YU45023B - Process for obtaining antipsychotic gamma carbolines - Google Patents

Process for obtaining antipsychotic gamma carbolines

Info

Publication number: YU45023B
Authority: YU; Yugoslavia
Prior art keywords: antipsychotic; obtaining; carbolines; gamma; gamma carbolines
Prior art date: 1985-09-16

Application number

YU1576/86A

Other languages

English (en)

Other versions

YU157686A (en

Inventor

M A M Abou-Gharbia

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-16

Filing date

1986-09-10

Publication date

1991-06-30

1986-09-10 Application filed by American Home Prod filed Critical American Home Prod

1988-04-30 Publication of YU157686A publication Critical patent/YU157686A/xx

1991-06-30 Publication of YU45023B publication Critical patent/YU45023B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

YU1576/86A 1985-09-16 1986-09-10 Process for obtaining antipsychotic gamma carbolines YU45023B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/776,180 US4636563A (en)	1985-09-16	1985-09-16	Antipsychotic γ-carbolines

Publications (2)

Publication Number	Publication Date
YU157686A YU157686A (en)	1988-04-30
YU45023B true YU45023B (en)	1991-06-30

Family

ID=25106686

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU1576/86A YU45023B (en)	1985-09-16	1986-09-10	Process for obtaining antipsychotic gamma carbolines

Country Status (28)

Country	Link
US (1)	US4636563A (es)
EP (1)	EP0223344B1 (es)
JP (1)	JPS6267083A (es)
KR (1)	KR900002245B1 (es)
CN (1)	CN1013864B (es)
AR (1)	AR242208A1 (es)
AT (1)	ATE55770T1 (es)
AU (1)	AU590605B2 (es)
CA (1)	CA1275099A (es)
CY (1)	CY1595A (es)
DE (1)	DE3673607D1 (es)
DK (1)	DK440686A (es)
EG (1)	EG18015A (es)
ES (1)	ES2002656A6 (es)
FI (1)	FI83318C (es)
GB (1)	GB2180536B (es)
GR (1)	GR862343B (es)
HK (1)	HK53491A (es)
HU (1)	HU195217B (es)
IL (1)	IL79956A0 (es)
MX (1)	MX3681A (es)
NO (1)	NO163619C (es)
NZ (1)	NZ217580A (es)
PH (1)	PH22515A (es)
PT (1)	PT83344B (es)
SU (1)	SU1442074A3 (es)
YU (1)	YU45023B (es)
ZA (1)	ZA866258B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5328905A (en) *	1987-07-20	1994-07-12	Duphar International Research B.V.	8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives
US5360800A (en) *	1987-09-03	1994-11-01	Glaxo Group Limited	Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
US4798896A (en) *	1988-01-19	1989-01-17	American Home Products Corporation	Antipsychotic gamma-carboline N-oxides
HU207078B (en) *	1988-08-02	1993-03-01	Glaxo Group Ltd	Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
JPH02167280A (ja) *	1988-08-15	1990-06-27	Glaxo Group Ltd	ラクタム誘導体
US5021569A (en) *	1990-06-12	1991-06-04	American Home Products Corporation	4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolytic activity
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
FR2715659B1 (fr) *	1994-02-03	1996-03-22	Synthelabo	Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
CN1109880A (zh) *	1994-02-03	1995-10-11	合成实验室公司	3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
JP3274579B2 (ja) *	1995-01-12	2002-04-15	住友製薬株式会社	脳血管障害に伴う精神症候治療剤
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
RU2106864C1 (ru) *	1995-10-23	1998-03-20	Николай Серафимович Зефиров	Средство для лечения болезни альцгеймера
US20070179174A1 (en) *	2003-12-08	2007-08-02	Bachurin Sergei O	Methods and compositions for slowing aging
RU2283108C2 (ru) *	2003-12-08	2006-09-10	Сергей Олегович Бачурин	ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
JP2009502959A (ja) *	2005-07-28	2009-01-29	ブリストル−マイヤーズスクイブカンパニー	セロトニン受容体アゴニストおよびアンタゴニストとしての置換テトラヒドロ−１ｈ−ピリド［４，３，ｂ］インドール
EP1937263A2 (en) *	2005-10-04	2008-07-02	Medivation, Inc.	Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease
RU2338537C2 (ru) *	2006-01-25	2008-11-20	Сергей Олегович Бачурин	СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670010A1 (de) *	1966-12-07	1970-07-30	Abbott Lab	Aroylalkylderivate von 1,2,3,4-Tetrahydro-5H-pyride-[4,3b]-indolen und Verfahren zur Herstellung derselben
US3522262A (en) *	1968-09-10	1970-07-28	Hoffmann La Roche	5-(pyridylalkyl)-pyridoindole derivatives
US3502688A (en) *	1968-09-10	1970-03-24	Hoffmann La Roche	5-(4-pyridylethyl)-pyridoindole derivatives
DE1952800C3 (de) *	1969-10-20	1974-04-18	Nautschno-Issledowatelskij Institut Farmakologii I Chimioterapii, Moskau	3,6-Dimethyl-l,2,3,4,4a,9a-hexahydro-gamma-carbolin-dihydrochlorid
US4001263A (en) *	1974-04-01	1977-01-04	Pfizer Inc.	5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
DE2621729A1 (de) *	1976-05-15	1977-12-08	Boehringer Sohn Ingelheim	Neue 2-(4-phenyl-4-cyanobutyl)-1,2, 3,4-tetrahydro-5(h)-pyrido- eckige klammer auf 4,3-b eckige klammer zu -indole und verfahren zu ihrer herstellung
US4224329A (en) *	1979-01-23	1980-09-23	Pfizer Inc.	2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4337250A (en) *	1979-07-30	1982-06-29	Pfizer Inc.	Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4672117A (en) *	1985-09-16	1987-06-09	American Home Products Corporation	Antipsychotic gamma-carbolines
PH25493A (en) *	1987-09-03	1991-07-24	Glaxo Group Ltd	2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b\|indol-1-ones , derivatives having 5-ht antagonist activity 3

1985
- 1985-09-16 US US06/776,180 patent/US4636563A/en not_active Expired - Fee Related
1986
- 1986-08-19 ZA ZA866258A patent/ZA866258B/xx unknown
- 1986-08-25 AU AU61813/86A patent/AU590605B2/en not_active Ceased
- 1986-09-02 DE DE8686306745T patent/DE3673607D1/de not_active Expired - Fee Related
- 1986-09-02 AT AT86306745T patent/ATE55770T1/de not_active IP Right Cessation
- 1986-09-02 EP EP86306745A patent/EP0223344B1/en not_active Expired - Lifetime
- 1986-09-03 GB GB8621226A patent/GB2180536B/en not_active Expired
- 1986-09-05 AR AR86305167A patent/AR242208A1/es active
- 1986-09-05 IL IL79956A patent/IL79956A0/xx not_active IP Right Cessation
- 1986-09-08 MX MX368186A patent/MX3681A/es unknown
- 1986-09-08 PH PH34230A patent/PH22515A/en unknown
- 1986-09-10 YU YU1576/86A patent/YU45023B/xx unknown
- 1986-09-10 PT PT83344A patent/PT83344B/pt not_active IP Right Cessation
- 1986-09-11 CA CA000517999A patent/CA1275099A/en not_active Expired - Fee Related
- 1986-09-12 ES ES8601849A patent/ES2002656A6/es not_active Expired
- 1986-09-12 SU SU864028180A patent/SU1442074A3/ru active
- 1986-09-12 JP JP61216964A patent/JPS6267083A/ja active Pending
- 1986-09-12 GR GR862343A patent/GR862343B/el unknown
- 1986-09-12 FI FI863692A patent/FI83318C/fi not_active IP Right Cessation
- 1986-09-13 CN CN86106194A patent/CN1013864B/zh not_active Expired
- 1986-09-15 EG EG581/86A patent/EG18015A/xx active
- 1986-09-15 NZ NZ217580A patent/NZ217580A/xx unknown
- 1986-09-15 DK DK440686A patent/DK440686A/da not_active Application Discontinuation
- 1986-09-15 NO NO863671A patent/NO163619C/no unknown
- 1986-09-15 KR KR1019860007738A patent/KR900002245B1/ko not_active IP Right Cessation
- 1986-09-15 HU HU863942A patent/HU195217B/hu not_active IP Right Cessation
1991
- 1991-07-11 HK HK534/91A patent/HK53491A/xx unknown
1992
- 1992-04-03 CY CY1595A patent/CY1595A/xx unknown

Also Published As

Publication number	Publication date
FI863692A (fi)	1987-03-17
DE3673607D1 (en)	1990-09-27
KR900002245B1 (ko)	1990-04-07
AU6181386A (en)	1987-03-19
GB2180536B (en)	1989-04-05
MX3681A (es)	1993-10-01
EP0223344A1 (en)	1987-05-27
NO863671D0 (no)	1986-09-15
NO863671L (no)	1987-03-17
NO163619C (no)	1990-06-27
ATE55770T1 (de)	1990-09-15
AU590605B2 (en)	1989-11-09
JPS6267083A (ja)	1987-03-26
US4636563A (en)	1987-01-13
FI83318C (fi)	1991-06-25
PT83344B (pt)	1988-07-29
FI83318B (fi)	1991-03-15
HK53491A (en)	1991-07-19
GB8621226D0 (en)	1986-10-08
PT83344A (pt)	1986-10-01
NZ217580A (en)	1988-07-28
GR862343B (en)	1987-01-12
ZA866258B (en)	1988-04-27
YU157686A (en)	1988-04-30
NO163619B (no)	1990-03-19
CN1013864B (zh)	1991-09-11
AR242208A1 (es)	1994-08-31
EP0223344B1 (en)	1990-08-22
HUT42478A (en)	1987-07-28
GB2180536A (en)	1987-04-01
CA1275099A (en)	1990-10-09
EG18015A (en)	1991-08-30
CY1595A (en)	1992-04-03
HU195217B (en)	1988-04-28
CN86106194A (zh)	1987-03-18
ES2002656A6 (es)	1988-09-16
DK440686D0 (da)	1986-09-15
IL79956A0 (en)	1986-12-31
KR870003103A (ko)	1987-04-15
PH22515A (en)	1988-09-12
SU1442074A3 (ru)	1988-11-30
DK440686A (da)	1987-03-17
FI863692A0 (fi)	1986-09-12

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GB8501831D0 (en)	1985-02-27	Measuring method & apparatus
RO91191B1 (ro)	1987-05-01	Procedeu de obtinere a xanthidrolului
YU45321B (en)	1992-05-28	Process for obtaining imidazocquinolinic derivatives