EA201592199A1 - Производные бипиразола в качестве ингибиторов jak - Google Patents

Производные бипиразола в качестве ингибиторов jak

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Publication number
EA201592199A1
EA201592199A1 EA201592199A EA201592199A EA201592199A1 EA 201592199 A1 EA201592199 A1 EA 201592199A1 EA 201592199 A EA201592199 A EA 201592199A EA 201592199 A EA201592199 A EA 201592199A EA 201592199 A1 EA201592199 A1 EA 201592199A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bipyrazol
derivatives
jak inhibitors
diseases
jak
Prior art date
Application number
EA201592199A
Other languages
English (en)
Other versions
EA036448B1 (ru
Inventor
Юнь-Лун Ли
Цзиньцун Чжо
Дин-Цюань Цянь
Сун Мей
Ганьфэн Цао
Юнчунь Пань
Цюнь Ли
Чжунцзян Цзя
Original Assignee
Инсайт Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA201592199A1 publication Critical patent/EA201592199A1/ru
Publication of EA036448B1 publication Critical patent/EA036448B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

В настоящем изобретении предложены соединения формулы Iили их фармацевтически приемлемые соли, а также их композиции и способы их применения, которые ингибируют активность Янус-киназы (JAK) и подходят для применения для лечения заболеваний, связанных с активностью JAK, включая, например, воспалительные заболевания, аутоиммунные заболевания, раковые заболевания и другие заболевания.
EA201592199A 2013-05-17 2014-05-16 Производные бипиразола в качестве ингибиторов jak EA036448B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824683P 2013-05-17 2013-05-17
PCT/US2014/038388 WO2014186706A1 (en) 2013-05-17 2014-05-16 Bipyrazole derivatives as jak inhibitors

Publications (2)

Publication Number Publication Date
EA201592199A1 true EA201592199A1 (ru) 2016-05-31
EA036448B1 EA036448B1 (ru) 2020-11-11

Family

ID=50983151

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202090291A EA039660B1 (ru) 2013-05-17 2014-05-16 Твердая форма производного бипиразола
EA201592199A EA036448B1 (ru) 2013-05-17 2014-05-16 Производные бипиразола в качестве ингибиторов jak

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA202090291A EA039660B1 (ru) 2013-05-17 2014-05-16 Твердая форма производного бипиразола

Country Status (35)

Country Link
US (6) US9382231B2 (ru)
EP (5) EP3231801B1 (ru)
JP (4) JP6415543B2 (ru)
KR (3) KR20220127371A (ru)
CN (2) CN107698569B (ru)
AR (2) AR096330A1 (ru)
AU (5) AU2014265279B2 (ru)
BR (1) BR112015028501B8 (ru)
CA (1) CA2911536C (ru)
CL (1) CL2015003355A1 (ru)
CR (2) CR20190156A (ru)
CY (3) CY1119105T1 (ru)
DK (3) DK3786162T3 (ru)
EA (2) EA039660B1 (ru)
ES (4) ES2720073T3 (ru)
FI (1) FI3786162T3 (ru)
HK (2) HK1221466A1 (ru)
HR (4) HRP20231048T1 (ru)
HU (4) HUE063817T2 (ru)
IL (4) IL242453B (ru)
LT (4) LT3231801T (ru)
ME (2) ME02763B (ru)
MX (2) MX2015015738A (ru)
MY (1) MY174788A (ru)
PE (2) PE20160126A1 (ru)
PH (2) PH12015502563B1 (ru)
PL (4) PL3231801T3 (ru)
PT (4) PT3786162T (ru)
RS (4) RS64591B1 (ru)
SG (2) SG10201709469SA (ru)
SI (4) SI2997023T1 (ru)
TR (1) TR201905814T4 (ru)
TW (2) TWI719401B (ru)
UA (1) UA117830C2 (ru)
WO (1) WO2014186706A1 (ru)

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