EA201491574A1 - Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car - Google Patents

Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car

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Publication number
EA201491574A1
EA201491574A1 EA201491574A EA201491574A EA201491574A1 EA 201491574 A1 EA201491574 A1 EA 201491574A1 EA 201491574 A EA201491574 A EA 201491574A EA 201491574 A EA201491574 A EA 201491574A EA 201491574 A1 EA201491574 A1 EA 201491574A1
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Prior art keywords
car
icos
long
application
tumor activity
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EA201491574A
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English (en)
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Карл Х. Джун
Сония Гедан Каррио
Янбин Чжао
Джон Шоллер
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201491574A1 publication Critical patent/EA201491574A1/ru

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Abstract

Настоящее изобретение относится к композициям и способам лечения злокачественной опухоли у человека. Изобретение включает введение генетически модифицированных клеток Th17, экспрессирующих CAR, содержащий антигенсвязывающий домен, трансмембранный домен и внутриклеточный сигнальный домен ICOS.
EA201491574A 2012-02-22 2013-02-22 Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car EA201491574A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261601910P 2012-02-22 2012-02-22
PCT/US2013/027366 WO2013126733A1 (en) 2012-02-22 2013-02-22 Use of icos-based cars to enhance antitumor activity and car persistence

Publications (1)

Publication Number Publication Date
EA201491574A1 true EA201491574A1 (ru) 2014-12-30

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EA201491574A EA201491574A1 (ru) 2012-02-22 2013-02-22 Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car

Country Status (14)

Country Link
US (3) US9714278B2 (ru)
EP (3) EP3747898B1 (ru)
JP (1) JP2015509717A (ru)
KR (1) KR20140135715A (ru)
CN (1) CN104159917A (ru)
AU (1) AU2013222288A1 (ru)
CA (2) CA3205751A1 (ru)
EA (1) EA201491574A1 (ru)
ES (1) ES2816450T3 (ru)
IL (1) IL233994A0 (ru)
IN (1) IN2014DN07414A (ru)
MX (1) MX2014010181A (ru)
SG (1) SG11201404769UA (ru)
WO (1) WO2013126733A1 (ru)

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