CL2020002398A1 - Inhibidores de secreción de proteínas basados en triazaciclododecansulfonamida ("tcd") - Google Patents
Inhibidores de secreción de proteínas basados en triazaciclododecansulfonamida ("tcd")Info
- Publication number
- CL2020002398A1 CL2020002398A1 CL2020002398A CL2020002398A CL2020002398A1 CL 2020002398 A1 CL2020002398 A1 CL 2020002398A1 CL 2020002398 A CL2020002398 A CL 2020002398A CL 2020002398 A CL2020002398 A CL 2020002398A CL 2020002398 A1 CL2020002398 A1 CL 2020002398A1
- Authority
- CL
- Chile
- Prior art keywords
- triazacyclododecanesulfonamide
- tcd
- based protein
- protein secretion
- secretion inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invención describe inhibidores de la secreción de proteínas basados en triazaciclododecansulfonamida ("TCD"), tales como inhibidores de Sec61, métodos para su preparación, composiciones farmacéuticas relacionadas y métodos para usar los mismos. Por ejemplo, describe compuestos de Fórmula (I) y sales y composiciones farmacéuticamente aceptables que incluyen las mismas. Los compuestos descritos aquí pueden usarse en el tratamiento de enfermedades que incluyen inflamación y/o cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643931P | 2018-03-16 | 2018-03-16 | |
| US201962803704P | 2019-02-11 | 2019-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020002398A1 true CL2020002398A1 (es) | 2021-02-12 |
Family
ID=66041635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020002398A CL2020002398A1 (es) | 2018-03-16 | 2020-09-16 | Inhibidores de secreción de proteínas basados en triazaciclododecansulfonamida ("tcd") |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11578055B2 (es) |
| EP (1) | EP3765447B1 (es) |
| JP (1) | JP2021518337A (es) |
| KR (1) | KR20200133238A (es) |
| AU (1) | AU2019236248B2 (es) |
| BR (1) | BR112020018767A2 (es) |
| CA (1) | CA3093972A1 (es) |
| CL (1) | CL2020002398A1 (es) |
| CO (1) | CO2020012484A2 (es) |
| DK (1) | DK3765447T3 (es) |
| ES (1) | ES2953139T3 (es) |
| FI (1) | FI3765447T3 (es) |
| HR (1) | HRP20230804T1 (es) |
| HU (1) | HUE062455T2 (es) |
| IL (1) | IL277252A (es) |
| JO (1) | JOP20200233A1 (es) |
| LT (1) | LT3765447T (es) |
| MA (1) | MA52008A (es) |
| MX (1) | MX2020009645A (es) |
| PE (1) | PE20210926A1 (es) |
| PH (1) | PH12020551493A1 (es) |
| PL (1) | PL3765447T3 (es) |
| PT (1) | PT3765447T (es) |
| RS (1) | RS64524B1 (es) |
| SG (1) | SG11202008841VA (es) |
| SI (1) | SI3765447T1 (es) |
| TW (1) | TWI818962B (es) |
| WO (1) | WO2019178510A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663161A (en) * | 1995-02-17 | 1997-09-02 | The Research Foundation Of State University Of New York | Anti-viral triaza compounds |
| WO2002080856A2 (en) | 2001-04-06 | 2002-10-17 | University And Community College System Of Nevada On Behalf Of The University Of Nevada, Reno | Triaza compound immunoregulatory agents |
-
2019
- 2019-03-15 CA CA3093972A patent/CA3093972A1/en active Pending
- 2019-03-15 ES ES19715609T patent/ES2953139T3/es active Active
- 2019-03-15 SI SI201930602T patent/SI3765447T1/sl unknown
- 2019-03-15 JP JP2020548935A patent/JP2021518337A/ja active Pending
- 2019-03-15 DK DK19715609.4T patent/DK3765447T3/da active
- 2019-03-15 TW TW108108893A patent/TWI818962B/zh active
- 2019-03-15 HR HRP20230804TT patent/HRP20230804T1/hr unknown
- 2019-03-15 MX MX2020009645A patent/MX2020009645A/es unknown
- 2019-03-15 BR BR112020018767-4A patent/BR112020018767A2/pt unknown
- 2019-03-15 MA MA052008A patent/MA52008A/fr unknown
- 2019-03-15 SG SG11202008841VA patent/SG11202008841VA/en unknown
- 2019-03-15 HU HUE19715609A patent/HUE062455T2/hu unknown
- 2019-03-15 LT LTEPPCT/US2019/022533T patent/LT3765447T/lt unknown
- 2019-03-15 US US16/979,457 patent/US11578055B2/en active Active
- 2019-03-15 FI FIEP19715609.4T patent/FI3765447T3/fi active
- 2019-03-15 RS RS20230647A patent/RS64524B1/sr unknown
- 2019-03-15 PT PT197156094T patent/PT3765447T/pt unknown
- 2019-03-15 JO JOP/2020/0233A patent/JOP20200233A1/ar unknown
- 2019-03-15 WO PCT/US2019/022533 patent/WO2019178510A1/en active Application Filing
- 2019-03-15 AU AU2019236248A patent/AU2019236248B2/en active Active
- 2019-03-15 PL PL19715609.4T patent/PL3765447T3/pl unknown
- 2019-03-15 KR KR1020207029261A patent/KR20200133238A/ko active Search and Examination
- 2019-03-15 EP EP19715609.4A patent/EP3765447B1/en active Active
- 2019-03-15 PE PE2020002281A patent/PE20210926A1/es unknown
-
2020
- 2020-09-09 IL IL277252A patent/IL277252A/en unknown
- 2020-09-15 PH PH12020551493A patent/PH12020551493A1/en unknown
- 2020-09-16 CL CL2020002398A patent/CL2020002398A1/es unknown
- 2020-10-06 CO CONC2020/0012484A patent/CO2020012484A2/es unknown
-
2022
- 2022-05-11 US US17/741,989 patent/US20220402891A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20230804T1 (hr) | 2023-11-10 |
| JP2021518337A (ja) | 2021-08-02 |
| TWI818962B (zh) | 2023-10-21 |
| US20220402891A1 (en) | 2022-12-22 |
| ES2953139T3 (es) | 2023-11-08 |
| PL3765447T3 (pl) | 2023-10-16 |
| CO2020012484A2 (es) | 2020-10-30 |
| DK3765447T3 (da) | 2023-08-21 |
| FI3765447T3 (fi) | 2023-08-15 |
| AU2019236248B2 (en) | 2024-01-18 |
| IL277252A (en) | 2020-10-29 |
| SI3765447T1 (sl) | 2023-10-30 |
| AU2019236248A1 (en) | 2020-10-01 |
| CA3093972A1 (en) | 2019-09-19 |
| PT3765447T (pt) | 2023-08-18 |
| SG11202008841VA (en) | 2020-10-29 |
| US11578055B2 (en) | 2023-02-14 |
| BR112020018767A2 (pt) | 2021-01-26 |
| MX2020009645A (es) | 2020-10-08 |
| HUE062455T2 (hu) | 2023-11-28 |
| US20210078974A1 (en) | 2021-03-18 |
| RS64524B1 (sr) | 2023-09-29 |
| JOP20200233A1 (ar) | 2020-09-15 |
| CN112262129A (zh) | 2021-01-22 |
| KR20200133238A (ko) | 2020-11-26 |
| TW202014183A (zh) | 2020-04-16 |
| PE20210926A1 (es) | 2021-05-19 |
| PH12020551493A1 (en) | 2021-09-01 |
| LT3765447T (lt) | 2023-08-10 |
| MA52008A (fr) | 2021-04-21 |
| EP3765447A1 (en) | 2021-01-20 |
| WO2019178510A1 (en) | 2019-09-19 |
| EP3765447B1 (en) | 2023-07-12 |
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