ECSP19043710A - Composiciones de aminoácidos y métodos de tratamiento de enfermedades hepáticas - Google Patents

Composiciones de aminoácidos y métodos de tratamiento de enfermedades hepáticas

Info

Publication number
ECSP19043710A
ECSP19043710A ECSENADI201943710A ECDI201943710A ECSP19043710A EC SP19043710 A ECSP19043710 A EC SP19043710A EC SENADI201943710 A ECSENADI201943710 A EC SENADI201943710A EC DI201943710 A ECDI201943710 A EC DI201943710A EC SP19043710 A ECSP19043710 A EC SP19043710A
Authority
EC
Ecuador
Prior art keywords
methods
amino acid
liver diseases
treatment
acid compositions
Prior art date
Application number
ECSENADI201943710A
Other languages
English (en)
Inventor
Chung-Wei Lee
Michael Hamill
Raffi Afeyan
Harry Luithardt
David Berry
Original Assignee
Axcella Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcella Health Inc filed Critical Axcella Health Inc
Publication of ECSP19043710A publication Critical patent/ECSP19043710A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30Dietetic or nutritional methods, e.g. for losing weight
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/02Acid
    • A23V2250/06Amino acid
    • A23V2250/0634N-Acetyl-Cysteine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente descripción proporciona composiciones farmacéuticas que comprenden entidades de aminoácidos y sus usos. También se revelan métodos para mejorar la función hepática y para tratar enfermedades hepáticas que comprenden la administración de una cantidad eficaz de las composiciones a un sujeto que lo necesita.
ECSENADI201943710A 2016-12-19 2019-06-19 Composiciones de aminoácidos y métodos de tratamiento de enfermedades hepáticas ECSP19043710A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662436073P 2016-12-19 2016-12-19
US201762443205P 2017-01-06 2017-01-06
US201762491773P 2017-04-28 2017-04-28
US201762545322P 2017-08-14 2017-08-14
US201762576267P 2017-10-24 2017-10-24

Publications (1)

Publication Number Publication Date
ECSP19043710A true ECSP19043710A (es) 2019-07-31

Family

ID=60957469

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201943710A ECSP19043710A (es) 2016-12-19 2019-06-19 Composiciones de aminoácidos y métodos de tratamiento de enfermedades hepáticas

Country Status (22)

Country Link
US (7) US11129804B2 (es)
EP (1) EP3554492A1 (es)
JP (2) JP2020504108A (es)
KR (1) KR20190099242A (es)
CN (2) CN115814053A (es)
AU (1) AU2017382170B2 (es)
BR (1) BR112019012529A2 (es)
CA (1) CA3046551A1 (es)
CL (1) CL2019001686A1 (es)
CO (1) CO2019006291A2 (es)
CU (1) CU20190058A7 (es)
EC (1) ECSP19043710A (es)
IL (3) IL296614A (es)
JO (1) JOP20190146A1 (es)
MA (1) MA51451A (es)
MX (2) MX2019007351A (es)
PE (1) PE20191136A1 (es)
PH (1) PH12019501414A1 (es)
SG (1) SG10201913946WA (es)
TW (1) TWI777999B (es)
WO (1) WO2018118941A1 (es)
ZA (1) ZA201903580B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
EP3615018A1 (en) 2017-04-28 2020-03-04 Axcella Health Inc. Amino acid compositions and their use for the treatment of traumatic brain injury
WO2019036442A1 (en) * 2017-08-14 2019-02-21 Axcella Health Inc. AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY
MA49906A (fr) 2017-08-14 2020-06-24 Axcella Health Inc Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie
EP3780973A4 (en) * 2018-04-18 2022-01-26 Ingenious Ingredients, LP COMPOSITIONS AND METHODS OF USE THEREOF FOR PROMOTING MUSCLE GROWTH AND FUNCTION
CU20200106A7 (es) 2018-06-20 2021-08-06 Axcella Health Inc Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
JP2021527670A (ja) 2018-06-20 2021-10-14 アクセラ・ヘルス・インコーポレイテッドAxcella Health Inc. 筋肉中の脂肪浸潤の治療のための組成物及び方法
EP3810168A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Methods of manufacturing amino acid compositions
EP3914273A4 (en) 2019-01-22 2022-08-03 The Regents of the University of California BIL ACIDS AND USE IN DISEASE TREATMENT
CN110037221A (zh) * 2019-05-28 2019-07-23 广州阿米乐生物技术有限公司 一种解酒固体饮料及其制备方法
BR112022001637A2 (pt) * 2019-07-30 2022-03-22 Kobiolabs Inc Kit para predizer ou diagnosticar doença hepática gordurosa não alcoólica e método para diagnosticar doença hepática gordurosa não alcoólica
EP4005578A4 (en) * 2019-07-30 2024-05-01 Kobiolabs, Inc. COMPOSITION AND METHODS FOR PREVENTING, RELIEVING OR TREATING LIVER INJURY
WO2021133948A1 (en) * 2019-12-23 2021-07-01 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders
KR20220130734A (ko) * 2020-03-16 2022-09-27 우한 바스트 컨덕트 사이언스 파운데이션 컴퍼니 리미티드 간경변증의 치료를 위한 구리 클러스터(CuCs) 및 조성물
AU2020436811B2 (en) * 2020-03-16 2024-07-04 Wuhan Vast Conduct Science Foundation Co., Ltd. Gold clusters (AuCs), composition and method for treatment of liver cirrhosis
US11938152B2 (en) 2020-08-06 2024-03-26 Kedar N Prasad High-dose antioxidants in cancer treatment
CN112394178B (zh) * 2020-11-16 2022-08-05 首都医科大学附属北京朝阳医院 莫西沙星相关肝损伤的生物标志物、试剂盒及应用
WO2022266480A1 (en) 2021-06-17 2022-12-22 Axcella Health Inc. Methods of predicting liver fat content and uses thereof
WO2023009444A1 (en) * 2021-07-26 2023-02-02 Axcella Health Inc. Amino acid compositions and methods for use in the treatment of post-acute sequelae of covid-19
WO2023208944A1 (en) * 2022-04-25 2023-11-02 Fundació Eurecat Pharmaceutical and nutraceutical compositions with a combination of amino acids and its use in diseases characterized by lipid accumulation in tissues
WO2024026307A1 (en) 2022-07-25 2024-02-01 Axcella Health Inc. Biomarker for long covid and fatigue
WO2024030909A1 (en) 2022-08-01 2024-02-08 Axcella Health Inc. Biomarkers of amino acid composition treatment response in long covid

Family Cites Families (333)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US693094A (en) 1900-08-13 1902-02-11 Hall Signal Co Signal and signaling-circuit.
US2457820A (en) 1945-12-27 1949-01-04 Merck & Co Inc Amino acid solution and process for preparing the same
US3012924A (en) 1956-12-17 1961-12-12 Libbey Owens Ford Glass Co Electrically conducting unit
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
US3832465A (en) 1971-12-09 1974-08-27 H Ghadimi Injectable amino acid composition commensurate to the anabolic need of the body and method of using same
US3988466A (en) 1973-06-01 1976-10-26 Kyowa Hakko Kogyo Co., Ltd. Prevention of gastric lesions
US3950529A (en) 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same
JPS5535049A (en) 1978-09-04 1980-03-11 Otsuka Pharmaceut Factory Inc Amino acid transfusion for cancerous patient
DE2906034C2 (de) 1979-02-16 1985-03-28 Maggi AG, Kempttal Verfahren zur Gewinnung von L-Leucin, L-Phenylalanin, L-Tyrosin, L-Cystin und von Gemischen aus L-Leucin und L-Isoleucin
CA1184499A (en) 1981-06-29 1985-03-26 David C. Madsen Nutritional composition for management of hepatic failure
US4898879A (en) 1981-06-29 1990-02-06 Baxter International Inc. Nurtitional composition for management of hepatic failure
JPS58126767A (ja) 1982-01-22 1983-07-28 Ajinomoto Co Inc 肝臓病患者用栄養組成物
US5298493A (en) 1983-04-20 1994-03-29 Clintec Nutrition Co. Compound for use in dietetics, reanimation and therapeutics containing protein fractions based on three types of minipeptides
CH658165A5 (fr) 1984-01-04 1986-10-31 Nestle Sa Produit alimentaire efficace dans le traitement de la lepre.
US5034377A (en) 1984-11-19 1991-07-23 Montefiore Hospital Association Of Western Pennsylvania Aqueous nutrient compositions comprising oligopeptides
JPS61186320A (ja) * 1985-02-12 1986-08-20 Morishita Seiyaku Kk アミノ酸製剤
US4871550A (en) 1986-09-05 1989-10-03 Millman Phillip L Nutrient composition for athletes and method of making and using the same
FR2618331B1 (fr) 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
US5028622A (en) 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
US5576351A (en) 1989-12-29 1996-11-19 Mcgaw, Inc. Use of arginine as an immunostimulator
CA2054358C (en) 1990-11-01 2004-12-28 Candis D. Kvamme High acid nutritional formulations
US5106836A (en) 1991-02-22 1992-04-21 Clintec Nutrition Co. Enteral diet
US5977073A (en) 1991-06-06 1999-11-02 Life Sciences' Technologies, Inc. Nutrient composition for treatment of immune disorders
US5780039A (en) 1992-04-23 1998-07-14 Novartis Nutrition Ag Orally-ingestible nutrition compositions having improved palatability
US5229136A (en) 1992-05-21 1993-07-20 Clintec Nutrition Co. Low caloric density enteral formulation designed to reduce diarrhea in tube-fed patients
US5276018A (en) 1992-07-17 1994-01-04 Brigham And Women's Hospital Composition comprising amino acids and methods for decreasing muscle breakdown
DE4229166A1 (de) 1992-09-01 1994-03-03 Deutsches Krebsforsch Mittel zur Aufrechterhaltung und/oder Steigerung der Muskelleistung und Körperzellmasse
US5356873A (en) 1992-11-05 1994-10-18 Clintec Nutrition Co. Method for providing nutritional requirements to patients having a chronic inflammation reaction
DE69331528T2 (de) 1992-12-23 2002-10-31 Abbott Laboratories, Abbott Park Medizinische nahrungsmittel für die ernährungsergänzung bei metabolischen erkrankungen von säuglingen/kleinkindern
US5348979A (en) * 1992-12-23 1994-09-20 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
US5571783A (en) 1993-03-09 1996-11-05 Clintec Nutrition Company Composition and method for treating patients with hepatic disease
US5891459A (en) 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
WO1995004529A1 (en) 1993-08-10 1995-02-16 Musashi Pty. Ltd. Composition for treatment of hangovers
US5438042B1 (en) 1993-10-08 1997-08-26 Sandoz Nutrition Ltd Enteral nutritional composition having amino acid profile
AU682894B2 (en) 1993-10-28 1997-10-23 Institut National De La Recherche Agronomique Composition based on amino acids intended for the treatment of sepsis or of an attack bringing about an inflammatory reaction, in animals and man
US5378722A (en) 1993-12-03 1995-01-03 Clintec Nutrition Co. Nutritional compositions for management of nitrogen metabolism
US5723446A (en) 1993-12-23 1998-03-03 Nestec Ltd. Enteral formulation designed for optimized nutrient absorption and wound healing
US5714472A (en) 1993-12-23 1998-02-03 Nestec Ltd. Enternal formulation designed for optimized nutrient absorption and wound healing
GB9403935D0 (en) 1994-03-01 1994-04-20 Sandoz Nutrition Ltd Improvements in or relating to organic compounds
US5719133A (en) 1994-09-21 1998-02-17 Novartis Nutrition Ag Adolescent dietary composition
IT1275434B (it) 1995-05-19 1997-08-07 Farmila Farma Milano Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante
US5728678A (en) 1995-06-06 1998-03-17 Nestec Ltd. Method and composition for providing nutrition to a renal failure patient
JP4280310B2 (ja) 1995-08-10 2009-06-17 佐々木化学工業株式会社 アミノ酸組成剤
US5733884A (en) 1995-11-07 1998-03-31 Nestec Ltd. Enteral formulation designed for optimized wound healing
US6087398A (en) 1996-03-01 2000-07-11 South Alabama Medical Science Foundation Sickle cell anemia treatment
US5716926A (en) 1996-07-26 1998-02-10 Paxton K. Beale Composition of pyruvate and protein and method for increasing protein concentration in a mammal
US6096785A (en) 1996-07-30 2000-08-01 Novartis Nutrition Ag Amino acid compositions and use thereof in treating renal dysfunction
JPH1053521A (ja) 1996-08-12 1998-02-24 Kagaku Gijutsu Shinko Jigyodan 脳内グルタミン酸の活性抑制剤および活性増強剤
US6544260B1 (en) 1996-08-20 2003-04-08 Oratec Interventions, Inc. Method for treating tissue in arthroscopic environment using precooling and apparatus for same
IT1289754B1 (it) 1996-12-16 1998-10-16 Professional Dietetics Srl Composizioni a base di aminoacidi
US6013273A (en) 1997-01-27 2000-01-11 Novartis Nutrition Ag Treatment of endotoxic shock
US5817329A (en) 1997-02-28 1998-10-06 Gardiner; Paul T. Nutritional supplement for increased muscle size and strength for body builders
US5849335A (en) 1997-06-02 1998-12-15 Nestec S.A. Composition and method for providing glutamine
EP1123013A1 (en) 1997-06-02 2001-08-16 Société des Produits Nestlé S.A. Product and method for providing glutamine
US6281244B1 (en) 1997-06-05 2001-08-28 Novartis Nutrition Ag Therapeutic use for glycine
CA2239582C (en) 1997-06-05 2008-04-22 Novartis Nutrition Ag A new therapeutic use for glycine
EP0891719A1 (en) 1997-07-14 1999-01-20 N.V. Nutricia Nutritional composition containing methionine
IT1294227B1 (it) 1997-08-01 1999-03-24 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione
TW473387B (en) 1997-09-30 2002-01-21 Chugai Pharmaceutical Co Ltd Pharmaceutical or food compositions for treating hepatic diseases or improving liver functions
US6288116B1 (en) 1998-05-13 2001-09-11 Novartis Nutrition Ag Method of administration of a nutritional product to a person having renal failure
US6203820B1 (en) 1998-05-28 2001-03-20 Brice E. Vickery Compositions and methods for enhancing protein anabolism and detoxification
US6103748A (en) 1998-06-19 2000-08-15 Bryan; Thomas B. Method of treating an autoimmune disorder
US6031000A (en) 1998-06-23 2000-02-29 Iowa State University Research Foundation, Inc. Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use
JP2000072669A (ja) 1998-08-24 2000-03-07 Inst Of Physical & Chemical Res アミノ酸・糖組成物
US6458338B1 (en) 1998-09-22 2002-10-01 Aeropharm Technology Incorporated Amino acid stabilized medicinal aerosol formulations
US20010041187A1 (en) 1998-10-20 2001-11-15 Carl W Hastings Performance-enhancing dietary supplement
EP1004302A3 (en) 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
US6051236A (en) 1998-11-12 2000-04-18 Pacifichealth Laboratories, Inc. Composition for optimizing muscle performance during exercise
US6143786A (en) 1999-02-02 2000-11-07 Novartis Nutrition Ag Oral arginine and insulin secretion
US6241996B1 (en) 1999-04-09 2001-06-05 Novartis Nutrition Ag Liquid soy nutritional products
US6346264B1 (en) 1999-04-27 2002-02-12 International Health Products And Services Ltd. Supplement for restoring growth hormone levels
AU8003800A (en) 1999-10-08 2001-04-23 Joyce Corinne Bechthold Methods and compositions for treating neurobehavioral disorders
GB9929497D0 (en) 1999-12-14 2000-02-09 Vitaflo Limited Improved amino acid mixtures for the treatment and/or management of certain diseases
CA2399500A1 (en) * 2000-02-01 2001-08-09 Muscletech Research And Development Inc. Alpha lipoic acid based food supplement for increasing lean muscle mass and strength
US6833350B2 (en) 2000-02-04 2004-12-21 Nestec S.A. Method for maintaining or improving the synthesis of mucins
US6521591B1 (en) 2000-02-10 2003-02-18 N.V. Nutricia Pharmaceutical composition for muscular anabolism
GB0009056D0 (en) 2000-04-12 2000-05-31 Nestle Sa Composition comprising free amino acids
EP1276392A2 (en) 2000-04-18 2003-01-22 Société des Produits Nestlé S.A. Nutritional modules
US6391332B1 (en) 2000-04-20 2002-05-21 Baxter International, Inc. Therapeutic micronutrient composition for severe trauma, burns and critical illness
US20030187049A1 (en) 2000-07-04 2003-10-02 Dioguardi Francesco Saverio Compositions based on aminoacids, suitable for improving muscle performance
IT1320783B1 (it) 2000-07-04 2003-12-10 Professional Dietetics Srl Composizioni a base di aminoacidi, atte al miglioramento delleprestazioni muscolari.
IT1320782B1 (it) 2000-07-04 2003-12-10 Professional Dietetics Srl Composizioni a base di aminoacidi, atte al trattamentodell'insufficienza cardiaca.
US6417293B1 (en) 2000-12-04 2002-07-09 Dow Corning Corporation Thermoplastic silicone elastomers formed from polyester resins
DE10060819A1 (de) 2000-12-07 2002-06-13 Cognis Deutschland Gmbh Verwendung von Polyetheramin-Derivaten zur dauerhaften Verbesserung der Klebstoff- und/oder Beschichtungs-Kompatibilität von Polyethylen-basierten Formkörpern, Fasern und Folien
DE10060818A1 (de) 2000-12-07 2002-06-13 Cognis Deutschland Gmbh Verwendung von Polyetheraminen zur dauerhaften Verbesserung der Klebstoff- und/oder Beschichtungs-Kompatibilität von Polyethylen-basierten Formkörpern, Fasern und Folien
WO2002069964A1 (en) 2001-03-05 2002-09-12 Ernest Stephen P Enteral formulation
ATE441409T1 (de) 2001-03-15 2009-09-15 Riken Aminosäurezusammensetzungen zur linderung einer fehlfunktion der leber
US20020193342A1 (en) 2001-05-09 2002-12-19 Hamman John P. Modifying undesirable tastes
ITTO20010580A1 (it) 2001-06-15 2002-12-15 Professional Dietetics Srl Composizioni a base di aminoacidi per il miglioramento della funzioneventricolare miocardica in pazienti affetti da diabete.
US6864230B2 (en) 2001-07-31 2005-03-08 Novartis Nutrition Ag Glutamine rich dietary composition
WO2003055481A1 (fr) 2001-12-25 2003-07-10 Ajinomoto Co., Inc. Inhibiteurs de fibrose des organes
WO2003061639A2 (en) 2002-01-25 2003-07-31 Diamedica Inc. Use of glutathione synthesis stimulating compounds in reducing insulin resistance
JP2003238401A (ja) 2002-02-20 2003-08-27 Ajinomoto Co Inc 疾患の治療、改善又は予防用医薬品及び飲食品
US20050176827A1 (en) 2002-05-10 2005-08-11 Lee Steve S. Compositions and methods for glycogen synthesis
US7338675B2 (en) 2002-05-10 2008-03-04 Tsi Health Sciences, Inc. Fenugreek seed bio-active compositions and methods for extracting same
ES2524000T3 (es) 2002-06-05 2014-12-03 Teva Czech Industries S.R.O. Reducción de la reticulación de la gelatina
WO2004019928A1 (ja) 2002-08-30 2004-03-11 Ajinomoto Co., Inc. 肝疾患治療剤
US20040087490A1 (en) 2002-09-20 2004-05-06 Troup John P. Nutritional compositions
US20040057983A1 (en) 2002-09-25 2004-03-25 David Schmidt Biomolecular wearable apparatus
US7037522B2 (en) 2002-09-27 2006-05-02 Western Holdings, L.L.C. Nocturnal muscle enhancing composition and method
JP2004123564A (ja) 2002-09-30 2004-04-22 Inst Of Physical & Chemical Res 中枢機能改善用アミノ酸組成物
JP2004182705A (ja) 2002-10-11 2004-07-02 Yasutoshi Koga ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物
US7547450B2 (en) 2002-10-24 2009-06-16 Nestec Ltd. Senior feline food
US8093292B2 (en) 2002-11-22 2012-01-10 Bionexus, Ltd. Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology
US7288570B2 (en) 2002-12-20 2007-10-30 Nutricia N.V. Stimulation of in vivo production of proteins
US20040120983A1 (en) 2002-12-23 2004-06-24 Philip Connolly Nutritional supplement
AU2003296176A1 (en) 2002-12-26 2004-07-22 Ajinomoto Co., Inc. Inhibitor for liver cancer onset and progress
JP4989836B2 (ja) 2002-12-26 2012-08-01 大塚製薬株式会社 経口栄養剤
MXPA05009933A (es) 2003-03-18 2005-11-04 Novartis Ag Composiciones que comprenden acidos grasos y aminoacidos.
US20040213838A1 (en) 2003-04-24 2004-10-28 Mazer Terrence B. Medical food tablets containing free amino acids
JP4528925B2 (ja) 2003-05-30 2010-08-25 独立行政法人理化学研究所 アミノ酸組成物及び補液
EP2382874A1 (en) 2003-06-23 2011-11-02 Nestec S.A. Amino acid supplementation for a healthy microbiota ecosystem
JP2005027524A (ja) 2003-07-08 2005-02-03 Ajinomoto Co Inc 経口アミノ酸組成物
WO2005017094A2 (en) 2003-08-19 2005-02-24 Bioadvantex Pharma Inc. N-acetyl compositions as adjunct therapy for treatment and prevention of cysteine/glutathione deficiency
ITTO20030789A1 (it) 2003-10-07 2005-04-08 Professional Dietetics Srl Composizione a base di amino acidi per il trattamento
CA2542652C (en) 2003-10-16 2014-05-13 Nestec S.A. Nutritional composition against side effects of chemotherapy or radiotherapy
EP1685833A1 (en) 2003-11-21 2006-08-02 Ajinomoto Co., Inc. Remedy for diabetes
ES2550608T3 (es) 2003-12-20 2015-11-11 Nestec S.A. Composición nutritiva para la curación de las heridas
KR20060124732A (ko) 2004-01-28 2006-12-05 아지노모토 가부시키가이샤 국소 뇌혈류 저하에 따른 신경계 장해의 예방 또는 치료용의약 조성물
JP4568870B2 (ja) 2004-02-27 2010-10-27 独立行政法人農業・食品産業技術総合研究機構 遊離アミノ酸を富化した食品素材及びその製造法
US20050233013A1 (en) * 2004-03-02 2005-10-20 Lee Steve S Methods for enhancing the transport of glucose for balancing blood sugar levels
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
JP4815752B2 (ja) 2004-04-01 2011-11-16 味の素株式会社 アミノ酸含有飲食品
WO2005110124A1 (en) 2004-04-15 2005-11-24 Abbott Laboratories Composition and methods for nutritional management of patients with hepatic disease
CN1582912A (zh) 2004-06-10 2005-02-23 武汉启瑞科技发展有限公司 L-鸟氨酸和 l-门冬氨酸组合物
US20060002913A1 (en) 2004-06-22 2006-01-05 Gehlsen Kurt R Use of histamine and related compounds to treat disorders affecting muscle function
KR20120125993A (ko) 2004-07-14 2012-11-19 아지노모토 가부시키가이샤 C형 간염 바이러스 양성 사람 간경변 환자용 간암 발생·진전 억제제
CN101018561A (zh) 2004-07-19 2007-08-15 N·V·努特里奇亚 使用天冬氨酸和维生素b12或生物素调节酮体的制剂
EP1637163A1 (en) 2004-09-21 2006-03-22 Andreas Kluge Indicator of therapeutic compliance
JP5177785B2 (ja) 2004-11-02 2013-04-10 味の素株式会社 周術期患者用薬剤
US8389576B2 (en) 2004-11-26 2013-03-05 Ucl Business Plc Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
US20090048153A1 (en) 2004-12-03 2009-02-19 University Of Maryland, Baltimore Composition for treating sulfur mustard toxicity and methods of using same
WO2006061992A1 (ja) 2004-12-10 2006-06-15 Ajinomoto Co., Inc. 肝疾患予防・治療用組成物
WO2006080086A1 (ja) 2005-01-31 2006-08-03 Takanobu Yamamoto 中枢神経系の疲労回復又は疲労予防のための組成物
CN1679941A (zh) 2005-02-02 2005-10-12 北京阜康仁生物制药科技有限公司 一种由牛磺酸和治疗肝病的药物组成的复方制剂及其制备方法
CA2537647A1 (en) 2005-03-01 2006-09-01 Six Star Formulations Ltd. Supplemental dietary composition for supporting muscle growth, recovery and strength
MX2007011264A (es) 2005-03-15 2008-03-12 Nestec Sa Composiciones nutricionales para modular la biodisponibilidad de vitamina c.
BRPI0614016A2 (pt) 2005-03-21 2011-03-01 Abbott Lab composição de aminoácido para melhorar toleráncia à glicose
EP1865944B1 (en) 2005-03-29 2018-08-29 Ajinomoto Co., Inc. Amino acid-containing composition used for preventing or remedying decrease in skeletal muscle mass of aged people, comprising L-leucine
CN101175416A (zh) 2005-04-06 2008-05-07 诺瓦提斯公司 从营养方面改善葡萄糖控制和胰岛素作用的方法和组合物
US8993627B2 (en) 2005-04-21 2015-03-31 Sentient Lifesciences, Inc. N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress
EP1890688A2 (en) 2005-06-14 2008-02-27 Nestec S.A. Nutritional method
JPWO2006137469A1 (ja) 2005-06-22 2009-01-22 味の素株式会社 代謝型グルタミン酸受容体活性化剤
US20100104548A1 (en) 2005-06-24 2010-04-29 Albert Einstein College Of Medicine Of Yeshiva University Modulation of amino acid metabolism in the hypothalamus
WO2007004613A1 (ja) 2005-07-01 2007-01-11 Ajinomoto Co., Inc. 炎症性腸疾患治療薬及びTNF-α産生抑制剤
JP2007023921A (ja) * 2005-07-19 2007-02-01 Toyota Motor Corp 内燃機関の制御装置
KR20080041675A (ko) 2005-08-04 2008-05-13 아지노모토 가부시키가이샤 산화형 알부민 저하제
JP5067160B2 (ja) 2005-08-05 2012-11-07 味の素株式会社 肝癌発生・進展抑制剤
US8148356B2 (en) 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
JP5371429B2 (ja) 2005-08-26 2013-12-18 ネステク ソシエテ アノニム 機能的な血管の完全性及び細胞生存を改善し、脳の虚血における又は虚血エピソード後のアポトーシスを減少するための組成物及び方法
EP1774973A1 (en) 2005-10-12 2007-04-18 Nutricia N.V. Leucine rich composition
CN101282657A (zh) 2005-10-28 2008-10-08 雀巢技术公司 支链氨基酸的使用方法
WO2007056176A2 (en) 2005-11-03 2007-05-18 Southwest Immunology, Inc. Compositions for preventing and reducing delayed onset muscle soreness
MX2008005936A (es) 2005-11-07 2008-10-01 Perque Llc Composiciones para regular trastornos metabolicos y metodos de uso de las mismas.
ES2363442T3 (es) 2005-11-30 2011-08-04 Nestec S.A. Combinación que comprende al menos una aminoácido y un inhibidor de pkr para utilizar en el tratamiento de la pérdida de masa muscular.
NZ568611A (en) 2005-12-19 2011-11-25 Abbott Lab Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance in type 1 and type 2 cytokine production
CA2631220A1 (en) 2006-01-09 2007-07-19 Nestec S.A. Treatment of stressed patients
DK1983849T3 (da) 2006-01-20 2013-07-08 Innova Food Ab Fødevaresammensætning omfattende aminosyrer
WO2007088160A1 (en) 2006-01-31 2007-08-09 Nestec S.A. Nutritional composition for low birth weight infants
WO2007133642A1 (en) 2006-05-11 2007-11-22 Garcia Ramon D Sport drink containing amino acids and carbohydrates
JP5100033B2 (ja) 2006-05-16 2012-12-19 大塚製薬株式会社 消化管及び腎臓の萎縮抑制剤
US20070286909A1 (en) 2006-06-07 2007-12-13 Daniel S. Smith Amino acid compositions
JP2008050277A (ja) 2006-08-22 2008-03-06 Ajinomoto Co Inc 鉄欠乏性貧血症治療用組成物
US9192593B2 (en) 2006-08-30 2015-11-24 Ajinomoto Co., Inc. Amino-acid containing composition for inhibiting accumulation of fat
MX2009003778A (es) 2006-10-19 2009-04-22 Nestec Sa Alimentacion a largo plazo para paciente de cancer.
US20080102137A1 (en) 2006-10-31 2008-05-01 Guffey Manning V R Composition and method for etiological treatment and prevention of diseases and/or complications associated with chronic glucose metabolism destabilization
GB0624879D0 (en) 2006-12-14 2007-01-24 Shs Int Ltd Treatment of pervasive development disorders
EP1932437A1 (en) 2006-12-15 2008-06-18 Nestec S.A. Infant formula
CN100518815C (zh) 2007-02-15 2009-07-29 北京苏里曼医药科技有限公司 一种氨基酸组合物
US20080268038A1 (en) 2007-04-26 2008-10-30 Wolfe Robert R Compositions and Approaches for Increasing Diet Induced Thermogenesis, Inducing Weight Loss and Maintaining Muscle Mass and Strength
CN101332209B (zh) 2007-06-25 2010-12-08 三菱制药(广州)有限公司 治疗肝性脑病的复方氨基酸注射液
US8455531B2 (en) 2007-09-18 2013-06-04 Thermolife International, Llc Amino acid compositions
US7777074B2 (en) 2007-09-18 2010-08-17 Thermolife International, Llc Amino acid compounds
US8466187B2 (en) 2007-09-18 2013-06-18 Thermolife International, Llc Amino acid compositions
KR100970664B1 (ko) 2007-10-11 2010-07-15 한화제약주식회사 L-오르니틴-l-아스파테이트를 함유한 겔제의 제조방법 및그 겔제
EP2057905A1 (en) 2007-11-12 2009-05-13 TIMA Foundation Composition for moderating Triglyceride and Cholesterol Levels
US20110077198A1 (en) 2007-11-26 2011-03-31 Michael John Tisdale Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition
CN101214050B (zh) 2007-12-28 2011-08-31 叶高山 一种具有提神、抗疲劳、醒酒功能的保健饮料
ES2773928T5 (es) 2008-01-04 2023-06-28 Nestle Sa Composiciones que comprenden ácidos grasos insaturados y compuestos de liberación de óxido nítrico y uso de las mismas para la intensificación de las funciones cognitivas y relacionadas
US7790688B2 (en) 2008-01-11 2010-09-07 Healthspan Solutions, Llc Compositions and methods for increasing muscle mass, strength, and functional performance in the elderly
US20090186098A1 (en) 2008-01-18 2009-07-23 Jose Briceno Sports drink composition
EP2095728B1 (en) 2008-01-25 2011-09-07 Cesar Gallia s.r.l. Amino acid concentrate in aqueous gel and fatigue-relieving drink obtainable by diluting said concentrate in water
US8716249B2 (en) 2008-01-31 2014-05-06 Energy Light Llc Compositions and methods for improving cardiovascular health
JP2011514323A (ja) 2008-02-05 2011-05-06 ヘルススパン ソリューションズ, エルエルシー 高齢者の年齢関連性及び年齢特異的健康状態の管理のための治療的栄養を使用するシステム及び方法
RU2500406C2 (ru) 2008-02-07 2013-12-10 Нестек С.А. Композиции и способы влияния на восстановление после напряженной физической активности
EP2098126A1 (en) 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate Bar
EP2098124A1 (en) 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate gel
CN102316730A (zh) 2008-05-09 2012-01-11 天雅瑞药业有限公司 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释
CA2727088A1 (en) 2008-06-04 2009-12-10 Phenolics, Llc Enteric-coated formulations of polyethylene glycol and one or more soluble amino acids for oral ingestion and enhanced uptake of same
US20100021573A1 (en) * 2008-07-22 2010-01-28 Michael J Gonzalez Compositions and methods for the prevention of cardiovascular disease
WO2010033424A2 (en) 2008-09-19 2010-03-25 Nestec S.A. Nutritional support of the immune system during anti-cancer treatment
EP2165713B1 (en) 2008-09-19 2012-11-14 Nestec S.A. Whey and thymus function
EP2351562A4 (en) 2008-10-27 2012-09-05 Ajinomoto Kk SOLID SOLUTION OF VALIN, ISOLEUCIN AND LEUCIN AND MANUFACTURING PROCESS THEREFOR
US8362080B2 (en) 2008-12-18 2013-01-29 Baylor College Of Medicine Increasing glutathione levels for therapy
KR20170034928A (ko) 2009-01-12 2017-03-29 바이오키어 인코포레이티드 당뇨병 치료 조성물 및 치료방법
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
WO2010108016A2 (en) 2009-03-18 2010-09-23 Healthspan Solutions, Llc Compositions and methods for sparing muscle in renal insufficiency and during hemodialysis
WO2010108542A1 (en) 2009-03-25 2010-09-30 Nestec S.A. A natural taste enhancing savoury base and a process for its preparation
ES2928586T3 (es) 2009-04-03 2022-11-21 Ocera Therapeutics Inc Fenilacetato de L-ornitina y métodos para elaborar el mismo
WO2010126353A1 (en) 2009-04-27 2010-11-04 N.V. Nutricia Pea-based protein mixture and use thereof in a liquid nutritional composition suitable for enteral feeding
US8703719B1 (en) 2009-05-18 2014-04-22 Bio-Engineered Supplements And Nutrition, Inc. Method and composition for improved muscle performance
EP2440200B8 (en) 2009-06-08 2014-10-15 UCL Business PLC Treatment of portal hypertension using l-ornithine phenylacetate
WO2010143939A1 (en) 2009-06-09 2010-12-16 N.V. Nutricia Nutrition for improving muscle strength in elderly
IN2012DN00486A (es) 2009-07-20 2015-05-22 Nestec Sa
WO2011030104A1 (en) 2009-09-09 2011-03-17 Rajiv Jalan Phenylacetate and/or phenylbutyrate (not ornithine) for reducing portal blood pressure
CN101664384B (zh) 2009-09-18 2011-09-14 杭州市第六人民医院 N-乙酰半胱氨酸盐木糖醇注射液及其制备方法和应用
BR112012006437A2 (pt) 2009-09-23 2016-04-19 Biokier Inc composições e métodos para tratamento do diabetes e outros distúrbios
WO2011044230A2 (en) 2009-10-06 2011-04-14 Goldstein Glenn A N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions
WO2011043647A1 (en) 2009-10-09 2011-04-14 N.V. Nutricia Amino acid composition with improved dispersibility
EP2327316B1 (en) 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
EP2327315B1 (en) 2009-11-29 2013-10-09 Nestec S.A. Dosing protocols for increasing protein synthesis in an active individual
JP2011132174A (ja) 2009-12-24 2011-07-07 Kirin Holdings Co Ltd 持久力向上剤
WO2011078654A1 (en) 2009-12-24 2011-06-30 N.V. Nutricia Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis
WO2011097273A1 (en) 2010-02-02 2011-08-11 Martek Biosciences Corporation Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine
CA2792396C (en) 2010-03-12 2018-09-11 Nestec S.A. Compositions for masking the flavor of nutrients and methods for making same
WO2011119023A1 (en) 2010-03-26 2011-09-29 N.V. Nutricia Low protein infant formula with increased essential amino acids
CN103025178B (zh) 2010-04-26 2015-02-11 雀巢产品技术援助有限公司 用于从胃肠外营养转换至肠内营养的营养组合物和方法
US8840950B2 (en) 2010-05-26 2014-09-23 Jacqueline M. Hibbert Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore
WO2012005568A1 (en) 2010-07-07 2012-01-12 N.V. Nutricia Nutritional composition for the stimulation of muscle protein synthesis
KR101213825B1 (ko) 2010-07-16 2012-12-18 서울대학교산학협력단 세린을 유효성분으로 함유하는 지방간 질환의 예방 및 치료용 조성물
MY173215A (en) 2010-07-21 2020-01-06 Cumberland Pharmaceuticals Inc Acetylcysteine compositions and methods of use thereof
US20120020947A1 (en) 2010-07-22 2012-01-26 Northern Innovations And Formulations Corp. Compositions and methods for increasing lean muscle mass after exercise
CN101912394B (zh) 2010-08-06 2013-11-06 岳茂兴 一种用于治疗凝血障碍出血的药物组合物及其用途
US8946473B2 (en) 2010-10-06 2015-02-03 Ocera Therapeutics, Inc. Methods of making L-ornithine phenyl acetate
EP2444083A1 (en) 2010-10-21 2012-04-25 Nestec S.A. Cysteine and food intake
EP2654462A1 (en) 2010-12-22 2013-10-30 Abbott Laboratories Nutritional products comprising calcium beta-hydroxy-beta methylbutyrate and conjugated linoleic acid
WO2012092035A1 (en) 2010-12-27 2012-07-05 Abbott Laboratories Methods for facilitating muscle recovery after a period of disuse using beta-hydroxy-beta-methylbutyrate
WO2012097061A1 (en) 2011-01-13 2012-07-19 Abbott Laboratories Nutritional compositions and methods for improving skeletal muscle protein metabolism
AU2012209285B2 (en) 2011-01-25 2016-11-17 Nestec S. A. Methods and compositions for treating, reducing or preventing deterioration of the visual system of animals
RU2491062C2 (ru) 2011-03-16 2013-08-27 Общество С Ограниченной Ответственностью "Биотехнологии Пущино" Композиции протекторов острых и хронических печеночных энцелопатий и способ лечения острых и хронических печеночных энцелопатий
MX359453B (es) 2011-03-18 2018-09-28 Nestec Sa Composiciones y métodos útiles para aliviar los padecimientos relacionados con la edad.
CN102327259A (zh) 2011-03-31 2012-01-25 姜国辉 具有显著化学性肝损伤保护功能的复合生物制剂
US11235008B2 (en) 2011-03-31 2022-02-01 Ganeden Biotech, Inc. Probiotic sports nutrition compositions
CA2830970A1 (en) 2011-04-12 2012-10-18 Nestec S.A. Nutritional compositions including branched chain fatty acids and methods of using same
EP2699110A1 (en) 2011-04-18 2014-02-26 Nestec S.A. Nutritional compositions having alpha-hica and alpha-ketoglutarate
US20120270860A1 (en) 2011-04-19 2012-10-25 Gihyun Yoon Methods for treating or preventing alcohol-related disorders or craving-related disorders
CA2831798A1 (en) 2011-04-21 2012-10-26 Nestec S.A. Nutritional compositions for enhancing performance and methods for making and using same
US8828426B2 (en) 2011-06-07 2014-09-09 Zx Pharma, Llc Multiparticulate L-carnitine compositions and related methods
WO2013006658A1 (en) 2011-07-05 2013-01-10 The Brigham And Women's Hospital, Inc. Treatment of acetaminophen-induced liver damage by the administration of modulators of nitric oxide
BR112014002779A2 (pt) 2011-08-08 2017-02-21 Ajinomoto Kk composição contendo aminoácido para o melhoramento da recuperação a partir de fadiga muscular
CA2845829A1 (en) 2011-08-19 2013-02-28 Musclepharm Corporation Compositions and methods for use in promoting lean body mass
EP2574333B1 (en) 2011-09-27 2017-01-11 Friulchem SpA N-acetylcysteine effervescent tablet and its therapeutical applications
EP2580967A1 (en) 2011-10-11 2013-04-17 Nestec S.A. Accelerating muscle recovery after immobilization-induced muscle atrophy
EP2583565A1 (en) 2011-10-21 2013-04-24 Nestec S.A. Use of whey protein micelles for enhancing energy expenditure and satiety
EP2583563A1 (en) 2011-10-21 2013-04-24 Nestec S.A. Whey protein micelles against muscle atrophy and sarcopenia
WO2013075095A1 (en) 2011-11-18 2013-05-23 The Board Of Trustees Of The University Of Arkansas Use of amino acid supplementation for improved muscle recovery
EP3437649A1 (en) 2011-11-21 2019-02-06 Emmaus Medical Inc. Methods and compositions for the treatment of diabetes and related symptoms
KR101909433B1 (ko) 2011-12-02 2018-10-18 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 키나제 저해제의 부작용 저감제
US20150004202A1 (en) 2012-01-19 2015-01-01 Shoichi Shirotake Antibacterial agent against plant disease-causing bacteria
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
US20150119339A1 (en) 2012-06-11 2015-04-30 Abbott Laboratories Use of hmb to improve health outcomes for hospitalized patients
WO2014020004A1 (en) 2012-07-31 2014-02-06 Nestec S.A. Nutritional composition for promoting musculoskeletal health in patients with inflammatory bowel disease (ibd)
US20150223501A1 (en) 2012-09-14 2015-08-13 Nestec S.A. Novel flavour compositions with improved flavour and/or flavour shelf-life
US9198889B2 (en) 2012-09-19 2015-12-01 Quality IP Holdings, LLC Methods for treating post-traumatic stress disorder
US8747921B2 (en) 2012-09-19 2014-06-10 Quality Ip Holdings, Inc. Methods for improving health in humans
US9066953B2 (en) 2012-09-20 2015-06-30 Quality IP Holdings, LLC Methods for increasing endurance and fat metabolism in humans
CN102961377A (zh) 2012-11-08 2013-03-13 湖北一半天制药有限公司 复方氨基酸注射液(20aa)的制备方法
US9410963B2 (en) 2012-12-04 2016-08-09 Nestec S.A. Hexanoylglycine as biomarker for the predisposition for weight gain and obesity
US10064900B2 (en) 2013-02-04 2018-09-04 Seres Therapeutics, Inc. Methods of populating a gastrointestinal tract
US10350185B2 (en) 2013-03-11 2019-07-16 University Of Florida Research Foundation, Incorporated Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications
RU2015143836A (ru) 2013-03-15 2017-04-27 Нусерт Сайенсиз, Инк. Лейцин и никотиновая кислота для снижения уровня липидов
CA2907667A1 (en) 2013-03-26 2014-10-02 Premier Nutrition Corporation Methods for enhancing muscle protein synthesis following concurrent training
BR112015025490B1 (pt) 2013-04-15 2022-05-03 Société des Produits Nestlé S.A. Uso de uma fonte de aminoácidos em combinação com o estímulo muscular elétrico
AU2014254147A1 (en) 2013-04-16 2015-12-03 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of brain injury
US20140357576A1 (en) 2013-05-31 2014-12-04 Nestec S.A. Methods for enhancement of muscle protein synthesis
PL3019024T3 (pl) 2013-06-28 2017-07-31 Nestec S.A. Kompozycje i sposoby do zwiększania wydolności podczas wysiłku fizycznego
EP3738590A1 (en) 2013-07-31 2020-11-18 Leeds Beckett University Dietary supplement comprising amino acids for the treatment of sarcopenia
RU2016110800A (ru) 2013-09-25 2017-10-30 Пронутриа Биосайенсис, Инк. Составы и композиции для поддержания и увеличения мышечной массы, силы и результативности, и способы их производства и использования
US20180125926A1 (en) 2013-09-25 2018-05-10 Axcella Health Inc. Compositions and Formulations and Methods of Production and Use Thereof
CA2923705C (en) 2013-10-09 2024-05-14 Nestec S.A. Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome
WO2015061607A1 (en) 2013-10-23 2015-04-30 Whitehead Institute For Biomedical Research Mtorc1 modulation by amino acids and uses thereof
SG11201607075TA (en) 2014-02-27 2016-09-29 Nusirt Sciences Inc Compositions and methods for the reduction or prevention of hepatic steatosis
GB2523578A (en) 2014-02-28 2015-09-02 Daniel Nelson A nutritional supplement
WO2015161448A1 (en) 2014-04-22 2015-10-29 Wuhan Ll Science And Technology Development Co., Ltd. Ornithine-containing or aspartate-containing compositions and the uses thereof
CN105092753B (zh) 2014-05-20 2016-09-07 中国科学院大连化学物理研究所 组合型胺类代谢标志物的应用及试剂盒
WO2016003263A1 (en) 2014-07-01 2016-01-07 N.V. Nutricia Amino acid based diet with improved taste
US10217645B2 (en) 2014-07-25 2019-02-26 Versum Materials Us, Llc Chemical mechanical polishing (CMP) of cobalt-containing substrate
US20160158305A1 (en) 2014-09-19 2016-06-09 Chip E. Thomson Additives and supplements
WO2016058919A1 (en) 2014-10-14 2016-04-21 Nestec S.A. Improvement in muscle functionality of elderly males
WO2016085887A1 (en) 2014-11-24 2016-06-02 Ucl Business Plc Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
MX368900B (es) 2014-12-04 2019-10-21 Professional Dietetics Spa Composicion a base de aminoacidos para recuperacion de fibroelastina en tejidos conectivos dermicos.
WO2016094316A1 (en) 2014-12-08 2016-06-16 Synaptamine, Inc. Anti-rds compounds and method of manufacture and administration thereof to induce dopamine homeostatis
EP3034074A1 (en) 2014-12-18 2016-06-22 Universitat De València, Estudi General Compound for treatment of myotonic dystrophy type 1
JP6959136B2 (ja) 2015-01-23 2021-11-02 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 患者の示差的な栄養所要量の決定方法
WO2016116585A1 (en) 2015-01-23 2016-07-28 Nestec S.A. Promotion of healing of intestinal mucosa using proline, serine and threonine
US10137108B2 (en) 2015-01-23 2018-11-27 Nestec S.A. Nutritional composition useful in the treatment of IBD patients
CN107106528A (zh) 2015-01-23 2017-08-29 雀巢产品技术援助有限公司 使用丝氨酸治疗或预防炎症
WO2016121829A1 (ja) 2015-01-27 2016-08-04 昇一 城武 ナノ粒子を有効成分とする皮膚炎の治療又は予防剤
WO2016128576A1 (en) 2015-02-13 2016-08-18 Nestec S.A. Treatment or prevention of surgery-induced cachexia and/or expression of myeloid-derived suppressor cells and pro-inflammatory cytokines
US20180036270A1 (en) 2015-02-13 2018-02-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College A method of protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via administration of n-acetylcysteine
FR3032883B1 (fr) * 2015-02-24 2017-03-17 International Nutrition Res Company Composition pour la prevention et le traitement de la steatose et de la steatohepatite metaboliques
US20160302451A1 (en) 2015-04-16 2016-10-20 Michael Hudnall Medical Food for Patients with Chronic Liver Disease
US20160338982A1 (en) 2015-04-20 2016-11-24 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
US10123985B2 (en) 2015-06-08 2018-11-13 Whitehead Institute For Biomedical Research Therapeutic strategies for treating mitochondrial disorders
CN107708446A (zh) 2015-06-22 2018-02-16 雀巢产品技术援助有限公司 用于增强动物体内神经形成的组合物和方法
MX2017016467A (es) 2015-06-30 2018-05-17 Nestec Sa Composicion adecuada para proteger microorganismos.
CA2991768C (en) 2015-07-15 2023-03-21 Unigen, Inc. Compositions, methods, and medical compositions for treatment of and maintaining the health of the liver
JP7008015B2 (ja) 2015-08-14 2022-01-25 ソシエテ・デ・プロデュイ・ネスレ・エス・アー ソフトな質感を維持するセミモイストフード組成物
JP6990170B2 (ja) 2015-08-18 2022-01-12 オセラ セラピューティクス, インコーポレイテッド L-オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも1つと組み合わせて用いる筋肉喪失の治療および予防
US11019817B2 (en) 2015-08-25 2021-06-01 Shoichi Shirotake Antimicrobial agent against germs which has excellent plant disease control effect
US20170079897A1 (en) 2015-09-20 2017-03-23 Matthew Brissette MINUS Composition for hair application and methods of hair care
US20200206174A1 (en) 2015-09-25 2020-07-02 Ocera Therapeutics, Inc. Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US20170196944A1 (en) 2015-09-28 2017-07-13 Robert Portman Method to reduce muscle atrophy following orthopedic surgery
CN108366983A (zh) 2015-11-13 2018-08-03 欧塞拉治疗有限公司 L-鸟氨酸苯乙酸盐制剂
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
BR112018008186B1 (pt) 2015-11-20 2021-11-23 Société des Produits Nestlé S.A. Composição que compreende micelas de proteína de soro de leite, e seus usos
CH713469B1 (de) 2015-12-21 2021-06-30 Nianjing Jianrong Bio Tech Co Ltd Zusammensetzung zum Behandeln von Motoneuron-Erkrankungen
EA201891592A1 (ru) 2016-01-08 2019-02-28 КОЛОНАРИКОНСЕПТС ЭлЭлСи Основанная на пищевых продуктах доставка терапевтического агента для лечения печеночной энцефалопатии
GB201600990D0 (en) 2016-01-19 2016-03-02 Abbott Lab Pharmaceutical or nutritional combination
US20190133147A1 (en) 2016-05-11 2019-05-09 Tsubo Solutions Pty Ltd Confectionery product
WO2017202939A1 (en) 2016-05-27 2017-11-30 Nestec S.A. Nutritional composition for treating or preventing impaired mobility
PL238958B1 (pl) 2016-06-29 2021-10-25 Olimp Laboratories Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja aminokwasowa do stosowania przed wysiłkiem fizycznym
US20180015122A1 (en) 2016-07-14 2018-01-18 Companion Supplements, LLC Pharmaceutical composition effective in preventing adverse effects associated with the use of glucocorticoids
US11033522B2 (en) 2016-08-09 2021-06-15 David C Scott Free amino acid preparation and uses thereof
JOP20190147A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض واضطرابات العضلات
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
SE540582C2 (en) 2016-12-22 2018-10-02 Scandibio Therapeutics Ab Substances for treatment of fatty liver-related conditions
CN106632605B (zh) 2016-12-22 2020-06-16 浙江海洋大学 利用金枪鱼下脚料制备的具有肝损伤修复作用的活性肽
EP3570826A4 (en) 2017-01-19 2020-09-23 Otologic Pharmaceutics, Inc. N-ACETYLCYSTEIN FORMULATIONS AND THEIR USES
EP3615018A1 (en) 2017-04-28 2020-03-04 Axcella Health Inc. Amino acid compositions and their use for the treatment of traumatic brain injury
CN107242552A (zh) 2017-07-07 2017-10-13 上海东锦食品集团有限公司 具有缓解体力疲劳及增强免疫力功能的保健食品组合物
WO2019036442A1 (en) 2017-08-14 2019-02-21 Axcella Health Inc. AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY
MA49906A (fr) 2017-08-14 2020-06-24 Axcella Health Inc Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie
CN108041501A (zh) 2017-12-22 2018-05-18 北京康比特体育科技股份有限公司 一种促进疲劳恢复的蛋白组合物及其制备方法
WO2019246310A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the reduction or treatment of inflammation
JP2021527670A (ja) 2018-06-20 2021-10-14 アクセラ・ヘルス・インコーポレイテッドAxcella Health Inc. 筋肉中の脂肪浸潤の治療のための組成物及び方法
CN112839708A (zh) 2018-06-20 2021-05-25 胺细拉健康公司 用于减少或治疗纤维化的组合物和方法
WO2019246221A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders
CU20200106A7 (es) 2018-06-20 2021-08-06 Axcella Health Inc Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
WO2019246299A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the reduction or treatment of insulin resistance and metabolic conditions
WO2019246256A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions for therapy and health containing amino acids with bitter taste
EP3810168A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Methods of manufacturing amino acid compositions
CN108524453A (zh) 2018-07-05 2018-09-14 扬子江药业集团广州海瑞药业有限公司 一种门冬氨酸鸟氨酸的药物组合物

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