ECSP15012804A - Alcoxipirazoles como activadores de guanilato ciclasa soluble - Google Patents

Alcoxipirazoles como activadores de guanilato ciclasa soluble

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Publication number
ECSP15012804A
ECSP15012804A ECIEPI201512804A ECPI201512804A ECSP15012804A EC SP15012804 A ECSP15012804 A EC SP15012804A EC IEPI201512804 A ECIEPI201512804 A EC IEPI201512804A EC PI201512804 A ECPI201512804 A EC PI201512804A EC SP15012804 A ECSP15012804 A EC SP15012804A
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EC
Ecuador
Prior art keywords
alcoxypyrazoles
compounds
cyclase activators
soluble
guanilate cyclase
Prior art date
Application number
ECIEPI201512804A
Other languages
English (en)
Inventor
Zhonghua Zhang
Michael D Lowe
John David Ginn
Christopher Ronald Sarko
Edward S Tasber
Jehrod Burnett Brenneman
Original Assignee
Gancia S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gancia S P A filed Critical Gancia S P A
Publication of ECSP15012804A publication Critical patent/ECSP15012804A/es

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

La presente invención se refiere a los compuestos de la Fórmula (I): (I) y a sales de estos aceptables desde el punto de vista farmacéutico, en donde R1 , R2, R3, R4, R5, R6 y R7 son como se definen en la presente. La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos, métodos para usar estos compuestos en el tratamiento de varias enfermedades y trastornos, procesos para preparar estos compuestos e intermediarios útiles en estos procesos.
ECIEPI201512804A 2012-09-07 2015-04-02 Alcoxipirazoles como activadores de guanilato ciclasa soluble ECSP15012804A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261697899P 2012-09-07 2012-09-07

Publications (1)

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ECSP15012804A true ECSP15012804A (es) 2015-12-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201512804A ECSP15012804A (es) 2012-09-07 2015-04-02 Alcoxipirazoles como activadores de guanilato ciclasa soluble

Country Status (38)

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US (2) US8906904B2 (es)
EP (1) EP2892891B1 (es)
JP (1) JP5970134B2 (es)
KR (1) KR101692707B1 (es)
CN (1) CN104619695B (es)
AP (1) AP2015008231A0 (es)
AR (1) AR092869A1 (es)
AU (1) AU2013312931B2 (es)
BR (1) BR112015004529B1 (es)
CA (1) CA2880494C (es)
CL (2) CL2015000255A1 (es)
CY (1) CY1122610T1 (es)
DK (1) DK2892891T3 (es)
EA (1) EA027244B1 (es)
EC (1) ECSP15012804A (es)
ES (1) ES2748798T3 (es)
GE (1) GEP20176631B (es)
HK (1) HK1210164A1 (es)
HR (1) HRP20191755T1 (es)
HU (1) HUE046996T2 (es)
IL (1) IL236987A (es)
LT (1) LT2892891T (es)
MA (1) MA37891B1 (es)
MD (1) MD4425C1 (es)
MX (1) MX338887B (es)
NZ (1) NZ703989A (es)
PE (1) PE20151001A1 (es)
PH (1) PH12015500457B1 (es)
PL (1) PL2892891T3 (es)
PT (1) PT2892891T (es)
RS (1) RS59394B1 (es)
SG (2) SG10201510668UA (es)
SI (1) SI2892891T1 (es)
TN (1) TN2015000054A1 (es)
TW (1) TWI586661B (es)
UA (1) UA115881C2 (es)
UY (1) UY35012A (es)
WO (1) WO2014039434A1 (es)

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AU2013312931B2 (en) 2017-06-22
PT2892891T (pt) 2019-11-05
DK2892891T3 (da) 2019-10-14
GEP20176631B (en) 2017-02-27
MD4425B1 (ro) 2016-06-30
RS59394B1 (sr) 2019-11-29
AU2013312931A1 (en) 2015-02-05
HUE046996T2 (hu) 2020-04-28
WO2014039434A1 (en) 2014-03-13
CN104619695B (zh) 2018-04-10
MX338887B (es) 2016-05-04
BR112015004529B1 (pt) 2022-06-21
ES2748798T3 (es) 2020-03-18
AP2015008231A0 (en) 2015-01-31
PH12015500457A1 (en) 2015-04-20
BR112015004529A2 (pt) 2017-07-04
PL2892891T3 (pl) 2020-01-31
TW201422607A (zh) 2014-06-16
MX2015002807A (es) 2015-05-15
NZ703989A (en) 2017-04-28
CA2880494A1 (en) 2014-03-13
JP2015527394A (ja) 2015-09-17
EA027244B1 (ru) 2017-07-31
CN104619695A (zh) 2015-05-13
UY35012A (es) 2014-03-31
CL2015000562A1 (es) 2015-06-12
SI2892891T1 (sl) 2019-11-29
MA37891A1 (fr) 2018-01-31
MD4425C1 (ro) 2017-01-31
EP2892891A1 (en) 2015-07-15
TWI586661B (zh) 2017-06-11
CA2880494C (en) 2021-09-21
US8906904B2 (en) 2014-12-09
LT2892891T (lt) 2020-01-27
EA201500298A1 (ru) 2015-08-31
PH12015500457B1 (en) 2015-04-20
HRP20191755T1 (hr) 2019-12-27
EP2892891B1 (en) 2019-07-31
BR112015004529A8 (pt) 2019-08-27
SG10201510668UA (en) 2016-01-28
AR092869A1 (es) 2015-05-06
MA37891B1 (fr) 2018-05-31
UA115881C2 (uk) 2018-01-10
CY1122610T1 (el) 2021-03-12
MD20150019A2 (ro) 2015-07-31
CL2015000255A1 (es) 2015-05-29
KR20150048765A (ko) 2015-05-07
PE20151001A1 (es) 2015-07-15
USRE46886E1 (en) 2018-06-05
TN2015000054A1 (en) 2016-06-29
JP5970134B2 (ja) 2016-08-17
IL236987A (en) 2017-02-28
US20140073629A1 (en) 2014-03-13
KR101692707B1 (ko) 2017-01-04
SG11201500861QA (en) 2015-04-29

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