HK1210164A1 - Alkoxy pyrazoles as soluble guanylate cyclase activators - Google Patents

Alkoxy pyrazoles as soluble guanylate cyclase activators

Info

Publication number
HK1210164A1
HK1210164A1 HK15110980.4A HK15110980A HK1210164A1 HK 1210164 A1 HK1210164 A1 HK 1210164A1 HK 15110980 A HK15110980 A HK 15110980A HK 1210164 A1 HK1210164 A1 HK 1210164A1
Authority
HK
Hong Kong
Prior art keywords
guanylate cyclase
soluble guanylate
cyclase activators
pyrazoles
alkoxy
Prior art date
Application number
HK15110980.4A
Other languages
English (en)
Chinese (zh)
Inventor
Jehrod Burnett Brenneman
John David Ginn
Michael D Lowe
Christopher Ronald Sarko
Edward S Tasber
Zhonghua Zhang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of HK1210164A1 publication Critical patent/HK1210164A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
HK15110980.4A 2012-09-07 2015-11-06 Alkoxy pyrazoles as soluble guanylate cyclase activators HK1210164A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261697899P 2012-09-07 2012-09-07
PCT/US2013/057826 WO2014039434A1 (en) 2012-09-07 2013-09-03 Alkoxy pyrazoles as soluble guanylate cyclase activators

Publications (1)

Publication Number Publication Date
HK1210164A1 true HK1210164A1 (en) 2016-04-15

Family

ID=49170904

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110980.4A HK1210164A1 (en) 2012-09-07 2015-11-06 Alkoxy pyrazoles as soluble guanylate cyclase activators

Country Status (38)

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US (2) US8906904B2 (xx)
EP (1) EP2892891B1 (xx)
JP (1) JP5970134B2 (xx)
KR (1) KR101692707B1 (xx)
CN (1) CN104619695B (xx)
AP (1) AP2015008231A0 (xx)
AR (1) AR092869A1 (xx)
AU (1) AU2013312931B2 (xx)
BR (1) BR112015004529B1 (xx)
CA (1) CA2880494C (xx)
CL (2) CL2015000255A1 (xx)
CY (1) CY1122610T1 (xx)
DK (1) DK2892891T3 (xx)
EA (1) EA027244B1 (xx)
EC (1) ECSP15012804A (xx)
ES (1) ES2748798T3 (xx)
GE (1) GEP20176631B (xx)
HK (1) HK1210164A1 (xx)
HR (1) HRP20191755T1 (xx)
HU (1) HUE046996T2 (xx)
IL (1) IL236987A (xx)
LT (1) LT2892891T (xx)
MA (1) MA37891B1 (xx)
MD (1) MD4425C1 (xx)
MX (1) MX338887B (xx)
NZ (1) NZ703989A (xx)
PE (1) PE20151001A1 (xx)
PH (1) PH12015500457A1 (xx)
PL (1) PL2892891T3 (xx)
PT (1) PT2892891T (xx)
RS (1) RS59394B1 (xx)
SG (2) SG11201500861QA (xx)
SI (1) SI2892891T1 (xx)
TN (1) TN2015000054A1 (xx)
TW (1) TWI586661B (xx)
UA (1) UA115881C2 (xx)
UY (1) UY35012A (xx)
WO (1) WO2014039434A1 (xx)

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JP5826393B2 (ja) 2011-08-12 2015-12-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 可溶性グアニル酸シクラーゼ活性化因子
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PE20151001A1 (es) * 2012-09-07 2015-07-15 Boehringer Ingelheim Int Alcoxipirazoles como activadores de guanilato ciclasa soluble

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GEP20176631B (en) 2017-02-27
AR092869A1 (es) 2015-05-06
TW201422607A (zh) 2014-06-16
PE20151001A1 (es) 2015-07-15
ECSP15012804A (es) 2015-12-31
EA027244B1 (ru) 2017-07-31
US20140073629A1 (en) 2014-03-13
KR101692707B1 (ko) 2017-01-04
SI2892891T1 (sl) 2019-11-29
AP2015008231A0 (en) 2015-01-31
HUE046996T2 (hu) 2020-04-28
CN104619695B (zh) 2018-04-10
MD4425B1 (ro) 2016-06-30
PH12015500457B1 (en) 2015-04-20
DK2892891T3 (da) 2019-10-14
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PL2892891T3 (pl) 2020-01-31
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UA115881C2 (uk) 2018-01-10
CL2015000255A1 (es) 2015-05-29
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BR112015004529A2 (pt) 2017-07-04
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BR112015004529B1 (pt) 2022-06-21
AU2013312931A1 (en) 2015-02-05
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EA201500298A1 (ru) 2015-08-31
LT2892891T (lt) 2020-01-27
WO2014039434A1 (en) 2014-03-13
MA37891B1 (fr) 2018-05-31
PH12015500457A1 (en) 2015-04-20
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CL2015000562A1 (es) 2015-06-12

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