EA201691246A1 - Комбинация гликозаминогликанов и циклодекстринов - Google Patents

Комбинация гликозаминогликанов и циклодекстринов

Info

Publication number
EA201691246A1
EA201691246A1 EA201691246A EA201691246A EA201691246A1 EA 201691246 A1 EA201691246 A1 EA 201691246A1 EA 201691246 A EA201691246 A EA 201691246A EA 201691246 A EA201691246 A EA 201691246A EA 201691246 A1 EA201691246 A1 EA 201691246A1
Authority
EA
Eurasian Patent Office
Prior art keywords
combination
cyclodextrins
glycosamino glycans
glycosamino
glycans
Prior art date
Application number
EA201691246A
Other languages
English (en)
Other versions
EA032372B1 (ru
Inventor
Анджело Пиццони
Паоло Пиццони
Original Assignee
Афарм С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Афарм С.Р.Л. filed Critical Афарм С.Р.Л.
Publication of EA201691246A1 publication Critical patent/EA201691246A1/ru
Publication of EA032372B1 publication Critical patent/EA032372B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

Настоящее изобретение касается инъецируемой комбинации двух специфических гликозаминогликанов, гиалуроновой кислоты и хондроитин сульфата с циклодекстринами и применения описанной комбинации для лечения заболеваний, связанных со скелетными системами, особенно при внутрисуставном введении, а также при внутрикожном введении.
EA201691246A 2013-12-18 2014-12-15 Комбинация гликозаминогликанов и циклодекстринов EA032372B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002116A ITMI20132116A1 (it) 2013-12-18 2013-12-18 Associazione di glicosamminoglicani e ciclodestrine
PCT/IB2014/002774 WO2015092516A1 (en) 2013-12-18 2014-12-15 Combination of glycosaminoglycans and cyclodextrins

Publications (2)

Publication Number Publication Date
EA201691246A1 true EA201691246A1 (ru) 2016-10-31
EA032372B1 EA032372B1 (ru) 2019-05-31

Family

ID=50115999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691246A EA032372B1 (ru) 2013-12-18 2014-12-15 Комбинация гликозаминогликанов и циклодекстринов

Country Status (13)

Country Link
US (1) US9974803B2 (ru)
EP (1) EP3082869B1 (ru)
CN (1) CN105899233B (ru)
BR (1) BR112016013834B1 (ru)
CA (1) CA2932987C (ru)
EA (1) EA032372B1 (ru)
ES (1) ES2707971T3 (ru)
IT (1) ITMI20132116A1 (ru)
MA (1) MA39077A1 (ru)
PT (1) PT3082869T (ru)
TN (1) TN2016000206A1 (ru)
TR (1) TR201819270T4 (ru)
WO (1) WO2015092516A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUB20153110A1 (it) * 2015-08-13 2017-02-13 Alfakjn S R L Composizione liquida iniettabile per uso nella terapia infiltrativa intra-articolare
IT201600075246A1 (it) 2016-07-19 2018-01-19 Jointherapeutics S R L Composizioni comprendenti una matrice polisaccaridica per il rilascio controllato di principi attivi.
IT201800010415A1 (it) * 2018-11-19 2020-05-19 Innate S R L Composizione iniettabile comprendente acido ialuronico e trealosio e uso della detta composizione.
KR20230019195A (ko) * 2020-06-02 2023-02-07 내셔널 유니버시티 오브 싱가포르 조성물들, 요법에서 그것들의 용도들 및 이의 방법들

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282717B6 (sk) * 2000-03-10 2002-11-06 �Stav Experiment�Lnej Farmakol�Gie Sav Spôsob prípravy ultravysokomolekulových hyalurónanov
FR2811572B1 (fr) 2000-07-17 2003-04-18 Adir Utilisation de cyclodextrines polysulfatees pour le traitement de l'arthrose
MXPA01011542A (es) * 2001-11-13 2003-05-22 Alcon Inc Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel.
AU2003279835B2 (en) * 2002-10-07 2009-09-10 Zymogenetics, Inc. Methods of administering FGF18
US8455458B2 (en) * 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
CN1451369A (zh) * 2003-03-13 2003-10-29 吉林大学 环糊精衍生物在化妆品中的应用
EP1967186B1 (en) * 2005-12-27 2015-03-11 Lion Corporation Composition for soft contact lens and adsorption suppressing method
CN100594029C (zh) * 2006-07-24 2010-03-17 凌沛学 一种关节腔内注射用药物组合物
US8394784B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
CN101259139A (zh) * 2008-03-13 2008-09-10 北京阜康仁生物制药科技有限公司 一种用于消炎镇痛的药用组合物
KR20110067130A (ko) * 2008-09-22 2011-06-21 아카리오스 비.브이. 약제로서 유용한 카르복시에틸화 사이클로덱스트린 폴리설페이트
ITPD20120098A1 (it) * 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
CH705713B1 (de) * 2012-09-21 2013-05-15 Labo Cosprophar Ag Dermokosmetische Zusammensetzung zur topischen Anwendung.
CN103301118A (zh) * 2013-06-27 2013-09-18 海南卫康制药(潜山)有限公司 注射用精氨酸布洛芬组合物

Also Published As

Publication number Publication date
EP3082869A1 (en) 2016-10-26
BR112016013834B1 (pt) 2022-11-22
EP3082869B1 (en) 2018-10-31
CN105899233B (zh) 2020-01-17
CA2932987C (en) 2021-10-12
PT3082869T (pt) 2019-02-06
ES2707971T3 (es) 2019-04-08
MA39077A1 (fr) 2017-11-30
CN105899233A (zh) 2016-08-24
BR112016013834A2 (ru) 2017-08-08
EA032372B1 (ru) 2019-05-31
CA2932987A1 (en) 2015-06-25
TN2016000206A1 (en) 2017-10-06
WO2015092516A1 (en) 2015-06-25
ITMI20132116A1 (it) 2015-06-19
TR201819270T4 (tr) 2019-01-21
US20170035799A1 (en) 2017-02-09
US9974803B2 (en) 2018-05-22

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