ECSP13012437A - Inhibidores de la tirosina-quinasa de bruton - Google Patents
Inhibidores de la tirosina-quinasa de brutonInfo
- Publication number
- ECSP13012437A ECSP13012437A ECSP13012437A ECSP13012437A EC SP13012437 A ECSP13012437 A EC SP13012437A EC SP13012437 A ECSP13012437 A EC SP13012437A EC SP13012437 A ECSP13012437 A EC SP13012437A
- Authority
- EC
- Ecuador
- Prior art keywords
- btk
- compounds
- useful
- tirosina
- quinasa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Esta solicitud se refiere a derivados de la 6-(2-hidroximetil-fenil)-2-metil-2H-piridazin-3-ona que se ajustan a la fórmula general I:en la que las variables X, R e Y4 tienen los significados aquí definidos, que inhiben la Btk. Los compuestos aquí descritos son útiles para modular la actividad de la Btk y para tratar enfermedades asociadas con una actividad excesiva de la Btk. Los compuestos son también útiles para tratar enfermedades inflamatorias y autoinmunes asociadas con una proliferación aberrante de las células B, por ejemplo la artritis reumatoide. Se describen también composiciones que contienen los compuestos de la fórmula I y por lo menos un vehículo, diluyente o excipiente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37288710P | 2010-08-12 | 2010-08-12 | |
US201161497093P | 2011-06-15 | 2011-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP13012437A true ECSP13012437A (es) | 2013-03-28 |
Family
ID=45565273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP13012437 ECSP13012437A (es) | 2010-08-12 | 2013-02-08 | Inhibidores de la tirosina-quinasa de bruton |
Country Status (21)
Country | Link |
---|---|
US (2) | US8481540B2 (es) |
EP (1) | EP2603500B1 (es) |
JP (1) | JP5823518B2 (es) |
KR (1) | KR101546167B1 (es) |
CN (1) | CN103153984B (es) |
AR (1) | AR082590A1 (es) |
AU (1) | AU2011288489A1 (es) |
BR (1) | BR112013003114A2 (es) |
CA (1) | CA2807634A1 (es) |
CL (1) | CL2013000391A1 (es) |
CO (1) | CO6620025A2 (es) |
EA (1) | EA201390207A1 (es) |
EC (1) | ECSP13012437A (es) |
ES (1) | ES2528371T3 (es) |
HK (1) | HK1186186A1 (es) |
MA (1) | MA34465B1 (es) |
MX (1) | MX2013001715A (es) |
PE (1) | PE20131153A1 (es) |
SG (1) | SG187747A1 (es) |
WO (1) | WO2012020008A1 (es) |
ZA (1) | ZA201300705B (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
DE102007061963A1 (de) * | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
MX2011006682A (es) | 2008-12-22 | 2011-07-13 | Merck Patent Gmbh | Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion. |
EP2709997B1 (en) | 2011-05-17 | 2016-06-29 | F.Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
EP2744804B1 (en) * | 2011-08-17 | 2017-05-17 | F. Hoffmann-La Roche AG | Inhibitors of bruton's tyrosine kinase |
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UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
AR088642A1 (es) | 2011-11-03 | 2014-06-25 | Genentech Inc | Compuestos de piperazina alquilados |
JP6258928B2 (ja) | 2012-06-13 | 2018-01-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン |
CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
AU2013299557B2 (en) | 2012-08-10 | 2017-06-22 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as Bruton's tyrosine kinase (BTK) inhibitors |
RU2015111133A (ru) * | 2012-09-13 | 2016-11-10 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы брутона |
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CA2891634A1 (en) * | 2012-11-30 | 2014-06-05 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
MX2015010983A (es) * | 2013-03-05 | 2015-10-26 | Hoffmann La Roche | Inhibidores de tirosina-cinasa de bruton. |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
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MA42918A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
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JP7402685B2 (ja) | 2016-08-16 | 2023-12-21 | ベイジーン スウィッツァーランド ゲーエムベーハー | (s)-7-(1-アクリロイルピペリジン-4-イル)-2-(4-フェノキシフェニル)-4,5,6,7-テトラ-ヒドロピラゾロ[1,5-a]ピリミジン-3-カルボキサミドの結晶形、その調製、及びその使用 |
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US7683064B2 (en) * | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
ES2420846T3 (es) * | 2008-02-05 | 2013-08-27 | F. Hoffmann-La Roche Ag | Nuevas piridinonas y piridazinonas |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
PE20100851A1 (es) * | 2008-06-24 | 2011-01-31 | Hoffmann La Roche | PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk |
EP2300459B1 (en) * | 2008-07-02 | 2013-05-29 | F. Hoffmann-La Roche AG | Novel phenylpyrazinones as kinase inhibitors |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
CN102292329B (zh) * | 2009-04-24 | 2014-09-03 | 霍夫曼-拉罗奇有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
CN103201277B (zh) * | 2010-09-01 | 2015-11-25 | 吉利德康涅狄格有限公司 | 哒嗪酮、其制备方法及使用方法 |
EP2709997B1 (en) * | 2011-05-17 | 2016-06-29 | F.Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
-
2011
- 2011-08-08 AR ARP110102870A patent/AR082590A1/es unknown
- 2011-08-09 CA CA2807634A patent/CA2807634A1/en not_active Abandoned
- 2011-08-09 JP JP2013523591A patent/JP5823518B2/ja not_active Expired - Fee Related
- 2011-08-09 ES ES11746518.7T patent/ES2528371T3/es active Active
- 2011-08-09 KR KR1020137006162A patent/KR101546167B1/ko not_active IP Right Cessation
- 2011-08-09 SG SG2013009246A patent/SG187747A1/en unknown
- 2011-08-09 AU AU2011288489A patent/AU2011288489A1/en not_active Abandoned
- 2011-08-09 MA MA35658A patent/MA34465B1/fr unknown
- 2011-08-09 EA EA201390207A patent/EA201390207A1/ru unknown
- 2011-08-09 BR BR112013003114A patent/BR112013003114A2/pt active Search and Examination
- 2011-08-09 CN CN201180048444.7A patent/CN103153984B/zh not_active Expired - Fee Related
- 2011-08-09 EP EP11746518.7A patent/EP2603500B1/en not_active Not-in-force
- 2011-08-09 WO PCT/EP2011/063657 patent/WO2012020008A1/en active Application Filing
- 2011-08-09 MX MX2013001715A patent/MX2013001715A/es unknown
- 2011-08-09 PE PE2013000232A patent/PE20131153A1/es not_active Application Discontinuation
- 2011-08-11 US US13/207,481 patent/US8481540B2/en not_active Expired - Fee Related
-
2013
- 2013-01-25 ZA ZA2013/00705A patent/ZA201300705B/en unknown
- 2013-01-31 CO CO13018558A patent/CO6620025A2/es not_active Application Discontinuation
- 2013-02-08 CL CL2013000391A patent/CL2013000391A1/es unknown
- 2013-02-08 EC ECSP13012437 patent/ECSP13012437A/es unknown
- 2013-03-01 US US13/781,815 patent/US8940741B2/en not_active Expired - Fee Related
- 2013-12-10 HK HK13113723.2A patent/HK1186186A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA201300705B (en) | 2014-06-25 |
JP2013533300A (ja) | 2013-08-22 |
PE20131153A1 (es) | 2013-10-05 |
EA201390207A1 (ru) | 2013-08-30 |
EP2603500B1 (en) | 2014-11-19 |
CN103153984A (zh) | 2013-06-12 |
KR20130038420A (ko) | 2013-04-17 |
WO2012020008A1 (en) | 2012-02-16 |
AU2011288489A1 (en) | 2013-02-07 |
EP2603500A1 (en) | 2013-06-19 |
CO6620025A2 (es) | 2013-02-15 |
US8940741B2 (en) | 2015-01-27 |
MA34465B1 (fr) | 2013-08-01 |
CL2013000391A1 (es) | 2013-09-23 |
US20130178461A1 (en) | 2013-07-11 |
CN103153984B (zh) | 2015-04-22 |
KR101546167B1 (ko) | 2015-08-20 |
ES2528371T3 (es) | 2015-02-09 |
MX2013001715A (es) | 2013-03-22 |
JP5823518B2 (ja) | 2015-11-25 |
US8481540B2 (en) | 2013-07-09 |
BR112013003114A2 (pt) | 2016-06-28 |
US20120040949A1 (en) | 2012-02-16 |
HK1186186A1 (en) | 2014-03-07 |
CA2807634A1 (en) | 2012-02-16 |
SG187747A1 (en) | 2013-03-28 |
AR082590A1 (es) | 2012-12-19 |
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