SK284013B6 - Farmaceutická kompozícia, spôsob jej prípravy a použitie - Google Patents

Farmaceutická kompozícia, spôsob jej prípravy a použitie Download PDF

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Publication number
SK284013B6
SK284013B6 SK620-98A SK62098A SK284013B6 SK 284013 B6 SK284013 B6 SK 284013B6 SK 62098 A SK62098 A SK 62098A SK 284013 B6 SK284013 B6 SK 284013B6
Authority
SK
Slovakia
Prior art keywords
composition
agent
mixture
hydroxyrisperidone
water
Prior art date
Application number
SK620-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK62098A3 (en
Inventor
Marc Karel Jozef Fran�Ois
Roger Carolus Augusta Embrechts
Herman Karel Borghijs
Johan Monbaliu
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8224016&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK284013(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK62098A3 publication Critical patent/SK62098A3/sk
Publication of SK284013B6 publication Critical patent/SK284013B6/sk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SK620-98A 1996-05-20 1997-05-12 Farmaceutická kompozícia, spôsob jej prípravy a použitie SK284013B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201429 1996-05-20
PCT/EP1997/002504 WO1997044039A1 (en) 1996-05-20 1997-05-12 Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters

Publications (2)

Publication Number Publication Date
SK62098A3 SK62098A3 (en) 2000-04-10
SK284013B6 true SK284013B6 (sk) 2004-08-03

Family

ID=8224016

Family Applications (1)

Application Number Title Priority Date Filing Date
SK620-98A SK284013B6 (sk) 1996-05-20 1997-05-12 Farmaceutická kompozícia, spôsob jej prípravy a použitie

Country Status (38)

Country Link
US (1) US6077843A (da)
EP (1) EP0904081B1 (da)
JP (1) JP3274687B2 (da)
KR (1) KR100358373B1 (da)
CN (1) CN1093762C (da)
AR (1) AR007194A1 (da)
AT (1) ATE208619T1 (da)
AU (1) AU715572B2 (da)
BG (1) BG62684B1 (da)
BR (1) BR9706824B8 (da)
CA (1) CA2236691C (da)
CY (2) CY2270B1 (da)
CZ (1) CZ291284B6 (da)
DE (2) DE69708284T2 (da)
DK (1) DK0904081T3 (da)
EA (1) EA000536B1 (da)
EE (1) EE03594B1 (da)
ES (1) ES2167745T3 (da)
FR (1) FR11C0035I2 (da)
HK (1) HK1017852A1 (da)
HR (1) HRP970276B1 (da)
HU (2) HU224025B1 (da)
ID (1) ID16927A (da)
IL (1) IL124551A (da)
LU (1) LU91842I2 (da)
MX (1) MX9804816A (da)
MY (1) MY126302A (da)
NO (2) NO315931B1 (da)
NZ (1) NZ330369A (da)
PL (1) PL188309B1 (da)
PT (1) PT904081E (da)
SI (1) SI0904081T1 (da)
SK (1) SK284013B6 (da)
TR (1) TR199800923T2 (da)
TW (1) TW487572B (da)
UA (1) UA61898C2 (da)
WO (1) WO1997044039A1 (da)
ZA (1) ZA974331B (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
ATE265846T1 (de) * 1998-02-25 2004-05-15 Abbott Lab Butorphanol enthaltende formulierungen mit verzögerter freisetzung
AU5489299A (en) * 1998-08-18 2000-03-14 Sepracor, Inc. Use of hydroxyrisperidone for the manufacture of a medicament for the treatment and prevention of psychoses, emesis and symptoms of withdrawal from alcohol and nicotine
KR100660594B1 (ko) 1999-03-31 2006-12-22 얀센 파마슈티카 엔.브이. 방출 조절형 제제중의 프리젤라틴화 전분
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
ES2310410T3 (es) * 2000-08-14 2009-01-01 Teva Pharmaceutical Industries Ltd. Preparacion de risperidona.
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
MXPA05001191A (es) * 2002-07-29 2005-09-12 Johnson & Johnson Metodos y formas de dosificacion para la administracion controlada de paliperidona.
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
ZA200602347B (en) 2003-10-23 2007-09-26 Otsuka Pharma Co Ltd Controlled release sterile injectable aripiprazole formulation and method
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
ES2245252B1 (es) * 2004-06-15 2007-03-01 Farmalider, S.A. Solucion acuosa de risperidona para administracion oral.
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006114384A1 (en) 2005-04-25 2006-11-02 Janssen Pharmaceutica N.V. Preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyridio[1,2-a]pyrimidin-4-one palmitate ester
PL116330U1 (en) 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
MX2009001114A (es) 2006-08-09 2009-02-10 Intarcia Therapeutics Inc Sistemas de suministro osmotico y ensambles de piston.
RU2459824C2 (ru) * 2007-04-19 2012-08-27 Юсинь ЛИ Новые соединения для лечения психических расстройств, их получение и применение
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US20090076035A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched paliperidone
EP2234617B1 (en) * 2007-12-19 2021-03-31 Janssen Pharmaceutica NV Dosing regimen associated with long acting injectable paliperidone esters
WO2009089076A2 (en) * 2008-01-10 2009-07-16 Teva Pharmaceutical Industries Ltd. Processes for the preparation and purification of paliperidone palmitate
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
AU2009289529B2 (en) 2008-09-04 2015-05-28 Amylin Pharmaceuticals, Llc Sustained release formulations using non-aqueous carriers
SI2462246T1 (en) 2009-09-28 2018-01-31 Intarcia Therapeutics, Inc. Fast-setting and / or cessation of substantially unchanged delivery of the product
WO2011053829A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutical Nv Dosing regimen associated with long-acting injectable paliperidone esters
WO2011074017A1 (en) * 2009-12-17 2011-06-23 Alkem Laboratories Ltd. A novel process for the preparation of paliperidone
TWI577377B (zh) 2010-09-16 2017-04-11 Viiv醫療保健公司 醫藥組合物
WO2012053654A1 (en) 2010-10-18 2012-04-26 Dainippon Sumitomo Pharma Co., Ltd. Sustained-release formulation for injection
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US8940749B2 (en) * 2011-05-31 2015-01-27 Ramamohan Rao Davuluri Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydor-9-hydroxy-2-methyl-4H-pyrido[ 1, 2-A]-pyrimidin-4-one(paliperidone) and paliperidone palmitate
WO2013046225A2 (en) * 2011-08-10 2013-04-04 Glenmark Generics Limited Process for the preparation of paliperidone palmitate
CN102993200B (zh) * 2011-09-10 2016-02-03 鲁翠涛 帕潘立酮氨基酸酯及其制备方法
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP4349323A2 (en) 2015-04-07 2024-04-10 JANSSEN Pharmaceutica NV Dosing regimen for missed doses for long-acting injectable paliperidone esters
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
EP3733694A1 (en) 2016-05-16 2020-11-04 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
JP2023551007A (ja) 2020-11-30 2023-12-06 ヤンセン ファーマシューティカ エヌ.ベー. パルミチン酸パリペリドン製剤の再懸濁を確実にする方法
IL303252A (en) 2020-11-30 2023-07-01 Janssen Pharmaceutica Nv Dosing regimens associated with delayed-release injectable formulations of paliperidone
SI4025188T1 (sl) 2020-11-30 2024-03-29 Janssen Pharmaceutica Nv Režimi odmerjanja, povezani s formulacijami paliperidona za injiciranje s podaljšanim sproščanjem
AU2021387679B2 (en) 2020-11-30 2024-01-18 Janssen Pharmaceutica Nv Dosing regimens associated with extended release paliperidone injectable formulations
HUP2100259A1 (hu) 2021-07-07 2023-01-28 Richter Gedeon Nyrt Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
CA3229731A1 (en) 2021-08-20 2023-02-23 Janssen Pharmaceutica Nv Dosing regimens associated with extended release paliperidone injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
US5254556A (en) * 1988-11-07 1993-10-19 Janssen Pharmaceutica N.V. 3-piperidinyl-1,2-benzisoxazoles
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
CZ293764B6 (cs) * 1993-11-19 2004-07-14 Janssen Pharmaceutica N. V. Farmaceutický prostředek s dostatečným a dlouhodobým uvolňováním léčiva, biodegradovatelné a biokompatibilní mikročástice, způsob jejich výroby a použití
DE69429820T3 (de) * 1993-11-19 2013-02-28 Alkermes Controlled Therapeutics, Inc. Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
KR100304179B1 (ko) * 1995-06-06 2001-11-22 게리 디. 스트리트, 스티븐 엘. 네스비트 항정신병제로서의벤즈이속사졸및인다졸유도체,이의제조방법및이를함유하는약제학적조성물
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
CN1093762C (zh) 2002-11-06
ATE208619T1 (de) 2001-11-15
BG102443A (en) 1999-06-30
HRP970276A2 (en) 1998-04-30
ES2167745T3 (es) 2002-05-16
FR11C0035I2 (fr) 2013-08-16
MY126302A (en) 2006-09-29
NO315931B1 (no) 2003-11-17
IL124551A (en) 2001-08-26
JP3274687B2 (ja) 2002-04-15
NO981984L (no) 1998-11-19
EA199800531A1 (ru) 1998-12-24
DK0904081T3 (da) 2002-02-25
HUP9901319A3 (en) 1999-11-29
ID16927A (id) 1997-11-20
US6077843A (en) 2000-06-20
DE69708284T2 (de) 2002-07-25
TR199800923T2 (xx) 1999-09-21
EP0904081A1 (en) 1999-03-31
WO1997044039A1 (en) 1997-11-27
NO2011015I2 (no) 2013-03-11
HUP9901319A2 (hu) 1999-08-30
FR11C0035I1 (da) 2011-07-10
HK1017852A1 (en) 1999-12-03
AU715572B2 (en) 2000-02-03
KR100358373B1 (ko) 2003-02-11
HU224025B1 (hu) 2005-05-30
PT904081E (pt) 2002-04-29
CY2011011I2 (el) 2016-12-14
HUS1100013I1 (hu) 2017-03-28
EP0904081B1 (en) 2001-11-14
EE9800136A (et) 1998-10-15
EA000536B1 (ru) 1999-10-28
DE122011100027I1 (de) 2011-11-17
HRP970276B1 (en) 2002-04-30
LU91842I2 (fr) 2011-09-20
ZA974331B (en) 1998-11-19
AR007194A1 (es) 1999-10-13
CY2011011I1 (el) 2016-12-14
BR9706824A (pt) 1999-03-23
CA2236691C (en) 2007-01-02
EE03594B1 (et) 2002-02-15
NO981984D0 (no) 1998-04-30
NO2011015I1 (no) 2011-09-19
AU2955997A (en) 1997-12-09
PL188309B1 (pl) 2005-01-31
CZ140198A3 (cs) 1999-04-14
CY2270B1 (en) 2003-07-04
NZ330369A (en) 2000-04-28
MX9804816A (es) 1998-10-31
DE69708284D1 (de) 2001-12-20
CN1206347A (zh) 1999-01-27
CA2236691A1 (en) 1997-11-27
CZ291284B6 (cs) 2003-01-15
BG62684B1 (bg) 2000-05-31
KR19990067603A (ko) 1999-08-25
UA61898C2 (en) 2003-12-15
PL327995A1 (en) 1999-01-04
SI0904081T1 (en) 2002-04-30
BR9706824B8 (pt) 2015-02-18
IL124551A0 (en) 1998-12-06
SK62098A3 (en) 2000-04-10
TW487572B (en) 2002-05-21
JP2000513718A (ja) 2000-10-17

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Legal Events

Date Code Title Description
SPCF Filing of an spc

Free format text: PRODUCT NAME: PALIPERIDON; REGISTRATION NO/DATE: EU/1/11/672/001 - EU/1/11/672/006 20110304

Spc suppl protection certif: 5007-2011

Filing date: 20110804

SPCG Grant of an spc

Free format text: PRODUCT NAME: PALIPERIDON; REGISTRATION NO/DATE: EU/1/11/672/001 - EU/1/11/672/006 20110304

Spc suppl protection certif: 186 5007-2011

Filing date: 20110804

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