ES2002656A6 - Un procedimiento para la produccion de gamma-carbolinas - Google Patents

Un procedimiento para la produccion de gamma-carbolinas

Info

Publication number
ES2002656A6
ES2002656A6 ES8601849A ES8601849A ES2002656A6 ES 2002656 A6 ES2002656 A6 ES 2002656A6 ES 8601849 A ES8601849 A ES 8601849A ES 8601849 A ES8601849 A ES 8601849A ES 2002656 A6 ES2002656 A6 ES 2002656A6
Authority
ES
Spain
Prior art keywords
carbolines
gamma
halogen
alkyl
antipsychotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601849A
Other languages
English (en)
Inventor
Magid Abdel-Meg Abou-Gharbia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of ES2002656A6 publication Critical patent/ES2002656A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE GAMMA-CARBOLINAS, DE FORMULA GENERAL (I) EN DONDE R1 ES HIDROGENO, HALOGENO, HIDROXILO O ALQUILO; R2 ES PIRIDILO, PIRACINILO, QUINOLINILO O QUINOXALINILO SUSTITUIDO O INSUSTITUIDO Y DICHOS SUSTITUYENTES SON ALQUILO, ALCOXILO, ALCOXICARBONILO, HALOGENO, CIANO O NITRO; Y N ES 2, 3, 4, 5, O 6. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UNA GAMMA©CARBOLINA DE FORMULA (II), APROPIADAMENTE SUSTITUIDA, CON HALOALQUIPIRIDINA, HALOALQUIL©PIRACINA, HALOALQUILQUINOXALINA (III) EN UN DISOLVENTE APROTICO, EN PRESENCIA DE UNA BASE SUAVE. TAMBIEN PUEDE REALIZARSE LA REACCION DE LA GAMMA©CARBOLINA (II) CON UNA VINILPIRIDINA, VINILPIRACINA, VINILQUINOLINA O VINILQUINOXALINA (IV) EN UN DISOLVENTE ALCOHOLICO, EN PRESENCIA DE CANTIDADES CATALITICAS DE ACIDO GLACIAL. LAS REACCIONES SE LLEVAN A CABO A REFLUJO, DURANTE 24©48 HORAS. ESTOS PRODUCTOS SUS SALES FARMACEUTICAMENTE ACEPTABLES, SON AGENTES ANTIPSICOTICOS Y ANXIOLITICOS.
ES8601849A 1985-09-16 1986-09-12 Un procedimiento para la produccion de gamma-carbolinas Expired ES2002656A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/776,180 US4636563A (en) 1985-09-16 1985-09-16 Antipsychotic γ-carbolines

Publications (1)

Publication Number Publication Date
ES2002656A6 true ES2002656A6 (es) 1988-09-16

Family

ID=25106686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601849A Expired ES2002656A6 (es) 1985-09-16 1986-09-12 Un procedimiento para la produccion de gamma-carbolinas

Country Status (28)

Country Link
US (1) US4636563A (es)
EP (1) EP0223344B1 (es)
JP (1) JPS6267083A (es)
KR (1) KR900002245B1 (es)
CN (1) CN1013864B (es)
AR (1) AR242208A1 (es)
AT (1) ATE55770T1 (es)
AU (1) AU590605B2 (es)
CA (1) CA1275099A (es)
CY (1) CY1595A (es)
DE (1) DE3673607D1 (es)
DK (1) DK440686A (es)
EG (1) EG18015A (es)
ES (1) ES2002656A6 (es)
FI (1) FI83318C (es)
GB (1) GB2180536B (es)
GR (1) GR862343B (es)
HK (1) HK53491A (es)
HU (1) HU195217B (es)
IL (1) IL79956A0 (es)
MX (1) MX3681A (es)
NO (1) NO163619C (es)
NZ (1) NZ217580A (es)
PH (1) PH22515A (es)
PT (1) PT83344B (es)
SU (1) SU1442074A3 (es)
YU (1) YU45023B (es)
ZA (1) ZA866258B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328905A (en) * 1987-07-20 1994-07-12 Duphar International Research B.V. 8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives
US5360800A (en) * 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
HU207078B (en) * 1988-08-02 1993-03-01 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
JPH02167280A (ja) * 1988-08-15 1990-06-27 Glaxo Group Ltd ラクタム誘導体
US5021569A (en) * 1990-06-12 1991-06-04 American Home Products Corporation 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolytic activity
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
FR2715659B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
RU2283108C2 (ru) * 2003-12-08 2006-09-10 Сергей Олегович Бачурин ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
US20070179174A1 (en) * 2003-12-08 2007-08-02 Bachurin Sergei O Methods and compositions for slowing aging
JP2009502959A (ja) * 2005-07-28 2009-01-29 ブリストル−マイヤーズ スクイブ カンパニー セロトニン受容体アゴニストおよびアンタゴニストとしての置換テトラヒドロ−１ｈ−ピリド［４，３，ｂ］インドール
WO2007041697A2 (en) * 2005-10-04 2007-04-12 Medivation, Inc. Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670010A1 (de) * 1966-12-07 1970-07-30 Abbott Lab Aroylalkylderivate von 1,2,3,4-Tetrahydro-5H-pyride-[4,3b]-indolen und Verfahren zur Herstellung derselben
US3522262A (en) * 1968-09-10 1970-07-28 Hoffmann La Roche 5-(pyridylalkyl)-pyridoindole derivatives
US3502688A (en) * 1968-09-10 1970-03-24 Hoffmann La Roche 5-(4-pyridylethyl)-pyridoindole derivatives
DE1952800C3 (de) * 1969-10-20 1974-04-18 Nautschno-Issledowatelskij Institut Farmakologii I Chimioterapii, Moskau 3,6-Dimethyl-l,2,3,4,4a,9a-hexahydro-gamma-carbolin-dihydrochlorid
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
DE2621729A1 (de) * 1976-05-15 1977-12-08 Boehringer Sohn Ingelheim Neue 2-(4-phenyl-4-cyanobutyl)-1,2, 3,4-tetrahydro-5(h)-pyrido- eckige klammer auf 4,3-b eckige klammer zu -indole und verfahren zu ihrer herstellung
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4337250A (en) * 1979-07-30 1982-06-29 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
DE3851597T2 (de) * 1987-09-03 1995-01-26 Glaxo Group Ltd Lactamderivate.

Also Published As

Publication number Publication date
EP0223344B1 (en) 1990-08-22
GR862343B (en) 1987-01-12
FI863692A0 (fi) 1986-09-12
US4636563A (en) 1987-01-13
GB8621226D0 (en) 1986-10-08
NO863671L (no) 1987-03-17
EP0223344A1 (en) 1987-05-27
CN86106194A (zh) 1987-03-18
EG18015A (en) 1991-08-30
MX3681A (es) 1993-10-01
CA1275099A (en) 1990-10-09
KR870003103A (ko) 1987-04-15
NO163619B (no) 1990-03-19
FI83318C (fi) 1991-06-25
PT83344B (pt) 1988-07-29
AU6181386A (en) 1987-03-19
HU195217B (en) 1988-04-28
HUT42478A (en) 1987-07-28
SU1442074A3 (ru) 1988-11-30
NO163619C (no) 1990-06-27
ZA866258B (en) 1988-04-27
PH22515A (en) 1988-09-12
ATE55770T1 (de) 1990-09-15
AU590605B2 (en) 1989-11-09
YU45023B (en) 1991-06-30
NO863671D0 (no) 1986-09-15
KR900002245B1 (ko) 1990-04-07
YU157686A (en) 1988-04-30
PT83344A (pt) 1986-10-01
FI83318B (fi) 1991-03-15
GB2180536B (en) 1989-04-05
HK53491A (en) 1991-07-19
GB2180536A (en) 1987-04-01
CY1595A (en) 1992-04-03
DE3673607D1 (en) 1990-09-27
JPS6267083A (ja) 1987-03-26
CN1013864B (zh) 1991-09-11
DK440686A (da) 1987-03-17
NZ217580A (en) 1988-07-28
AR242208A1 (es) 1994-08-31
FI863692A (fi) 1987-03-17
DK440686D0 (da) 1986-09-15
IL79956A0 (en) 1986-12-31

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-12