

Publications (1)

Publication Number Publication Date
ES2071636T3 true ES2071636T3 (es) 1995-07-01

Family

ID=6364340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89117433T Expired - Lifetime ES2071636T3 (es) 1988-10-04 1989-09-21 Uso de acidos oxapenem-3-carboxilicos estables para la fabricacion de medicamentos inhibidores de la b-lactamasa.

Country Status (20)

Country Link
US (1) US5108747A (es)
EP (1) EP0362622B1 (es)
JP (1) JP2654201B2 (es)
KR (1) KR900005977A (es)
CN (1) CN1041596A (es)
AT (1) ATE120369T1 (es)
AU (1) AU623932B2 (es)
CA (1) CA2000058A1 (es)
DD (1) DD284806A5 (es)
DE (2) DE3833693A1 (es)
DK (1) DK486589A (es)
ES (1) ES2071636T3 (es)
FI (1) FI894653A (es)
HU (1) HUT53650A (es)
IE (1) IE68344B1 (es)
IL (1) IL91813A0 (es)
NO (1) NO893727L (es)
NZ (1) NZ230827A (es)
PT (1) PT91873B (es)
ZA (1) ZA897505B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027928A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung
DE4142423A1 (de) * 1991-12-20 1993-06-24 Pfaendler Hans Rudolf ((ls)-hydroxyalkyl)oxapenem-3-carbonsaeuren und ihre verwendung als betalactamasehemmer
GB9421816D0 (en) * 1994-10-29 1994-12-14 Smithkline Beecham Plc Novel compounds
BR0114762A (pt) 2000-10-19 2003-10-07 Amura Ltd Composições farmacêuticas contendo ácidos oxapenem-3-carboxìlicos
GB2369358A (en) * 2000-10-19 2002-05-29 Amura Ltd Oxapenems and pharmaceutical compositions thereof
EP1199077A1 (en) * 2000-10-19 2002-04-24 Amura Limited Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers
GB0106428D0 (en) * 2001-03-15 2001-05-02 Amura Ltd Antibacterial composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren

Also Published As

Publication number Publication date
AU4233589A (en) 1990-04-12
CN1041596A (zh) 1990-04-25
NO893727L (no) 1990-04-05
JPH02145519A (ja) 1990-06-05
DE58909140D1 (de) 1995-05-04
PT91873A (pt) 1990-04-30
CA2000058A1 (en) 1990-04-04
KR900005977A (ko) 1990-05-07
NO893727D0 (no) 1989-09-19
JP2654201B2 (ja) 1997-09-17
FI894653A (fi) 1990-04-05
EP0362622B1 (de) 1995-03-29
IE893157L (en) 1990-04-04
PT91873B (pt) 1995-09-12
IL91813A0 (en) 1990-06-10
DE3833693A1 (de) 1990-04-05
DK486589D0 (da) 1989-10-03
EP0362622A1 (de) 1990-04-11
ATE120369T1 (de) 1995-04-15
US5108747A (en) 1992-04-28
DD284806A5 (de) 1990-11-28
AU623932B2 (en) 1992-05-28
NZ230827A (en) 1991-05-28
ZA897505B (en) 1990-07-25
HUT53650A (en) 1990-11-28
FI894653A0 (fi) 1989-10-02
DK486589A (da) 1990-04-05
IE68344B1 (en) 1996-06-12

Similar Documents

Publication Publication Date Title
ES2095432T3 (es) Derivados de 2,4-tiazolidin-diona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
SE8700499D0 (sv) Novel pharmacologically active compounds
AU1454988A (en) Stable pharmaceutical w/o emulsion composition
MX9205432A (es) Compuestos inhibidores de la biosintesis de leucotrienos y composicion farmaceutica que los contiene.
IL90912A0 (en) Condensed heterocyclic compounds,their manufacture and pharmaceutical compositions containing them
PT91731A (pt) Processo para a preparacao de composicoes farmaceuticas contendo ciclosporinas
AR027162A1 (es) Compuestos de 2-fenil-3-fenoxilo-feniltio-benzotiofeno, sales farmaceuticamente aceptables de los mismos y composiciones farmaceuticas que los contienen
MX9204354A (es) Compuestos heterociclicos de 5 miembros, procedimiento para prepararlos y composiciones farmaceuticas que los contienen.
ES2075202T3 (es) Nuevas arilpiridazinas, su preparacion, su utilizacion, y medicamentos que las contienen.
ES2081187T3 (es) Nuevas naftil-alquil-aminas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ES2157993T3 (es) Benzoilguanidinas, su preparacion y su uso en medicamentos.
IT1231012B (it) Composizione farmaceutica per uso orale contenente nac.
MX9202544A (es) Compuestos de diaminoftalimidas substituidas y analogas, procedimiento para su preparacion y preparados farmaceuticos que los contienen.
PT89729A (pt) Processo para a preparacao de derivados de cefalosporina e de composicoes farmaceuticas que os contem
KR960703863A (ko) 암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
ES2071636T3 (es) Uso de acidos oxapenem-3-carboxilicos estables para la fabricacion de medicamentos inhibidores de la b-lactamasa.
MX171542B (es) Composiciones farmaceuticas que contienen deoxirribonucleosidos para cicatrizacion de heridas
MX9400165A (es) Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen.
BR9808126A (pt) Quinoxalinodionas
NO903291L (no) Renin-hemmende aminooligohydroksyderivater.
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
BR9203744A (pt) Compostos processos para sua preparacao e composicao farmaceutica contendo-os
MX9102627A (es) Composicion farmaceutica de dobutamina para administracion transdermica.
PT93581A (pt) Processo para a preparacao de derivados cefalosporanicos e de composicoes farmaceuticas que os contem
MX9101421A (es) Composiciones farmaceuticas que comprenden naproxen y sodio de naproxen e hidrocloruro de pseudoefedrina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 362622

Country of ref document: ES