EP2078037A4 - Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexine - Google Patents

Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexine

Info

Publication number
EP2078037A4
EP2078037A4 EP07815526A EP07815526A EP2078037A4 EP 2078037 A4 EP2078037 A4 EP 2078037A4 EP 07815526 A EP07815526 A EP 07815526A EP 07815526 A EP07815526 A EP 07815526A EP 2078037 A4 EP2078037 A4 EP 2078037A4
Authority
EP
European Patent Office
Prior art keywords
receptor
dimers
oligomers
releasing hormone
hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07815526A
Other languages
German (de)
English (en)
Other versions
EP2078037A1 (fr
Inventor
Kevin Donald George Pfleger
Ruth Marie Seeber
Heng Boon See
Karin Ann Eidne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dimerix Bioscience Pty Ltd
Original Assignee
Dimerix Bioscience Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006906292A external-priority patent/AU2006906292A0/en
Application filed by Dimerix Bioscience Pty Ltd filed Critical Dimerix Bioscience Pty Ltd
Publication of EP2078037A1 publication Critical patent/EP2078037A1/fr
Publication of EP2078037A4 publication Critical patent/EP2078037A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP07815526A 2006-11-10 2007-11-09 Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexine Withdrawn EP2078037A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2006906292A AU2006906292A0 (en) 2006-11-10 Detection System and Uses Therefor
PCT/AU2007/001723 WO2008055314A1 (fr) 2006-11-10 2007-11-09 Hétéro-dimères/-oligomères de récepteur à hormone de libération de la thyrotropine et de récepteur à orexine

Publications (2)

Publication Number Publication Date
EP2078037A1 EP2078037A1 (fr) 2009-07-15
EP2078037A4 true EP2078037A4 (fr) 2010-01-27

Family

ID=39364112

Family Applications (3)

Application Number Title Priority Date Filing Date
EP07815525A Not-in-force EP2080012B1 (fr) 2006-11-10 2007-11-09 Procédé d'évaluation de substances d'essai sur récepteurs associées
EP20130159448 Withdrawn EP2605015A1 (fr) 2006-11-10 2007-11-09 Trousses d'évaluation de l'interaction d'une substance d'essai avex deux récepteurs associés
EP07815526A Withdrawn EP2078037A4 (fr) 2006-11-10 2007-11-09 Hetero-dimeres/-oligomeres de recepteur a hormone de liberation de la thyrotropine et de recepteur a orexine

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP07815525A Not-in-force EP2080012B1 (fr) 2006-11-10 2007-11-09 Procédé d'évaluation de substances d'essai sur récepteurs associées
EP20130159448 Withdrawn EP2605015A1 (fr) 2006-11-10 2007-11-09 Trousses d'évaluation de l'interaction d'une substance d'essai avex deux récepteurs associés

Country Status (11)

Country Link
US (3) US20100234417A1 (fr)
EP (3) EP2080012B1 (fr)
JP (2) JP5313149B2 (fr)
KR (1) KR20090083925A (fr)
CN (1) CN101657715B (fr)
AU (2) AU2007317204A1 (fr)
CA (2) CA2669088C (fr)
DK (1) DK2080012T3 (fr)
IL (1) IL198639A (fr)
WO (2) WO2008055313A1 (fr)
ZA (1) ZA200903529B (fr)

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BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
BRPI0813583A2 (pt) * 2007-07-13 2014-12-30 Prometheus Lab Inc Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo
EP2210104A4 (fr) * 2007-11-01 2011-02-23 Univ Arizona State Procédés acellulaires destinés à détecter des interactions protéine-ligand
WO2009108637A1 (fr) 2008-02-25 2009-09-03 Prometheus Laboratories, Inc. Sélection d’un médicament pour le traitement du cancer du sein à partir des matrices d’anticorps
JP2012521967A (ja) * 2009-03-27 2012-09-20 ディメリックス バイオサイエンス ピーティーワイ リミテッド 新規な受容体のヘテロ二量体／ヘテロオリゴマー
ES2627909T3 (es) 2009-07-15 2017-08-01 Diatech Holdings, Inc. Selección de fármacos para el tratamiento del cáncer gástrico usando matrices basadas en anticuercuerpos
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CA2821985C (fr) 2011-01-11 2019-07-09 Dimerix Bioscience Pty Ltd Polytherapie
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
KR101851425B1 (ko) 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
IE20120542A1 (en) * 2012-12-19 2014-07-02 Provost Fellows Foundation Scholars And Other Members Of Board Of The College Of The Holy And Undivi Novel TRH binding site in human CNS
KR102192554B1 (ko) 2013-03-13 2020-12-18 에스케이바이오팜 주식회사 탈력발작의 치료
JP6863897B2 (ja) 2015-01-09 2021-04-21 アダルタ・リミテッド Ｃｘｃｒ４結合分子
KR102085554B1 (ko) * 2018-02-21 2020-03-06 영남대학교 산학협력단 사카로마이세스 세레비시애의 g-단백질 연결 수용체에 대한 알파 팩터의 친화도 측정방법
CN111089971B (zh) * 2019-12-11 2021-01-15 浙江大学 一种膜电位调控下的蛋白相互作用定量检测装置

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US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
NL8720442A (nl) 1986-08-18 1989-04-03 Clinical Technologies Ass Afgeefsystemen voor farmacologische agentia.
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5891646A (en) 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
EP1137940A4 (fr) * 1998-10-23 2004-06-02 Glaxo Group Ltd Procede d'identification de ligands de recepteurs nucleaires
DE60026603T2 (de) 1999-12-22 2007-03-01 PerkinElmer BioSignal Inc., Montréal Biolumineszenz-Resonanz-Energie-Transfer(BRET)-System mit großer spektraler Auflösung zwischen der Donator- und der Akzeptoremissionswellenlänge sowie dessen Verwendun
US6893827B1 (en) * 2000-02-07 2005-05-17 Applera Corporation Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
US20030096299A1 (en) * 2001-07-09 2003-05-22 Valerie Wittamer Natural ligand of G protein coupled receptor ChemR23 and uses thereof
NZ554913A (en) * 2001-12-14 2009-01-31 Targacept Inc Methods and compositions for the treatment of central nervous system disorders
FR2836475B1 (fr) * 2002-02-26 2007-02-23 Aventis Pharma Sa Procede de detection de ligands du recepteur de la leptine
DE10218785A1 (de) 2002-04-26 2003-11-13 Infineon Technologies Ag Halbleiterspeichereinrichtung und Betriebsverfahren für eine Halbleiterspeichereinrichtung
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
JP2004093527A (ja) 2002-09-04 2004-03-25 Center For Advanced Science & Technology Incubation Ltd 蛍光共鳴エネルギー転移を用いた蛋白質の分析方法
ATE500270T1 (de) * 2003-05-20 2011-03-15 Univ Glasgow Materialien und methoden die sich auf g-protein gekoppelte rezeptor oligomere beziehen
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Title
HANYALOGLU A C ET AL: "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.", J BIOL CHEM, vol. 277, no. 52, 27 December 2002 (2002-12-27), pages 50422 - 50430, XP002559469 *
MJ BINGHAM ET AL: "Eating, sleeping and rewarding: Orexin receptors and their antagonists", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, no. 5, 1 September 2006 (2006-09-01), pages 551 - 559, XP008100419 *
PFLEGER K D G ET AL: "Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells.", BIOCHEM J, vol. 385, no. Pt 3, 1 February 2005 (2005-02-01), pages 625 - 637, XP002559470 *
RIEHL J ET AL: "Chronic Oral Administration of CG-3703, a thyrotropin Releasing Hormone Analog, Increase Wake and Decreases Cataplexy in canine Narcolepsy", NEUROPSYCHOPHARMACOLOGY, vol. 23, no. 1, 1 January 2000 (2000-01-01), pages 34 - 45, XP008105405 *

Also Published As

Publication number Publication date
EP2080012A1 (fr) 2009-07-22
US20100021457A1 (en) 2010-01-28
ZA200903529B (en) 2010-03-31
WO2008055314A1 (fr) 2008-05-15
CN101657715A (zh) 2010-02-24
JP2010509572A (ja) 2010-03-25
AU2007317204A1 (en) 2008-05-15
WO2008055313A1 (fr) 2008-05-15
IL198639A (en) 2015-01-29
US20130065253A1 (en) 2013-03-14
CN101657715B (zh) 2012-07-25
EP2080012A4 (fr) 2010-01-27
AU2007317203A1 (en) 2008-05-15
US8568997B2 (en) 2013-10-29
CA2669088A1 (fr) 2008-05-15
JP2010510175A (ja) 2010-04-02
US8283127B2 (en) 2012-10-09
CA2669088C (fr) 2016-04-05
EP2080012B1 (fr) 2013-03-20
DK2080012T3 (da) 2013-06-17
EP2078037A1 (fr) 2009-07-15
CA2669185A1 (fr) 2008-05-15
US20100234417A1 (en) 2010-09-16
IL198639A0 (en) 2010-02-17
KR20090083925A (ko) 2009-08-04
EP2605015A1 (fr) 2013-06-19
JP5313149B2 (ja) 2013-10-09
AU2007317203B2 (en) 2010-12-16

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Ipc: C07K 16/28 20060101ALI20091215BHEP

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