EA201792185A2 - Модуляция экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3) - Google Patents

Модуляция экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3)

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Publication number
EA201792185A2
EA201792185A2 EA201792185A EA201792185A EA201792185A2 EA 201792185 A2 EA201792185 A2 EA 201792185A2 EA 201792185 A EA201792185 A EA 201792185A EA 201792185 A EA201792185 A EA 201792185A EA 201792185 A2 EA201792185 A2 EA 201792185A2
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EA
Eurasian Patent Office
Prior art keywords
expression
activator
transcription
modulation
signal transducer
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EA201792185A
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English (en)
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EA201792185A3 (ru
Inventor
Эрик И. Суэйзи
Сьюзан М. Фрейер
Роберт А. Маклеод
Янсу Ким
Original Assignee
Айонис Фармасьютикалз, Инк.
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Application filed by Айонис Фармасьютикалз, Инк. filed Critical Айонис Фармасьютикалз, Инк.
Publication of EA201792185A2 publication Critical patent/EA201792185A2/ru
Publication of EA201792185A3 publication Critical patent/EA201792185A3/ru

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Abstract

Здесь раскрыты антисмысловые соединения и способы снижения экспрессии мРНК и белка STAT3. Такие способы, соединения и композиции являются полезными для лечения, предупреждения или облегчения гиперпролиферативных заболеваний.
EA201792185A 2011-04-01 2012-03-30 Модуляция экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3) EA201792185A3 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161471001P 2011-04-01 2011-04-01
US201161471015P 2011-04-01 2011-04-01
US201161471035P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161558308P 2011-11-10 2011-11-10
US201161558316P 2011-11-10 2011-11-10

Publications (2)

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EA201792185A2 true EA201792185A2 (ru) 2018-06-29
EA201792185A3 EA201792185A3 (ru) 2018-10-31

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ID=46932413

Family Applications (2)

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EA201391329A EA029317B1 (ru) 2011-04-01 2012-03-30 Одноцепочечный антисмысловой модифицированный олигонуклеотид для ингибирования экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3) и его применение для лечения гиперпролиферативного заболевания
EA201792185A EA201792185A3 (ru) 2011-04-01 2012-03-30 Модуляция экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3)

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EA201391329A EA029317B1 (ru) 2011-04-01 2012-03-30 Одноцепочечный антисмысловой модифицированный олигонуклеотид для ингибирования экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3) и его применение для лечения гиперпролиферативного заболевания

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US (4) US8816056B2 (ru)
EP (2) EP3466960A3 (ru)
JP (1) JP5943993B2 (ru)
KR (2) KR102050469B1 (ru)
CN (2) CN107012144A (ru)
AU (1) AU2012236206C1 (ru)
BR (1) BR112013024768B1 (ru)
CA (1) CA2831915C (ru)
CL (1) CL2013002773A1 (ru)
CO (1) CO6821885A2 (ru)
CY (1) CY1121460T1 (ru)
DK (1) DK2697243T3 (ru)
DO (1) DOP2013000216A (ru)
EA (2) EA029317B1 (ru)
EC (1) ECSP13012909A (ru)
ES (1) ES2709495T3 (ru)
GT (1) GT201300232A (ru)
HR (1) HRP20182169T1 (ru)
HU (1) HUE042173T2 (ru)
IL (2) IL228569A (ru)
LT (1) LT2697243T (ru)
ME (1) ME03317B (ru)
MX (1) MX340086B (ru)
MY (1) MY163004A (ru)
NI (1) NI201300101A (ru)
PE (2) PE20181518A1 (ru)
PL (1) PL2697243T3 (ru)
PT (1) PT2697243T (ru)
RS (1) RS58489B1 (ru)
SG (1) SG193504A1 (ru)
SI (1) SI2697243T1 (ru)
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