EA202190405A1 - КРИСТАЛЛИЧЕСКИЙ ПОЛИМОРФ 8-БРОМ-2-(1-МЕТИЛПИПЕРИДИН-4-ИЛАМИНО)-4-(4-ФЕНОКСИФЕНИЛАМИНО)ПИРИДО[4,3-d]ПИРИМИДИН-5(6H)-ОН ГИДРОХЛОРИДА И СПОСОБ ЕГО ПОЛУЧЕНИЯ - Google Patents

КРИСТАЛЛИЧЕСКИЙ ПОЛИМОРФ 8-БРОМ-2-(1-МЕТИЛПИПЕРИДИН-4-ИЛАМИНО)-4-(4-ФЕНОКСИФЕНИЛАМИНО)ПИРИДО[4,3-d]ПИРИМИДИН-5(6H)-ОН ГИДРОХЛОРИДА И СПОСОБ ЕГО ПОЛУЧЕНИЯ

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Publication number
EA202190405A1
EA202190405A1 EA202190405A EA202190405A EA202190405A1 EA 202190405 A1 EA202190405 A1 EA 202190405A1 EA 202190405 A EA202190405 A EA 202190405A EA 202190405 A EA202190405 A EA 202190405A EA 202190405 A1 EA202190405 A1 EA 202190405A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenoxyphenylamino
methylpiperidin
pyrido
hydrochloride
crystalline polymorph
Prior art date
Application number
EA202190405A
Other languages
English (en)
Inventor
Дзунг-Хо КИМ
Дзанг-Сик Чой
Хее Киу Ли
Сонг-Еун Парк
Донг-Сик ДЗУНГ
Юнг-геун Чой
Дзонг-Сунг Кох
Се-Вон Ким
Дзаекиоо Ли
Original Assignee
Оскотек Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оскотек Инк. filed Critical Оскотек Инк.
Publication of EA202190405A1 publication Critical patent/EA202190405A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к кристаллическому полиморфу 8-бром-2-(1-метилпиперидин-4-иламино)-4-(4-феноксифениламино)пиридо[4,3-d]пиримидин-5(6H)-он гидрохлорида, который может эффективно подавлять FLT3 и обладает превосходной стабильностью даже в условиях высокой температуры и влажной среды, и к способу его получения.
EA202190405A 2018-08-23 2019-08-12 КРИСТАЛЛИЧЕСКИЙ ПОЛИМОРФ 8-БРОМ-2-(1-МЕТИЛПИПЕРИДИН-4-ИЛАМИНО)-4-(4-ФЕНОКСИФЕНИЛАМИНО)ПИРИДО[4,3-d]ПИРИМИДИН-5(6H)-ОН ГИДРОХЛОРИДА И СПОСОБ ЕГО ПОЛУЧЕНИЯ EA202190405A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020180098681A KR20200022712A (ko) 2018-08-23 2018-08-23 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
PCT/KR2019/010210 WO2020040467A1 (ko) 2018-08-23 2019-08-12 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6h)-온 염산염의 결정다형체 및 그 제조방법

Publications (1)

Publication Number Publication Date
EA202190405A1 true EA202190405A1 (ru) 2021-05-28

Family

ID=69593288

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190405A EA202190405A1 (ru) 2018-08-23 2019-08-12 КРИСТАЛЛИЧЕСКИЙ ПОЛИМОРФ 8-БРОМ-2-(1-МЕТИЛПИПЕРИДИН-4-ИЛАМИНО)-4-(4-ФЕНОКСИФЕНИЛАМИНО)ПИРИДО[4,3-d]ПИРИМИДИН-5(6H)-ОН ГИДРОХЛОРИДА И СПОСОБ ЕГО ПОЛУЧЕНИЯ

Country Status (17)

Country Link
US (1) US11731969B2 (ru)
EP (1) EP3842434B1 (ru)
JP (2) JP2021535088A (ru)
KR (1) KR20200022712A (ru)
CN (1) CN112566914A (ru)
AU (1) AU2019325764B2 (ru)
BR (1) BR112021003298A2 (ru)
CA (1) CA3108373C (ru)
CL (1) CL2021000276A1 (ru)
EA (1) EA202190405A1 (ru)
ES (1) ES2952445T3 (ru)
IL (1) IL281030A (ru)
MX (1) MX2021001860A (ru)
MY (1) MY194696A (ru)
SG (1) SG11202101114WA (ru)
WO (1) WO2020040467A1 (ru)
ZA (1) ZA202101025B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
TW202340177A (zh) 2021-12-30 2023-10-16 美商拜歐米富士恩股份有限公司 作為 flt3抑制劑之吡嗪化合物
WO2023225005A1 (en) 2022-05-17 2023-11-23 Biomea Fusion, Inc. Flt3 combination therapy for cancer and compositions therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1436295A4 (en) * 2001-09-07 2007-07-11 Teva Pharma CRISTALLINE FORMS OF VALACYCLOVIR HYDROCHLORIDE
JP2008507565A (ja) 2005-05-23 2008-03-13 テバ ファーマシューティカル インダストリーズ リミティド シナカルセトの精製
TR201802464T4 (tr) * 2009-10-29 2018-03-21 Genosco Ki̇naz i̇nhi̇bi̇törleri̇
EA031267B1 (ru) 2012-03-22 2018-12-28 Оскотек, Инк. Замещенные пиридопиримидиновые соединения и их применение в качестве flt3 ингибиторов
KR20150002952A (ko) * 2013-06-27 2015-01-08 주식회사 오스코텍 피리도피리미딘 유도체를 함유하는 대사성 골 질환의 예방 및 치료용 약학 조성물
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법

Also Published As

Publication number Publication date
ES2952445T3 (es) 2023-10-31
CN112566914A (zh) 2021-03-26
JP2021535088A (ja) 2021-12-16
KR20200022712A (ko) 2020-03-04
EP3842434A1 (en) 2021-06-30
SG11202101114WA (en) 2021-03-30
EP3842434B1 (en) 2023-08-02
WO2020040467A1 (ko) 2020-02-27
MY194696A (en) 2022-12-15
AU2019325764A1 (en) 2021-03-04
EP3842434C0 (en) 2023-08-02
US11731969B2 (en) 2023-08-22
JP2023071814A (ja) 2023-05-23
MX2021001860A (es) 2021-04-19
CA3108373C (en) 2023-05-16
EP3842434A4 (en) 2022-06-08
IL281030A (en) 2021-04-29
CL2021000276A1 (es) 2021-07-19
ZA202101025B (en) 2022-09-28
BR112021003298A2 (pt) 2021-05-11
CA3108373A1 (en) 2020-02-27
AU2019325764B2 (en) 2022-03-03
US20210292322A1 (en) 2021-09-23

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