US3941763A
(en)
|
1975-03-28 |
1976-03-02 |
American Home Products Corporation |
PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
US4215051A
(en)
|
1979-08-29 |
1980-07-29 |
Standard Oil Company (Indiana) |
Formation, purification and recovery of phthalic anhydride
|
US4456591A
(en)
|
1981-06-25 |
1984-06-26 |
Baxter Travenol Laboratories, Inc. |
Therapeutic method for activating factor VII
|
AU561343B2
(en)
|
1981-10-19 |
1987-05-07 |
Genentech Inc. |
Human immune interferon by recombinant dna
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
US6936694B1
(en)
|
1982-05-06 |
2005-08-30 |
Intermune, Inc. |
Manufacture and expression of large structural genes
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
US5189015A
(en)
|
1984-05-30 |
1993-02-23 |
Alfa-Laval Agri International Ab |
Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability
|
US5077204A
(en)
|
1984-06-21 |
1991-12-31 |
Chiron Corporation |
Yeast endopeptidase for basic amino-acid site cleavage, preparation and use
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
US4889919A
(en)
|
1986-08-13 |
1989-12-26 |
Zymogenetics, Inc. |
Biologically active PDGF derived A-chain homodimers
|
DK525384D0
(da)
|
1984-11-05 |
1984-11-05 |
Nordisk Insulinlab |
Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
|
US5157021A
(en)
|
1985-03-15 |
1992-10-20 |
Novo Nordisk A/S |
Insulin derivatives and pharmaceutical preparations containing these derivatives
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
US5981216A
(en)
|
1985-04-01 |
1999-11-09 |
Alusuisse Holdings A.G. |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
US4868112A
(en)
|
1985-04-12 |
1989-09-19 |
Genetics Institute, Inc. |
Novel procoagulant proteins
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
US4745055A
(en)
|
1985-05-07 |
1988-05-17 |
California Biotechnology Inc. |
Fused protein for enzyme immunoassay system
|
KR910006424B1
(ko)
|
1985-08-21 |
1991-08-24 |
인코텍스 비.브이 |
편성브리프(brief) 제조방법
|
US5180583A
(en)
|
1985-11-26 |
1993-01-19 |
Hedner Ulla K E |
Method for the treatment of bleeding disorders
|
ATE87663T1
(de)
|
1986-01-03 |
1993-04-15 |
Genetics Inst |
Verfahren zur herstellung von faktor-viii:c-typ- proteinen.
|
US4786726A
(en)
|
1986-01-06 |
1988-11-22 |
Blood Systems, Inc. |
Factor IX therapeutic blood product, means and methods of preparing same
|
US5595886A
(en)
|
1986-01-27 |
1997-01-21 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
US5543502A
(en)
|
1986-06-24 |
1996-08-06 |
Novo Nordisk A/S |
Process for producing a coagulation active complex of factor VIII fragments
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
EP0832981A1
(en)
|
1987-02-17 |
1998-04-01 |
Pharming B.V. |
DNA sequences to target proteins to the mammary gland for efficient secretion
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
US6060447A
(en)
|
1987-05-19 |
2000-05-09 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
US5171844A
(en)
|
1987-06-12 |
1992-12-15 |
Gist-Brocades N.W. |
Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
US6346513B1
(en)
|
1987-06-12 |
2002-02-12 |
Baxter Trading Gmbh |
Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
US5892019A
(en)
|
1987-07-15 |
1999-04-06 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Production of a single-gene-encoded immunoglobulin
|
FR2619314B1
(fr)
|
1987-08-11 |
1990-06-15 |
Transgene Sa |
Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
|
US4994371A
(en)
|
1987-08-28 |
1991-02-19 |
Davie Earl W |
DNA preparation of Christmas factor and use of DNA sequences
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
US6018026A
(en)
|
1988-01-22 |
2000-01-25 |
Zymogenetics, Inc. |
Biologically active dimerized and multimerized polypeptide fusions
|
US5234830A
(en)
|
1988-02-03 |
1993-08-10 |
Suntory Limited |
DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region
|
JP2643968B2
(ja)
|
1988-02-03 |
1997-08-25 |
サントリー株式会社 |
Kex2エンドプロテアーゼ及びその製造方法
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
WO1990005183A1
(en)
|
1988-10-31 |
1990-05-17 |
Immunex Corporation |
Interleukin-4 receptors
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
AU648020B2
(en)
|
1989-02-21 |
1994-04-14 |
Washington University |
Modified forms of reproductive hormones
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
US6406697B1
(en)
|
1989-02-23 |
2002-06-18 |
Genentech, Inc. |
Hybrid immunoglobulins
|
US5766883A
(en)
|
1989-04-29 |
1998-06-16 |
Delta Biotechnology Limited |
Polypeptides
|
SE8901687D0
(sv)
|
1989-05-11 |
1989-05-11 |
Alfa Laval Agri Int |
Fibronectin binding protein as well as its preparation
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
US5395760A
(en)
|
1989-09-05 |
1995-03-07 |
Immunex Corporation |
DNA encoding tumor necrosis factor-α and -β receptors
|
DK0939121T4
(da)
|
1989-09-12 |
2008-02-04 |
Ahp Mfg B V |
TNF-bindende proteiner
|
US5935815A
(en)
|
1989-10-25 |
1999-08-10 |
Katholieke Universiteit Leuven |
Process for micro biological production of proteins
|
US5633076A
(en)
|
1989-12-01 |
1997-05-27 |
Pharming Bv |
Method of producing a transgenic bovine or transgenic bovine embryo
|
SE465222C5
(sv)
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
US5648273A
(en)
|
1989-12-27 |
1997-07-15 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Hepatic growth factor receptor is the MET proto-oncogene
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
WO1991010741A1
(en)
|
1990-01-12 |
1991-07-25 |
Cell Genesys, Inc. |
Generation of xenogeneic antibodies
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
GB9009106D0
(en)
|
1990-04-23 |
1990-06-20 |
3I Res Expl Ltd |
Processes and intermediates for synthetic antibody derivatives
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
US5453491A
(en)
|
1990-09-11 |
1995-09-26 |
Kiyoshi Takatsu |
Murine interleukin-5 receptor
|
IE914102A1
(en)
|
1990-11-26 |
1992-06-03 |
Genetics Inst |
Expression of pace in host cells and methods of use thereof
|
EP0564531B1
(en)
|
1990-12-03 |
1998-03-25 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
DE69123241T2
(de)
|
1990-12-14 |
1997-04-17 |
Cell Genesys Inc |
Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
|
EP0575545B1
(en)
|
1991-03-15 |
2003-05-21 |
Amgen Inc. |
Pegylation of polypeptides
|
US5374617A
(en)
|
1992-05-13 |
1994-12-20 |
Oklahoma Medical Research Foundation |
Treatment of bleeding with modified tissue factor in combination with FVIIa
|
CA2102224A1
(en)
|
1991-04-19 |
1992-10-20 |
Toshio Kitamura |
Human interleukin-3-receptor component
|
DE69226877T2
(de)
|
1991-05-31 |
1999-03-11 |
Genentech Inc |
Behandlung der hiv-assoziierten immun-thrombopenie purpura
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
US5227158A
(en)
|
1991-06-10 |
1993-07-13 |
Genentech, Inc. |
Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
|
US5346991A
(en)
|
1991-06-13 |
1994-09-13 |
Genentech, Inc. |
Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
MX9204374A
(es)
|
1991-07-25 |
1993-03-01 |
Idec Pharma Corp |
Anticuerpo recombinante y metodo para su produccion.
|
US5116753A
(en)
|
1991-07-30 |
1992-05-26 |
The Salk Institute For Biological Studies |
Maintenance of pancreatic islets
|
KR100254759B1
(ko)
|
1992-01-23 |
2000-05-01 |
플레믹 크리스티안 |
단량체 및 이량체 항체-단편 융합 단백질
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
WO1993016177A1
(en)
|
1992-02-11 |
1993-08-19 |
Cell Genesys, Inc. |
Homogenotization of gene-targeting events
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
US6037452A
(en)
|
1992-04-10 |
2000-03-14 |
Alpha Therapeutic Corporation |
Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
|
CA2131003A1
(en)
|
1992-05-26 |
1993-12-09 |
Raymond G. Goodwin |
Novel cytokine that binds cd30
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
JP3905921B2
(ja)
|
1992-10-02 |
2007-04-18 |
ジェネティクス インスチチュート リミテッド ライアビリティー カンパニー |
凝固第▲viii▼因子を含む組成物及びその製造方法並びに安定剤としての界面活性剤の使用方法
|
US6277975B1
(en)
|
1992-10-23 |
2001-08-21 |
Genetics Institute, Inc. |
Fusions of P-selectin ligand protein and polynucleotides encoding same
|
ATE236987T1
(de)
|
1992-11-13 |
2003-04-15 |
Idec Pharma Corp |
Konsensus-kozak-sequenzen zur säugetier- exprimierung
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
WO1994028017A1
(en)
|
1993-06-01 |
1994-12-08 |
The Scripps Research Institute |
Human mutant tissue factor compositions useful as tissue factor antagonists
|
US6518013B1
(en)
|
1993-06-07 |
2003-02-11 |
Trimeris, Inc. |
Methods for the inhibition of epstein-barr virus transmission employing anti-viral peptides capable of abrogating viral fusion and transmission
|
US6479055B1
(en)
|
1993-06-07 |
2002-11-12 |
Trimeris, Inc. |
Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
|
US5464933A
(en)
|
1993-06-07 |
1995-11-07 |
Duke University |
Synthetic peptide inhibitors of HIV transmission
|
US6017536A
(en)
|
1993-06-07 |
2000-01-25 |
Trimeris, Inc. |
Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
|
US5621039A
(en)
|
1993-06-08 |
1997-04-15 |
Hallahan; Terrence W. |
Factor IX- polymeric conjugates
|
US6310180B1
(en)
|
1993-06-21 |
2001-10-30 |
Vanderbilt University |
Method for synthesis of proteins
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
US6740734B1
(en)
|
1994-01-14 |
2004-05-25 |
Biovitrum Ab |
Bacterial receptor structures
|
DE69521789T2
(de)
|
1994-02-01 |
2002-04-25 |
Us Health |
Fusionierte proteine die antikörper-teile und nicht-antikörper-teile enthalten
|
DE4405426A1
(de)
|
1994-02-21 |
1995-08-24 |
Boehringer Mannheim Gmbh |
Pharmazeutisches Präparat enthaltend Plasminogenaktivator (t-PA) oder dessen Derivate
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
US6372716B1
(en)
|
1994-04-26 |
2002-04-16 |
Genetics Institute, Inc. |
Formulations for factor IX
|
US5648240A
(en)
|
1994-05-24 |
1997-07-15 |
Texas A&M University |
MHC II analog from Staphylococcus aureus
|
GB9415379D0
(en)
|
1994-07-29 |
1994-09-21 |
Smithkline Beecham Plc |
Novel compounds
|
US5596080A
(en)
|
1994-10-03 |
1997-01-21 |
E. I. Du Pont De Nemours And Company |
Crosslinking processes/agents for zein
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6086875A
(en)
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5591573A
(en)
|
1995-04-10 |
1997-01-07 |
Alpha Therapeutic Corporation |
Method and system for testing blood samples
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
US5579277A
(en)
|
1995-05-01 |
1996-11-26 |
Apple Computer, Inc. |
System and method for interleaving memory banks
|
US6184344B1
(en)
|
1995-05-04 |
2001-02-06 |
The Scripps Research Institute |
Synthesis of proteins by native chemical ligation
|
US5686292A
(en)
|
1995-06-02 |
1997-11-11 |
Genentech, Inc. |
Hepatocyte growth factor receptor antagonist antibodies and uses thereof
|
US5811524A
(en)
|
1995-06-07 |
1998-09-22 |
Idec Pharmaceuticals Corporation |
Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
|
US6475491B1
(en)
|
1995-06-07 |
2002-11-05 |
Trimeris, Inc. |
Treatment of HIV and other viral infections using combinatorial therapy
|
US6685940B2
(en)
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
US5840529A
(en)
|
1995-08-02 |
1998-11-24 |
Clinical Research Institute Of Montreal |
Mammalian pro-hormone convertase
|
EP0848755B2
(en)
|
1995-09-08 |
2011-02-09 |
Genentech, Inc. |
Vegf-related protein
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
GB9524973D0
(en)
|
1995-12-06 |
1996-02-07 |
Lynxvale Ltd |
Viral vectors
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
US5770700A
(en)
*
|
1996-01-25 |
1998-06-23 |
Genetics Institute, Inc. |
Liquid factor IX formulations
|
CA2198968C
(en)
|
1996-03-04 |
2010-02-09 |
Toyofumi Masuda |
Process for production of secretory kex2 derivatives
|
US6458563B1
(en)
|
1996-06-26 |
2002-10-01 |
Emory University |
Modified factor VIII
|
CA2258153C
(en)
|
1996-07-03 |
2004-08-17 |
Genentech, Inc. |
Hepatocyte growth factor receptor agonists and uses thereof
|
CA2203745A1
(en)
|
1996-07-26 |
1998-01-26 |
Robert Day |
Pro-protein converting enzyme
|
AU3968897A
(en)
|
1996-08-02 |
1998-02-25 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
US6159462A
(en)
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
IN184589B
(ru)
|
1996-10-16 |
2000-09-09 |
Alza Corp |
|
ZA977959B
(en)
*
|
1996-10-16 |
1998-03-23 |
Alza Corp |
Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity.
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
US6271349B1
(en)
|
1996-12-23 |
2001-08-07 |
Immunex Corporation |
Receptor activator of NF-κB
|
DE69738841D1
(de)
|
1996-12-23 |
2008-08-28 |
Immunex Corp |
Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie
|
TW502011B
(en)
|
1997-02-05 |
2002-09-11 |
Ajinomoto Kk |
Process for producing n-long-chain acyl acidic amino acids or salts thereof
|
EP0971724B1
(en)
|
1997-02-14 |
2010-01-20 |
American Red Cross |
Expression of active human factor ix in mammary tissue of transgenic animals
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
CA2225189C
(en)
|
1997-03-06 |
2010-05-25 |
Queen's University At Kingston |
Canine factor viii gene, protein and methods of use
|
EP0981637B1
(en)
|
1997-03-14 |
2005-05-25 |
Biogen Idec Inc. |
Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
|
EP0985039B1
(en)
|
1997-06-12 |
2008-02-20 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
ES2235336T3
(es)
|
1997-06-13 |
2005-07-01 |
Gryphon Therapeutics, Inc. |
Ligacion quimica nativa en fase solida de peptidos desprotegidos o protegidos en la cisteina n-terminal en solucion acuosa.
|
US6310183B1
(en)
|
1997-09-10 |
2001-10-30 |
Novo Nordisk A/S |
Coagulation factor VIIa composition
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
US6008321A
(en)
|
1998-03-16 |
1999-12-28 |
Pharmacopeia, Inc. |
Universal linker for combinatorial synthesis
|
US6281331B1
(en)
|
1998-03-23 |
2001-08-28 |
Trimeris, Inc. |
Methods and compositions for peptide synthesis
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
DK1068241T3
(da)
|
1998-04-02 |
2008-02-04 |
Genentech Inc |
Antistofvarianter og fragmenter deraf
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
CA2331607A1
(en)
|
1998-05-06 |
1999-11-11 |
Temple University - Of The Commonwealth System Of Higher Education |
Reversal of proinflammatory response by ligating the macrophage fc.gamma.ri receptor
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
US6355782B1
(en)
|
1998-07-09 |
2002-03-12 |
Baylor College Of Medicine |
Hypohidrotic ectodermal dyplasia genes and proteins
|
CA2335274A1
(en)
|
1998-07-15 |
2000-01-27 |
Genentech, Inc. |
Tissue factor protein variants with increased affinity for coagulation factor fvii/fviia
|
CN1309770A
(zh)
|
1998-07-31 |
2001-08-22 |
***·E·卡罗尔 |
确定抗凝治疗因子的设备和方法
|
CA2341029A1
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
US6927044B2
(en)
|
1998-09-25 |
2005-08-09 |
Regeneron Pharmaceuticals, Inc. |
IL-1 receptor based cytokine traps
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
EP1127154B1
(en)
|
1998-11-06 |
2008-09-10 |
Novo Nordisk Health Care AG |
Method for the production of fvii
|
US6280994B1
(en)
|
1998-11-25 |
2001-08-28 |
Zymogenetics, Inc. |
Zace 1: a human metalloenzyme
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
JP2002535967A
(ja)
|
1999-01-06 |
2002-10-29 |
ジェネンテック・インコーポレーテッド |
インシュリン様成長因子(igf)i変異体
|
PT1141014E
(pt)
|
1999-01-06 |
2005-04-29 |
Genentech Inc |
Variante mutante do factor de crescimento semelhante a insulina (igf-i)
|
ES2694002T3
(es)
|
1999-01-15 |
2018-12-17 |
Genentech, Inc. |
Polipéptido que comprende una región Fc de IgG1 humana variante
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6602977B1
(en)
|
1999-04-19 |
2003-08-05 |
Biovitrum Ab |
Receptor structures
|
CA2373735A1
(en)
|
1999-07-02 |
2001-01-11 |
Genentech, Inc. |
Fviia antagonists
|
US6469136B1
(en)
|
1999-07-07 |
2002-10-22 |
Trimeris, Inc. |
Methods and composition for peptide synthesis
|
JP2001151694A
(ja)
|
1999-09-17 |
2001-06-05 |
Takeda Chem Ind Ltd |
タンパク質粉体の製造法
|
DE19963859A1
(de)
|
1999-12-30 |
2001-07-12 |
Apotech Res & Dev Ltd |
Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
|
EP1252192B1
(en)
|
2000-02-11 |
2006-08-16 |
MERCK PATENT GmbH |
Enhancing the circulating half-life of antibody-based fusion proteins
|
CA2405709A1
(en)
|
2000-04-12 |
2001-10-25 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
AU5208401A
(en)
|
2000-04-28 |
2001-11-12 |
Inflazyme Pharm Ltd |
3-nitrogen-6,7-dioxygen steroids and uses related thereto
|
ATE448301T1
(de)
|
2000-09-08 |
2009-11-15 |
Univ Zuerich |
Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
|
US7138119B2
(en)
|
2000-09-15 |
2006-11-21 |
Progenics Pharmaceuticals, Inc. |
Compositions and methods for inhibition of HIV-1 infection
|
US7615537B2
(en)
|
2000-10-25 |
2009-11-10 |
Genzyme Corporation |
Methods for treating blood coagulation disorders
|
AU2002226028A1
(en)
|
2000-11-14 |
2002-05-27 |
Board Of Regents, Unversity Of Texas Systems |
Mutant human factor ix with an increased resistance to inhibition by heparin
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
ES2649037T3
(es)
|
2000-12-12 |
2018-01-09 |
Medimmune, Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
US20030203845A1
(en)
|
2001-02-05 |
2003-10-30 |
Knudsen Jens Bjerre |
Combined use of factor VII polypeptides and factor IX polypeptides
|
US7419949B2
(en)
|
2001-07-16 |
2008-09-02 |
Novo Noridsk Healthcare A/G |
Single-dose administration of factor VIIa
|
MXPA04001982A
(es)
|
2001-09-04 |
2004-06-07 |
Merck Patent Gmbh |
Factor ix modificado.
|
ES2288900T3
(es)
|
2001-10-05 |
2008-02-01 |
Affimed Therapeutics Ag |
Anticuerpo de origen humano para inhibir la agregacion de trombocitos.
|
FR2831170B1
(fr)
|
2001-10-19 |
2004-03-19 |
Inst Nat Sante Rech Med |
Proteines c modifiees activables directement par la thrombine
|
US20030078180A1
(en)
|
2001-10-24 |
2003-04-24 |
Benchmark Research & Technology, Inc. |
Contaminant-tolerant foaming additive
|
CA2471363C
(en)
|
2001-12-21 |
2014-02-11 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
KR101271635B1
(ko)
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
US20080194481A1
(en)
|
2001-12-21 |
2008-08-14 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
US20040018557A1
(en)
|
2002-03-01 |
2004-01-29 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
CN100343393C
(zh)
|
2002-03-15 |
2007-10-17 |
布赖汉姆妇女医院 |
适合治疗剂全身性递送的中央气道给药
|
CA2495251C
(en)
|
2002-08-14 |
2018-03-06 |
Macrogenics, Inc. |
Fc.gamma.riib-specific antibodies and methods of use thereof
|
DK2345671T3
(en)
|
2002-09-27 |
2016-02-15 |
Xencor Inc |
Optimized Fc variants and methods for their formation
|
AU2003286467B2
(en)
|
2002-10-15 |
2009-10-01 |
Abbvie Biotherapeutics Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
GB2395337B
(en)
|
2002-11-14 |
2005-12-28 |
Gary Michael Wilson |
Warning Unit
|
JP2006524039A
(ja)
|
2003-01-09 |
2006-10-26 |
マクロジェニクス,インコーポレーテッド |
変異型Fc領域を含む抗体の同定および作製ならびにその利用法
|
US7041635B2
(en)
|
2003-01-28 |
2006-05-09 |
In2Gen Co., Ltd. |
Factor VIII polypeptide
|
HUE058897T2
(hu)
|
2003-02-26 |
2022-09-28 |
Nektar Therapeutics |
Polimer VIII-as faktor egység konjugátumok
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
DK2298347T3
(en)
|
2003-05-06 |
2016-01-11 |
Biogen Hemophilia Inc |
COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER
|
CA2522690A1
(en)
|
2003-05-06 |
2004-11-25 |
Syntonix Pharmaceuticals, Inc. |
Inhibition of drug binding to serum albumin
|
WO2004108885A2
(en)
|
2003-05-06 |
2004-12-16 |
Syntonix Pharmaceuticals, Inc. |
Fc chimeric proteins with anti-hiv drugs
|
US7212798B1
(en)
|
2003-07-17 |
2007-05-01 |
Cisco Technology, Inc. |
Adaptive AGC in a wireless network receiver
|
JP2005060378A
(ja)
|
2003-07-28 |
2005-03-10 |
Yamanouchi Pharmaceut Co Ltd |
生理活性蛋白質含有凍結乾燥製剤
|
US20050152979A1
(en)
|
2003-09-05 |
2005-07-14 |
Cell Therapeutics, Inc. |
Hydrophobic drug compositions containing reconstitution enhancer
|
CA2545539A1
(en)
|
2003-10-15 |
2005-04-28 |
Pdl Biopharma, Inc. |
Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
EP1697415A1
(en)
|
2003-11-12 |
2006-09-06 |
Biogen Idec MA Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
BRPI0406605B8
(pt)
|
2003-11-13 |
2021-05-25 |
Hanmi Holdings Co Ltd |
conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo
|
US8263084B2
(en)
|
2003-11-13 |
2012-09-11 |
Hanmi Science Co., Ltd |
Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate
|
US8110665B2
(en)
|
2003-11-13 |
2012-02-07 |
Hanmi Holdings Co., Ltd. |
Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
|
EP1684790A4
(en)
|
2003-11-18 |
2008-04-30 |
Iconic Therapeutics Inc |
HOMOGENEOUS PREPARATIONS OF CHIMERIC PROTEINS
|
AU2004298789A1
(en)
|
2003-12-19 |
2005-06-30 |
Novo Nordisk Health Care Ag |
Stabilised compositions of factor VII polypeptides
|
EP1697520A2
(en)
|
2003-12-22 |
2006-09-06 |
Xencor, Inc. |
Fc polypeptides with novel fc ligand binding sites
|
US20080089892A1
(en)
|
2004-01-12 |
2008-04-17 |
Eli Lilly And Co. |
Fc Region Variants
|
BRPI0509117A
(pt)
|
2004-03-04 |
2007-08-28 |
Wyeth Corp |
método de liofilização para melhorar a cristalização de excipientes
|
EP1737890A2
(en)
|
2004-03-24 |
2007-01-03 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
EP2471813B1
(en)
|
2004-07-15 |
2014-12-31 |
Xencor, Inc. |
Optimized Fc variants
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
EP1824988B1
(en)
|
2004-11-12 |
2017-04-19 |
Bayer HealthCare LLC |
Site-directed modification of fviii
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
MX2007005884A
(es)
|
2004-11-16 |
2008-02-12 |
Amgen Mountain View Inc |
Andamios de proteina y usos de los mismos.
|
PT1827483E
(pt)
|
2004-12-15 |
2014-09-25 |
Swedish Orphan Biovitrum Ab Publ |
Formulações terapêuticas do fator de crescimento de queratinócitos
|
US20060162552A1
(en)
|
2005-01-26 |
2006-07-27 |
Mohawk Valley Energy Solutions, Inc. |
Systems and methods for controlling room air quality
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
|
EP2377554A1
(en)
|
2005-07-22 |
2011-10-19 |
Amgen, Inc |
Concentrated protein lyophilates, methods and uses
|
JP2009504157A
(ja)
|
2005-08-12 |
2009-02-05 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
アルブミン融合タンパク質
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
US7666622B2
(en)
|
2005-10-19 |
2010-02-23 |
Regeneron Pharmaceuticals, Inc. |
Monomeric self-associating fusion polypeptides and therapeutic uses thereof
|
EP1942868B2
(en)
|
2005-11-01 |
2023-10-04 |
Wyeth LLC |
Sodium chloride solution for drug reconstitution or dilution
|
US8048848B2
(en)
|
2006-02-03 |
2011-11-01 |
Prolor Biotech Ltd. |
Long-acting interferons and derivatives thereof and methods thereof
|
US8759292B2
(en)
|
2006-02-03 |
2014-06-24 |
Prolor Biotech, Llc |
Long-acting coagulation factors and methods of producing same
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
EP1820508A1
(en)
|
2006-02-21 |
2007-08-22 |
CSL Behring GmbH |
Coagulation factor X polypeptides with modified activation properties
|
SI2402754T2
(sl)
|
2006-03-06 |
2023-09-29 |
Amunix Operating Inc. |
Nestrukturirani rekombinantni polimeri in njihove uporabe
|
WO2007109254A2
(en)
|
2006-03-17 |
2007-09-27 |
Biogen Idec Ma Inc. |
Stabilized polypeptide compositions
|
WO2007112005A2
(en)
|
2006-03-24 |
2007-10-04 |
Syntonix Pharmaceuticals, Inc. |
Pc5 as a factor ix propeptide processing enzyme
|
CA2644642C
(en)
|
2006-04-04 |
2016-01-26 |
Zymenex A/S |
A process for concentration of a polypeptide
|
EP2007885B1
(en)
|
2006-04-11 |
2010-07-21 |
CSL Behring GmbH |
Method of increasing the in vivo recovery of therapeutic polypeptides
|
CN104593348A
(zh)
|
2006-05-24 |
2015-05-06 |
诺沃—诺迪斯克保健股份有限公司 |
具有延长的体内半寿期的因子ix类似物
|
US7939632B2
(en)
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
JP5800458B2
(ja)
|
2006-06-14 |
2015-10-28 |
ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー |
血液凝固因子を有するタンパク質分解によって切断可能な融合タンパク質
|
WO2007149406A2
(en)
|
2006-06-19 |
2007-12-27 |
Nautilus Technology Llc |
Modified coagulation factor ix polypeptides and use thereof for treatment
|
WO2008022151A1
(en)
|
2006-08-15 |
2008-02-21 |
Inspiration Biopharmaceuticals, Inc. |
Prophylactic treatment of hemophilia
|
US8015841B2
(en)
|
2006-09-08 |
2011-09-13 |
Praxair Technology, Inc. |
Cryogenic refrigeration system for lyophilization
|
BRPI0716744A2
(pt)
|
2006-09-14 |
2016-10-04 |
Human Genome Sciences Inc |
proteínas de fusão de albumina
|
US7700734B2
(en)
|
2007-01-09 |
2010-04-20 |
Shu-Wha Lin |
Recombinant human factor IX and use thereof
|
EP2144930A1
(en)
|
2007-04-18 |
2010-01-20 |
ZymoGenetics, Inc. |
Single chain fc, methods of making and methods of treatment
|
CN101970678B
(zh)
|
2007-06-21 |
2014-08-20 |
慕尼黑科技大学 |
具有增加的体内和/或体外稳定性的生物学活性蛋白
|
CA2695374A1
(en)
|
2007-08-15 |
2009-02-19 |
Amunix, Inc. |
Compositions and methods for modifying properties of biologically active polypeptides
|
CA2702363A1
(en)
|
2007-10-15 |
2009-04-23 |
The University Of North Carolina At Chapel Hill |
Human factor ix variants with an extended half life
|
US20100316625A1
(en)
|
2007-12-21 |
2010-12-16 |
Inspiration Biopharmaceuticals, Inc. |
Stabilized factor ix formulations containing trehalose
|
JP2011507919A
(ja)
|
2007-12-27 |
2011-03-10 |
バクスター・インターナショナル・インコーポレイテッド |
修飾第ix因子
|
TWI465247B
(zh)
|
2008-04-11 |
2014-12-21 |
Catalyst Biosciences Inc |
經修飾的因子vii多肽和其用途
|
AU2009244633A1
(en)
|
2008-04-16 |
2009-11-12 |
Bayer Healthcare Llc |
Modified Factor IX polypeptides and uses thereof
|
KR20110015551A
(ko)
|
2008-04-16 |
2011-02-16 |
바이엘 헬스케어 엘엘씨 |
제ix인자의 부위-지정 변형
|
EP2268807A2
(en)
|
2008-04-21 |
2011-01-05 |
Novo Nordisk A/S |
Hyperglycosylated human coagulation factor ix
|
MX2010011672A
(es)
|
2008-04-24 |
2011-03-02 |
Celtic Pharma Peg Ltd |
Conjugados del factor ix con vidas medias extendidas.
|
US9884019B2
(en)
|
2008-08-05 |
2018-02-06 |
Wyeth Llc |
Lyophilization above collapse
|
AU2009284113B2
(en)
|
2008-08-21 |
2015-05-14 |
Octapharma Ag |
Recombinantly produced human factor VIII and IX
|
WO2010035001A1
(en)
*
|
2008-09-24 |
2010-04-01 |
Stabilitech Ltd |
Method for preserving polypeptides using a sugar and polyethyleneimine
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
CN102348715B
(zh)
|
2009-02-03 |
2017-12-08 |
阿穆尼克斯运营公司 |
延伸重组多肽和包含该延伸重组多肽的组合物
|
US8716448B2
(en)
|
2009-02-03 |
2014-05-06 |
Amunix Operating Inc. |
Coagulation factor VII compositions and methods of making and using same
|
EP2396347B1
(en)
|
2009-02-11 |
2017-04-12 |
Albumedix A/S |
Albumin variants and conjugates
|
ES2427627T3
(es)
|
2009-04-06 |
2013-10-31 |
Novo Nordisk A/S |
Entrega dirigida de proteínas de Factor VIII a plaquetas
|
PT2440228T
(pt)
|
2009-06-08 |
2018-12-24 |
Amunix Operating Inc |
Polipéptidos de regulação da glicose e métodos de preparação e utilização dos mesmos
|
EP2440241B1
(en)
|
2009-06-08 |
2017-08-09 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
US20120114646A1
(en)
|
2009-06-18 |
2012-05-10 |
Wyeth Llc |
Lyophilized formulations for small modular immunopharmaceuticals
|
ES2524974T3
(es)
|
2009-06-25 |
2014-12-16 |
The University Of North Carolina At Chapel Hill |
Moléculas del Factor VII quimérico
|
US20120121580A1
(en)
|
2009-07-28 |
2012-05-17 |
Merck Sharp & Dohme Corp. |
Methods for producing high concentration lyophilized pharmaceutical formulations
|
WO2011028344A2
(en)
|
2009-08-25 |
2011-03-10 |
Amunix Operating Inc. |
Interleukin-1 receptor antagonist compositions and methods of making and using same
|
EP2470561A1
(en)
|
2009-08-27 |
2012-07-04 |
Novo Nordisk A/S |
Targeting tissue factor to activated platelets
|
CN102741280B
(zh)
|
2009-10-30 |
2015-12-02 |
诺维信生物制药丹麦公司 |
白蛋白变体
|
EP2353588B1
(en)
|
2010-01-21 |
2015-04-15 |
Agricultural Technology Research Institute |
A sustained release preparation of factor IX
|
CA2789886A1
(en)
*
|
2010-02-24 |
2011-09-01 |
Arecor Limited |
Stable compositions of factor ix
|
AR081066A1
(es)
|
2010-04-02 |
2012-06-06 |
Hanmi Holdings Co Ltd |
Conjugado de insulina donde se usa un fragmento de inmunoglobulina
|
EP3508573A1
(en)
|
2010-07-09 |
2019-07-10 |
Bioverativ Therapeutics Inc. |
Systems for factor viii processing and methods thereof
|
EP2591006B1
(en)
|
2010-07-09 |
2019-04-24 |
Bioverativ Therapeutics Inc. |
Processable single chain molecules and polypeptides made using same
|
KR20230156435A
(ko)
|
2010-07-09 |
2023-11-14 |
바이오버라티브 테라퓨틱스 인크. |
인자 ix 폴리펩티드 및 이들의 사용 방법
|
HUE026794T2
(en)
|
2010-09-30 |
2016-07-28 |
Toyama Chemical Co Ltd |
The oleum salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
|
CN104011072B
(zh)
|
2011-05-05 |
2018-10-12 |
阿尔布梅迪克斯医疗有限公司 |
白蛋白变体
|
EP2780364A2
(en)
|
2011-11-18 |
2014-09-24 |
Eleven Biotherapeutics, Inc. |
Proteins with improved half-life and other properties
|
NZ626945A
(en)
|
2012-01-12 |
2016-10-28 |
Biogen Ma Inc |
Chimeric factor viii polypeptides and uses thereof
|
CA2863329C
(en)
|
2012-01-12 |
2023-01-03 |
Biogen Idec Ma Inc. |
Methods of reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
|
CN111548418A
(zh)
|
2012-02-15 |
2020-08-18 |
比奥贝拉蒂治疗公司 |
因子viii组合物及其制备和使用方法
|
EP2858659B1
(en)
|
2012-06-08 |
2019-12-25 |
Bioverativ Therapeutics Inc. |
Procoagulant compounds
|
PT2882450T
(pt)
|
2012-07-11 |
2020-02-19 |
Bioverativ Therapeutics Inc |
Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo
|
TWI810729B
(zh)
|
2012-09-25 |
2023-08-01 |
美商百歐維拉提夫治療公司 |
Fix多肽的應用
|
WO2014070953A1
(en)
|
2012-10-30 |
2014-05-08 |
Biogen Idec Ma Inc. |
Methods of Using FVIII Polypeptide
|
EP2956002B1
(en)
|
2013-02-16 |
2017-09-06 |
Albumedix A/S |
Pharmacokinetic animal model
|
AU2014228938B2
(en)
|
2013-03-15 |
2019-05-02 |
Bioverativ Therapeutics Inc. |
Factor IX polypeptide formulations
|
HUE047933T2
(hu)
|
2013-03-15 |
2020-05-28 |
Bioverativ Therapeutics Inc |
Faktor VIII polipeptid készítmények
|
SI3091997T1
(sl)
|
2014-01-10 |
2022-10-28 |
Bioverativ Therapeutics Inc. |
Himerni proteini faktorja VIII in njihova uporaba
|
MX2016012447A
(es)
*
|
2014-03-24 |
2017-01-06 |
Biogen Ma Inc |
Formulaciones de factor ix liofilizadas.
|
CA3044838A1
(en)
|
2016-12-02 |
2018-06-07 |
Bioverativ Therapeutics Inc. |
Methods of inducing immune tolerance to clotting factors
|
IL266972B2
(en)
|
2016-12-02 |
2024-04-01 |
Bioverativ Therapeutics Inc |
Methods for the treatment of hemophilic arthritis with the help of chimeric blood coagulation factors
|