ECSP13012548A - Inhibidores de oxadiazol de la producción de leucotrienos. - Google Patents

Inhibidores de oxadiazol de la producción de leucotrienos.

Info

Publication number
ECSP13012548A
ECSP13012548A ECSP13012548A ECSP13012548A EC SP13012548 A ECSP13012548 A EC SP13012548A EC SP13012548 A ECSP13012548 A EC SP13012548A EC SP13012548 A ECSP13012548 A EC SP13012548A
Authority
EC
Ecuador
Prior art keywords
leucotrene
oxadiazol
inhibitors
production
compounds
Prior art date
Application number
Other languages
English (en)
Inventor
Doris Riether
Renee Zindell
Alexandra Bartolozzi
Weimin Liu
Tina Marie Morwick
Zhidong Chen
Todd Bosanac
Lombaert Stephane De
Heather Tye
John D Dines
Pui Leng Loke
Alan Olague
Lifen Wu
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44720163&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012548(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP13012548A publication Critical patent/ECSP13012548A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención se refiere a compuestos de la fórmula (I) y (IA):I IAy sus sales farmacéuticamente aceptables, en donde R1- R5 son tal como se definen en la presente. La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos, métodos de uso de estos compuestos en el tratamiento de diversas enfermedades y trastornos, procesos para preparar estos compuestos e intermediarios de utilidad en estos procesos.
ECSP13012548 2010-09-23 2013-04-11 Inhibidores de oxadiazol de la producción de leucotrienos. ECSP13012548A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38573310P 2010-09-23 2010-09-23
US201161533349P 2011-09-12 2011-09-12

Publications (1)

Publication Number Publication Date
ECSP13012548A true ECSP13012548A (es) 2013-06-28

Family

ID=44720163

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012548 ECSP13012548A (es) 2010-09-23 2013-04-11 Inhibidores de oxadiazol de la producción de leucotrienos.

Country Status (18)

Country Link
US (1) US8575201B2 (es)
EP (1) EP2619197B1 (es)
JP (1) JP5713511B2 (es)
KR (1) KR20130109122A (es)
CN (1) CN103261193A (es)
AU (1) AU2011305667A1 (es)
BR (1) BR112013008638A2 (es)
CA (1) CA2812449A1 (es)
CL (1) CL2013000788A1 (es)
CO (1) CO6710902A2 (es)
EA (1) EA201300389A1 (es)
EC (1) ECSP13012548A (es)
IN (1) IN2013DN02555A (es)
MX (1) MX2013003202A (es)
PE (1) PE20131398A1 (es)
SG (1) SG188604A1 (es)
WO (1) WO2012040139A1 (es)
ZA (1) ZA201301747B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5862669B2 (ja) * 2010-08-26 2016-02-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
PE20131398A1 (es) 2010-09-23 2013-12-19 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos
US8580825B2 (en) * 2010-09-23 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
EP3495359A1 (en) * 2013-02-04 2019-06-12 Janssen Pharmaceutica NV Flap modulators
ES2596248T3 (es) 2013-11-26 2017-01-05 Citrage N-Carbamoilputrescina para mejorar la síntesis de proteínas musculares

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0013014A (pt) 1999-08-06 2002-04-16 Janssen Pharmaceutica Nv Derivados de 6-aza uracila inibindo interleucina-5
JP2007502300A (ja) * 2003-08-13 2007-02-08 カイロン　コーポレイション Ｇｓｋ−３インヒビターおよびその使用
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
DE602005013272D1 (de) 2004-10-18 2009-04-23 Merck & Co Inc Diphenyl-substituierte alkane als flap-inhibitoren
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2007120574A2 (en) 2006-04-11 2007-10-25 Merck & Co., Inc. Diaryl substituted alkanes
EP2452683A3 (en) 2006-06-26 2012-08-22 Amgen Inc. Methods for treating atherosclerosis
AU2007293373A1 (en) * 2006-09-01 2008-03-13 Merck Sharp & Dohme Corp. Inhibitors of 5 -lipoxygenase activating protein (FLAP)
JP2010524861A (ja) 2007-04-20 2010-07-22 メルク フロスト カナダ リミテツド ステアロイル−補酵素ａデルタ−９デサチュラーゼの阻害剤としての新規な複素環式芳香族化合物
EP2546232A1 (en) 2007-06-20 2013-01-16 Merck Sharp & Dohme Corp. Diphenyl Substituted Alkanes
WO2009048547A1 (en) 2007-10-10 2009-04-16 Merck & Co., Inc. Diphenyl substituted cycloalkanes
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
MX2011004570A (es) * 2008-10-31 2011-06-17 Merck Sharp & Dohme Antagonistas del receptor p2x3 para el tratamiento del dolor.
JP2012516885A (ja) 2009-02-04 2012-07-26 ファイザー・インク ４−アミノ−７，８−ジヒドロピリド［４，３−ｄ］ピリミジン−５（６Ｈ）−オン誘導体
MX2012013031A (es) 2010-05-12 2012-12-17 Univ Vanderbilt Potenciadores alostericos mglur4 de sulfona heterociclica, composiciones y metodos para tratar disfuncion neurologica.
EP2606045B1 (en) * 2010-08-16 2016-01-06 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
JP5862669B2 (ja) * 2010-08-26 2016-02-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
US8580825B2 (en) * 2010-09-23 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
PE20131398A1 (es) 2010-09-23 2013-12-19 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos

Also Published As

Publication number Publication date
AU2011305667A1 (en) 2013-03-21
US8575201B2 (en) 2013-11-05
CN103261193A (zh) 2013-08-21
WO2012040139A1 (en) 2012-03-29
PE20131398A1 (es) 2013-12-19
EP2619197A1 (en) 2013-07-31
MX2013003202A (es) 2013-04-24
IN2013DN02555A (es) 2015-08-07
CL2013000788A1 (es) 2013-06-28
KR20130109122A (ko) 2013-10-07
CO6710902A2 (es) 2013-07-15
SG188604A1 (en) 2013-04-30
EP2619197B1 (en) 2015-08-05
JP2013537909A (ja) 2013-10-07
ZA201301747B (en) 2014-08-27
EA201300389A1 (ru) 2013-09-30
CA2812449A1 (en) 2012-03-29
JP5713511B2 (ja) 2015-05-07
BR112013008638A2 (pt) 2016-06-21
US20120295896A1 (en) 2012-11-22

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