EA202091894A1 - Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомы - Google Patents
Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомыInfo
- Publication number
- EA202091894A1 EA202091894A1 EA202091894A EA202091894A EA202091894A1 EA 202091894 A1 EA202091894 A1 EA 202091894A1 EA 202091894 A EA202091894 A EA 202091894A EA 202091894 A EA202091894 A EA 202091894A EA 202091894 A1 EA202091894 A1 EA 202091894A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fluoro
- pyridin
- methoxyphenyl
- amine
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Изобретение относится к применению 5-фтор-4-(4-фтор-2-метоксифенил)-N-{4-[(S-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина (соединение A), более предпочтительно (+)5-фтор-4-(4-фтор-2-метоксифенил)-N-{4-[(S-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина (соединение A'), для лечения диффузной В-крупноклеточной лимфомы (DLBCL), в особенности для диффузной В-крупноклеточной лимфомы из В-клеток зародышевого центра и в особенности для диффузной В-крупноклеточной лимфомы, клетки которой имеют амплификацию или транслокацию гена MYC и/или гена BCL2 и/или сверхэкспрессию MYC и/или BCL2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18156576 | 2018-02-13 | ||
PCT/EP2019/053407 WO2019158517A1 (en) | 2018-02-13 | 2019-02-12 | Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091894A1 true EA202091894A1 (ru) | 2020-12-28 |
Family
ID=61223765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091894A EA202091894A1 (ru) | 2018-02-13 | 2019-02-12 | Применение 5-фтор-4-(4-фтор-2-метоксифенил)-n-{4-[(s-метилсульфонимидоил)метил]пиридин-2-ил}пиридин-2-амина для лечения диффузной в-крупноклеточной лимфомы |
Country Status (16)
Country | Link |
---|---|
US (1) | US11701347B2 (ru) |
EP (1) | EP3752487A1 (ru) |
JP (1) | JP7280286B2 (ru) |
KR (1) | KR20200119800A (ru) |
CN (1) | CN111727183B (ru) |
AU (1) | AU2019221019A1 (ru) |
BR (1) | BR112020016389A2 (ru) |
CA (1) | CA3090843A1 (ru) |
CL (1) | CL2020002087A1 (ru) |
EA (1) | EA202091894A1 (ru) |
IL (1) | IL276437B2 (ru) |
JO (1) | JOP20200196A1 (ru) |
MA (1) | MA51820A (ru) |
MX (1) | MX2020008447A (ru) |
SG (1) | SG11202006470RA (ru) |
WO (1) | WO2019158517A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019221019A1 (en) | 2018-02-13 | 2020-07-23 | Bayer Aktiengesellschaft | Use of 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large B-cell lymphoma |
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-
2019
- 2019-02-12 AU AU2019221019A patent/AU2019221019A1/en active Pending
- 2019-02-12 MX MX2020008447A patent/MX2020008447A/es unknown
- 2019-02-12 JO JOP/2020/0196A patent/JOP20200196A1/ar unknown
- 2019-02-12 JP JP2020565543A patent/JP7280286B2/ja active Active
- 2019-02-12 BR BR112020016389-9A patent/BR112020016389A2/pt unknown
- 2019-02-12 CN CN201980013294.2A patent/CN111727183B/zh active Active
- 2019-02-12 CA CA3090843A patent/CA3090843A1/en active Pending
- 2019-02-12 SG SG11202006470RA patent/SG11202006470RA/en unknown
- 2019-02-12 KR KR1020207022928A patent/KR20200119800A/ko unknown
- 2019-02-12 EA EA202091894A patent/EA202091894A1/ru unknown
- 2019-02-12 EP EP19704618.8A patent/EP3752487A1/en active Pending
- 2019-02-12 US US16/969,460 patent/US11701347B2/en active Active
- 2019-02-12 IL IL276437A patent/IL276437B2/en unknown
- 2019-02-12 MA MA051820A patent/MA51820A/fr unknown
- 2019-02-12 WO PCT/EP2019/053407 patent/WO2019158517A1/en unknown
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2020
- 2020-08-12 CL CL2020002087A patent/CL2020002087A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN111727183A (zh) | 2020-09-29 |
AU2019221019A1 (en) | 2020-07-23 |
SG11202006470RA (en) | 2020-08-28 |
WO2019158517A1 (en) | 2019-08-22 |
JP2021514386A (ja) | 2021-06-10 |
CA3090843A1 (en) | 2019-08-22 |
JP7280286B2 (ja) | 2023-05-23 |
IL276437A (en) | 2020-09-30 |
EP3752487A1 (en) | 2020-12-23 |
KR20200119800A (ko) | 2020-10-20 |
CL2020002087A1 (es) | 2020-12-11 |
IL276437B1 (en) | 2023-11-01 |
JOP20200196A1 (ar) | 2020-08-13 |
US11701347B2 (en) | 2023-07-18 |
CN111727183B (zh) | 2023-12-29 |
BR112020016389A2 (pt) | 2020-12-15 |
MX2020008447A (es) | 2020-09-28 |
IL276437B2 (en) | 2024-03-01 |
MA51820A (fr) | 2021-05-19 |
US20210015806A1 (en) | 2021-01-21 |
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