EE03594B1 - Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine - Google Patents

Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine

Info

Publication number: EE03594B1
Authority: EE; Estonia
Prior art keywords: preparation; pharmaceutical composition; composition suitable; depot administration; depot
Prior art date: 1996-05-20

Application number

EE9800136A

Other languages

English (en)

Estonian (et)

Other versions

EE9800136A (et

Inventor

Karel Jozef Fran�ois Marc

Carolus Augusta Embrechts Roger

Karel Borghijs Herman

Monbaliu Johan

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-20

Filing date

1997-05-12

Publication date

2002-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8224016&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03594(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-12 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1998-10-15 Publication of EE9800136A publication Critical patent/EE9800136A/xx

2002-02-15 Publication of EE03594B1 publication Critical patent/EE03594B1/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

EE9800136A 1996-05-20 1997-05-12 Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine EE03594B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96201429		1996-05-20
PCT/EP1997/002504 WO1997044039A1 (en)	1996-05-20	1997-05-12	Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters

Publications (2)

Publication Number	Publication Date
EE9800136A EE9800136A (et)	1998-10-15
EE03594B1 true EE03594B1 (et)	2002-02-15

Family

ID=8224016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800136A EE03594B1 (et)	1996-05-20	1997-05-12	Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine

Country Status (38)

Country	Link
US (1)	US6077843A (da)
EP (1)	EP0904081B1 (da)
JP (1)	JP3274687B2 (da)
KR (1)	KR100358373B1 (da)
CN (1)	CN1093762C (da)
AR (1)	AR007194A1 (da)
AT (1)	ATE208619T1 (da)
AU (1)	AU715572B2 (da)
BG (1)	BG62684B1 (da)
BR (1)	BR9706824B8 (da)
CA (1)	CA2236691C (da)
CY (2)	CY2270B1 (da)
CZ (1)	CZ291284B6 (da)
DE (2)	DE122011100027I1 (da)
DK (1)	DK0904081T3 (da)
EA (1)	EA000536B1 (da)
EE (1)	EE03594B1 (da)
ES (1)	ES2167745T3 (da)
FR (1)	FR11C0035I2 (da)
HK (1)	HK1017852A1 (da)
HR (1)	HRP970276B1 (da)
HU (2)	HU224025B1 (da)
ID (1)	ID16927A (da)
IL (1)	IL124551A (da)
LU (1)	LU91842I2 (da)
MX (1)	MX9804816A (da)
MY (1)	MY126302A (da)
NO (2)	NO315931B1 (da)
NZ (1)	NZ330369A (da)
PL (1)	PL188309B1 (da)
PT (1)	PT904081E (da)
SI (1)	SI0904081T1 (da)
SK (1)	SK284013B6 (da)
TR (1)	TR199800923T2 (da)
TW (1)	TW487572B (da)
UA (1)	UA61898C2 (da)
WO (1)	WO1997044039A1 (da)
ZA (1)	ZA974331B (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA72189C2 (uk) *	1997-11-17	2005-02-15	Янссен Фармацевтика Н.В.	Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
AU753278B2 (en) *	1998-02-25	2002-10-10	Abbott Laboratories	Butorphanol sustained release formulations
AU5489299A (en) *	1998-08-18	2000-03-14	Sepracor, Inc.	Use of hydroxyrisperidone for the manufacture of a medicament for the treatment and prevention of psychoses, emesis and symptoms of withdrawal from alcohol and nicotine
ATE313319T1 (de)	1999-03-31	2006-01-15	Janssen Pharmaceutica Nv	Vorgelatinierte stärke in einer formulierung mit gesteuerter freigabe
US6495164B1 (en) *	2000-05-25	2002-12-17	Alkermes Controlled Therapeutics, Inc. I	Preparation of injectable suspensions having improved injectability
SK2982003A3 (en) *	2000-08-14	2004-10-05	Teva Pharma	Preparation of risperidone
US7666445B2 (en) *	2000-10-20	2010-02-23	The Trustees Of The University Of Pennsylvania	Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
GB0216416D0 (en) *	2002-07-15	2002-08-21	Novartis Ag	Organic compounds
US20050232995A1 (en)	2002-07-29	2005-10-20	Yam Nyomi V	Methods and dosage forms for controlled delivery of paliperidone and risperidone
ATE373472T1 (de) *	2002-07-29	2007-10-15	Alza Corp	Verfahren und dosierformen für die kontrollierte abgabe von paliperidon
GB0322994D0 (en) *	2003-10-01	2003-11-05	Novartis Ag	Organic compounds
ES2315721T5 (es)	2003-10-23	2012-08-24	Otsuka Pharmaceutical Co., Ltd.	Formulación de aripiprazol inyectable estéril de liberación controlada y procedimiento
US8221778B2 (en) *	2005-01-12	2012-07-17	The Trustees Of The University Of Pennsylvania	Drug-containing implants and methods of use thereof
US8329203B2 (en) *	2004-01-12	2012-12-11	The Trustees Of The University Of Pennsylvania	Drug-containing implants and methods of use thereof
EP1711124A4 (en) *	2004-01-12	2011-06-01	Univ Pennsylvania	LONG-TERM RELEASE PREPARATIONS AND METHODS OF USE THEREOF
ES2245252B1 (es) *	2004-06-15	2007-03-01	Farmalider, S.A.	Solucion acuosa de risperidona para administracion oral.
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
WO2006114384A1 (en)	2005-04-25	2006-11-02	Janssen Pharmaceutica N.V.	Preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyridio[1,2-a]pyrimidin-4-one palmitate ester
PL116330U1 (en)	2005-10-31	2007-04-02	Alza Corp	Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
AU2007284759B2 (en)	2006-08-09	2010-10-28	Intarcia Therapeutics, Inc.	Osmotic delivery systems and piston assemblies
DK2154138T3 (da) *	2007-04-19	2015-11-02	Youxin Li	Nye forbindelser til behandling af psykotiske lidelser, fremstillingsmetoder og anvendelser deraf
CN105688191A (zh)	2007-04-23	2016-06-22	精达制药公司	促胰岛素释放肽的混悬制剂及其应用
US20090076035A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched paliperidone
CN105560176A (zh) *	2007-12-19	2016-05-11	詹森药业有限公司	与长效注射用帕潘立酮酯相关的给药方案
US20090209757A1 (en) *	2008-01-10	2009-08-20	Santiago Ini	Processes for the preparation and purification of paliperidone palmitate
DK2240155T3 (da)	2008-02-13	2012-09-17	Intarcia Therapeutics Inc	Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
ES2809178T5 (es)	2008-09-04	2024-04-29	Amylin Pharmaceuticals Llc	Formulaciones de liberación sostenida que usan portadores no acuosos
MX352878B (es)	2009-09-28	2017-12-13	Intarcia Therapeutics Inc	Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
NZ599558A (en)	2009-10-30	2014-09-26	Janssen Pharmaceutica Nv	Dosing regimen associated with long-acting injectable paliperidone esters
US20120259116A1 (en) *	2009-12-17	2012-10-11	Rajiv Kumar	Novel Process for the Preparation of Paliperidone
TWI577377B (zh)	2010-09-16	2017-04-11	Ｖｉｉｖ醫療保健公司	醫藥組合物
CN103249416B (zh)	2010-10-18	2019-06-04	大日本住友制药株式会社	注射用缓释制剂
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012164582A1 (en)	2011-05-31	2012-12-06	Ramamohan Rao Davuluri	Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[ 1, 2-a]-pyrimidin-4-one (paliperidone) and paliperidone palmitate.
WO2013046225A2 (en) *	2011-08-10	2013-04-04	Glenmark Generics Limited	Process for the preparation of paliperidone palmitate
CN102993200B (zh) *	2011-09-10	2016-02-03	鲁翠涛	帕潘立酮氨基酸酯及其制备方法
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
US10525057B2 (en)	2013-09-24	2020-01-07	Otsuka Pharmaceutical Co., Ltd.	Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
LT3744326T (lt)	2015-04-07	2023-12-27	Janssen Pharmaceutica Nv	Dozavimo schema praleistoms ilgai veikiančių injekcinių paliperidono esterių dozėms
CN113598842A (zh)	2015-06-03	2021-11-05	因塔西亚制药公司	植入物放置和移除***
MX2018014016A (es)	2016-05-16	2019-08-01	Intarcia Therapeutics Inc	Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos.
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
EP3565580B1 (en)	2017-01-03	2024-03-06	i2o Therapeutics, Inc.	Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
FI4025187T3 (fi)	2020-11-30	2024-02-13	Janssen Pharmaceutica Nv	Pitkävaikutteisiin injektoitaviin paliperidoniformulaatioihin liittyviä annosteluohjelmia
WO2022111859A1 (en)	2020-11-30	2022-06-02	Janssen Pharmaceutica Nv	Dosing regimens associated with extended release paliperidone injectable formulations
KR20230116836A (ko)	2020-11-30	2023-08-04	얀센 파마슈티카 엔.브이.	서방형 팔리페리돈 주사용 제형과 관련된 투약 요법
JP2023551007A (ja)	2020-11-30	2023-12-06	ヤンセンファーマシューティカエヌ．ベー．	パルミチン酸パリペリドン製剤の再懸濁を確実にする方法
HUP2100259A1 (hu)	2021-07-07	2023-01-28	Richter Gedeon Nyrt	Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
WO2023021008A1 (en)	2021-08-20	2023-02-23	Janssen Pharmaceutica Nv	Dosing regimens associated with extended release paliperidone injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5254556A (en) *	1988-11-07	1993-10-19	Janssen Pharmaceutica N.V.	3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) *	1988-11-07	1992-10-27	Janssen Pharmaceutica N.V.	3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
CA2000786C (en) *	1988-11-07	1999-01-26	Cornelus G. M. Janssen	3-piperidinyl-1,2-benzisoxazoles
TW376319B (en) *	1993-04-28	1999-12-11	Janssen Pharmaceutica Nv	Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
US5650173A (en) *	1993-11-19	1997-07-22	Alkermes Controlled Therapeutics Inc. Ii	Preparation of biodegradable microparticles containing a biologically active agent
EP2275089A1 (en) *	1993-11-19	2011-01-19	Alkermes Controlled Therapeutics, Inc.	Preparation of biodegradable microparticles containing a biologically active agent
KR100354270B1 (ko) *	1993-11-19	2003-02-11	알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii	마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
MX9709451A (es) *	1995-06-06	1998-02-28	Hoechst Marion Roussel Inc	Derivados de benzisoxazol e indazol como agentes antipsicoticos.
US5792477A (en) *	1996-05-07	1998-08-11	Alkermes Controlled Therapeutics, Inc. Ii	Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

1997
- 1997-05-01 TW TW086105768A patent/TW487572B/zh not_active IP Right Cessation
- 1997-05-12 EE EE9800136A patent/EE03594B1/xx active Protection Beyond IP Right Term
- 1997-05-12 SI SI9730272T patent/SI0904081T1/xx unknown
- 1997-05-12 SK SK620-98A patent/SK284013B6/sk not_active IP Right Cessation
- 1997-05-12 NZ NZ330369A patent/NZ330369A/xx not_active IP Right Cessation
- 1997-05-12 EP EP97923912A patent/EP0904081B1/en not_active Expired - Lifetime
- 1997-05-12 JP JP54150097A patent/JP3274687B2/ja not_active Expired - Lifetime
- 1997-05-12 AU AU29559/97A patent/AU715572B2/en not_active Expired
- 1997-05-12 PT PT97923912T patent/PT904081E/pt unknown
- 1997-05-12 HU HU9901319A patent/HU224025B1/hu active Protection Beyond IP Right Term
- 1997-05-12 IL IL12455197A patent/IL124551A/xx not_active IP Right Cessation
- 1997-05-12 AT AT97923912T patent/ATE208619T1/de active
- 1997-05-12 WO PCT/EP1997/002504 patent/WO1997044039A1/en active IP Right Grant
- 1997-05-12 BR BRPI9706824-1B8A patent/BR9706824B8/pt not_active IP Right Cessation
- 1997-05-12 KR KR10-1998-0703629A patent/KR100358373B1/ko active IP Right Review Request
- 1997-05-12 CZ CZ19981401A patent/CZ291284B6/cs not_active IP Right Cessation
- 1997-05-12 DE DE201112100027 patent/DE122011100027I1/de active Pending
- 1997-05-12 TR TR1998/00923T patent/TR199800923T2/xx unknown
- 1997-05-12 DK DK97923912T patent/DK0904081T3/da active
- 1997-05-12 CA CA002236691A patent/CA2236691C/en not_active Expired - Lifetime
- 1997-05-12 DE DE69708284T patent/DE69708284T2/de not_active Expired - Lifetime
- 1997-05-12 ES ES97923912T patent/ES2167745T3/es not_active Expired - Lifetime
- 1997-05-12 EA EA199800531A patent/EA000536B1/ru not_active IP Right Cessation
- 1997-05-12 CN CN97191494A patent/CN1093762C/zh not_active Expired - Lifetime
- 1997-05-12 US US09/180,659 patent/US6077843A/en not_active Expired - Lifetime
- 1997-05-12 PL PL97327995A patent/PL188309B1/pl unknown
- 1997-05-19 ZA ZA974331A patent/ZA974331B/xx unknown
- 1997-05-19 MY MYPI97002172A patent/MY126302A/en unknown
- 1997-05-19 ID IDP971649A patent/ID16927A/id unknown
- 1997-05-19 AR ARP970102112A patent/AR007194A1/es active IP Right Grant
- 1997-05-20 HR HR970276A patent/HRP970276B1/xx not_active IP Right Cessation
- 1997-12-05 UA UA98052747A patent/UA61898C2/uk unknown
1998
- 1998-04-30 NO NO19981984A patent/NO315931B1/no not_active IP Right Cessation
- 1998-05-12 BG BG102443A patent/BG62684B1/bg unknown
- 1998-06-15 MX MX9804816A patent/MX9804816A/es unknown
1999
- 1999-07-10 HK HK99102949A patent/HK1017852A1/xx not_active IP Right Cessation
2002
- 2002-04-25 CY CY0200021A patent/CY2270B1/xx unknown
2011
- 2011-07-20 LU LU91842C patent/LU91842I2/fr unknown
- 2011-08-18 CY CY2011011C patent/CY2011011I2/el unknown
- 2011-08-18 HU HUS1100013C patent/HUS1100013I1/hu unknown
- 2011-08-29 NO NO2011015C patent/NO2011015I2/no unknown
- 2011-09-02 FR FR11C0035C patent/FR11C0035I2/fr active Active

Also Published As

Publication number	Publication date
BR9706824A (pt)	1999-03-23
SK284013B6 (sk)	2004-08-03
AU715572B2 (en)	2000-02-03
CZ140198A3 (cs)	1999-04-14
NO2011015I2 (no)	2013-03-11
DK0904081T3 (da)	2002-02-25
HUS1100013I1 (hu)	2017-03-28
BR9706824B8 (pt)	2015-02-18
WO1997044039A1 (en)	1997-11-27
PT904081E (pt)	2002-04-29
MY126302A (en)	2006-09-29
NZ330369A (en)	2000-04-28
JP2000513718A (ja)	2000-10-17
HU224025B1 (hu)	2005-05-30
AR007194A1 (es)	1999-10-13
CY2270B1 (en)	2003-07-04
ID16927A (id)	1997-11-20
CZ291284B6 (cs)	2003-01-15
JP3274687B2 (ja)	2002-04-15
NO981984D0 (no)	1998-04-30
US6077843A (en)	2000-06-20
MX9804816A (es)	1998-10-31
CN1206347A (zh)	1999-01-27
KR19990067603A (ko)	1999-08-25
LU91842I2 (fr)	2011-09-20
EA000536B1 (ru)	1999-10-28
KR100358373B1 (ko)	2003-02-11
CY2011011I1 (el)	2016-12-14
TW487572B (en)	2002-05-21
UA61898C2 (en)	2003-12-15
FR11C0035I1 (da)	2011-07-10
HK1017852A1 (en)	1999-12-03
IL124551A (en)	2001-08-26
DE69708284D1 (de)	2001-12-20
NO981984L (no)	1998-11-19
EP0904081B1 (en)	2001-11-14
TR199800923T2 (xx)	1999-09-21
ATE208619T1 (de)	2001-11-15
CN1093762C (zh)	2002-11-06
EA199800531A1 (ru)	1998-12-24
IL124551A0 (en)	1998-12-06
HUP9901319A3 (en)	1999-11-29
SI0904081T1 (en)	2002-04-30
EP0904081A1 (en)	1999-03-31
HUP9901319A2 (hu)	1999-08-30
DE122011100027I1 (de)	2011-11-17
NO315931B1 (no)	2003-11-17
EE9800136A (et)	1998-10-15
CA2236691A1 (en)	1997-11-27
PL188309B1 (pl)	2005-01-31
SK62098A3 (en)	2000-04-10
ZA974331B (en)	1998-11-19
CY2011011I2 (el)	2016-12-14
NO2011015I1 (no)	2011-09-19
AU2955997A (en)	1997-12-09
CA2236691C (en)	2007-01-02
PL327995A1 (en)	1999-01-04
BG102443A (en)	1999-06-30
FR11C0035I2 (fr)	2013-08-16
BG62684B1 (bg)	2000-05-31
HRP970276B1 (en)	2002-04-30
DE69708284T2 (de)	2002-07-25
ES2167745T3 (es)	2002-05-16
HRP970276A2 (en)	1998-04-30

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-10-17	AA1Y	Spc filed	Free format text: PRODUCT NAME: XEPLION - PALIPERIDOON; REG NO/DATE: C(2011)1604 04.03.2011 Spc suppl protection certif: C20110009 Filing date: 20110725
2011-10-17	FG1Y	Spc granted	Free format text: PRODUCT NAME: XEPLION - PALIPERIDOON; REG NO/DATE: C(2011)1604 04.03.2011 Spc suppl protection certif: C20110009 00042 Filing date: 20110725 Extension date: 20220512

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