EE200000059A - Tetrahüdro-gamma-karboliinid - Google Patents

Tetrahüdro-gamma-karboliinid

Info

Publication number
EE200000059A
EE200000059A EEP200000059A EEP200000059A EE200000059A EE 200000059 A EE200000059 A EE 200000059A EE P200000059 A EEP200000059 A EE P200000059A EE P200000059 A EEP200000059 A EE P200000059A EE 200000059 A EE200000059 A EE 200000059A
Authority
EE
Estonia
Prior art keywords
optionally substituted
6alkyl
aryl
carbolines
tetrahydro
Prior art date
Application number
EEP200000059A
Other languages
English (en)
Inventor
Edmond Josephine Kennis Ludo
Carolus Mertens Josephus
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200000059A publication Critical patent/EE200000059A/et
Publication of EE04496B1 publication Critical patent/EE04496B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200000059A 1997-09-08 1998-09-01 Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid EE04496B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202761A EP0905136A1 (en) 1997-09-08 1997-09-08 Tetrahydro gamma-carbolines
PCT/EP1998/005710 WO1999012926A1 (en) 1997-09-08 1998-09-01 Tetrahydro gamma-carbolines

Publications (2)

Publication Number Publication Date
EE200000059A true EE200000059A (et) 2000-10-16
EE04496B1 EE04496B1 (et) 2005-06-15

Family

ID=8228715

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000059A EE04496B1 (et) 1997-09-08 1998-09-01 Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid

Country Status (28)

Country Link
US (2) US6303614B1 (et)
EP (2) EP0905136A1 (et)
JP (1) JP2001515899A (et)
KR (1) KR100603896B1 (et)
CN (1) CN1110496C (et)
AT (1) ATE243209T1 (et)
AU (1) AU752410B2 (et)
BR (1) BR9811769A (et)
CA (1) CA2301807A1 (et)
CZ (1) CZ297220B6 (et)
DE (1) DE69815700T2 (et)
EE (1) EE04496B1 (et)
ES (1) ES2202902T3 (et)
HK (1) HK1029107A1 (et)
HR (1) HRP20000108A2 (et)
HU (1) HUP0003577A3 (et)
ID (1) ID23954A (et)
IL (1) IL134894A (et)
MY (1) MY129176A (et)
NO (1) NO315236B1 (et)
NZ (1) NZ503096A (et)
PL (1) PL191863B1 (et)
RU (1) RU2208614C2 (et)
SK (1) SK285594B6 (et)
TR (1) TR200000616T2 (et)
TW (1) TW531539B (et)
WO (1) WO1999012926A1 (et)
ZA (1) ZA988161B (et)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319539T3 (es) * 2003-09-17 2009-05-08 Janssen Pharmaceutica Nv Compuestos heterociclicos condensados como moduladores del receptor de serotonina.
CN101318961B (zh) * 2003-09-17 2012-11-28 詹森药业有限公司 稠合杂环化合物
EP1905774B1 (en) * 2003-09-17 2013-02-20 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as serotonin receptor modulators
KR20060135023A (ko) 2004-04-12 2006-12-28 다이쇼 세이야꾸 가부시끼가이샤 환상 아민 화합물
MX2007009783A (es) 2005-02-17 2007-08-22 Wyeth Corp Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfusionados.
FR2885905A1 (fr) * 2005-05-23 2006-11-24 Trophos Sa Nouveaux composes chimiques et leurs utilisations comme medicament
WO2007009485A1 (en) * 2005-07-22 2007-01-25 Pharma C S.A. Substituted 8-phenoxy-y-carboline derivatives with 5ht1 activity
US20090215801A9 (en) * 2005-11-15 2009-08-27 Astrazeneca Ab, Sodertaije, Swedenastex Thereapeutics Ltd Novel 2-Aminopyrimidinone Derivatives And Their Use
US7637410B2 (en) * 2006-10-06 2009-12-29 Tyco Healthcare Group Lp Surgical instrument including a locking assembly
AU2008302751A1 (en) * 2007-09-20 2009-03-26 D2E, Llc Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
EP2236511A4 (en) 2007-12-21 2011-04-13 Alla Chem Llc LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF
RU2374245C1 (ru) 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
CN105399674B (zh) 2015-12-31 2017-02-15 青岛清原化合物有限公司 吡唑类化合物或其盐、制备方法、除草剂组合物及用途
CN106631941B (zh) * 2016-12-30 2018-09-28 青岛瀚生生物科技股份有限公司 一种2-甲基-3氯苯基甲硫醚的制备方法
GB201704325D0 (en) 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds
CN110698474B (zh) * 2019-11-14 2021-11-02 福州大学 一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
DE69531476T2 (de) * 1994-09-12 2004-06-09 Lilly Industries Ltd., Basingstoke Serotonergische Modulatoren

Also Published As

Publication number Publication date
IL134894A (en) 2005-03-20
CZ2000726A3 (cs) 2000-07-12
NO20000737L (no) 2000-05-08
RU2208614C2 (ru) 2003-07-20
NO315236B1 (no) 2003-08-04
EE04496B1 (et) 2005-06-15
NO20000737D0 (no) 2000-02-14
HUP0003577A3 (en) 2003-05-28
IL134894A0 (en) 2001-05-20
EP1015451A1 (en) 2000-07-05
DE69815700T2 (de) 2004-04-29
US6303614B1 (en) 2001-10-16
AU9742198A (en) 1999-03-29
TR200000616T2 (tr) 2000-07-21
EP1015451B1 (en) 2003-06-18
CN1269800A (zh) 2000-10-11
HRP20000108A2 (en) 2000-12-31
BR9811769A (pt) 2000-08-29
ATE243209T1 (de) 2003-07-15
MY129176A (en) 2007-03-30
ID23954A (id) 2000-06-08
KR20010022391A (ko) 2001-03-15
ES2202902T3 (es) 2004-04-01
HUP0003577A2 (hu) 2001-09-28
JP2001515899A (ja) 2001-09-25
CA2301807A1 (en) 1999-03-18
CN1110496C (zh) 2003-06-04
ZA988161B (en) 2000-03-22
NZ503096A (en) 2001-11-30
CZ297220B6 (cs) 2006-10-11
TW531539B (en) 2003-05-11
SK285594B6 (sk) 2007-04-05
EP0905136A1 (en) 1999-03-31
US6506768B2 (en) 2003-01-14
SK2992000A3 (en) 2001-03-12
PL339143A1 (en) 2000-12-04
WO1999012926A1 (en) 1999-03-18
US20020103209A1 (en) 2002-08-01
HK1029107A1 (en) 2001-03-23
KR100603896B1 (ko) 2006-07-25
DE69815700D1 (en) 2003-07-24
AU752410B2 (en) 2002-09-19
PL191863B1 (pl) 2006-07-31

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

MM4A Lapsed by not paying the annual fees

Effective date: 20070901