EP2078037A4 - Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexine - Google Patents
Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexineInfo
- Publication number
- EP2078037A4 EP2078037A4 EP07815526A EP07815526A EP2078037A4 EP 2078037 A4 EP2078037 A4 EP 2078037A4 EP 07815526 A EP07815526 A EP 07815526A EP 07815526 A EP07815526 A EP 07815526A EP 2078037 A4 EP2078037 A4 EP 2078037A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor
- dimers
- oligomers
- releasing hormone
- hetero
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006906292A AU2006906292A0 (en) | 2006-11-10 | Detection System and Uses Therefor | |
PCT/AU2007/001723 WO2008055314A1 (fr) | 2006-11-10 | 2007-11-09 | Hétéro-dimères/-oligomères de récepteur à hormone de libération de la thyrotropine et de récepteur à orexine |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2078037A1 EP2078037A1 (fr) | 2009-07-15 |
EP2078037A4 true EP2078037A4 (fr) | 2010-01-27 |
Family
ID=39364112
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07815525A Not-in-force EP2080012B1 (fr) | 2006-11-10 | 2007-11-09 | Procédé d'évaluation de substances d'essai sur récepteurs associées |
EP20130159448 Withdrawn EP2605015A1 (fr) | 2006-11-10 | 2007-11-09 | Trousses d'évaluation de l'interaction d'une substance d'essai avex deux récepteurs associés |
EP07815526A Withdrawn EP2078037A4 (fr) | 2006-11-10 | 2007-11-09 | Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexine |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07815525A Not-in-force EP2080012B1 (fr) | 2006-11-10 | 2007-11-09 | Procédé d'évaluation de substances d'essai sur récepteurs associées |
EP20130159448 Withdrawn EP2605015A1 (fr) | 2006-11-10 | 2007-11-09 | Trousses d'évaluation de l'interaction d'une substance d'essai avex deux récepteurs associés |
Country Status (11)
Country | Link |
---|---|
US (3) | US20100234417A1 (fr) |
EP (3) | EP2080012B1 (fr) |
JP (2) | JP5313149B2 (fr) |
KR (1) | KR20090083925A (fr) |
CN (1) | CN101657715B (fr) |
AU (2) | AU2007317204A1 (fr) |
CA (2) | CA2669088C (fr) |
DK (1) | DK2080012T3 (fr) |
IL (1) | IL198639A (fr) |
WO (2) | WO2008055313A1 (fr) |
ZA (1) | ZA200903529B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
BRPI0813583A2 (pt) * | 2007-07-13 | 2014-12-30 | Prometheus Lab Inc | Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo |
EP2210104A4 (fr) * | 2007-11-01 | 2011-02-23 | Univ Arizona State | Procédés acellulaires destinés à détecter des interactions protéine-ligand |
WO2009108637A1 (fr) | 2008-02-25 | 2009-09-03 | Prometheus Laboratories, Inc. | Sélection d’un médicament pour le traitement du cancer du sein à partir des matrices d’anticorps |
JP2012521967A (ja) * | 2009-03-27 | 2012-09-20 | ディメリックス バイオサイエンス ピーティーワイ リミテッド | 新規な受容体のヘテロ二量体/ヘテロオリゴマー |
ES2627909T3 (es) | 2009-07-15 | 2017-08-01 | Diatech Holdings, Inc. | Selección de fármacos para el tratamiento del cáncer gástrico usando matrices basadas en anticuercuerpos |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
CA2821985C (fr) | 2011-01-11 | 2019-07-09 | Dimerix Bioscience Pty Ltd | Polytherapie |
US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
KR101851425B1 (ko) | 2011-09-02 | 2018-04-23 | 네스텍 소시에테아노님 | 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링 |
IE20120542A1 (en) * | 2012-12-19 | 2014-07-02 | Provost Fellows Foundation Scholars And Other Members Of Board Of The College Of The Holy And Undivi | Novel TRH binding site in human CNS |
KR102192554B1 (ko) | 2013-03-13 | 2020-12-18 | 에스케이바이오팜 주식회사 | 탈력발작의 치료 |
JP6863897B2 (ja) | 2015-01-09 | 2021-04-21 | アダルタ・リミテッド | Cxcr4結合分子 |
KR102085554B1 (ko) * | 2018-02-21 | 2020-03-06 | 영남대학교 산학협력단 | 사카로마이세스 세레비시애의 g-단백질 연결 수용체에 대한 알파 팩터의 친화도 측정방법 |
CN111089971B (zh) * | 2019-12-11 | 2021-01-15 | 浙江大学 | 一种膜电位调控下的蛋白相互作用定量检测装置 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4391904A (en) * | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
NL8720442A (nl) | 1986-08-18 | 1989-04-03 | Clinical Technologies Ass | Afgeefsystemen voor farmacologische agentia. |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5891646A (en) | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
EP1137940A4 (fr) * | 1998-10-23 | 2004-06-02 | Glaxo Group Ltd | Procede d'identification de ligands de recepteurs nucleaires |
DE60026603T2 (de) | 1999-12-22 | 2007-03-01 | PerkinElmer BioSignal Inc., Montréal | Biolumineszenz-Resonanz-Energie-Transfer(BRET)-System mit großer spektraler Auflösung zwischen der Donator- und der Akzeptoremissionswellenlänge sowie dessen Verwendun |
US6893827B1 (en) * | 2000-02-07 | 2005-05-17 | Applera Corporation | Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation |
US20030096299A1 (en) * | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
NZ554913A (en) * | 2001-12-14 | 2009-01-31 | Targacept Inc | Methods and compositions for the treatment of central nervous system disorders |
FR2836475B1 (fr) * | 2002-02-26 | 2007-02-23 | Aventis Pharma Sa | Procede de detection de ligands du recepteur de la leptine |
DE10218785A1 (de) | 2002-04-26 | 2003-11-13 | Infineon Technologies Ag | Halbleiterspeichereinrichtung und Betriebsverfahren für eine Halbleiterspeichereinrichtung |
DE10230141B4 (de) * | 2002-07-04 | 2004-07-15 | Priontype Gmbh | Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc) |
JP2004093527A (ja) | 2002-09-04 | 2004-03-25 | Center For Advanced Science & Technology Incubation Ltd | 蛍光共鳴エネルギー転移を用いた蛋白質の分析方法 |
ATE500270T1 (de) * | 2003-05-20 | 2011-03-15 | Univ Glasgow | Materialien und methoden die sich auf g-protein gekoppelte rezeptor oligomere beziehen |
US7049076B2 (en) * | 2003-07-09 | 2006-05-23 | Sentigen Biosciences, Inc. | Method for assaying protein—protein interaction |
US7488583B2 (en) | 2003-09-25 | 2009-02-10 | Odyssey Thera, Inc. | Fragment complementation assays for G-protein-coupled receptors and their signaling pathways |
WO2005050182A1 (fr) * | 2003-11-19 | 2005-06-02 | Dimerix Biosciences Pty Ltd | Systeme de reseau de transfert d'energie de resonance destine a une detection a composants multiples |
CN1627072A (zh) * | 2003-12-11 | 2005-06-15 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 一种蛋白质芯片,其制备方法及用途 |
-
2007
- 2007-11-09 AU AU2007317204A patent/AU2007317204A1/en not_active Abandoned
- 2007-11-09 WO PCT/AU2007/001722 patent/WO2008055313A1/fr active Application Filing
- 2007-11-09 CN CN2007800496772A patent/CN101657715B/zh not_active Expired - Fee Related
- 2007-11-09 CA CA2669088A patent/CA2669088C/fr not_active Expired - Fee Related
- 2007-11-09 EP EP07815525A patent/EP2080012B1/fr not_active Not-in-force
- 2007-11-09 DK DK07815525.6T patent/DK2080012T3/da active
- 2007-11-09 CA CA002669185A patent/CA2669185A1/fr not_active Abandoned
- 2007-11-09 JP JP2009535526A patent/JP5313149B2/ja not_active Expired - Fee Related
- 2007-11-09 AU AU2007317203A patent/AU2007317203B2/en not_active Ceased
- 2007-11-09 EP EP20130159448 patent/EP2605015A1/fr not_active Withdrawn
- 2007-11-09 US US12/514,034 patent/US20100234417A1/en not_active Abandoned
- 2007-11-09 US US12/442,899 patent/US8283127B2/en active Active
- 2007-11-09 EP EP07815526A patent/EP2078037A4/fr not_active Withdrawn
- 2007-11-09 KR KR1020097011945A patent/KR20090083925A/ko not_active Application Discontinuation
- 2007-11-09 WO PCT/AU2007/001723 patent/WO2008055314A1/fr active Application Filing
- 2007-11-09 JP JP2009535527A patent/JP2010510175A/ja not_active Ceased
-
2009
- 2009-05-07 IL IL198639A patent/IL198639A/en active IP Right Grant
- 2009-05-21 ZA ZA200903529A patent/ZA200903529B/xx unknown
-
2012
- 2012-09-10 US US13/608,855 patent/US8568997B2/en active Active
Non-Patent Citations (4)
Title |
---|
HANYALOGLU A C ET AL: "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.", J BIOL CHEM, vol. 277, no. 52, 27 December 2002 (2002-12-27), pages 50422 - 50430, XP002559469 * |
MJ BINGHAM ET AL: "Eating, sleeping and rewarding: Orexin receptors and their antagonists", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, no. 5, 1 September 2006 (2006-09-01), pages 551 - 559, XP008100419 * |
PFLEGER K D G ET AL: "Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells.", BIOCHEM J, vol. 385, no. Pt 3, 1 February 2005 (2005-02-01), pages 625 - 637, XP002559470 * |
RIEHL J ET AL: "Chronic Oral Administration of CG-3703, a thyrotropin Releasing Hormone Analog, Increase Wake and Decreases Cataplexy in canine Narcolepsy", NEUROPSYCHOPHARMACOLOGY, vol. 23, no. 1, 1 January 2000 (2000-01-01), pages 34 - 45, XP008105405 * |
Also Published As
Publication number | Publication date |
---|---|
EP2080012A1 (fr) | 2009-07-22 |
US20100021457A1 (en) | 2010-01-28 |
ZA200903529B (en) | 2010-03-31 |
WO2008055314A1 (fr) | 2008-05-15 |
CN101657715A (zh) | 2010-02-24 |
JP2010509572A (ja) | 2010-03-25 |
AU2007317204A1 (en) | 2008-05-15 |
WO2008055313A1 (fr) | 2008-05-15 |
IL198639A (en) | 2015-01-29 |
US20130065253A1 (en) | 2013-03-14 |
CN101657715B (zh) | 2012-07-25 |
EP2080012A4 (fr) | 2010-01-27 |
AU2007317203A1 (en) | 2008-05-15 |
US8568997B2 (en) | 2013-10-29 |
CA2669088A1 (fr) | 2008-05-15 |
JP2010510175A (ja) | 2010-04-02 |
US8283127B2 (en) | 2012-10-09 |
CA2669088C (fr) | 2016-04-05 |
EP2080012B1 (fr) | 2013-03-20 |
DK2080012T3 (da) | 2013-06-17 |
EP2078037A1 (fr) | 2009-07-15 |
CA2669185A1 (fr) | 2008-05-15 |
US20100234417A1 (en) | 2010-09-16 |
IL198639A0 (en) | 2010-02-17 |
KR20090083925A (ko) | 2009-08-04 |
EP2605015A1 (fr) | 2013-06-19 |
JP5313149B2 (ja) | 2013-10-09 |
AU2007317203B2 (en) | 2010-12-16 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20090330 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 16/28 20060101ALI20091215BHEP Ipc: C07K 14/72 20060101ALI20091215BHEP Ipc: A61K 38/22 20060101ALI20091215BHEP Ipc: G01N 33/78 20060101ALI20091215BHEP Ipc: G01N 33/566 20060101ALI20091215BHEP Ipc: G01N 33/74 20060101ALI20091215BHEP Ipc: G01N 33/542 20060101AFI20091215BHEP |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20091230 |
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17Q | First examination report despatched |
Effective date: 20100329 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20101009 |