EA202091333A1 - Способы активации, модификации и экспансии t-клеток для лечения рака и связанных с ним злокачественных заболеваний - Google Patents

Способы активации, модификации и экспансии t-клеток для лечения рака и связанных с ним злокачественных заболеваний

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Publication number
EA202091333A1
EA202091333A1 EA202091333A EA202091333A EA202091333A1 EA 202091333 A1 EA202091333 A1 EA 202091333A1 EA 202091333 A EA202091333 A EA 202091333A EA 202091333 A EA202091333 A EA 202091333A EA 202091333 A1 EA202091333 A1 EA 202091333A1
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Prior art keywords
cells
activation
expansion
methods
cancer
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EA202091333A
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English (en)
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Моник Дао
Мелинда Мата
Александра Новика
Янник Биллиард
Стеффен Уолтер
Сара Миссель
Сабрина Куттруфф-Кокуй
Норбет Хилф
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Имматикс Юс, Инк.
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Publication of EA202091333A1 publication Critical patent/EA202091333A1/ru

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Abstract

Настоящее изобретение относится к экспансии и активации Т-клеток. В одном аспекте настоящее изобретение относится к экспансии и активации Т-клеток, которые могут применяться для трансгенной экспрессии. В другом аспекте изобретение относится к экспансии и активации Т-клеток при истощении - и/или -ТКР-положительных клеток. В настоящем изобретении также предложены популяции Т-клеток, включающие экспансированные Т-клетки и истощенные по содержанию или с уменьшенным содержанием - и/или -ТКР-положительных клеток. Кроме того, предложены способы применения предложенных популяций Т-клеток.
EA202091333A 2017-11-27 2018-11-26 Способы активации, модификации и экспансии t-клеток для лечения рака и связанных с ним злокачественных заболеваний EA202091333A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017127984.9A DE102017127984B4 (de) 2017-11-27 2017-11-27 Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
PCT/US2018/062442 WO2019104269A1 (en) 2017-11-27 2018-11-26 Methods for activating, modifying and expanding gamma delta t cells for the treatment of cancer and related malignancies

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EA202091333A1 true EA202091333A1 (ru) 2020-08-25

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Country Status (13)

Country Link
US (2) US11690872B2 (ru)
EP (1) EP3717634A1 (ru)
JP (1) JP7258364B2 (ru)
KR (1) KR20200090233A (ru)
CN (1) CN111727242A (ru)
AU (1) AU2018372206A1 (ru)
CA (1) CA3083595A1 (ru)
DE (1) DE102017127984B4 (ru)
EA (1) EA202091333A1 (ru)
MX (1) MX2020005503A (ru)
SG (1) SG11202004910SA (ru)
TW (1) TW201925464A (ru)
WO (1) WO2019104269A1 (ru)

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TW201925464A (zh) 2019-07-01
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