EE9900465A - Uued ühendid - Google Patents

Uued ühendid

Info

Publication number: EE9900465A
Authority: EE; Estonia
Prior art keywords: pct; date; new compounds; sec; pub
Prior art date: 1997-04-15

Application number

EEP199900465A

Other languages

English (en)

Inventor

Cheshire David

Cooper Martin

Donald David

Thorne Philip

Original Assignee

Astra Pharmaceuticals Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-15

Filing date

1998-04-07

Publication date

2000-04-17

1998-04-07 Application filed by Astra Pharmaceuticals Limited filed Critical Astra Pharmaceuticals Limited

2000-04-17 Publication of EE9900465A publication Critical patent/EE9900465A/et

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

EEP199900465A 1997-04-15 1998-04-07 Uued ühendid EE9900465A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9701398A SE9701398D0 (sv)	1997-04-15	1997-04-15	Novel compounds
PCT/SE1998/000640 WO1998046606A1 (en)	1997-04-15	1998-04-07	Novel compounds

Publications (1)

Publication Number	Publication Date
EE9900465A true EE9900465A (et)	2000-04-17

Family

ID=20406576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900465A EE9900465A (et)	1997-04-15	1998-04-07	Uued ühendid

Country Status (21)

Country	Link
US (1)	US6028074A (et)
EP (1)	EP0975636B1 (et)
JP (1)	JP2001520645A (et)
KR (1)	KR20010006350A (et)
CN (1)	CN1259951A (et)
AT (1)	ATE245648T1 (et)
AU (1)	AU733066B2 (et)
BR (1)	BR9808540A (et)
CA (1)	CA2286078A1 (et)
DE (1)	DE69816608T2 (et)
EE (1)	EE9900465A (et)
HU (1)	HUP0002104A3 (et)
ID (1)	ID22746A (et)
IL (1)	IL132153A0 (et)
IS (1)	IS5198A (et)
NO (1)	NO995006D0 (et)
PL (1)	PL336230A1 (et)
SE (1)	SE9701398D0 (et)
SK (1)	SK135699A3 (et)
TR (1)	TR199902538T2 (et)
WO (1)	WO1998046606A1 (et)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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SE9801399D0 (sv)	1998-04-21	1998-04-21	Astra Pharma Prod	Method and apparatus for filling containers
GC0000177A (en) *	1998-12-17	2006-03-29	Smithkline Beecham	Thrombopoietin mimetics
CY2010012I2 (el)	2000-05-25	2020-05-29	Novartis Ag	Μιμητικα θρομβοποιητινης
JP2004527541A (ja)	2001-03-01	2004-09-09	スミスクライン・ビーチャム・コーポレイション	トロンボポエチン模倣物
JP2005511500A (ja)	2001-08-31	2005-04-28	ザロックフェラーユニバーシティー	脳におけるホスホジエステラーゼ活性およびホスホジエステラーゼ１ｂ媒介シグナル伝達の調節
TWI280128B (en)	2002-05-22	2007-05-01	Smithkline Beecham Corp	3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
TW200526638A (en)	2003-10-22	2005-08-16	Smithkline Beecham Corp	2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
US9226885B2 (en) *	2005-05-24	2016-01-05	Allium Vitalis Incorporated	Personal care and medicinal products incorporating bound organosulfur groups
KR20140022114A (ko)	2005-06-06	2014-02-21	다케다 야쿠힌 고교 가부시키가이샤	유기 화합물
AU2007256633B2 (en) *	2006-06-06	2013-09-12	Intra-Cellular Therapies, Inc.	Organic compounds
EP2081431B1 (en)	2006-11-13	2013-01-16	Intra-Cellular Therapies, Inc.	Organic compounds
JP5837278B2 (ja)	2006-12-05	2015-12-24	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	新規使用
ECSP077628A (es)	2007-05-03	2008-12-30	Smithkline Beechman Corp	Nueva composición farmacéutica
WO2009073210A1 (en) *	2007-12-06	2009-06-11	Intra-Cellular Therapies, Inc	Organic compounds
EP2240490B1 (en)	2007-12-06	2013-09-04	Takeda Pharmaceutical Company Limited	Organic compounds
EA201170773A1 (ru)	2008-12-06	2012-01-30	Интра-Селлулар Терапиз, Инк.	Органические соединения
EP2358204B1 (en)	2008-12-06	2015-08-05	Intra-Cellular Therapies, Inc.	4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors.
PE20110834A1 (es)	2008-12-06	2011-12-14	Intra Cellular Therapies Inc	DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1)
SG171775A1 (en)	2008-12-06	2011-07-28	Intra Cellular Therapies Inc	Organic compounds
PE20120209A1 (es)	2008-12-06	2012-03-18	Intra Cellular Therapies Inc	DERIVADOS DE IMIDAZO-[1,2-a]-PIRAZOLO [4,3-e]PIRIMIDINA O PIRIMIDO-[1,2-a]-PIRAZOLO [4,3-e]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1)
JP5813511B2 (ja) *	2008-12-06	2015-11-17	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
US11464781B2 (en)	2009-02-25	2022-10-11	Intra-Cellular Therapies, Inc.	PDE1 inhibitors for ophthalmic disorders
SG174403A1 (en)	2009-03-23	2011-10-28	Glenmark Pharmaceuticals Sa	Isothiazolo-pyrimidinedione derivatives as trpa1 modulators
EP2708538B1 (en)	2009-03-23	2015-08-12	Glenmark Pharmaceuticals S.A.	Process for preparing fused pyrimidine-dione derivatives, useful as as TRPA1 modulators
SG184767A1 (en)	2009-03-23	2012-10-30	Glenmark Pharmaceuticals Sa	Furopyrimidinedione derivatives as trpa1 modulators
US8623880B2 (en)	2009-03-23	2014-01-07	Glenmark Pharmaceuticals S.A.	Fused pyrimidine-dione derivatives as TRPA1 modulators
US9468637B2 (en)	2009-05-13	2016-10-18	Intra-Cellular Therapies, Inc.	Organic compounds
ES2605593T3 (es)	2009-05-29	2017-03-15	Novartis Ag	Métodos de administración de compuestos agonistas de trombopoyetina
SG10201507362TA (en)	2009-08-05	2015-10-29	Intra Cellular Therapies Inc	Novel Regulatory Proteins And Inhibitors
JP5911854B2 (ja)	2010-05-31	2016-04-27	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
TW201206937A (en)	2010-05-31	2012-02-16	Intra Cellular Therapies Inc	Organic compounds
JP5894148B2 (ja)	2010-05-31	2016-03-23	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
US9434730B2 (en)	2010-05-31	2016-09-06	Intra-Cellular Therapies, Inc.	PDE1 inhibitor compounds
JP6051210B2 (ja)	2011-06-10	2016-12-27	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
IN2014MN02467A (et)	2012-06-08	2015-07-10	Glenmark Pharmaceuticals Sa
US9801882B2 (en)	2013-02-17	2017-10-31	Intra-Cellular Therapies, Inc.	Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
ES2717688T3 (es)	2013-03-15	2019-06-24	Intra Cellular Therapies Inc	Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP
US9073936B2 (en)	2013-03-15	2015-07-07	Intra-Cellular Therapies, Inc.	Organic compounds
JP6696904B2 (ja)	2014-01-08	2020-05-20	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	製剤および医薬組成物
US9884872B2 (en)	2014-06-20	2018-02-06	Intra-Cellular Therapies, Inc.	Organic compounds
DK3177627T3 (da)	2014-08-07	2019-10-21	Intra Cellular Therapies Inc	Imidazo[1,2-a]-pyrazolo[4,3-e]-pyrimidin-4-on-derivater med pde1-hæmmende aktivitet
US9546175B2 (en)	2014-08-07	2017-01-17	Intra-Cellular Therapies, Inc.	Organic compounds
US10285992B2 (en)	2014-08-07	2019-05-14	Intra-Cellular Therapies, Inc.	Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
EP3725789B1 (en)	2014-09-17	2022-03-09	Intra-Cellular Therapies, Inc.	7,8-dihydro-[2h]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5h)-one derivatives as phosphodiesterase 1 (pde1) inhibitors for treating diseases, disorders or injuries of the central nervous system (cns)
JP6608933B2 (ja)	2014-12-06	2019-11-20	イントラ−セルラー・セラピーズ・インコーポレイテッド	有機化合物
JP6608934B2 (ja)	2014-12-06	2019-11-20	イントラ−セルラー・セラピーズ・インコーポレイテッド	有機化合物
JP2019510039A (ja)	2016-03-28	2019-04-11	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	新規組成物および方法
CN109311886B (zh) *	2016-06-23	2021-11-09	豪夫迈·罗氏有限公司	[1,2,3]***并[4,5-d]嘧啶衍生物
ES2906107T3 (es)	2016-09-12	2022-04-13	Intra Cellular Therapies Inc	Usos novedosos
WO2019152697A1 (en)	2018-01-31	2019-08-08	Intra-Cellular Therapies, Inc.	Novel uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
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EP0077372A1 (de) *	1981-04-22	1983-04-27	Byk Gulden Lomberg Chemische Fabrik GmbH	NEUE PYRAZOLO(3,4-d)PYRIMIDINE, VERFAHREN ZU DEREN HERSTELLUNG UND SIE ENTHALTENDE ARZNEIMITTEL
US4603203A (en) *	1983-12-14	1986-07-29	Takeda Chemical Industries, Ltd.	3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
EP0237289A3 (en) *	1986-03-14	1988-07-27	Takeda Chemical Industries, Ltd.	Pyrazolo [3,4-d] pyrimidine derivatives, their production and use
TW370529B (en) *	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
DK0674624T3 (da) *	1992-12-17	1999-09-13	Pfizer	Pyrazoler med CRF-antagonistisk aktivitet

1997
- 1997-04-15 SE SE9701398A patent/SE9701398D0/xx unknown
1998
- 1998-04-07 ID IDW991207A patent/ID22746A/id unknown
- 1998-04-07 KR KR1019997009435A patent/KR20010006350A/ko not_active Application Discontinuation
- 1998-04-07 TR TR1999/02538T patent/TR199902538T2/xx unknown
- 1998-04-07 AU AU70909/98A patent/AU733066B2/en not_active Ceased
- 1998-04-07 DE DE69816608T patent/DE69816608T2/de not_active Expired - Fee Related
- 1998-04-07 JP JP54380398A patent/JP2001520645A/ja not_active Ceased
- 1998-04-07 CN CN98806075A patent/CN1259951A/zh active Pending
- 1998-04-07 WO PCT/SE1998/000640 patent/WO1998046606A1/en active IP Right Grant
- 1998-04-07 EP EP98917859A patent/EP0975636B1/en not_active Expired - Lifetime
- 1998-04-07 PL PL98336230A patent/PL336230A1/xx unknown
- 1998-04-07 HU HU0002104A patent/HUP0002104A3/hu unknown
- 1998-04-07 CA CA002286078A patent/CA2286078A1/en not_active Abandoned
- 1998-04-07 EE EEP199900465A patent/EE9900465A/et unknown
- 1998-04-07 BR BR9808540-9A patent/BR9808540A/pt not_active IP Right Cessation
- 1998-04-07 AT AT98917859T patent/ATE245648T1/de not_active IP Right Cessation
- 1998-04-07 SK SK1356-99A patent/SK135699A3/sk unknown
- 1998-04-07 IL IL13215398A patent/IL132153A0/xx unknown
- 1998-08-07 US US09/068,304 patent/US6028074A/en not_active Expired - Fee Related
1999
- 1999-09-27 IS IS5198A patent/IS5198A/is unknown
- 1999-10-14 NO NO995006A patent/NO995006D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0975636A1 (en)	2000-02-02
PL336230A1 (en)	2000-06-19
DE69816608T2 (de)	2004-04-15
HUP0002104A2 (hu)	2001-01-29
AU7090998A (en)	1998-11-11
NO995006L (no)	1999-10-14
DE69816608D1 (de)	2003-08-28
ATE245648T1 (de)	2003-08-15
SK135699A3 (en)	2000-05-16
NO995006D0 (no)	1999-10-14
TR199902538T2 (xx)	2000-02-21
AU733066B2 (en)	2001-05-03
CA2286078A1 (en)	1998-10-22
KR20010006350A (ko)	2001-01-26
US6028074A (en)	2000-02-22
HUP0002104A3 (en)	2002-03-28
BR9808540A (pt)	2000-05-23
IL132153A0 (en)	2001-03-19
JP2001520645A (ja)	2001-10-30
CN1259951A (zh)	2000-07-12
EP0975636B1 (en)	2003-07-23
SE9701398D0 (sv)	1997-04-15
IS5198A (is)	1999-09-27
WO1998046606A1 (en)	1998-10-22
ID22746A (id)	1999-12-09

Publication	Publication Date	Title
EE9900465A (et)	2000-04-17	Uued ühendid
EE200000318A (et)	2001-08-15	Uudsed ühendid
EE9900539A (et)	2000-06-15	Uued ühendid
EE9900315A (et)	2000-02-15	Pürrolo[3,4-d]pürimidinooni derivaadid ja nende kasutamine ravimitena
DE69736441D1 (de)	2006-09-14	Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
SE9702772D0 (sv)	1997-07-22	Novel compounds
HUT75776A (en)	1997-05-28	Pyrazolo and pyrrolopyridines, their using, pharmaceutical compositions containing them and intermediates
HUP0104318A2 (hu)	2002-03-28	cGMP PDE-5 inhibitort tartalmazó szabályzottan hatóanyagot felszabadító gyógyászati készítmények
MXPA04003668A (es)	2004-07-22	Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos.
HK1075450A1 (en)	2005-12-16	heterocyclic compunds, process for their preparation and pharmaceutical compositions containing thenm and thier use in medicine
HUP0002346A1 (hu)	2001-05-28	Emlősök elmezavarainak kezelésére szolgáló gyógyszerkészítmény
DE69911785D1 (de)	2003-11-06	Triazolo[4,5-d]pyrimidin-verbindungen
HUP0100611A2 (hu)	2001-09-28	Triazin vegyületek, és ilyeneket tartalmazó gyógyszerkészítmények a központi idegrendszer elváltozásainak kezelésére
AU3862997A (en)	1998-02-20	Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
AU7436098A (en)	1998-11-13	Use of mizolastine for preparing a medicine for treating inflammation