ECSP12012322A - Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico - Google Patents

Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico

Info

Publication number
ECSP12012322A
ECSP12012322A ECSP12012322A ECSP12012322A EC SP12012322 A ECSP12012322 A EC SP12012322A EC SP12012322 A ECSP12012322 A EC SP12012322A EC SP12012322 A ECSP12012322 A EC SP12012322A
Authority
EC
Ecuador
Prior art keywords
alkyl
cycloalkyl
group
therapeutic use
optionally substituted
Prior art date
Application number
Other languages
English (en)
Inventor
Frank Marguet
Combes Sylvain Cote-Des
Jacques Froissant
Jean-François Gibert
Christophe Pacaud
Frèdéric Puech
Antoine Ravet
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697541&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12012322(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP12012322A publication Critical patent/ECSP12012322A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Compuestos que responden a la fórmula general (I) en la que R2 representa un grupo alquilo-C1-10, cicloalquilo-C3-10, cicloalquil-C3-7-alquilo-C1-6, alquilo-C1-6-cicloalquilo-C3-7, cicloalquil-C3-7-cicloalquilo-C3-7, alquiltio-C1-6-alquilo-C-1-10, alcoxi-C1-6-alquilo-C1-10, hidroxi-alquilo-C1-10, hidroxi-alquil-C1-6-cicloalquil-C3-7-alquilo-C1-6, hidroxi-cicloalquilo-C3-10, fluoroalquilo-C1-10, fluorocicloalquilo-C3-10; un grupo heterocíclico sustituido opcionalmente; un grupo alquilo-C1-10 sustituido con un grupo heterocíclico sustituido opcionalmente; X6 representa un grupo elegido entre el átomo de hidrógeno, de flúor, de cloro o de bromo o un grupo alquilo-C1-6, cicloalquilo-C3 7, cicloalquil-C3-7-alquilo-C1-6, fluoroalquilo-C1-6 o ciano; y R7 representa un grupo arilo tal como fenilo o naftilo, sustituidos opcionalmente con uno o varios sustituyentes en el estado de base o de sal de adición a un ácido. Uso terapéutico.
ECSP12012322 2010-06-03 2012-12-03 Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico ECSP12012322A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1054372A FR2960876B1 (fr) 2010-06-03 2010-06-03 Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ECSP12012322A true ECSP12012322A (es) 2013-03-28

Family

ID=42697541

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12012322 ECSP12012322A (es) 2010-06-03 2012-12-03 Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico

Country Status (38)

Country Link
US (2) US8791119B2 (es)
EP (1) EP2588480B1 (es)
JP (1) JP5995841B2 (es)
KR (1) KR20130113928A (es)
CN (1) CN103168041B (es)
AR (1) AR081832A1 (es)
AU (1) AU2011268651B2 (es)
BR (1) BR112012030697A2 (es)
CA (1) CA2801154C (es)
CL (1) CL2012003360A1 (es)
CO (1) CO6602113A2 (es)
CR (1) CR20120595A (es)
CY (1) CY1118512T1 (es)
DK (1) DK2588480T3 (es)
DO (1) DOP2012000296A (es)
EA (1) EA201291364A1 (es)
EC (1) ECSP12012322A (es)
ES (1) ES2603420T3 (es)
FR (1) FR2960876B1 (es)
GT (1) GT201200319A (es)
HR (1) HRP20161494T1 (es)
HU (1) HUE030650T2 (es)
IL (1) IL223364A (es)
LT (1) LT2588480T (es)
MA (1) MA34360B1 (es)
MX (1) MX2012014084A (es)
NI (1) NI201200176A (es)
NZ (1) NZ603947A (es)
PE (1) PE20130259A1 (es)
PL (1) PL2588480T3 (es)
PT (1) PT2588480T (es)
SG (1) SG186143A1 (es)
SI (1) SI2588480T1 (es)
TN (1) TN2012000520A1 (es)
TW (1) TWI487707B (es)
UY (1) UY33428A (es)
WO (1) WO2011161537A2 (es)
ZA (1) ZA201209071B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
TW201605859A (zh) 2013-11-14 2016-02-16 必治妥美雅史谷比公司 作為酪蛋白激酶１δ／ε抑制劑之新穎經取代之吡唑并－哌
JP6307989B2 (ja) * 2014-04-02 2018-04-11 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
WO2018189214A1 (en) * 2017-04-12 2018-10-18 F. Hoffmann-La Roche Ag A method for labeling of aldehyde containing target molecules
JP2020528062A (ja) * 2017-07-27 2020-09-17 江蘇恒瑞医薬股▲ふん▼有限公司 ピペラジンヘテロアリール誘導体、その製造方法、およびその医薬での使用
WO2024002157A1 (en) * 2022-06-29 2024-01-04 Insilico Medicine Ip Limited Inhibitors of fgfr2 and fgfr3 and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ513096A (en) 1999-02-01 2003-01-31 Univ Virginia Compositions for treating inflammatory response
NZ531378A (en) * 2001-09-19 2006-11-30 Aventis Pharma S Indolizines as kinase protein inhibitors suitable for treating solid tumours
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
WO2005061498A1 (en) * 2003-12-11 2005-07-07 Aventis Pharmaceuticals Inc. Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon
GB0328900D0 (en) 2003-12-12 2004-01-14 Glaxo Group Ltd Novel compounds
US8304408B2 (en) * 2007-05-24 2012-11-06 The Regents Of The University Of California Wnt signaling inhibitors, and methods for making and using them
ATE512968T1 (de) * 2007-07-27 2011-07-15 Sanofi Aventis 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung
EP2229395A1 (en) * 2008-01-17 2010-09-22 Grünenthal GmbH Substituted sulfonamide derivatives
US20090192147A1 (en) * 2008-01-30 2009-07-30 Wyeth [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
KR20130113928A (ko) 2013-10-16
ZA201209071B (en) 2014-02-26
SI2588480T1 (sl) 2016-12-30
FR2960876A1 (fr) 2011-12-09
HRP20161494T1 (hr) 2016-12-16
DOP2012000296A (es) 2013-02-28
IL223364A (en) 2015-06-30
LT2588480T (lt) 2016-12-12
AU2011268651B2 (en) 2016-09-01
AR081832A1 (es) 2012-10-24
FR2960876B1 (fr) 2012-07-27
CA2801154C (en) 2018-01-09
GT201200319A (es) 2014-01-17
US9233965B2 (en) 2016-01-12
PT2588480T (pt) 2016-11-21
WO2011161537A3 (en) 2012-03-01
EA201291364A1 (ru) 2013-05-30
HUE030650T2 (en) 2017-05-29
US20140336189A1 (en) 2014-11-13
UY33428A (es) 2011-12-30
WO2011161537A2 (en) 2011-12-29
CL2012003360A1 (es) 2013-04-01
MX2012014084A (es) 2013-01-29
JP2013527226A (ja) 2013-06-27
US20130090340A1 (en) 2013-04-11
CN103168041B (zh) 2015-08-26
CA2801154A1 (en) 2011-12-29
ES2603420T3 (es) 2017-02-27
CO6602113A2 (es) 2013-01-18
EP2588480B1 (en) 2016-08-17
EP2588480A2 (en) 2013-05-08
TWI487707B (zh) 2015-06-11
JP5995841B2 (ja) 2016-09-21
PE20130259A1 (es) 2013-03-22
NI201200176A (es) 2013-02-06
AU2011268651A1 (en) 2012-12-20
CN103168041A (zh) 2013-06-19
DK2588480T3 (en) 2016-12-12
TW201202248A (en) 2012-01-16
US8791119B2 (en) 2014-07-29
NZ603947A (en) 2014-12-24
TN2012000520A1 (en) 2014-04-01
SG186143A1 (en) 2013-01-30
CR20120595A (es) 2013-01-03
CY1118512T1 (el) 2017-07-12
MA34360B1 (fr) 2013-07-03
BR112012030697A2 (pt) 2019-09-24
PL2588480T3 (pl) 2017-08-31

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