EA201400623A1 - Новые 2h-индазолы в качестве антагонистов рецептора ep - Google Patents

Новые 2h-индазолы в качестве антагонистов рецептора ep

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Publication number
EA201400623A1
EA201400623A1 EA201400623A EA201400623A EA201400623A1 EA 201400623 A1 EA201400623 A1 EA 201400623A1 EA 201400623 A EA201400623 A EA 201400623A EA 201400623 A EA201400623 A EA 201400623A EA 201400623 A1 EA201400623 A1 EA 201400623A1
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EA
Eurasian Patent Office
Prior art keywords
new
indasols
epceptor
antagonists
indazoles
Prior art date
Application number
EA201400623A
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English (en)
Inventor
Нико Бройер
Анне Менгель
Ульрике Рён
Андреа Ротгери
Бернд Бухманн
Бернхард Линденталь
Антониус Тер-Лак
Original Assignee
Байер Интеллектчуал Проперти Гмбх
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47278803&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400623(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Интеллектчуал Проперти Гмбх filed Critical Байер Интеллектчуал Проперти Гмбх
Publication of EA201400623A1 publication Critical patent/EA201400623A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Изобретение относится к новым 2H-индазолам общей формулы (I), способам их получения и их применению для изготовления лекарственных средств для лечения заболеваний и показаний, которые связаны с рецептором ЕР.
EA201400623A 2011-11-28 2012-11-26 Новые 2h-индазолы в качестве антагонистов рецептора ep EA201400623A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011087170 2011-11-28
DE102012206715 2012-04-24
PCT/EP2012/073556 WO2013079425A1 (en) 2011-11-28 2012-11-26 Novel 2h-indazoles as ep2 receptor antagonists

Publications (1)

Publication Number Publication Date
EA201400623A1 true EA201400623A1 (ru) 2014-11-28

Family

ID=47278803

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400623A EA201400623A1 (ru) 2011-11-28 2012-11-26 Новые 2h-индазолы в качестве антагонистов рецептора ep

Country Status (25)

Country Link
US (1) US9062041B2 (ru)
EP (1) EP2785707B1 (ru)
JP (1) JP6192654B2 (ru)
KR (1) KR20140103984A (ru)
CN (1) CN104144922B (ru)
AR (1) AR089011A1 (ru)
AU (1) AU2012344015A1 (ru)
BR (1) BR112014012459A2 (ru)
CA (1) CA2856769A1 (ru)
CL (1) CL2014001392A1 (ru)
CO (1) CO6970595A2 (ru)
CR (1) CR20140257A (ru)
DO (1) DOP2014000114A (ru)
EA (1) EA201400623A1 (ru)
EC (1) ECSP14002542A (ru)
ES (1) ES2665510T3 (ru)
HK (1) HK1203938A1 (ru)
IL (1) IL232503A (ru)
IN (1) IN2014CN03854A (ru)
MX (1) MX2014006433A (ru)
PE (1) PE20141579A1 (ru)
PH (1) PH12014501195A1 (ru)
SG (1) SG11201402269RA (ru)
TW (1) TW201326154A (ru)
WO (1) WO2013079425A1 (ru)

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TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
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