EA201600002A1 - Производные пролекарства замещенных триазолопиридинов - Google Patents
Производные пролекарства замещенных триазолопиридиновInfo
- Publication number
- EA201600002A1 EA201600002A1 EA201600002A EA201600002A EA201600002A1 EA 201600002 A1 EA201600002 A1 EA 201600002A1 EA 201600002 A EA201600002 A EA 201600002A EA 201600002 A EA201600002 A EA 201600002A EA 201600002 A1 EA201600002 A1 EA 201600002A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- triazolopiridines
- substituted
- mps
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Настоящее изобретение относится к производным пролекарств ингибиторов Mps-1 киназы формулы (I), к способам их получения, а также к их применению для лечения и/или профилактики заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13171508 | 2013-06-11 | ||
PCT/EP2014/061779 WO2014198647A2 (en) | 2013-06-11 | 2014-06-06 | Prodrug derivatives of substituted triazolopyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201600002A1 true EA201600002A1 (ru) | 2016-06-30 |
Family
ID=48576905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201600002A EA201600002A1 (ru) | 2013-06-11 | 2014-06-06 | Производные пролекарства замещенных триазолопиридинов |
Country Status (35)
Country | Link |
---|---|
US (1) | US9586958B2 (ru) |
EP (1) | EP3008062B1 (ru) |
JP (1) | JP2016526534A (ru) |
KR (1) | KR20160019492A (ru) |
CN (1) | CN105377848A (ru) |
AP (1) | AP2015008898A0 (ru) |
AR (1) | AR096585A1 (ru) |
AU (1) | AU2014280356A1 (ru) |
CA (1) | CA2914745A1 (ru) |
CL (1) | CL2015003605A1 (ru) |
CR (1) | CR20150659A (ru) |
CU (1) | CU20150176A7 (ru) |
DK (1) | DK3008062T3 (ru) |
DO (1) | DOP2015000299A (ru) |
EA (1) | EA201600002A1 (ru) |
ES (1) | ES2626790T3 (ru) |
HK (1) | HK1221955A1 (ru) |
HR (1) | HRP20170717T1 (ru) |
HU (1) | HUE033131T2 (ru) |
IL (1) | IL242847A0 (ru) |
LT (1) | LT3008062T (ru) |
MA (1) | MA38654B1 (ru) |
MX (1) | MX2015017119A (ru) |
NI (1) | NI201500176A (ru) |
PE (1) | PE20160156A1 (ru) |
PH (1) | PH12015502746A1 (ru) |
PL (1) | PL3008062T3 (ru) |
PT (1) | PT3008062T (ru) |
RS (1) | RS56034B1 (ru) |
SG (1) | SG11201509858QA (ru) |
SI (1) | SI3008062T1 (ru) |
TN (1) | TN2015000545A1 (ru) |
UY (1) | UY35610A (ru) |
WO (1) | WO2014198647A2 (ru) |
ZA (1) | ZA201508868B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA41136A (fr) * | 2014-12-09 | 2017-10-17 | Bayer Pharma AG | Composés pour le traitement d'un cancer |
ES2966392T3 (es) | 2015-04-17 | 2024-04-22 | Crossfire Oncology Holding B V | Biomarcadores pronósticos para quimioterapia inhibidora de TTK |
CN109310686B (zh) | 2016-04-04 | 2022-06-21 | 凯莫森特里克斯股份有限公司 | 可溶性C5aR拮抗剂 |
WO2023113478A1 (en) * | 2021-12-15 | 2023-06-22 | Sillajen, Inc. | Methods of treating neoplastic diseases |
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ATE340176T1 (de) | 1996-08-28 | 2006-10-15 | Pfizer | Substituierte 6,5-heterobicyclische-derivate |
EP0991628B1 (en) | 1997-05-28 | 2005-01-12 | Aventis Pharmaceuticals Inc | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR P56lck TYROSINE KINASES |
US6514989B1 (en) | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
JP2004346016A (ja) | 2003-05-22 | 2004-12-09 | Otsuka Chemical Co Ltd | トリフルオロメチルキノキサリン化合物、その製造方法、及び有害生物防除剤 |
AU2004275694B2 (en) | 2003-06-30 | 2008-03-06 | Bizbiotech Co., Ltd. | Compounds, compositions and methods |
JP2008515874A (ja) | 2004-10-07 | 2008-05-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌薬 |
US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
WO2007065010A2 (en) | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
EA200870592A1 (ru) | 2006-05-31 | 2009-08-28 | Галапагос Н.В. | Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний |
CN101528231A (zh) | 2006-08-16 | 2009-09-09 | 埃克塞利希斯股份有限公司 | 在癌症的治疗中使用pi3k和mek调控剂 |
JP5336375B2 (ja) | 2006-08-30 | 2013-11-06 | セルゾーム リミテッド | キナーゼ阻害剤としてのトリアゾール誘導体 |
US7592342B2 (en) | 2007-05-10 | 2009-09-22 | Smithkline Beecham Corporation | Quinoxaline derivatives as PI3 kinase inhibitors |
MX2010000716A (es) | 2007-07-18 | 2010-03-26 | Novartis Ag | Compuestos de heteroarilo biciclicos y su uso como inhibidores de cinasa. |
EP2173354A4 (en) | 2007-08-09 | 2011-10-05 | Glaxosmithkline Llc | CHINOXALIN DERIVATIVES AS PI3 KINASE INHIBITORS |
NZ584138A (en) | 2007-08-23 | 2011-10-28 | Astrazeneca Ab | 2-anilinopurin-8-ones as inhibitors of ttk/mps1 for the treatment of proliferative disorders |
CA2691448A1 (en) | 2007-08-31 | 2009-03-05 | Dominique Swinnen | Triazolopyridine compounds and their use as ask inhibitors |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
MX2010005700A (es) | 2007-11-27 | 2010-06-11 | Cellzome Ltd | Amino triazoles como inhibidores pi3k. |
US8415376B2 (en) | 2008-05-30 | 2013-04-09 | Amgen Inc. | Inhibitors of PI3 kinase |
TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
NZ594508A (en) | 2009-02-13 | 2013-12-20 | Fovea Pharmaceuticals | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
CA2760077A1 (en) | 2009-04-29 | 2010-11-04 | Marcus Koppitz | Substituted imidazoquinoxalines |
TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
EP2473498A1 (en) | 2009-09-04 | 2012-07-11 | Bayer Pharma Aktiengesellschaft | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
EP2343295A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
EP2343297A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
UY33452A (es) * | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
EA023766B1 (ru) | 2011-04-21 | 2016-07-29 | Байер Интеллектчуал Проперти Гмбх | Триазолопиридины |
UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
EP2825540B1 (en) | 2012-03-14 | 2016-09-14 | Bayer Intellectual Property GmbH | Substituted imidazopyridazines |
PE20150354A1 (es) * | 2012-07-10 | 2015-03-21 | Bayer Pharma AG | Metodos para preparar triazolopiridinas sustituidas |
AR096469A1 (es) * | 2013-06-06 | 2015-12-30 | Bayer Pharma AG | Composiciones farmacéuticas que comprenden compuestos del tipo triazolpiridinas |
CN105431435A (zh) * | 2013-06-07 | 2016-03-23 | 拜耳制药股份公司 | 具有作为mps-1抑制剂的活性的取代的***并吡啶类 |
CA2914668A1 (en) * | 2013-06-10 | 2014-12-18 | Volker Schulze | Novel compounds for the treatment of cancer |
EP3007692A1 (en) * | 2013-06-11 | 2016-04-20 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer comprising a mps-1 kinase inhibitor and a mitotic inhibitor |
-
2014
- 2014-06-06 US US14/897,951 patent/US9586958B2/en not_active Expired - Fee Related
- 2014-06-06 KR KR1020167000270A patent/KR20160019492A/ko not_active Application Discontinuation
- 2014-06-06 AP AP2015008898A patent/AP2015008898A0/xx unknown
- 2014-06-06 JP JP2016518941A patent/JP2016526534A/ja active Pending
- 2014-06-06 PL PL14728949T patent/PL3008062T3/pl unknown
- 2014-06-06 CA CA2914745A patent/CA2914745A1/en not_active Abandoned
- 2014-06-06 LT LTEP14728949.0T patent/LT3008062T/lt unknown
- 2014-06-06 MA MA38654A patent/MA38654B1/fr unknown
- 2014-06-06 PE PE2015002605A patent/PE20160156A1/es not_active Application Discontinuation
- 2014-06-06 RS RS20170534A patent/RS56034B1/sr unknown
- 2014-06-06 MX MX2015017119A patent/MX2015017119A/es unknown
- 2014-06-06 HU HUE14728949A patent/HUE033131T2/en unknown
- 2014-06-06 CN CN201480040729.XA patent/CN105377848A/zh active Pending
- 2014-06-06 PT PT147289490T patent/PT3008062T/pt unknown
- 2014-06-06 EP EP14728949.0A patent/EP3008062B1/en active Active
- 2014-06-06 AU AU2014280356A patent/AU2014280356A1/en not_active Abandoned
- 2014-06-06 DK DK14728949.0T patent/DK3008062T3/en active
- 2014-06-06 ES ES14728949.0T patent/ES2626790T3/es active Active
- 2014-06-06 TN TN2015000545A patent/TN2015000545A1/en unknown
- 2014-06-06 EA EA201600002A patent/EA201600002A1/ru unknown
- 2014-06-06 SI SI201430219A patent/SI3008062T1/sl unknown
- 2014-06-06 WO PCT/EP2014/061779 patent/WO2014198647A2/en active Application Filing
- 2014-06-06 SG SG11201509858QA patent/SG11201509858QA/en unknown
- 2014-06-11 UY UY0001035610A patent/UY35610A/es not_active Application Discontinuation
- 2014-06-11 AR ARP140102239A patent/AR096585A1/es unknown
-
2015
- 2015-11-30 IL IL242847A patent/IL242847A0/en unknown
- 2015-12-03 ZA ZA2015/08868A patent/ZA201508868B/en unknown
- 2015-12-09 PH PH12015502746A patent/PH12015502746A1/en unknown
- 2015-12-11 NI NI201500176A patent/NI201500176A/es unknown
- 2015-12-11 CR CR20150659A patent/CR20150659A/es unknown
- 2015-12-11 CU CUP2015000176A patent/CU20150176A7/es unknown
- 2015-12-11 DO DO2015000299A patent/DOP2015000299A/es unknown
- 2015-12-11 CL CL2015003605A patent/CL2015003605A1/es unknown
-
2016
- 2016-08-29 HK HK16110219.6A patent/HK1221955A1/zh unknown
-
2017
- 2017-05-12 HR HRP20170717TT patent/HRP20170717T1/hr unknown
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