PL2064238T3 - Struktura krystaliczna receptora hormonu tyreotropowego - Google Patents

Struktura krystaliczna receptora hormonu tyreotropowego

Info

Publication number
PL2064238T3
PL2064238T3 PL07804094T PL07804094T PL2064238T3 PL 2064238 T3 PL2064238 T3 PL 2064238T3 PL 07804094 T PL07804094 T PL 07804094T PL 07804094 T PL07804094 T PL 07804094T PL 2064238 T3 PL2064238 T3 PL 2064238T3
Authority
PL
Poland
Prior art keywords
crystal structure
stimulating hormone
hormone receptor
thyroid stimulating
thyroid
Prior art date
Application number
PL07804094T
Other languages
English (en)
Inventor
Jane Sanders
Jadwiga Furmaniak
Smith Bernard Rees
Original Assignee
Rsr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0617237A external-priority patent/GB0617237D0/en
Priority claimed from GB0703070A external-priority patent/GB0703070D0/en
Application filed by Rsr Ltd filed Critical Rsr Ltd
Publication of PL2064238T3 publication Critical patent/PL2064238T3/pl

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30Drug targeting using structural data; Docking or binding prediction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • B01D15/3828Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50Molecular design, e.g. of drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
PL07804094T 2006-08-30 2007-08-30 Struktura krystaliczna receptora hormonu tyreotropowego PL2064238T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84096706P 2006-08-30 2006-08-30
GB0617237A GB0617237D0 (en) 2006-08-31 2006-08-31 Crystal structure
US90168507P 2007-02-16 2007-02-16
GB0703070A GB0703070D0 (en) 2007-02-16 2007-02-16 Crystal structure
PCT/GB2007/003286 WO2008025991A1 (en) 2006-08-30 2007-08-30 Crystal structure of the thsr receptor
EP07804094.6A EP2064238B1 (en) 2006-08-31 2007-08-30 Crystal structure of the thyroid stimulating hormone receptor

Publications (1)

Publication Number Publication Date
PL2064238T3 true PL2064238T3 (pl) 2013-12-31

Family

ID=49323709

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07804094T PL2064238T3 (pl) 2006-08-30 2007-08-30 Struktura krystaliczna receptora hormonu tyreotropowego

Country Status (5)

Country Link
US (3) US8097699B2 (pl)
EP (1) EP2064238B1 (pl)
ES (1) ES2426925T3 (pl)
PL (1) PL2064238T3 (pl)
WO (1) WO2008025991A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097699B2 (en) 2006-08-30 2012-01-17 Rsr Limited Crystal structure of thyroid stimulating hormone receptor
EP2617734B1 (en) 2008-12-24 2015-07-15 RSR Limited Human anti tshr antibodies
GB2527286A (en) 2014-06-11 2015-12-23 Rsr Ltd Glycoprotein hormone receptor mutations
CN114113637B (zh) * 2021-12-07 2024-03-12 郑州安图生物工程股份有限公司 一种促甲状腺激素受体抗原试剂及促甲状腺激素受体抗体定量检测试剂盒

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE145240T1 (de) 1989-12-14 1996-11-15 Brahms Diagnostica Gmbh Polypeptide mit thyrotropinrezeptor-aktivität, kodierende nukleinsäuresequenzen für solche rezeptoren und verwendung dieser polypeptide
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
EP1436323A4 (en) 2001-09-06 2005-03-16 Biogen Idec Inc CRYSTALLINE STRUCTURE OF BAFF AND USE FOR THE DESIGN OF MEDICAMENTS
JP5314234B2 (ja) * 2002-11-29 2013-10-16 アールエスアール リミテッド チロトロピン受容体の結合対象及びその使用
US7558717B2 (en) 2004-04-28 2009-07-07 Vertex Pharmaceuticals Incorporated Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
GB0418181D0 (en) 2004-08-13 2004-09-15 Rsr Ltd Thyrotrophin receptor preparations,thyrotrophin receptor epitopes,antibody and hormone interactions therewith,and uses thereof
US7605168B2 (en) 2004-09-03 2009-10-20 Plexxikon, Inc. PDE4B inhibitors
US8097699B2 (en) 2006-08-30 2012-01-17 Rsr Limited Crystal structure of thyroid stimulating hormone receptor
WO2011019556A1 (en) 2009-08-11 2011-02-17 Janssen Pharmaceutica Nv CO-CRYSTALLIZATION OF ERR-A α WITH A LIGAND THAT FORMS A REVERSIBLE CONVALENT BOND

Also Published As

Publication number Publication date
US20120087911A1 (en) 2012-04-12
US20100233189A1 (en) 2010-09-16
US20140074448A1 (en) 2014-03-13
WO2008025991A1 (en) 2008-03-06
EP2064238B1 (en) 2013-07-17
ES2426925T3 (es) 2013-10-25
US8097699B2 (en) 2012-01-17
US9147036B2 (en) 2015-09-29
EP2064238A1 (en) 2009-06-03

Similar Documents

Publication Publication Date Title
HK1244694A1 (zh) 新穎的胰高血糖素受體拮抗劑
EP2047252A4 (en) STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAINE
IL195755A0 (en) Pharmaceutical compositions containing antibodies against a beta-subunit of the insulin receptor
HK1136302A1 (en) Progesterone receptor antagonists
GB2436905B (en) Vibrator
GB2438255B (en) Vibrator
EP1773337A4 (en) MODULATORS OF NUCLEAR RECEPTORS
TWI370135B (en) Analogs of ghrelin substituted at the n-terminal
HK1135993A1 (en) Glucagon/glp-1 receptor co-agonists /glp-1
GB0700345D0 (en) Vibrator
EP2078037A4 (en) HETERODIMERS / OLIGOMERS OF THE RECEPTOR FOR THE THYROTROPIN RELEASING HORMONE OF THE OREXIN RECEPTOR
IL179462A0 (en) Use of the receptor gpr86
EP1806147A4 (en) USE OF IMMUNOSUPPRESSIVE RECEPTOR
PL2064238T3 (pl) Struktura krystaliczna receptora hormonu tyreotropowego
IL191815A0 (en) Compounds with medicinal effects due to interaction with the glucocorticoid receptor
HK1118757A1 (en) Self starting vibrator
GB0421538D0 (en) Liquid crystal structure
GB0611136D0 (en) Crystal structure
EP2152894A4 (en) HUMAN BNP IMMUNE-SPECIFIC ANTIBODIES
GB0615934D0 (en) Crystal structure
GB0716322D0 (en) Crystal structure
HK1096405A1 (en) Progesterone receptor modulators
GB2436133B (en) Anchoring device
ZA200907546B (en) New progesterone receptor modulators
GB0617237D0 (en) Crystal structure