EA201491226A1 - НОВОЕ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ p75 - Google Patents

НОВОЕ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ p75

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Publication number
EA201491226A1
EA201491226A1 EA201491226A EA201491226A EA201491226A1 EA 201491226 A1 EA201491226 A1 EA 201491226A1 EA 201491226 A EA201491226 A EA 201491226A EA 201491226 A EA201491226 A EA 201491226A EA 201491226 A1 EA201491226 A1 EA 201491226A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
receptors
new therapeutic
therapeutic application
medicament
Prior art date
Application number
EA201491226A
Other languages
English (en)
Other versions
EA028616B1 (ru
Inventor
Роберта Аваллоне
Марко Барони
Тициано Крочи
Original Assignee
Санофи
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47429839&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491226(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофи filed Critical Санофи
Publication of EA201491226A1 publication Critical patent/EA201491226A1/ru
Publication of EA028616B1 publication Critical patent/EA028616B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к применению антагониста рецепторов р75 или его фармацевтически приемлемых солей в получении лекарственного средства для применения при лечении и/или профилактике гиперактивности мочевого пузыря.
EA201491226A 2011-12-20 2012-12-20 ПРИМЕНЕНИЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ p75 ДЛЯ ЛЕЧЕНИЯ ГИПЕРАКТИВНОСТИ МОЧЕВОГО ПУЗЫРЯ EA028616B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306709.4 2011-12-20
EP11306709.4A EP2606894A1 (en) 2011-12-20 2011-12-20 Novel therapeutic use of p75 receptor antagonists
PCT/EP2012/076494 WO2013092918A1 (en) 2011-12-20 2012-12-20 Novel therapeutic use of p75 receptor antagonists

Publications (2)

Publication Number Publication Date
EA201491226A1 true EA201491226A1 (ru) 2014-10-30
EA028616B1 EA028616B1 (ru) 2017-12-29

Family

ID=47429839

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491226A EA028616B1 (ru) 2011-12-20 2012-12-20 ПРИМЕНЕНИЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ p75 ДЛЯ ЛЕЧЕНИЯ ГИПЕРАКТИВНОСТИ МОЧЕВОГО ПУЗЫРЯ

Country Status (24)

Country Link
US (2) US20140296513A1 (ru)
EP (2) EP2606894A1 (ru)
JP (2) JP6275649B2 (ru)
KR (1) KR20140103151A (ru)
CN (1) CN104144688B (ru)
AR (1) AR089344A1 (ru)
AU (2) AU2012356922B2 (ru)
BR (1) BR112014014933A2 (ru)
CA (1) CA2859582A1 (ru)
CL (1) CL2014001619A1 (ru)
CO (1) CO6990740A2 (ru)
CR (1) CR20140298A (ru)
DO (1) DOP2014000137A (ru)
EA (1) EA028616B1 (ru)
HK (1) HK1198580A1 (ru)
IL (1) IL233189A0 (ru)
MA (1) MA35850B1 (ru)
MX (1) MX2014007673A (ru)
PE (1) PE20141854A1 (ru)
PH (1) PH12014501390A1 (ru)
SG (1) SG11201403390QA (ru)
TN (1) TN2014000269A1 (ru)
UY (1) UY34535A (ru)
WO (1) WO2013092918A1 (ru)

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3236243A1 (de) 1982-09-30 1984-04-05 Merck Patent Gmbh, 6100 Darmstadt Schwefelhaltige indolderivate
FR2744448B1 (fr) 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
JP2001503397A (ja) 1996-10-21 2001-03-13 アレリックス バイオファーマシューティカルズ インコーポレイテッド ニューロトロフィンアンタゴニスト組成物
AU749271B2 (en) 1997-07-01 2002-06-20 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
DE19826841A1 (de) 1998-06-16 1999-12-23 Merck Patent Gmbh Arylalkanoylpyridazine
GB9905010D0 (en) 1999-03-04 1999-04-28 Merck Sharp & Dohme Therapeutic agents
CA2369945A1 (en) 1999-04-06 2000-10-12 James L. Kelley Neurotrophic thio substituted pyrimidines
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
FR2803593B1 (fr) 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
UA77526C2 (en) 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862968B1 (fr) 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
FR2862967B1 (fr) 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
EP1797054A2 (en) 2004-08-02 2007-06-20 OSI Pharmaceuticals, Inc. Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
WO2007030939A2 (en) * 2005-09-15 2007-03-22 Painceptor Pharma Corporation Methods of modulating neurotrophin-mediated activity
US20110071180A1 (en) 2008-03-05 2011-03-24 Targacept, Inc. Sub-type selective amides of diazabicycloalkanes
PE20091717A1 (es) 2008-03-24 2009-11-25 Medivation Technologies Inc Pirido[3,4-b] indoles como moduladores de receptores de histamina
CN101284838B (zh) 2008-06-06 2011-05-04 天津药物研究院 含噻吩并吡啶的哌嗪类衍生物、其制备方法和用途
FR2932482B1 (fr) 2008-06-13 2010-10-08 Sanofi Aventis Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75
FR2932481B1 (fr) 2008-06-13 2010-10-08 Sanofi Aventis Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.
JP2010254641A (ja) * 2009-04-28 2010-11-11 Astellas Pharma Inc アゾールカルボキサミド化合物又はその塩
FR2953836B1 (fr) 2009-12-14 2012-03-16 Sanofi Aventis Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75
FR2953839A1 (fr) 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75

Also Published As

Publication number Publication date
CN104144688A (zh) 2014-11-12
PE20141854A1 (es) 2014-12-11
NZ626485A (en) 2016-11-25
CA2859582A1 (en) 2013-06-27
US9763940B2 (en) 2017-09-19
JP6275649B2 (ja) 2018-02-07
IL233189A0 (en) 2014-07-31
US20170056400A1 (en) 2017-03-02
EA028616B1 (ru) 2017-12-29
AU2012356922A1 (en) 2014-07-17
KR20140103151A (ko) 2014-08-25
CN104144688B (zh) 2017-03-22
DOP2014000137A (es) 2014-07-31
AR089344A1 (es) 2014-08-13
BR112014014933A2 (pt) 2017-06-13
US20140296513A1 (en) 2014-10-02
WO2013092918A1 (en) 2013-06-27
CR20140298A (es) 2014-10-29
AU2017248550A1 (en) 2017-11-09
JP2015500863A (ja) 2015-01-08
HK1198580A1 (en) 2015-04-30
CL2014001619A1 (es) 2014-10-17
JP2018030865A (ja) 2018-03-01
EP2793889A1 (en) 2014-10-29
EP2606894A1 (en) 2013-06-26
SG11201403390QA (en) 2014-07-30
MX2014007673A (es) 2014-11-14
TN2014000269A1 (en) 2015-09-30
UY34535A (es) 2013-07-31
CO6990740A2 (es) 2014-07-10
AU2012356922B2 (en) 2017-11-09
MA35850B1 (fr) 2014-12-01
PH12014501390A1 (en) 2014-09-22

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG TJ TM