CY1118512T1 - Παραγωγα 3,4-διϋδροπυρρολο[1,2-α]πυραζινο-2,8(1η)-δικαρβοξαμιδιου, παρασκευη αυτων και θεραπευτικη χρηση αυτων - Google Patents
Παραγωγα 3,4-διϋδροπυρρολο[1,2-α]πυραζινο-2,8(1η)-δικαρβοξαμιδιου, παρασκευη αυτων και θεραπευτικη χρηση αυτωνInfo
- Publication number
- CY1118512T1 CY1118512T1 CY20161101179T CY161101179T CY1118512T1 CY 1118512 T1 CY1118512 T1 CY 1118512T1 CY 20161101179 T CY20161101179 T CY 20161101179T CY 161101179 T CY161101179 T CY 161101179T CY 1118512 T1 CY1118512 T1 CY 1118512T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- cycloalkyl
- group
- therapeutic use
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Ενώσεις οι οποίες αντιστοιχούν στον γενικό τύπο (I) όπου το R2 αντιπροσωπεύει μια ομάδα C1-10-αλκυλ, C3-10- κυκλοαλκυλ, C3-7-κυκλοαλκυλ-C1-6-αλκυλ, C1-6-αλκυλ-C3-7-κυκλοαλκυλ, C3-7-κυκλοαλκυλ-C3-7-κυκλοαλκυλ, C1-6-αλκυλθειο-C-1-10-αλκυλ, C1-6-αλκοξυ-C1-10-αλκυλ, υδροξυ-C1-10-αλκυλ, υδροξυ-C1-6-αλκυλ-C3-7-κυκλοαλκυλ-C1-6αλκυλ, υδροξυ-C3-10-κυκλοαλκυλ, C1-10-φθοροαλκυλ ή C3-10-φθοροκυκλοαλκυλ, μια προαιρετικώς υποκατεστημένη ετεροκυκλική ομάδα, μια ομάδα C1-10-αλκυλ υποκατεστημένη με μια προαιρετικώς υποκατεστημένη ετεροκυκλική ομάδα, το Xe αντιπροσωπεύει μια ομάδα η οποία επιλέγεται από άτομα υδρογόνου, φθορίου, χλωρίου και βρωμίου ή μια ομάδα C1-6-αλκυλ, C3-7-κυκλοαλκυλ, C3-7- κυκλοαλκυλ-C1-6-αλκυλ, C1-6-φθοροαλκυλ ή κυανό, και το R7 αντιπροσωπεύει μια αρυλ ομάδα όπως φαινυλ ή ναφθυλ, προαιρετικώς υποκατεστημένη με έναν ή περισσότερους υποκαταστάτες, στη μορφή της βάσης ή ενός άλατος προσθήκης οξέος. Θεραπευτική χρήση.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1054372A FR2960876B1 (fr) | 2010-06-03 | 2010-06-03 | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
| PCT/IB2011/001594 WO2011161537A2 (en) | 2010-06-03 | 2011-06-01 | 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118512T1 true CY1118512T1 (el) | 2017-07-12 |
Family
ID=42697541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101179T CY1118512T1 (el) | 2010-06-03 | 2016-11-16 | Παραγωγα 3,4-διϋδροπυρρολο[1,2-α]πυραζινο-2,8(1η)-δικαρβοξαμιδιου, παρασκευη αυτων και θεραπευτικη χρηση αυτων |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US8791119B2 (el) |
| EP (1) | EP2588480B1 (el) |
| JP (1) | JP5995841B2 (el) |
| KR (1) | KR20130113928A (el) |
| CN (1) | CN103168041B (el) |
| AR (1) | AR081832A1 (el) |
| AU (1) | AU2011268651B2 (el) |
| BR (1) | BR112012030697A2 (el) |
| CA (1) | CA2801154C (el) |
| CL (1) | CL2012003360A1 (el) |
| CO (1) | CO6602113A2 (el) |
| CR (1) | CR20120595A (el) |
| CY (1) | CY1118512T1 (el) |
| DK (1) | DK2588480T3 (el) |
| DO (1) | DOP2012000296A (el) |
| EA (1) | EA201291364A1 (el) |
| EC (1) | ECSP12012322A (el) |
| ES (1) | ES2603420T3 (el) |
| FR (1) | FR2960876B1 (el) |
| GT (1) | GT201200319A (el) |
| HR (1) | HRP20161494T1 (el) |
| HU (1) | HUE030650T2 (el) |
| IL (1) | IL223364A (el) |
| LT (1) | LT2588480T (el) |
| MA (1) | MA34360B1 (el) |
| MX (1) | MX2012014084A (el) |
| NI (1) | NI201200176A (el) |
| NZ (1) | NZ603947A (el) |
| PE (1) | PE20130259A1 (el) |
| PL (1) | PL2588480T3 (el) |
| PT (1) | PT2588480T (el) |
| SG (1) | SG186143A1 (el) |
| SI (1) | SI2588480T1 (el) |
| TN (1) | TN2012000520A1 (el) |
| TW (1) | TWI487707B (el) |
| UY (1) | UY33428A (el) |
| WO (1) | WO2011161537A2 (el) |
| ZA (1) | ZA201209071B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2960876B1 (fr) * | 2010-06-03 | 2012-07-27 | Sanofi Aventis | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
| UY35834A (es) * | 2013-11-14 | 2015-05-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Piperazinas de pirazolo sustituido como inhibidores de caseína quinasa 1 delta y epsilon |
| JP6307989B2 (ja) * | 2014-04-02 | 2018-04-11 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
| CN110709523B (zh) * | 2017-04-12 | 2023-07-11 | 豪夫迈·罗氏有限公司 | 使用经pictet spengler反应获得的加标签的核苷的测序反应方法 |
| JP2020528062A (ja) * | 2017-07-27 | 2020-09-17 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ピペラジンヘテロアリール誘導体、その製造方法、およびその医薬での使用 |
| TW202412758A (zh) * | 2022-06-29 | 2024-04-01 | 香港商英矽智能科技知識產權有限公司 | Fgfr2與fgfr3抑制劑及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1150991B1 (en) | 1999-02-01 | 2004-04-07 | University of Virginia Patent Foundation | Compositions for treating inflammatory response |
| MXPA04002243A (es) * | 2001-09-19 | 2004-06-29 | Aventis Pharma Sa | Compuestos quimicos. |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| ATE428711T1 (de) | 2003-12-11 | 2009-05-15 | Aventis Pharma Inc | Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3- cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i- epsilon |
| GB0328900D0 (en) | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
| US8304408B2 (en) * | 2007-05-24 | 2012-11-06 | The Regents Of The University Of California | Wnt signaling inhibitors, and methods for making and using them |
| NZ582871A (en) | 2007-07-27 | 2011-09-30 | Sanofi Aventis | 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide and 2,3,4,5- tetrahydropyrrolo[1,2-a][1,4]-diazepine-7-carboxamide derivatives, preparation and therapeutic use thereof |
| EP2229395A1 (en) * | 2008-01-17 | 2010-09-22 | Grünenthal GmbH | Substituted sulfonamide derivatives |
| WO2009097515A2 (en) * | 2008-01-30 | 2009-08-06 | Wyeth | [a]-fused indole compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| FR2960876B1 (fr) * | 2010-06-03 | 2012-07-27 | Sanofi Aventis | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
-
2010
- 2010-06-03 FR FR1054372A patent/FR2960876B1/fr not_active Expired - Fee Related
-
2011
- 2011-06-01 BR BR112012030697A patent/BR112012030697A2/pt not_active IP Right Cessation
- 2011-06-01 DK DK11781590.2T patent/DK2588480T3/en active
- 2011-06-01 KR KR1020127031424A patent/KR20130113928A/ko active Search and Examination
- 2011-06-01 LT LTEP11781590.2T patent/LT2588480T/lt unknown
- 2011-06-01 MX MX2012014084A patent/MX2012014084A/es active IP Right Grant
- 2011-06-01 EA EA201291364A patent/EA201291364A1/ru unknown
- 2011-06-01 EP EP11781590.2A patent/EP2588480B1/en active Active
- 2011-06-01 CN CN201180038277.8A patent/CN103168041B/zh not_active Expired - Fee Related
- 2011-06-01 NZ NZ603947A patent/NZ603947A/en not_active IP Right Cessation
- 2011-06-01 JP JP2013513006A patent/JP5995841B2/ja not_active Expired - Fee Related
- 2011-06-01 SG SG2012088795A patent/SG186143A1/en unknown
- 2011-06-01 ES ES11781590.2T patent/ES2603420T3/es active Active
- 2011-06-01 MA MA35524A patent/MA34360B1/fr unknown
- 2011-06-01 HU HUE11781590A patent/HUE030650T2/en unknown
- 2011-06-01 PE PE2012002257A patent/PE20130259A1/es not_active Application Discontinuation
- 2011-06-01 AU AU2011268651A patent/AU2011268651B2/en not_active Ceased
- 2011-06-01 CA CA2801154A patent/CA2801154C/en not_active Expired - Fee Related
- 2011-06-01 SI SI201131022A patent/SI2588480T1/sl unknown
- 2011-06-01 PL PL11781590T patent/PL2588480T3/pl unknown
- 2011-06-01 WO PCT/IB2011/001594 patent/WO2011161537A2/en active Application Filing
- 2011-06-01 PT PT117815902T patent/PT2588480T/pt unknown
- 2011-06-02 AR ARP110101901A patent/AR081832A1/es not_active Application Discontinuation
- 2011-06-03 TW TW100119696A patent/TWI487707B/zh not_active IP Right Cessation
- 2011-06-03 UY UY0001033428A patent/UY33428A/es unknown
-
2012
- 2012-10-31 TN TNP2012000520A patent/TN2012000520A1/en unknown
- 2012-11-22 DO DO2012000296A patent/DOP2012000296A/es unknown
- 2012-11-26 CR CR20120595A patent/CR20120595A/es unknown
- 2012-11-27 GT GT201200319A patent/GT201200319A/es unknown
- 2012-11-29 IL IL223364A patent/IL223364A/en not_active IP Right Cessation
- 2012-11-29 US US13/688,916 patent/US8791119B2/en not_active Expired - Fee Related
- 2012-11-30 NI NI201200176A patent/NI201200176A/es unknown
- 2012-11-30 CL CL2012003360A patent/CL2012003360A1/es unknown
- 2012-11-30 ZA ZA2012/09071A patent/ZA201209071B/en unknown
- 2012-12-03 CO CO12218640A patent/CO6602113A2/es active IP Right Grant
- 2012-12-03 EC ECSP12012322 patent/ECSP12012322A/es unknown
-
2014
- 2014-07-23 US US14/339,112 patent/US9233965B2/en not_active Expired - Fee Related
-
2016
- 2016-11-11 HR HRP20161494TT patent/HRP20161494T1/hr unknown
- 2016-11-16 CY CY20161101179T patent/CY1118512T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1118512T1 (el) | Παραγωγα 3,4-διϋδροπυρρολο[1,2-α]πυραζινο-2,8(1η)-δικαρβοξαμιδιου, παρασκευη αυτων και θεραπευτικη χρηση αυτων | |
| CY1123626T1 (el) | Ετεροκυκλικοι αναστολεις πρωτεϊνικης κινασης | |
| CY1119534T1 (el) | Παραγωγα φωσφορου ως αναστολεις κινασης | |
| CY1123407T1 (el) | Σταθερες υδατικες φαρμακοτεχνικες μορφες της αδαλιμουμαμπης | |
| CY1117374T1 (el) | Παραγωγα ιμιδαζοπυριδινης, διαδικασια για την παρασκευη αυτων και θεραπευτικη χρηση αυτων | |
| CY1121468T1 (el) | Συνδυασμος παραγωγων πυρρολο[2,3-d]πυριμιδινης με εναν ή περισσοτερους επιπροσθετους παραγοντες ως αναστολεις των σχετικων me janus (ιανος) kinασων (jak) | |
| CY1119049T1 (el) | Υποκατεστημενα πυρρολιδινο-2-καρβοξαμιδια | |
| CY1118129T1 (el) | 5-αλκυνυλ-πυριμιδινες | |
| CY1117197T1 (el) | Ενωσεις τριαζολοπυριδινης ως αναστολεις της κινασης ριμ | |
| CY1110232T1 (el) | Παραγωγα 2-αρυλ-6-φαινυλ-ιμιδαζο[1,2-α]πυριδιν, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη αγωγη | |
| CY1114539T1 (el) | Η χρησιμοτητα των ιμιδαζοπυριδαζινοκαρβονιτριλιων ως αναστολεων κινασων | |
| RS54840B1 (sr) | 1-(3,3-dimetilbutil)-3-(2-fluoro-4-metil-5-(7-metil-2-(metilamino)pirido(2,3-d)pirimidin-6-il)fenil)urea kao inhibitor raf kinaze za tretman kancera | |
| CO6950483A2 (es) | 5,7-imidazo[1,2-c]pirimidinas sustituidas | |
| ECSP088145A (es) | Derivados bicíclicos como inhibidores de la cinasa p38 | |
| CY1113549T1 (el) | Πολυυποκατεστημενα παραγωγα των 2-αρυλο-6-φαινυλ-ιμιδαζο[1,2-α]πυριδινων, η παρασκευη τους και η θεραπευτικη εφαρμογη τους | |
| HN2010000432A (es) | Derivados de 2-alquiltio-2-quinoliniloxi-acetamida como fungicidas | |
| ECSP099786A (es) | Pirazol amidas de ácido carboxílico útiles como microbicidas | |
| NI201200191A (es) | Derivados de indolizina, su procedimiento de preparación y su aplicación en terapéutica | |
| MX2015003538A (es) | Derivados de 3-fenilisoxazolina con accion herbicida. | |
| EA201390199A1 (ru) | 2-замещенные-8-алкил-7-оксо-7,8-дигидропиридо[2,3-d]пиримидин-6-карбонитрилы и их применение | |
| ECSP11011206A (es) | Nuevos herbicidas. | |
| UY32553A (es) | Nuevos derivados de la pirrolidinadiona espiroheterocíclicos 3-sustituidos | |
| CY1125082T1 (el) | Υποκατεστημενα τριαζολια και μεθοδοι που σχετιζονται με αυτα | |
| EA201491376A1 (ru) | Производные 1h-пирроло[2,3-b]пиридина и их применение в качестве ингибиторов киназы | |
| UY32667A (es) | Nuevos derivados de furano espiroheterocíclico y tiofuranodiona |