ATE376059T1 - Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) - Google Patents
Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps)Info
- Publication number
- ATE376059T1 ATE376059T1 AT01946643T AT01946643T ATE376059T1 AT E376059 T1 ATE376059 T1 AT E376059T1 AT 01946643 T AT01946643 T AT 01946643T AT 01946643 T AT01946643 T AT 01946643T AT E376059 T1 ATE376059 T1 AT E376059T1
- Authority
- AT
- Austria
- Prior art keywords
- vlps
- influenza virus
- particles
- wild
- assembly
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21365600P | 2000-06-23 | 2000-06-23 | |
US28441101P | 2001-04-17 | 2001-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE376059T1 true ATE376059T1 (de) | 2007-11-15 |
Family
ID=26908276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01946643T ATE376059T1 (de) | 2000-06-23 | 2001-06-21 | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
Country Status (17)
Country | Link |
---|---|
US (2) | US7556940B2 (de) |
EP (1) | EP1294892B1 (de) |
JP (1) | JP5008244B2 (de) |
KR (1) | KR100877019B1 (de) |
CN (1) | CN1196788C (de) |
AT (1) | ATE376059T1 (de) |
AU (2) | AU2001268662A1 (de) |
BR (1) | BRPI0111830B8 (de) |
CA (1) | CA2410297C (de) |
CY (1) | CY1107835T1 (de) |
DE (1) | DE60130987T2 (de) |
DK (1) | DK1294892T3 (de) |
ES (1) | ES2295175T3 (de) |
IL (1) | IL153290A0 (de) |
MX (1) | MXPA02012254A (de) |
PT (1) | PT1294892E (de) |
WO (1) | WO2002000885A2 (de) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0250488A (ja) * | 1988-08-11 | 1990-02-20 | Nec Corp | 超伝導配線 |
EP1294892B1 (de) * | 2000-06-23 | 2007-10-17 | Wyeth Holdings Corporation | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
US9045727B2 (en) | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
US20060088909A1 (en) * | 2002-05-17 | 2006-04-27 | Compans Richard W | Virus-like particles, methods of preparation, and immunogenic compositions |
US20060121468A1 (en) * | 2002-06-26 | 2006-06-08 | Allnutt F C T | Viruses and virus-like particles for multiple antigen and target display |
ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
EP1664322B1 (de) | 2003-05-22 | 2013-07-10 | Fraunhofer USA, Inc. | Rekombinantes trägermolekül zur expression, zuführung und reinigung von zielpolypeptiden |
US8992939B2 (en) | 2003-07-11 | 2015-03-31 | Novavax, Inc. | Highly efficient influenza matrix (M1) proteins |
AU2011218606B2 (en) * | 2003-07-11 | 2012-01-12 | Novavax, Inc | Functional influenza virus-like particles (VLPS) |
US8551756B2 (en) * | 2003-07-11 | 2013-10-08 | Novavax, Inc. | Avian influenza chimeric VLPS |
US8080255B2 (en) | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
US8506967B2 (en) | 2003-07-11 | 2013-08-13 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
CA2567446C (en) * | 2004-05-21 | 2018-01-02 | Chiron Corporation | Alphavirus vectors for respiratory pathogen vaccines |
CA2597928A1 (en) * | 2005-02-16 | 2006-08-24 | Lentigen Corporation | Lentiviral vectors and their use |
ES2310062B1 (es) | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
WO2007117264A2 (en) | 2005-08-03 | 2007-10-18 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
CA2625406C (en) * | 2005-10-18 | 2016-08-09 | Novavax, Inc. | Functional influenza virus like particles (vlps) |
PT2529747T (pt) | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
WO2007066334A1 (en) * | 2005-12-06 | 2007-06-14 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved influenza vaccine |
IN2014DN08830A (de) * | 2006-02-02 | 2015-07-10 | Globeimmune Inc | |
KR20080106434A (ko) * | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | Hpv 항원, 백신 조성물 및 관련된 방법 |
US8277816B2 (en) * | 2006-02-13 | 2012-10-02 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
KR20080106433A (ko) * | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | 인플루엔자 항원, 백신 조성물 및 관련 방법 |
EP3011969A1 (de) | 2006-03-07 | 2016-04-27 | Vaxinnate Corporation | Zusammensetzungen mit hämagglutinin, verfahren zur herstellung und verfahren zur verwendung davon |
WO2007126788A2 (en) * | 2006-03-27 | 2007-11-08 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the treatment and prevention of viral infection |
US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
WO2007130330A2 (en) * | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Polyvalent influenza virus-like particle (vlp) compositions |
WO2007130327A2 (en) * | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
KR100702034B1 (ko) * | 2006-05-12 | 2007-03-30 | 삼성전자주식회사 | 반도체 장치, 이 장치의 전원 노이즈 감소 방법 및 인쇄회로 기판 |
US8153115B2 (en) | 2006-06-15 | 2012-04-10 | Ben-Gurion University Of The Negev Research And Development Authority | Virus-like particles for treatment of viral infections |
BRPI0714721A2 (pt) | 2006-07-14 | 2013-04-24 | Sanofi Pasteur Biologics Co | construÇço de vacinas de vÍrus recombinante por inserÇço direta mediada por transpàson de determinantes imunolàgicos estranhos em proteÍnas de vÍrus vetorial |
JP2009544322A (ja) * | 2006-07-27 | 2009-12-17 | リゴサイト ファーマシューティカルズ インコーポレイテッド | キメラウイルス様粒子 |
WO2008094197A2 (en) | 2006-07-27 | 2008-08-07 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
JP2010504760A (ja) * | 2006-09-29 | 2010-02-18 | サノフィ パスツール バイオロジクス カンパニー | 組換え型ライノウイルスベクター |
WO2008058396A1 (en) * | 2006-11-15 | 2008-05-22 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines for influenza |
US20110045022A1 (en) * | 2006-12-06 | 2011-02-24 | Theodore Tsai | Vaccines including antigen from four strains of influenza virus |
WO2008100609A1 (en) * | 2007-02-16 | 2008-08-21 | The Salk Institute For Biological Studies | A novel antitoxin and vaccine platform based on nodavirus vlps |
CN101687024A (zh) * | 2007-04-28 | 2010-03-31 | 美国弗劳恩霍夫股份有限公司 | 锥虫抗原、疫苗组合物和相关方法 |
US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
EP2178558B1 (de) | 2007-07-11 | 2014-04-30 | iBio, Inc. | Yersinia pestis-antigene, impfstoffzusammensetzungen und zugehörige verfahren |
KR101580660B1 (ko) | 2007-08-02 | 2015-12-28 | 바이오앤드백스 파마슈티칼즈, 리미티드. | 다중체 다중-에피토프 인플루엔자 백신 |
CA2696764A1 (en) * | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
KR101956910B1 (ko) * | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs) |
WO2009128949A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of dengue viral proteins and methods of use |
CA2742288A1 (en) * | 2008-07-30 | 2010-02-04 | Folia Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
EA023662B1 (ru) | 2009-02-10 | 2016-06-30 | Новартис Аг | Вакцины против гриппа со сниженным количеством сквалена |
EP2952581A1 (de) * | 2009-05-01 | 2015-12-09 | Redbiotec AG | Rekombinante virusähnliche partikel, die durch einen mehrfachgenvektor codiert sind |
JP2012525830A (ja) * | 2009-05-08 | 2012-10-25 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 均質化を含む細胞培養からのウイルスの製造方法 |
PL222497B1 (pl) * | 2009-06-26 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej |
ES2566361T3 (es) | 2009-07-02 | 2016-04-12 | Massachusetts Institute Of Technology | Composiciones y métodos para diagnosticar y/o tratar una infección gripal |
EP2483307A1 (de) | 2009-09-29 | 2012-08-08 | Fraunhofer USA, Inc. | Influenza-hämagglutinin-antikörper, zusammensetzungen daraus und zugehörige verfahren |
WO2011046925A1 (en) * | 2009-10-12 | 2011-04-21 | Technovax, Inc. | Respiratory syncytial virus (rsv) virus-like particles (vlps) |
US8920812B2 (en) | 2009-11-03 | 2014-12-30 | Takeda Vaccines, Inc. | Chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus Gag-based VLPS |
CN102822343B (zh) * | 2009-12-28 | 2017-10-20 | 赛诺菲疫苗技术公司 | 微藻中异源多肽的生产,微藻胞外体、组合物及其制备方法和用途 |
WO2011090712A2 (en) * | 2009-12-28 | 2011-07-28 | Ligocyte Pharmaceuticals, Inc. | Methods for stabilizing influenza antigen enveloped virus-based virus-like particle solutions |
EP2536428B1 (de) | 2010-02-18 | 2018-12-05 | Technovax, Inc. | Universelle influenza-impfstoffe mit virusartigen partikeln |
CN102373181B (zh) * | 2010-08-09 | 2014-06-11 | 中山大学 | 猪流感病毒和猪蓝耳病病毒混合病毒样颗粒、制备方法和应用 |
CN102370976B (zh) * | 2010-08-09 | 2014-06-11 | 中山大学 | 猪流感病毒和猪***病毒的混合病毒样颗粒、制备方法和应用 |
CN102373182A (zh) * | 2010-08-09 | 2012-03-14 | 中山大学 | 禽流感和传染性囊病混合病毒样颗粒、制备方法和应用 |
CN102373183A (zh) * | 2010-08-09 | 2012-03-14 | 中山大学 | 禽流感和新城疫混合病毒样颗粒、制备方法和应用 |
CN102373184A (zh) * | 2010-08-09 | 2012-03-14 | 中山大学 | 禽流感和传染性支气管炎混合病毒样颗粒、制备方法和应用 |
CA2811023A1 (en) | 2010-09-21 | 2012-03-29 | Massachusetts Institute Of Technology | Influenza treatment and/or characterization; human-adapted ha polypeptides; vaccines |
RU2663718C2 (ru) | 2010-10-04 | 2018-08-08 | Массачусетс Инститьют Оф Текнолоджи | Полипептиды гемагглютининов, а также связанные с ними реагенты и способы |
US9821051B1 (en) | 2010-10-28 | 2017-11-21 | Seqirus UK Limited | Reducing hospitalization in elderly influenza vaccine recipients |
WO2012114323A1 (en) | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
US9580475B2 (en) | 2011-06-20 | 2017-02-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for H1N1 influenza |
EP2739307B1 (de) * | 2011-08-01 | 2017-09-06 | Emory University | Ligand-haltige vlps und entsprechende verfahren |
EP4241785A3 (de) * | 2011-09-20 | 2023-09-27 | Icahn School of Medicine at Mount Sinai | Influenzavirus-impfstoffe und verwendungen davon |
ES2657875T3 (es) | 2012-03-22 | 2018-03-07 | Fraunhofer Usa Inc. | Partículas tipo virus que comprenden una proteína de la matriz de un virus encapsulado de plantas y usos de las mismas |
BR112014023900A2 (pt) | 2012-03-30 | 2020-11-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Polipeptídeo de hemaglutimina de influenza recombinante, molécula de ácido nucleicoisolada, vetor, célula isolada, partícula semelhante ao vírus da influenza, proteína de fusão, composição, e uso |
TWI434933B (zh) * | 2012-04-17 | 2014-04-21 | Nat Univ Tsing Hua | 抗多型禽流感病毒之dna疫苗及其組合物 |
US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
CN104797594A (zh) | 2012-11-27 | 2015-07-22 | 高等教育联邦***-匹兹堡大学 | 计算优化的广泛反应性h1n1流感抗原 |
NZ627796A (en) | 2012-12-18 | 2017-07-28 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
CN104436157A (zh) | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | 流感疫苗和治疗 |
US10080792B2 (en) | 2013-09-23 | 2018-09-25 | Engen Bio, Inc. | Influenza vaccine and therapy |
US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
KR101729387B1 (ko) | 2015-04-17 | 2017-04-21 | 경희대학교 산학협력단 | 곤충세포 발현시스템을 이용한 인플루엔자 백신 소재 m1-m2-na-ha 바이러스 유사 입자의 제조방법 |
WO2017044890A1 (en) * | 2015-09-10 | 2017-03-16 | Academia Sinica | Bird flu vaccine combination comprising virus-like particles and novel adjuvants |
CN109641041A (zh) | 2016-06-15 | 2019-04-16 | 西奈山伊坎医学院 | 流感病毒血细胞凝集素蛋白及其用途 |
WO2018080889A1 (en) * | 2016-10-31 | 2018-05-03 | Georgia State University Research Foundation, Inc. | A virus like particle of hepatitis b virus pre-s protein |
CA3058652A1 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
EP3851120A4 (de) | 2018-09-11 | 2022-04-27 | Shanghai Public Health Clinical Center | Immunogen für influenza-impfstoff mit breitem spektrum und anwendung davon |
MX2023012554A (es) | 2018-12-12 | 2023-11-08 | Cambridge Tech Llc | Vacuna universal contra la gripe. |
CN116063409A (zh) * | 2022-09-09 | 2023-05-05 | 中山大学·深圳 | 一种乙型流感Mosaic重组蛋白、重组质粒及其构建方法和应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4009258A (en) * | 1972-09-25 | 1977-02-22 | The Mount Sinai School Of Medicine Of The City University Of New York | Influenza vaccine containing a recombinant, antigenically hybridized virus and method of using the same |
US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
US6001634A (en) * | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
US5298244A (en) * | 1990-10-25 | 1994-03-29 | University Of Saskatchewan | Assembled viral particles and their use in a vaccine to rotaviral disease |
US5830877A (en) * | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
EP1067956B1 (de) | 1998-04-03 | 2007-03-14 | University Of Iowa Research Foundation | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
MXPA01003228A (es) | 1998-09-30 | 2003-06-24 | American Cyanamid Co | Holotoxina de colera mutante como un coadyuvante. |
MXPA01010082A (es) * | 1999-04-06 | 2002-04-24 | Wisconsin Alumni Res Found | Virus recombinantes de influenza para vacunas y terapia de genes. |
EP1294892B1 (de) * | 2000-06-23 | 2007-10-17 | Wyeth Holdings Corporation | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
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MXPA02012254A (es) | 2003-04-25 |
CN1437655A (zh) | 2003-08-20 |
US7556940B2 (en) | 2009-07-07 |
ES2295175T3 (es) | 2008-04-16 |
JP2004501647A (ja) | 2004-01-22 |
DE60130987D1 (de) | 2007-11-29 |
KR100877019B1 (ko) | 2009-01-07 |
CA2410297A1 (en) | 2002-01-03 |
AU2007201727B2 (en) | 2009-06-04 |
EP1294892B1 (de) | 2007-10-17 |
BRPI0111830B8 (pt) | 2021-05-25 |
US20090239261A1 (en) | 2009-09-24 |
DE60130987T2 (de) | 2008-07-24 |
EP1294892A2 (de) | 2003-03-26 |
US20050186621A1 (en) | 2005-08-25 |
WO2002000885A9 (en) | 2002-05-10 |
PT1294892E (pt) | 2008-01-16 |
CY1107835T1 (el) | 2013-06-19 |
JP5008244B2 (ja) | 2012-08-22 |
DK1294892T3 (da) | 2008-01-28 |
WO2002000885A2 (en) | 2002-01-03 |
WO2002000885A3 (en) | 2002-08-08 |
KR20030013463A (ko) | 2003-02-14 |
IL153290A0 (en) | 2003-07-06 |
AU2001268662A1 (en) | 2002-01-08 |
AU2007201727A1 (en) | 2007-05-10 |
BR0111830B1 (pt) | 2014-12-02 |
CN1196788C (zh) | 2005-04-13 |
BR0111830A (pt) | 2003-03-25 |
CA2410297C (en) | 2011-03-15 |
US8859231B2 (en) | 2014-10-14 |
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