MX2015010983A - Inhibidores de tirosina-cinasa de bruton. - Google Patents

Inhibidores de tirosina-cinasa de bruton.

Info

Publication number
MX2015010983A
MX2015010983A MX2015010983A MX2015010983A MX2015010983A MX 2015010983 A MX2015010983 A MX 2015010983A MX 2015010983 A MX2015010983 A MX 2015010983A MX 2015010983 A MX2015010983 A MX 2015010983A MX 2015010983 A MX2015010983 A MX 2015010983A
Authority
MX
Mexico
Prior art keywords
compounds
btk
bruton
inhibitors
tyrosine kinase
Prior art date
Application number
MX2015010983A
Other languages
English (en)
Inventor
Francisco Javier Lopez-Tapia
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015010983A publication Critical patent/MX2015010983A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Esta solicitud describe compuestos de acuerdo con la fórmula genérica (I) ; en donde todas las variables se definen como de describe en la presente, que inhiben BTK. Los compuestos descritos en la presente son útiles para modular la actividad de BTK y para tratar enfermedades asociadas con actividad excesiva de BTK. Los compuestos son además útiles para tratar enfermedades inflamatorias y autoinmunitarias asociadas con proliferación anormal de células B, tal como artritis reumatoide. También se describen composiciones que contienen compuestos de la fórmula I y al menos un portador diluyente o excipiente.
MX2015010983A 2013-03-05 2014-03-03 Inhibidores de tirosina-cinasa de bruton. MX2015010983A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361772954P 2013-03-05 2013-03-05
PCT/EP2014/054018 WO2014135474A1 (en) 2013-03-05 2014-03-03 Inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
MX2015010983A true MX2015010983A (es) 2015-10-26

Family

ID=50190455

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015010983A MX2015010983A (es) 2013-03-05 2014-03-03 Inhibidores de tirosina-cinasa de bruton.

Country Status (11)

Country Link
US (1) US9663494B2 (es)
EP (1) EP2964642B1 (es)
JP (1) JP2016510051A (es)
KR (1) KR101763504B1 (es)
CN (1) CN105143215B (es)
BR (1) BR112015021806A2 (es)
CA (1) CA2903137C (es)
HK (1) HK1218416A1 (es)
MX (1) MX2015010983A (es)
RU (1) RU2015141360A (es)
WO (1) WO2014135474A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015006162A (es) * 2012-11-16 2015-08-14 Hoffmann La Roche Inhibidores de la tirosina-cinasa de bruton.
CA3001484A1 (en) 2015-10-19 2017-04-27 Board Of Regents, The University Of Texas System Piperazinyl norbenzomorphan compounds and methods for using the same
WO2017190109A1 (en) * 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Sigma receptor binders
US11100492B2 (en) 2018-02-19 2021-08-24 Peter Garrett General purpose re-loadable card aggregation implementation
BR112020020832A2 (pt) 2018-04-13 2021-01-19 Cancer Research Technology Limited Inibidores de bcl6
JP2024503237A (ja) * 2020-12-20 2024-01-25 グアンジョウ・ルペン・ファーマシューティカル・カンパニー・リミテッド Ｂｔｋ分解誘導薬
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2499017T3 (es) * 2007-10-23 2014-09-26 F. Hoffmann-La Roche Ag Nuevos inhibidores de quinasa
MX2010008197A (es) * 2008-02-05 2010-08-23 Hoffmann La Roche Nuevas piridinonas y piridazinonas.
US8299077B2 (en) * 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
SG175287A1 (en) * 2009-04-24 2011-11-28 Hoffmann La Roche Inhibitors of bruton's tyrosine kinase
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
CA2881761A1 (en) * 2012-09-13 2014-03-20 Christine E. Brotherton-Pleiss Inhibitors of bruton's tyrosine kinase
BR112015010121A2 (pt) * 2012-11-30 2017-07-11 Hoffmann La Roche inibidores de quinase de tirosina de bruton

Also Published As

Publication number Publication date
CN105143215A (zh) 2015-12-09
EP2964642A1 (en) 2016-01-13
CN105143215B (zh) 2017-12-08
KR20150119944A (ko) 2015-10-26
US9663494B2 (en) 2017-05-30
JP2016510051A (ja) 2016-04-04
RU2015141360A (ru) 2017-04-10
US20150376166A1 (en) 2015-12-31
CA2903137C (en) 2017-07-18
EP2964642B1 (en) 2017-11-15
BR112015021806A2 (pt) 2017-07-18
WO2014135474A1 (en) 2014-09-12
HK1218416A1 (zh) 2017-02-17
KR101763504B1 (ko) 2017-07-31
CA2903137A1 (en) 2014-09-12

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