EA201490790A1 - Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1 - Google Patents

Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1

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Publication number
EA201490790A1
EA201490790A1 EA201490790A EA201490790A EA201490790A1 EA 201490790 A1 EA201490790 A1 EA 201490790A1 EA 201490790 A EA201490790 A EA 201490790A EA 201490790 A EA201490790 A EA 201490790A EA 201490790 A1 EA201490790 A1 EA 201490790A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glyukagon
gastrin
receptor agonists
peptide conjugates
conjugates
Prior art date
Application number
EA201490790A
Other languages
English (en)
Other versions
EA028951B1 (ru
EA028951B9 (ru
Inventor
Якоб Линд Толборг
Трине Сковлунд Риге Нееруп
Келд Фосгерау
Торбен Остерлунд
Дорте Леннерт Кристенсен Алмхолт
Лоун Фрост Ларсен
Original Assignee
Зилэнд Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зилэнд Фарма А/С filed Critical Зилэнд Фарма А/С
Publication of EA201490790A1 publication Critical patent/EA201490790A1/ru
Publication of EA028951B1 publication Critical patent/EA028951B1/ru
Publication of EA028951B9 publication Critical patent/EA028951B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2207—Gastrins; Cholecystokinins [CCK]
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
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    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

Настоящее изобретение относится, среди прочего, к некоторым конъюгатам пептидов и к применению указанных конъюгатов для лечения различных заболеваний и нарушений, включая диабет (1 типа и/или 2 типа), а также заболеваний и нарушений, связанных с диабетом.
EA201490790A 2011-11-03 2012-11-02 Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1 EA028951B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161555435P 2011-11-03 2011-11-03
PCT/EP2012/071766 WO2013064669A1 (en) 2011-11-03 2012-11-02 Glp-1 receptor agonist peptide gastrin conjugates

Publications (3)

Publication Number Publication Date
EA201490790A1 true EA201490790A1 (ru) 2014-10-30
EA028951B1 EA028951B1 (ru) 2018-01-31
EA028951B9 EA028951B9 (ru) 2018-05-31

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EA201490790A EA028951B9 (ru) 2011-11-03 2012-11-02 Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1

Country Status (13)

Country Link
US (2) US9259477B2 (ru)
EP (1) EP2773377B1 (ru)
JP (1) JP6359972B2 (ru)
KR (1) KR20140100947A (ru)
CN (1) CN104144704B (ru)
AR (1) AR088636A1 (ru)
AU (1) AU2012331053A1 (ru)
BR (1) BR112014010780A2 (ru)
CA (1) CA2853884A1 (ru)
EA (1) EA028951B9 (ru)
MX (1) MX2014005351A (ru)
TW (1) TW201326194A (ru)
WO (1) WO2013064669A1 (ru)

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EA023925B1 (ru) 2010-04-27 2016-07-29 Зилэнд Фарма А/С Пептидные конъюгаты агонистов рецептора glp-1 и их применение
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CA2929459C (en) 2013-11-06 2022-05-03 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
BR112016009995B1 (pt) 2013-11-06 2023-04-18 Zealand Pharma A/S Compostos agonistas triplos glucagon-glp-1-gip
TWI705973B (zh) 2014-10-29 2020-10-01 丹麥商西蘭製藥公司 Ｇｉｐ促效劑化合物及方法
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
US10829527B2 (en) * 2016-03-10 2020-11-10 Shenzhen Hightide Biopharmaceutical, Ltd. Conjugates of islet neogenesis peptides and analogs, and methods thereof
AU2017371516C1 (en) 2016-12-09 2021-09-02 Zealand Pharma A/S Acylated GLP-1/GLP-2 dual agonists
EP3645558A2 (en) * 2017-06-29 2020-05-06 UREKA Sarl Pro-drug peptide with improved pharmaceutical properties
CN109248323B (zh) * 2017-07-14 2023-09-08 杭州先为达生物科技有限公司 酰化的glp-1衍生物
CN109331173B (zh) * 2018-12-17 2021-05-07 中国医学科学院医学实验动物研究所 胃泌素-二氧化硅微球及其用途
CN112759640B (zh) * 2020-12-09 2023-09-08 江苏师范大学 一类glp-1/胃泌素受体双重激动剂及其应用

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US20140336107A1 (en) 2014-11-13
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US9259477B2 (en) 2016-02-16
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WO2013064669A1 (en) 2013-05-10
US9861706B2 (en) 2018-01-09
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