ECSP13012770A - Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina - Google Patents

Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina

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Publication number
ECSP13012770A
ECSP13012770A ECSP13012770A ECSP13012770A EC SP13012770 A ECSP13012770 A EC SP13012770A EC SP13012770 A ECSP13012770 A EC SP13012770A EC SP13012770 A ECSP13012770 A EC SP13012770A
Authority
EC
Ecuador
Prior art keywords
phenyl
piperidin
diamine
methyl
isopropoxi
Prior art date
Application number
Other languages
English (en)
Inventor
Lili Feng
Piotr Karpinski
Baoqing Gong
Liladhar Murlidhar Waykole
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45464892&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012770(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP13012770A publication Critical patent/ECSP13012770A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención describe formas cristalinas específicas de la 5-cloro-N-(2-isopropoxi-5-metil-4-(piperidin-4-il-fenil)-N-2-(iso-propil-sulfonil)-fenil)-2,4-diamina. La presente invención se refiere además a los métodos para la preparación de estas formas cristalinas, a composiciones farmacéuticas que comprenden dichas formas cristalinas, y a los métodos para utilizar las formas cristalinas y las composiciones farmacéuticas para tratar enfermedades.
ECSP13012770 2010-12-17 2013-07-16 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina ECSP13012770A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17

Publications (1)

Publication Number Publication Date
ECSP13012770A true ECSP13012770A (es) 2013-10-31

Family

ID=45464892

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012770 ECSP13012770A (es) 2010-12-17 2013-07-16 Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina

Country Status (35)

Country Link
US (2) US9309229B2 (es)
EP (3) EP2651918B1 (es)
JP (1) JP5916752B2 (es)
KR (4) KR20130130022A (es)
CN (7) CN114989139A (es)
AR (2) AR084309A1 (es)
AU (1) AU2011343775B2 (es)
BR (1) BR112013015000A2 (es)
CA (1) CA2821102C (es)
CL (1) CL2013001723A1 (es)
CO (1) CO6801792A2 (es)
CY (2) CY1119474T1 (es)
DK (2) DK2651918T3 (es)
EC (1) ECSP13012770A (es)
ES (3) ES2643016T3 (es)
GT (1) GT201300153A (es)
HR (2) HRP20171477T1 (es)
HU (1) HUE041845T2 (es)
IL (1) IL226474A (es)
LT (2) LT2651918T (es)
MA (1) MA34771B1 (es)
MX (1) MX338210B (es)
MY (2) MY177742A (es)
NZ (1) NZ610713A (es)
PE (1) PE20140698A1 (es)
PL (2) PL2651918T3 (es)
PT (2) PT2651918T (es)
RS (1) RS57771B1 (es)
RU (2) RU2746159C2 (es)
SG (2) SG10201510082XA (es)
SI (2) SI2651918T1 (es)
TN (1) TN2013000216A1 (es)
TW (2) TWI576343B (es)
WO (1) WO2012082972A1 (es)
ZA (1) ZA201303599B (es)

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CN105272921A (zh) * 2014-06-09 2016-01-27 江苏奥赛康药业股份有限公司 一种制备Ceritinib的方法及其中间体化合物
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CN105294650A (zh) * 2014-08-01 2016-02-03 江苏奥赛康药业股份有限公司 一种Ceritinib化合物及其药物组合物
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CN105622577A (zh) * 2014-11-29 2016-06-01 江苏先声药业有限公司 一种色瑞替尼的新晶型及其制备方法
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WO2016098042A1 (en) * 2014-12-19 2016-06-23 Novartis Ag Use of ceritinib (ldk-378) in the treatment of fes or fer mediated disorders, in particular proliferative disorders
EP3328848A1 (en) 2015-07-28 2018-06-06 Zentiva, K.S. Solid forms of ceritinib free base
CN105061397B (zh) * 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用
CN106699743B (zh) 2015-11-05 2020-06-12 湖北生物医药产业技术研究院有限公司 嘧啶类衍生物及其用途
WO2017152858A1 (zh) * 2016-03-11 2017-09-14 苏州晶云药物科技有限公司 色瑞替尼的晶型及其制备方法
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JP2019196359A (ja) * 2019-06-17 2019-11-14 ノバルティス アーゲー ピリミジン誘導体およびそれらの中間体を調製する化学的方法
GB201915618D0 (en) 2019-10-28 2019-12-11 Univ Oslo ALK inhibitors for treatment of ALK-negative cancer and antibody-mediated diseases
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EP3328848A1 (en) 2015-07-28 2018-06-06 Zentiva, K.S. Solid forms of ceritinib free base
CN105061397B (zh) 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用

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ZA201303599B (en) 2014-02-26
MY164810A (en) 2018-01-30
LT3121171T (lt) 2018-11-12
US9309229B2 (en) 2016-04-12
TWI576343B (zh) 2017-04-01
CN107056751A (zh) 2017-08-18
AR122395A2 (es) 2022-09-07
CL2013001723A1 (es) 2013-12-27
ES2905973T3 (es) 2022-04-12
NZ610713A (en) 2014-10-31
PE20140698A1 (es) 2014-06-11
CN106008462A (zh) 2016-10-12
AR084309A1 (es) 2013-05-08
PL3121171T3 (pl) 2019-01-31
RU2599785C3 (ru) 2019-04-24
WO2012082972A1 (en) 2012-06-21
TW201307299A (zh) 2013-02-16
AU2011343775A1 (en) 2013-07-18
EP3453708B1 (en) 2021-10-27
EP2651918A1 (en) 2013-10-23
CN106831716A (zh) 2017-06-13
CA2821102A1 (en) 2012-06-21
EP2651918B1 (en) 2017-07-12
SG10201510082XA (en) 2016-01-28
KR20200039021A (ko) 2020-04-14
MA34771B1 (fr) 2013-12-03
AU2011343775B2 (en) 2015-12-03
KR102325775B1 (ko) 2021-11-12
RU2746159C2 (ru) 2021-04-08
JP5916752B2 (ja) 2016-05-11
RU2013132947A (ru) 2015-01-27
RU2016136823A3 (es) 2020-02-06
MY177742A (en) 2020-09-23
LT2651918T (lt) 2017-10-10
RU2016136823A (ru) 2018-12-11
IL226474A (en) 2016-03-31
TWI576344B (zh) 2017-04-01
HUE041845T2 (hu) 2019-05-28
RU2599785C2 (ru) 2016-10-20
KR20180032680A (ko) 2018-03-30
DK3121171T3 (en) 2018-12-10
US20160175305A1 (en) 2016-06-23
SG190856A1 (en) 2013-07-31
CN103282359A (zh) 2013-09-04
GT201300153A (es) 2014-06-09
TW201629021A (zh) 2016-08-16
KR20190022903A (ko) 2019-03-06
HRP20171477T1 (hr) 2017-11-17
EP3453708B8 (en) 2022-03-16
DK2651918T3 (en) 2017-10-23
TN2013000216A1 (en) 2014-11-10
EP3453708A1 (en) 2019-03-13
CY1121017T1 (el) 2019-12-11
PT3121171T (pt) 2018-11-27
PL2651918T3 (pl) 2017-12-29
MX2013006952A (es) 2013-07-15
CA2821102C (en) 2019-06-11
BR112013015000A2 (pt) 2016-08-09
PT2651918T (pt) 2017-10-17
MX338210B (es) 2016-04-07
SI2651918T1 (sl) 2017-10-30
CN104262324A (zh) 2015-01-07
JP2013545812A (ja) 2013-12-26
HRP20181737T1 (hr) 2018-12-28
CN112125884A (zh) 2020-12-25
CO6801792A2 (es) 2013-11-29
EP3121171B1 (en) 2018-08-15
RS57771B1 (sr) 2018-12-31
KR20130130022A (ko) 2013-11-29
ES2643016T3 (es) 2017-11-21
EP3121171A1 (en) 2017-01-25
ES2696526T3 (es) 2019-01-16
CY1119474T1 (el) 2018-04-04
US20130274279A1 (en) 2013-10-17
CN114989139A (zh) 2022-09-02
SI3121171T1 (sl) 2018-11-30
IL226474A0 (en) 2013-07-31

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