EE05202B1 - Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga - Google Patents

Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga

Info

Publication number: EE05202B1
Authority: EE; Estonia
Prior art keywords: biotin; polysaccharides; covalent bond; antithrombotic activity; derivative
Prior art date: 2000-09-22

Application number

EEP200300114A

Other languages

English (en)

Estonian (et)

Inventor

Duchaussoy Philippe

Herbert Jean-Marc

Petitou Maurice

Savi Pierre

Original Assignee

Sanofi-Synthlabo

Akzo Nobel N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-22

Filing date

2001-09-20

Publication date

2009-08-17

2001-09-20 Application filed by Sanofi-Synthlabo, Akzo Nobel N.V. filed Critical Sanofi-Synthlabo

2005-02-15 Publication of EE200300114A publication Critical patent/EE200300114A/xx

2009-08-17 Publication of EE05202B1 publication Critical patent/EE05202B1/xx

Links

YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title 2
230000002785 anti-thrombosis Effects 0.000 title 1
229960002685 biotin Drugs 0.000 title 1
235000020958 biotin Nutrition 0.000 title 1
239000011616 biotin Substances 0.000 title 1
150000001615 biotins Chemical class 0.000 title 1
150000004676 glycans Chemical class 0.000 title 1
229920001282 polysaccharide Polymers 0.000 title 1
239000005017 polysaccharide Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Neurology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

EEP200300114A 2000-09-22 2001-09-20 Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga EE05202B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0012094A FR2814463B1 (fr)	2000-09-22	2000-09-22	Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
PCT/FR2001/002918 WO2002024754A1 (fr)	2000-09-22	2001-09-20	Polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Publications (2)

Publication Number	Publication Date
EE200300114A EE200300114A (et)	2005-02-15
EE05202B1 true EE05202B1 (et)	2009-08-17

Family

ID=8854579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300114A EE05202B1 (et)	2000-09-22	2001-09-20	Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga

Country Status (40)

Country	Link
US (3)	US6844329B2 (xx)
EP (1)	EP1322673B1 (xx)
JP (2)	JP5016778B2 (xx)
KR (2)	KR100891388B1 (xx)
CN (1)	CN1235914C (xx)
AR (1)	AR030774A1 (xx)
AT (1)	ATE374215T1 (xx)
AU (2)	AU2001291960C1 (xx)
BG (1)	BG66191B1 (xx)
BR (1)	BR0114007A (xx)
CA (1)	CA2418815C (xx)
CY (1)	CY1108076T1 (xx)
CZ (1)	CZ300856B6 (xx)
DE (1)	DE60130669T2 (xx)
DK (1)	DK1322673T3 (xx)
EA (1)	EA005133B1 (xx)
EC (1)	ECSP034514A (xx)
EE (1)	EE05202B1 (xx)
ES (1)	ES2292625T3 (xx)
FR (1)	FR2814463B1 (xx)
GE (1)	GEP20053616B (xx)
HK (1)	HK1053316A1 (xx)
HR (1)	HRP20030219B1 (xx)
HU (2)	HU1400034D0 (xx)
IL (2)	IL154848A0 (xx)
IS (1)	IS2550B (xx)
ME (2)	ME00080B (xx)
MX (1)	MXPA03002483A (xx)
NO (2)	NO332905B1 (xx)
NZ (1)	NZ524472A (xx)
PE (1)	PE20020471A1 (xx)
PL (1)	PL206727B1 (xx)
PT (1)	PT1322673E (xx)
RS (1)	RS50730B (xx)
SI (1)	SI1322673T1 (xx)
SK (2)	SK287054B6 (xx)
TW (1)	TWI308153B (xx)
UA (1)	UA79736C2 (xx)
WO (1)	WO2002024754A1 (xx)
ZA (1)	ZA200301692B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2814463B1 (fr) *	2000-09-22	2002-11-15	Sanofi Synthelabo	Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
FR2874924B1 (fr)	2004-09-09	2006-12-01	Sanofi Aventis Sa	Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) *	2004-12-23	2013-08-01	Merck Sharp & Dohme	包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) *	2005-02-01	2012-11-11	Msd Oss Bv	Conjugates of a polypeptide and an oligosaccharide
KR20080055960A (ko) *	2005-10-10	2008-06-19	엔.브이.오가논	바이오틴 라벨을 포함하는 항응고 항혈전 이중 억제제
ES2362011T3 (es) *	2005-10-10	2011-06-27	N.V. Organon	Inhibidores duales antitrombóticos anticoagulantes que comprenden una marca de biotina.
CN1317035C (zh) *	2005-10-24	2007-05-23	天津大学	基于酰肼基的微粒表面多重生物功能因子组装方法
EP1886696A1 (en) *	2006-08-03	2008-02-13	Endotis Pharma	Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins
FR2912409B1 (fr) *	2007-02-14	2012-08-24	Sanofi Aventis	Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
EP2145624A1 (en)	2008-07-18	2010-01-20	Sanofi-Aventis	Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
TW201006479A (en) *	2008-07-18	2010-02-16	Sanofi Aventis	Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2233143A1 (en)	2009-03-24	2010-09-29	Sanofi-Aventis	Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
FR2935386B1 (fr) *	2008-08-26	2010-09-10	Sanofi Aventis	Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
EP2323605A4 (en) *	2008-09-10	2014-02-05	Syneron Medical Ltd	TRANSDERMAL RELEASE OF OLIGOSACCHARIDES
CA3014688A1 (en)	2008-12-19	2010-07-15	Supernus Pharmaceuticals, Inc.	Use of molindone for the treatment of aggression, irritability, or impulsivity
FR2952935B1 (fr) *	2009-11-20	2011-12-02	Sanofi Aventis	Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle
CN102892411B (zh)	2009-12-18	2015-01-21	恩多提斯药业公司	含有合成的低聚糖的药物口服剂型
CZ302510B6 (cs) *	2010-03-29	2011-06-22	Univerzita Palackého v Olomouci	Efektivní zpusob biotinylace sloucenin s karboxylovou skupinou pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
CZ302669B6 (cs) *	2010-03-29	2011-08-24	Univerzita Palackého v Olomouci	Efektivní zpusob biotinylace aminosloucenin pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
WO2011123497A1 (en)	2010-03-31	2011-10-06	Supernus Pharmaceuticals Inc.	Stabilized formulations of cns compounds
FR2964660B1 (fr) *	2010-09-10	2012-09-28	Sanofi Aventis	Nouveaux polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
EP2614089A1 (fr) *	2010-09-10	2013-07-17	Sanofi-Aventis	Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
EP2484366A1 (en)	2011-02-07	2012-08-08	Sanofi	Idrabiotaparinux for the treatment of pulmonary embolism and for the secondary prevention of venous thromboembolic events
WO2012172104A1 (en)	2011-06-17	2012-12-20	Endotis Pharma	Synthetic pentasaccharides having short half-life and high activity
AU2013344920A1 (en) *	2012-11-13	2015-04-30	Supernus Pharmaceuticals, Inc.	Method of treatment of aggression
WO2015195404A1 (en)	2014-06-20	2015-12-23	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Methods for detection of an analyte by movement of tethered microparticles
WO2016205239A1 (en)	2015-06-15	2016-12-22	The United States Of America, As Represented By The Secretary Department Of Health And Human Services	Non-hormonal mammalian sperm decoy contraception based on the n-terminus of the zp2 protein
WO2018076025A1 (en)	2016-10-21	2018-04-26	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Molecular nanotags
CN108976318B (zh) *	2017-06-01	2021-03-30	首都医科大学	单-6-(生物素酰胺基)-6-脱氧-β-环糊精及其制备方法和应用
WO2019133727A1 (en)	2017-12-29	2019-07-04	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Universal influenza virus probe set for enrichment of any influenza virus nucleic acid
CA3144968A1 (en)	2019-07-09	2021-01-14	Optimvia Llc	Methods for synthesizing anticoagulant polysaccharides
CN114556685B (zh) *	2019-10-17	2024-04-02	株式会社自动网络技术研究所	布线模块
WO2022056078A1 (en)	2020-09-11	2022-03-17	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Rnase h-assisted detection assay for rna (radar)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3960884A (en) *	1974-04-24	1976-06-01	Sergei Ivanovich Zavyalov	Method of preparing racemic biotin
AU563351C (en) *	1982-01-15	2003-06-19	Glaxo Group Limited	Synthesis of oligosaccharides
IL102758A (en) *	1991-08-23	1997-03-18	Akzo Nv	Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
WO2000002050A1 (en) *	1998-07-07	2000-01-13	Department Of Radiation Oncology, University Of Washington	Trifunctional reagent for conjugation to a biomolecule
US20010023288A1 (en) *	1999-07-07	2001-09-20	Wilbur D. Scott	Trifunctional reagent for conjugation to a biomolecule
FR2751334B1 (fr) *	1996-07-19	1998-10-16	Sanofi Sa	Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773804B1 (fr) *	1998-01-19	2000-02-18	Sanofi Sa	Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
FR2773801B1 (fr) *	1998-01-19	2000-05-12	Sanofi Sa	Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
GB2335490B (en) *	1998-03-20	2003-05-14	Ortho Clinical Diagnostics	An assay surface that permits an analyte releasiing step
US6492503B1 (en)	1998-07-31	2002-12-10	Seikagaku Corporation	Glycosaminoglycan and drug compositions containing the same
FR2814463B1 (fr) *	2000-09-22	2002-11-15	Sanofi Synthelabo	Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

2000
- 2000-09-22 FR FR0012094A patent/FR2814463B1/fr not_active Expired - Fee Related
2001
- 2001-09-20 SK SK356-2003A patent/SK287054B6/sk not_active IP Right Cessation
- 2001-09-20 SI SI200130786T patent/SI1322673T1/sl unknown
- 2001-09-20 KR KR1020037004108A patent/KR100891388B1/ko not_active IP Right Cessation
- 2001-09-20 CN CNB018161588A patent/CN1235914C/zh not_active Expired - Fee Related
- 2001-09-20 JP JP2002529162A patent/JP5016778B2/ja not_active Expired - Fee Related
- 2001-09-20 US US10/381,154 patent/US6844329B2/en not_active Expired - Lifetime
- 2001-09-20 PL PL363368A patent/PL206727B1/pl unknown
- 2001-09-20 ES ES01972171T patent/ES2292625T3/es not_active Expired - Lifetime
- 2001-09-20 IL IL15484801A patent/IL154848A0/xx unknown
- 2001-09-20 ME MEP-2008-236A patent/ME00080B/me unknown
- 2001-09-20 NZ NZ524472A patent/NZ524472A/en not_active IP Right Cessation
- 2001-09-20 DK DK01972171T patent/DK1322673T3/da active
- 2001-09-20 AT AT01972171T patent/ATE374215T1/de active
- 2001-09-20 BR BR0114007-8A patent/BR0114007A/pt active Search and Examination
- 2001-09-20 UA UA2003021719A patent/UA79736C2/uk unknown
- 2001-09-20 MX MXPA03002483A patent/MXPA03002483A/es active IP Right Grant
- 2001-09-20 ME MEP-236/08A patent/MEP23608A/xx unknown
- 2001-09-20 PT PT01972171T patent/PT1322673E/pt unknown
- 2001-09-20 RS YUP-197/03A patent/RS50730B/sr unknown
- 2001-09-20 WO PCT/FR2001/002918 patent/WO2002024754A1/fr active Application Filing
- 2001-09-20 AU AU2001291960A patent/AU2001291960C1/en not_active Ceased
- 2001-09-20 AU AU9196001A patent/AU9196001A/xx active Pending
- 2001-09-20 KR KR1020087009747A patent/KR20080049139A/ko not_active Application Discontinuation
- 2001-09-20 CA CA2418815A patent/CA2418815C/en not_active Expired - Fee Related
- 2001-09-20 SK SK5031-2009A patent/SK287218B6/sk not_active IP Right Cessation
- 2001-09-20 HU HUP1400034 patent/HU1400034D0/hu not_active Application Discontinuation
- 2001-09-20 EA EA200300237A patent/EA005133B1/ru not_active IP Right Cessation
- 2001-09-20 HU HU0303551A patent/HUP0303551A3/hu not_active Application Discontinuation
- 2001-09-20 GE GE5103A patent/GEP20053616B/en unknown
- 2001-09-20 CZ CZ20030814A patent/CZ300856B6/cs not_active IP Right Cessation
- 2001-09-20 DE DE60130669T patent/DE60130669T2/de not_active Expired - Lifetime
- 2001-09-20 EP EP01972171A patent/EP1322673B1/fr not_active Expired - Lifetime
- 2001-09-20 EE EEP200300114A patent/EE05202B1/xx not_active IP Right Cessation
- 2001-09-20 AR ARP010104436A patent/AR030774A1/es not_active Application Discontinuation
- 2001-09-21 PE PE2001000952A patent/PE20020471A1/es not_active Application Discontinuation
- 2001-09-21 TW TW090123340A patent/TWI308153B/zh not_active IP Right Cessation
2003
- 2003-02-28 IS IS6733A patent/IS2550B/is unknown
- 2003-02-28 ZA ZA200301692A patent/ZA200301692B/en unknown
- 2003-03-10 IL IL154848A patent/IL154848A/en not_active IP Right Cessation
- 2003-03-14 EC EC2003004514A patent/ECSP034514A/es unknown
- 2003-03-20 NO NO20031295A patent/NO332905B1/no not_active IP Right Cessation
- 2003-03-20 BG BG107650A patent/BG66191B1/bg unknown
- 2003-03-21 HR HR20030219A patent/HRP20030219B1/xx not_active IP Right Cessation
- 2003-08-05 HK HK03105615A patent/HK1053316A1/xx not_active IP Right Cessation
2005
- 2005-01-14 US US11/035,717 patent/US7943595B2/en not_active Expired - Fee Related
2007
- 2007-12-04 CY CY20071101542T patent/CY1108076T1/el unknown
2011
- 2011-02-28 US US13/036,143 patent/US8318696B2/en not_active Expired - Fee Related
- 2011-03-16 NO NO20110401A patent/NO20110401L/no not_active Application Discontinuation
2012
- 2012-02-10 JP JP2012027377A patent/JP2012131809A/ja active Pending

Also Published As

Publication number	Publication date
EP1322673A1 (fr)	2003-07-02
SK287054B6 (sk)	2009-10-07
WO2002024754A1 (fr)	2002-03-28
YU19703A (sh)	2006-05-25
DK1322673T3 (da)	2008-01-14
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Publication	Publication Date	Title
EE05202B1 (et)	2009-08-17	Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga
AU2001291960A1 (en)	2002-06-20	Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative
NO994071D0 (no)	1999-08-24	Epotilones med en modifisert sidekjede
NL1002223C2 (nl)	1996-11-26	Dilatatiekatheter met zijopening.
ITRM20000041A0 (it)	2000-01-25	Derivati glicosamminoglicani parzialmente desolfatati non anticoagulanti ad attivita' antiangiogenica.
DE60014371D1 (de)	2004-11-04	Polysaccharidderivat
DE59909585D1 (de)	2004-07-01	Gebläse mit vorgegebener Kennlinie
ID28773A (id)	2001-07-05	Penunjukan-tanah dengan tekanan-sama
FI991261A (fi)	2000-12-03	Trie-rakenteeseen perustuva funktionaalinen muisti
DK1066190T3 (da)	2002-04-02	Fladt kompositlegeme, navnlig et køretøjskarosserielement
IT1309297B1 (it)	2002-01-22	Convogliatore a tasche.
FR2776990B1 (fr)	2000-05-19	Sac avec auto-fermeture
DK199900347U3 (da)	1999-11-12	En brændeovn
SE0000392L (sv)	2000-08-09	Förbindningsstycke
IT1297187B1 (it)	1999-08-03	Oggetto personale, particolarmente a pendaglio
DE29715961U1 (de)	1997-11-27	Möbel mit gerundetem Korpus
IT244906Y1 (it)	2002-03-14	Termocamino a doppio accumulatore.
IT1309158B1 (it)	2002-01-16	Aspirazione a valvole sfasate
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CA106000S (en)	2007-03-06	Single x-buck door
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ES1044650Y (es)	2000-09-16	Aplique luminoso transformable en percha.
FI4484U1 (fi)	2000-07-20	Laitteisto puutavaralokeron yhteydessä
IT1310303B1 (it)	2002-02-11	Valvola a lamelle e collettore in gomma costruiti separatamente edassemblati in pezzo unico.
SE9803818D0 (sv)	1998-11-09	Kort-fodral med hål på sidan