ES2002617A6 - Un procedimiento para la preparacion de gamma-carbolinas - Google Patents

Un procedimiento para la preparacion de gamma-carbolinas

Info

Publication number
ES2002617A6
ES2002617A6 ES8601848A ES8601848A ES2002617A6 ES 2002617 A6 ES2002617 A6 ES 2002617A6 ES 8601848 A ES8601848 A ES 8601848A ES 8601848 A ES8601848 A ES 8601848A ES 2002617 A6 ES2002617 A6 ES 2002617A6
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
halogen
carbolines
gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601848A
Other languages
English (en)
Inventor
Magid Abdel-Meg Abou-Gharbia
Usha Rajni Patel
Reinhard Peter Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of ES2002617A6 publication Critical patent/ES2002617A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE GAMMA-CARBOLINAS, DE FORMULA GENERAL (I), EN DONDE: R1 ES HIDROGENO, HALOGENO, HIDROXILO O ALQUILO; R2 ES PIRIDINILO, PIRACINILO, QUINOLINILO O QUINOZALINILO SUSTITUIDO O INSUSTITUIDO Y DICHOS SUSTITUYENTES SON ALQUILO, ALCOXILO, ALCOXICARBONILO, HALOGENO, CIANO O NITRO; R5 ES HIDROGENO, ALQUILO, FENILO, HALOFENILO, METILFENILO, TRIFLUORO METILFENILO, CIANOFENILO O NITROFENILO; R6 ES HIDROGENO, FENILO, METILFENILO, ETILFENILO, METOXIFENILO, ETOXIFENILO, HALOFENILO, TRIFLUOROMETILFENILO, CIANOFENILO O NITROFENILO; CON LA SALVEDAD DE QUE UNO DE R5 Y R6 ES DISTINTO DE HIDROGENO, Y N ES UN NUMERO ENTERO DE 1 A 7. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UNA GAMMA©CARBOLINA, DE FORMULA (II) APROPIADAMENTE, SUSTITUIDA, CON HALOALQUILPIRIDINA, HALOALQUILPIRACINA, HALOALQUILQUINOLINA O HALOALQUILQUINOXALINA (III) EN UN DISOLVENTE APROTICO, EN PRESENCIA DE UNA BASE SUAVE. TAMBIEN PUEDE REALIZARSE LA REACCION DE LA GAMMA©CARBOLINA (II) CON UNA VINILPIRIDINA,VINILPIRACINA, VINILQUINOLINA O VINILQUINOXALINA (IV) EN UN DISOLVENTE ALCOHOLICO, CON ACIDO ACETICO GLACIAL COMO CATALIZADOR. LAS REACCIONES SE LLEVAN A CABO A REFLUJO, DURANTE 24©48 HORAS. ESTOS PRODUCTOS, O SUS SALES FARMACEUTICAMENTE ACEPTABLES, SON AGENTES ANTIPSICOTICOS Y ANXIOLITICOS.
ES8601848A 1985-09-16 1986-09-12 Un procedimiento para la preparacion de gamma-carbolinas Expired ES2002617A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/776,349 US4672117A (en) 1985-09-16 1985-09-16 Antipsychotic gamma-carbolines

Publications (1)

Publication Number Publication Date
ES2002617A6 true ES2002617A6 (es) 1988-09-01

Family

ID=25107141

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601848A Expired ES2002617A6 (es) 1985-09-16 1986-09-12 Un procedimiento para la preparacion de gamma-carbolinas

Country Status (15)

Country Link
US (1) US4672117A (es)
EP (1) EP0222474B1 (es)
JP (1) JPS6270374A (es)
KR (1) KR900002246B1 (es)
AT (1) ATE57184T1 (es)
AU (1) AU583941B2 (es)
CA (1) CA1275100A (es)
DE (1) DE3674721D1 (es)
DK (1) DK440486A (es)
ES (1) ES2002617A6 (es)
GB (1) GB2180535B (es)
GR (1) GR862344B (es)
HU (1) HU194564B (es)
PT (1) PT83345B (es)
ZA (1) ZA866259B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
US5360800A (en) * 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
HU207078B (en) * 1988-08-02 1993-03-01 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
WO1995018092A1 (fr) * 1993-12-28 1995-07-06 Maruho Co., Ltd. Derive de l'aminocetone
EP0905136A1 (en) * 1997-09-08 1999-03-31 Janssen Pharmaceutica N.V. Tetrahydro gamma-carbolines
JP2004015286A (ja) * 2002-06-05 2004-01-15 Seiko Epson Corp ディジタルカメラ
BRPI0509893A (pt) * 2004-04-12 2007-10-30 Taisho Pharmaceutical Co Ltd composto de amina cìclica
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
EP2175724A4 (en) * 2007-08-01 2010-09-15 Medivation Neurology Inc METHOD AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA USING ANTIPSYCHOTIC COMBINATION THERAPY

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522262A (en) * 1968-09-10 1970-07-28 Hoffmann La Roche 5-(pyridylalkyl)-pyridoindole derivatives
US3502688A (en) * 1968-09-10 1970-03-24 Hoffmann La Roche 5-(4-pyridylethyl)-pyridoindole derivatives
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4337250A (en) * 1979-07-30 1982-06-29 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
PH25493A (en) * 1987-09-03 1991-07-24 Glaxo Group Ltd 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3

Also Published As

Publication number Publication date
ATE57184T1 (de) 1990-10-15
DK440486D0 (da) 1986-09-15
GR862344B (en) 1987-01-12
AU583941B2 (en) 1989-05-11
CA1275100A (en) 1990-10-09
HUT42480A (en) 1987-07-28
DK440486A (da) 1987-03-17
GB2180535A (en) 1987-04-01
ZA866259B (en) 1988-03-30
JPS6270374A (ja) 1987-03-31
HU194564B (en) 1988-02-29
US4672117A (en) 1987-06-09
PT83345B (pt) 1988-07-29
AU6181486A (en) 1987-03-19
KR900002246B1 (ko) 1990-04-07
PT83345A (pt) 1986-10-01
GB8621225D0 (en) 1986-10-08
EP0222474B1 (en) 1990-10-03
GB2180535B (en) 1989-04-05
KR870003104A (ko) 1987-04-15
DE3674721D1 (en) 1990-11-08
EP0222474A1 (en) 1987-05-20

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-12