EA201691649A1 - Способ получения противогрибковых соединений - Google Patents

Способ получения противогрибковых соединений

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Publication number
EA201691649A1
EA201691649A1 EA201691649A EA201691649A EA201691649A1 EA 201691649 A1 EA201691649 A1 EA 201691649A1 EA 201691649 A EA201691649 A EA 201691649A EA 201691649 A EA201691649 A EA 201691649A EA 201691649 A1 EA201691649 A1 EA 201691649A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fiber connections
obtaining anti
preparation
relates
compound
Prior art date
Application number
EA201691649A
Other languages
English (en)
Other versions
EA037587B1 (ru
Inventor
Уиллиам Дж. Хекстра
Кристофер М. Йейтс
Марк Бенке
Асаф Алимарданов
Скотт А. Дэвид
Дуглас Франклин Фрай
Original Assignee
Ваймет Фармасьютикалс, Инк.
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сервисис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ваймет Фармасьютикалс, Инк., Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сервисис filed Critical Ваймет Фармасьютикалс, Инк.
Publication of EA201691649A1 publication Critical patent/EA201691649A1/ru
Publication of EA037587B1 publication Critical patent/EA037587B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Artificial Filaments (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Изобретение относится к способу получения соединения 1, которое полезно в качестве противогрибкового средства. В частности, настоящее изобретение относится к получению новой методики получения соединения 1 и его замещенных производных.
EA201691649A 2014-03-19 2015-03-19 Способ получения противогрибковых соединений EA037587B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461955615P 2014-03-19 2014-03-19
PCT/US2015/021491 WO2015143172A1 (en) 2014-03-19 2015-03-19 Antifungal compound process

Publications (2)

Publication Number Publication Date
EA201691649A1 true EA201691649A1 (ru) 2016-12-30
EA037587B1 EA037587B1 (ru) 2021-04-19

Family

ID=54145323

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691649A EA037587B1 (ru) 2014-03-19 2015-03-19 Способ получения противогрибковых соединений

Country Status (14)

Country Link
US (2) US10173998B2 (ru)
EP (1) EP3119745B1 (ru)
JP (1) JP6509897B2 (ru)
KR (1) KR102151082B1 (ru)
CN (2) CN109970629B (ru)
AU (1) AU2015231226B2 (ru)
BR (1) BR112016020937B1 (ru)
CA (1) CA2942968C (ru)
EA (1) EA037587B1 (ru)
ES (1) ES2815373T3 (ru)
HU (1) HUE052446T2 (ru)
MX (1) MX365494B (ru)
PL (1) PL3119745T3 (ru)
WO (1) WO2015143172A1 (ru)

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MX369357B (es) * 2014-03-19 2019-11-06 Mycovia Pharmaceuticals Inc Procedimiento de compuesto antifungico.
EP3119754A4 (en) * 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
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Also Published As

Publication number Publication date
CA2942968C (en) 2022-03-15
BR112016020937B1 (pt) 2022-09-20
EP3119745A4 (en) 2017-08-23
WO2015143172A1 (en) 2015-09-24
ES2815373T3 (es) 2021-03-29
US20170088539A1 (en) 2017-03-30
BR112016020937A2 (ru) 2017-08-15
JP6509897B2 (ja) 2019-05-08
EP3119745A1 (en) 2017-01-25
CN109970629B (zh) 2023-04-11
PL3119745T3 (pl) 2021-01-25
US10173998B2 (en) 2019-01-08
AU2015231226A1 (en) 2016-10-06
CN106458900A (zh) 2017-02-22
CN106458900B (zh) 2019-01-01
US20190161469A1 (en) 2019-05-30
HUE052446T2 (hu) 2021-04-28
US10392365B2 (en) 2019-08-27
EP3119745B1 (en) 2020-08-05
AU2015231226B2 (en) 2019-04-04
MX2016012056A (es) 2017-04-27
EA037587B1 (ru) 2021-04-19
MX365494B (es) 2019-06-05
KR20160138012A (ko) 2016-12-02
JP2017509644A (ja) 2017-04-06
CA2942968A1 (en) 2015-09-24
KR102151082B1 (ko) 2020-09-03
CN109970629A (zh) 2019-07-05

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