MA20150428A1 - Sel de l-malate de dérivés de 2,7-diaza-spiro[4.5]déc-7-yle et ses formes cristallines à titre d'agonistes des récepteurs de ghreline - Google Patents

Sel de l-malate de dérivés de 2,7-diaza-spiro[4.5]déc-7-yle et ses formes cristallines à titre d'agonistes des récepteurs de ghreline

Info

Publication number
MA20150428A1
MA20150428A1 MA37470A MA37470A MA20150428A1 MA 20150428 A1 MA20150428 A1 MA 20150428A1 MA 37470 A MA37470 A MA 37470A MA 37470 A MA37470 A MA 37470A MA 20150428 A1 MA20150428 A1 MA 20150428A1
Authority
MA
Morocco
Prior art keywords
diaza
spiro
dec
crystalline forms
malate salt
Prior art date
Application number
MA37470A
Other languages
English (en)
Inventor
Ameet Vijay Ambarkhane
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48626496&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA20150428(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA20150428A1 publication Critical patent/MA20150428A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Cette invention concerne : le sel de l-malate du 2-amino-n-[(r)-l- benzyloxyméthyl-2-((4s,5r)-2-méthyl-l-oxo-4-phényl-2,7-diaza- spiro[4.5]déc-7-yl)-2-oxo-éthyl]-2-méthylpropionamide, le sel de l-malate du 2-amino-n-((2r)-3-(benzyloxy)-l-(2-méthyl-l-oxo-4-p-tolyl-2,7- diazaspiro[4.5]décan-7-yl)-l-oxopropan-2-yl)-2-méthylpropanamide et le sel de l-malate du 2-amino-n-((r)-l-benzyloxyméthyl-2-[(4s,5r)-4-fluoro- phényl)-2-méthyl-l-oxo-2,7-diaza-spiro[4,5]déc-7-yl]-2-oxoéthyl)-2- méthylpropionamide et leurs formes cristallines ; des compositions pharmaceutiques les contenant et l'utilisation desdits composés pour traiter un trouble ou une maladie médié par le récepteur de ghreline.
MA37470A 2012-05-03 2013-05-02 Sel de l-malate de dérivés de 2,7-diaza-spiro[4.5]déc-7-yle et ses formes cristallines à titre d'agonistes des récepteurs de ghreline MA20150428A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261642116P 2012-05-03 2012-05-03
PCT/IB2013/053492 WO2013164790A1 (fr) 2012-05-03 2013-05-02 Sel de l-malate de dérivés de 2,7-diaza-spiro[4.5]déc-7-yle et ses formes cristallines à titre d'agonistes des récepteurs de ghreline

Publications (1)

Publication Number Publication Date
MA20150428A1 true MA20150428A1 (fr) 2015-11-30

Family

ID=48626496

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37470A MA20150428A1 (fr) 2012-05-03 2013-05-02 Sel de l-malate de dérivés de 2,7-diaza-spiro[4.5]déc-7-yle et ses formes cristallines à titre d'agonistes des récepteurs de ghreline

Country Status (20)

Country Link
US (1) US20130296358A1 (fr)
EP (1) EP2852591A1 (fr)
JP (1) JP2015525202A (fr)
KR (1) KR20150003771A (fr)
CN (1) CN104271579A (fr)
AR (1) AR093748A1 (fr)
AU (1) AU2013255458A1 (fr)
BR (1) BR112014026210A2 (fr)
CA (1) CA2867043A1 (fr)
CO (1) CO7111286A2 (fr)
CU (1) CU20130159A7 (fr)
EA (1) EA201491990A1 (fr)
IL (1) IL235215A0 (fr)
MA (1) MA20150428A1 (fr)
PE (1) PE20142443A1 (fr)
PH (1) PH12014502446A1 (fr)
SG (1) SG11201405810UA (fr)
TN (2) TN2013000441A1 (fr)
TW (1) TW201348235A (fr)
WO (1) WO2013164790A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020005992A2 (pt) * 2017-09-28 2020-09-29 Biogen Inc novos sais

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Also Published As

Publication number Publication date
SG11201405810UA (en) 2014-11-27
KR20150003771A (ko) 2015-01-09
US20130296358A1 (en) 2013-11-07
JP2015525202A (ja) 2015-09-03
TN2014000400A1 (en) 2015-12-21
PH12014502446A1 (en) 2015-01-12
IL235215A0 (en) 2014-12-31
AR093748A1 (es) 2015-06-24
CA2867043A1 (fr) 2013-11-07
WO2013164790A1 (fr) 2013-11-07
TW201348235A (zh) 2013-12-01
CN104271579A (zh) 2015-01-07
EP2852591A1 (fr) 2015-04-01
TN2013000441A1 (en) 2015-03-30
EA201491990A1 (ru) 2015-02-27
PE20142443A1 (es) 2015-01-28
CU20130159A7 (es) 2014-02-28
BR112014026210A2 (pt) 2017-06-27
CO7111286A2 (es) 2014-11-10
AU2013255458A1 (en) 2014-10-09

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