BRPI0717219B8 - composição imunogênica, e, uso de uma composição imunogênica - Google Patents
composição imunogênica, e, uso de uma composição imunogênicaInfo
- Publication number
- BRPI0717219B8 BRPI0717219B8 BRPI0717219A BRPI0717219A BRPI0717219B8 BR PI0717219 B8 BRPI0717219 B8 BR PI0717219B8 BR PI0717219 A BRPI0717219 A BR PI0717219A BR PI0717219 A BRPI0717219 A BR PI0717219A BR PI0717219 B8 BRPI0717219 B8 BR PI0717219B8
- Authority
- BR
- Brazil
- Prior art keywords
- immunogenic composition
- composition
- oil
- antigen
- water emulsion
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 230000002163 immunogen Effects 0.000 title abstract 5
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000007764 o/w emulsion Substances 0.000 abstract 2
- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
composição imunogênica, e, uso de uma composição imunogênica. a presente invenção proporciona composição imunogênica compreendendo um antígeno ou composição de antígeno e composição adjuvante compreendendo uma emulsão de óleo-em-água, sendo quantidade efetiva a dita emulsão de óleo-em-água compreende 0,5 - 10 mg de óleo metabolizável, 0,5 - 11 mg de tocol e 0,1 - 4 mg de agente emulsificador, por dose para humano.
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0620336.8A GB0620336D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GB0620336.8 | 2006-10-12 | ||
GB0620337.6 | 2006-10-12 | ||
GB0620337A GB0620337D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GB0620815A GB0620815D0 (en) | 2006-10-19 | 2006-10-19 | Vaccine |
GB0620816.9 | 2006-10-19 | ||
GB0620815.1 | 2006-10-19 | ||
GB0620816A GB0620816D0 (en) | 2006-10-19 | 2006-10-19 | vaccine |
PCT/EP2006/069979 WO2007071711A2 (en) | 2005-12-22 | 2006-12-20 | Vaccine |
PCT/EP2006/069977 WO2007071710A2 (en) | 2005-12-22 | 2006-12-20 | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
GB0707697A GB0707697D0 (en) | 2007-04-20 | 2007-04-20 | Vaccine |
GB0711357A GB0711357D0 (en) | 2007-06-12 | 2007-06-12 | Vaccine |
GB0711357.4 | 2007-06-12 | ||
GB0712062A GB0712062D0 (en) | 2007-06-21 | 2007-06-21 | Vaccine |
PCT/EP2007/060743 WO2008043774A1 (en) | 2006-10-12 | 2007-10-10 | Vaccine comprising an oil in water emulsion adjuvant |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0717219A2 BRPI0717219A2 (pt) | 2015-05-26 |
BRPI0717219B1 BRPI0717219B1 (pt) | 2021-01-19 |
BRPI0717219B8 true BRPI0717219B8 (pt) | 2021-05-25 |
Family
ID=40551582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0717219A BRPI0717219B8 (pt) | 2006-10-12 | 2007-10-10 | composição imunogênica, e, uso de uma composição imunogênica |
Country Status (18)
Country | Link |
---|---|
US (2) | US20100183667A1 (pt) |
JP (2) | JP5230632B2 (pt) |
KR (1) | KR101151202B1 (pt) |
CN (1) | CN101522218B (pt) |
AU (1) | AU2007306381B2 (pt) |
BR (1) | BRPI0717219B8 (pt) |
CA (1) | CA2664619C (pt) |
CR (1) | CR10726A (pt) |
DK (1) | DK2086582T3 (pt) |
EA (1) | EA015817B1 (pt) |
ES (1) | ES2397714T3 (pt) |
HR (1) | HRP20130023T1 (pt) |
IL (1) | IL197512A (pt) |
MA (1) | MA30866B1 (pt) |
MX (1) | MX2009003325A (pt) |
NO (1) | NO20091022L (pt) |
PT (1) | PT2086582E (pt) |
WO (1) | WO2008043774A1 (pt) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
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DE60015084T2 (de) * | 1999-02-26 | 2006-02-16 | Chiron S.R.L. | Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden |
DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
DK1861120T3 (en) | 2005-03-23 | 2016-07-25 | Glaxosmithkline Biologicals Sa | Use of an influenza virus and an oil-in-water emulsion adjuvant to induce CD 4 T cell and / or enhanced B memory cell response |
EA200900024A1 (ru) | 2006-07-17 | 2009-06-30 | Глаксосмитклайн Байолоджикалс С.А. | Противогриппозная вакцина |
BRPI0717219B8 (pt) | 2006-10-12 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição imunogênica, e, uso de uma composição imunogênica |
AU2007318026B2 (en) | 2006-11-03 | 2013-04-18 | Merck Sharp & Dohme (Holdings) Pty Ltd | Canine Lyme disease vaccine |
PE20090146A1 (es) * | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
ES2535101T3 (es) | 2008-03-18 | 2015-05-05 | Novartis Ag | Mejoras en la preparación de antígenos en vacuna de virus de la gripe |
MX2010011393A (es) * | 2008-04-16 | 2010-11-09 | Glaxosmithkline Biolog Sa | Vacuna. |
ES2678694T3 (es) * | 2008-04-16 | 2018-08-16 | Glaxosmithkline Biologicals Sa | Vacuna |
ES2761697T3 (es) | 2008-08-28 | 2020-05-20 | Novartis Ag | Proceso para preparar una emulsión de aceite en agua que contiene escualeno procedente de levaduras |
WO2010032138A2 (en) | 2008-09-18 | 2010-03-25 | Novartis Ag | Vaccine adjuvant combinations |
ES2608841T3 (es) * | 2009-02-10 | 2017-04-17 | Seqirus UK Limited | Vacunas contra la gripe con cantidades reducidas de escualeno |
ES2552383T3 (es) | 2009-02-10 | 2015-11-27 | Novartis Ag | Regímenes de vacuna de la gripe para cepas asociadas a pandemias |
US20120093860A1 (en) | 2009-02-10 | 2012-04-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
EP2398821B1 (en) | 2009-02-17 | 2017-08-30 | GlaxoSmithKline Biologicals S.A. | Inactivated dengue virus vaccine with aluminium-free adjuvant |
BRPI1009829A2 (pt) | 2009-03-24 | 2016-11-16 | Novartis Ag | combinações de proteína de ligação de fator h meningocócico e conjugados de sacarídeos pneumocócicos |
RU2508126C2 (ru) | 2009-04-14 | 2014-02-27 | Новартис Аг | Композиции для иммунизации против staphylococcus aureus |
JP5836266B2 (ja) | 2009-05-21 | 2015-12-24 | ノバルティス アーゲー | 非内因性polIプロモーターを使用した逆遺伝学 |
CN102666860B (zh) | 2009-07-31 | 2015-06-17 | 诺华股份有限公司 | 反向遗传*** |
GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
AU2010309404B2 (en) | 2009-10-20 | 2015-07-09 | Seqirus UK Limited | Improved reverse genetics methods for virus rescue |
GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
KR20120129927A (ko) | 2010-01-27 | 2012-11-28 | 글락소 그룹 리미티드 | 변형된 투베르쿨로시스 항원 |
CA2793510A1 (en) | 2010-03-18 | 2012-02-16 | Novartis Ag | Adjuvanted vaccines for serogroup b meningococcus |
EA027142B1 (ru) | 2010-05-12 | 2017-06-30 | Новартис Аг | Улучшенные способы получения сквалена |
JP5876036B2 (ja) | 2010-05-21 | 2016-03-02 | ノバルティス アーゲー | インフルエンザウイルス再集合方法 |
GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
EP2768528A1 (en) | 2011-10-20 | 2014-08-27 | Novartis AG | Adjuvanted influenza b virus vaccines for pediatric priming |
US20140335507A1 (en) | 2011-12-12 | 2014-11-13 | Novartis Ag | Assays for influenza virus hemagglutinins |
US20150044251A1 (en) | 2011-12-23 | 2015-02-12 | Novartis Ag | Stable compositions for immunising against staphylococcus aureus |
CA2813723A1 (en) | 2012-03-02 | 2013-09-02 | Novartis Ag | Influenza virus reassortment |
US9375471B2 (en) | 2012-03-08 | 2016-06-28 | Glaxosmithkline Biologicals Sa | Adjuvanted formulations of booster vaccines |
PL2890394T3 (pl) | 2012-08-31 | 2019-12-31 | Glaxosmithkline Biologicals Sa | Stabilizowane białka do immunizacji przeciw staphylococcus aureus |
JP2015528456A (ja) | 2012-08-31 | 2015-09-28 | ノバルティス アーゲー | Staphylococcusaureusに対する免疫化のための安定化されたタンパク質 |
US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
EP3620172A1 (en) | 2012-10-12 | 2020-03-11 | GlaxoSmithKline Biologicals SA | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
JP6340011B2 (ja) | 2012-11-30 | 2018-06-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | シュードモナス抗原および抗原の組み合わせ |
MX2015006927A (es) | 2012-12-03 | 2016-02-05 | Novartis Ag | Redistribucion de virus de la influenza. |
PT2928489T (pt) | 2012-12-05 | 2019-05-28 | Glaxosmithkline Biologicals Sa | Composição imunogénica |
WO2014095771A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Conjugates for protecting against diphtheria and/or tetanus |
JP6525469B2 (ja) | 2013-03-13 | 2019-06-05 | ノバルティス アーゲー | インフルエンザb型ウイルス再集合 |
CN105120898A (zh) * | 2013-03-19 | 2015-12-02 | 生物技术工具公司 | 过敏原制剂 |
KR20160030097A (ko) | 2013-05-10 | 2016-03-16 | 노파르티스 아게 | 인플루엔자 백신에서 기면증 위험의 방지 |
HRP20211452T1 (hr) * | 2013-05-14 | 2021-12-24 | Zoetis Services Llc | Novi cjepivni pripravci koji sadrže imunostimulacijske oligonukleotide |
DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
CA2914604A1 (en) | 2013-06-06 | 2014-12-11 | Novartis Ag | Influenza virus reassortment |
US10105431B2 (en) * | 2014-01-21 | 2018-10-23 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
PT3122378T (pt) | 2014-03-26 | 2020-03-04 | Glaxosmithkline Biologicals Sa | Antigénios estafilocócicos mutantes |
CA2949881A1 (en) * | 2014-05-26 | 2015-12-03 | Becton Dickinson France | Method for storing an emulsion-adjuvanted vaccine in a lubricated medical injection device |
WO2016087479A1 (en) | 2014-12-02 | 2016-06-09 | Novartis Ag | Manufacture of surfactant-containing compositions |
JP6830070B2 (ja) | 2015-07-07 | 2021-02-17 | セキラス ユーケー リミテッドSeqirus UK Limited | インフルエンザ効力アッセイ |
BE1024160B9 (fr) | 2015-12-22 | 2017-12-06 | Glaxosmithkline Biologicals Sa | Formulation immunogène |
WO2018058230A1 (en) * | 2016-09-27 | 2018-04-05 | Immunovaccine Technologies Inc. | Methods of using low dose volume b-cell epitope compositions for inducing an antibody immune response in human subjects |
CN106511996B (zh) * | 2016-11-04 | 2019-09-10 | 江苏省农业科学院 | 用于***疫苗的复乳型佐剂及其制备方法 |
EP3576759A4 (en) | 2017-01-31 | 2020-11-11 | Merck Sharp & Dohme Corp. | PROCESS FOR THE PREPARATION OF CAPSULE POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F |
CN109652384B (zh) * | 2019-02-21 | 2021-10-26 | 昆明理工大学 | 一种体外培养戊型肝炎病毒的方法 |
KR20220128613A (ko) | 2019-11-18 | 2022-09-21 | 세퀴러스 피티와이 리미티드 | 재배열 인플루엔자 바이러스의 제조 방법 |
KR20210117832A (ko) * | 2020-03-20 | 2021-09-29 | 강원대학교산학협력단 | Gla-se를 포함하는 수족구병 백신 조성물 |
WO2022002783A1 (en) | 2020-06-29 | 2022-01-06 | Glaxosmithkline Biologicals Sa | Adjuvants |
CA3190375A1 (en) | 2020-08-24 | 2022-03-03 | Natalie ANOSOVA | Covid-19 vaccines with tocopherol-containing squalene emulsion adjuvants |
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WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
KR20240033309A (ko) * | 2022-09-05 | 2024-03-12 | 주식회사 차백신연구소 | 에멀전 제형의 면역증강제 조성물 및 이의 제조 방법 |
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- 2007-10-10 CN CN200780038231XA patent/CN101522218B/zh active Active
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- 2007-10-10 WO PCT/EP2007/060743 patent/WO2008043774A1/en active Application Filing
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- 2007-10-10 JP JP2009531831A patent/JP5230632B2/ja active Active
- 2007-10-10 KR KR1020097009716A patent/KR101151202B1/ko active IP Right Grant
- 2007-10-10 US US12/445,090 patent/US20100183667A1/en not_active Abandoned
- 2007-10-10 ES ES07821111T patent/ES2397714T3/es active Active
- 2007-10-10 DK DK07821111.7T patent/DK2086582T3/da active
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Also Published As
Publication number | Publication date |
---|---|
CN101522218B (zh) | 2012-09-26 |
AU2007306381B2 (en) | 2011-12-08 |
BRPI0717219B1 (pt) | 2021-01-19 |
US9700605B2 (en) | 2017-07-11 |
MA30866B1 (fr) | 2009-11-02 |
BRPI0717219A2 (pt) | 2015-05-26 |
EA015817B1 (ru) | 2011-12-30 |
CN101522218A (zh) | 2009-09-02 |
KR20090066323A (ko) | 2009-06-23 |
IL197512A0 (en) | 2011-08-01 |
JP2013067646A (ja) | 2013-04-18 |
ES2397714T3 (es) | 2013-03-08 |
CA2664619C (en) | 2012-12-11 |
WO2008043774A1 (en) | 2008-04-17 |
CR10726A (es) | 2009-05-25 |
AU2007306381A1 (en) | 2008-04-17 |
KR101151202B1 (ko) | 2012-06-11 |
CA2664619A1 (en) | 2008-04-17 |
IL197512A (en) | 2013-10-31 |
NO20091022L (no) | 2009-04-27 |
MX2009003325A (es) | 2009-04-09 |
JP5767201B2 (ja) | 2015-08-19 |
US20150359863A1 (en) | 2015-12-17 |
HRP20130023T1 (hr) | 2013-02-28 |
JP5230632B2 (ja) | 2013-07-10 |
DK2086582T3 (da) | 2013-02-04 |
PT2086582E (pt) | 2013-01-25 |
JP2010505907A (ja) | 2010-02-25 |
EA200900350A1 (ru) | 2009-10-30 |
US20100183667A1 (en) | 2010-07-22 |
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